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Q8R0V5

- I23O2_MOUSE

UniProt

Q8R0V5 - I23O2_MOUSE

Protein

Indoleamine 2,3-dioxygenase 2

Gene

Ido2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.1 Publication

    Catalytic activityi

    L-tryptophan + O2 = N-formyl-L-kynurenine.1 Publication

    Cofactori

    Binds 1 heme group per subunit.By similarity

    Enzyme regulationi

    Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan).By similarity

    Kineticsi

    Do not accept D-tryptophan as substrate.

    1. KM=38.85 mM for L-tryptophan1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi340 – 3401Iron (heme proximal ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. indoleamine 2,3-dioxygenase activity Source: MGI
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tryptophan catabolic process to kynurenine Source: MGI

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00333; UER00453.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Indoleamine 2,3-dioxygenase 2 (EC:1.13.11.-)
    Short name:
    IDO-2
    Alternative name(s):
    Indoleamine 2,3-dioxygenase-like protein 1
    Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
    Gene namesi
    Name:Ido2
    Synonyms:Indol1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2142489. Ido2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Indoleamine 2,3-dioxygenase 2PRO_0000285263Add
    BLAST

    Proteomic databases

    PaxDbiQ8R0V5.
    PRIDEiQ8R0V5.

    PTM databases

    PhosphoSiteiQ8R0V5.

    Expressioni

    Tissue specificityi

    Highest in kidney, followed by epididymis and liver (at protein level). Detected in the tails of the spermatozoa in the testis and in the kidney tubules (at protein level).1 Publication

    Gene expression databases

    CleanExiMM_INDOL1.
    GenevestigatoriQ8R0V5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8R0V5. 1 interaction.
    MINTiMINT-1869768.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R0V5.
    SMRiQ8R0V5. Positions 12-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the indoleamine 2,3-dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG73554.
    GeneTreeiENSGT00390000002154.
    HOGENOMiHOG000190192.
    InParanoidiQ8R0V5.

    Family and domain databases

    InterProiIPR000898. Indolamine_dOase.
    [Graphical view]
    PfamiPF01231. IDO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R0V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLEVPLSLG RYHISEEYGF LLPNPLEALP DHYKPWMEIA LRLPHLIENR    50
    QLRAHVYRMP LLDCRFLKSY REQRLAHMAL AAITMGFVWQ EGEGQPQKVL 100
    PRSLAIPFVE VSRNLGLPPI LVHSDLVLTN WTKRNPEGPL EISNLETIIS 150
    FPGGESLRGF ILVTVLVEKA AVPGLKALVQ GMEAIRQHSQ DTLLEALQQL 200
    RLSIQDITRA LAQMHDYVDP DIFYSVIRIF LSGWKDNPAM PVGLVYEGVA 250
    TEPLKYSGGS AAQSSVLHAF DEFLGIEHCK ESVGFLHRMR DYMPPSHKAF 300
    LEDLHVAPSL RDYILASGPG DCLMAYNQCV EALGELRSYH INVVARYIIS 350
    AATRARSRGL TNPSPHALED RGTGGTAMLS FLKSVREKTM EALLCPGA 398
    Length:398
    Mass (Da):44,468
    Last modified:October 3, 2012 - v2
    Checksum:i8916CCFE1E8B8B35
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti249 – 2491V → A in AAH26393. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC114602 Genomic DNA. No translation available.
    BC026393 mRNA. Translation: AAH26393.1.
    UniGeneiMm.219580.

    Genome annotation databases

    EnsembliENSMUST00000033953; ENSMUSP00000033953; ENSMUSG00000031549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC114602 Genomic DNA. No translation available.
    BC026393 mRNA. Translation: AAH26393.1 .
    UniGenei Mm.219580.

    3D structure databases

    ProteinModelPortali Q8R0V5.
    SMRi Q8R0V5. Positions 12-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R0V5. 1 interaction.
    MINTi MINT-1869768.

    Chemistry

    ChEMBLi CHEMBL2189159.

    PTM databases

    PhosphoSitei Q8R0V5.

    Proteomic databases

    PaxDbi Q8R0V5.
    PRIDEi Q8R0V5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033953 ; ENSMUSP00000033953 ; ENSMUSG00000031549 .

    Organism-specific databases

    MGIi MGI:2142489. Ido2.

    Phylogenomic databases

    eggNOGi NOG73554.
    GeneTreei ENSGT00390000002154.
    HOGENOMi HOG000190192.
    InParanoidi Q8R0V5.

    Enzyme and pathway databases

    UniPathwayi UPA00333 ; UER00453 .

    Miscellaneous databases

    PROi Q8R0V5.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_INDOL1.
    Genevestigatori Q8R0V5.

    Family and domain databases

    InterProi IPR000898. Indolamine_dOase.
    [Graphical view ]
    Pfami PF01231. IDO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    3. "Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice."
      Ball H.J., Sanchez-Perez A., Weiser S., Austin C.J.D., Astelbauer F., Miu J., McQuillan J.A., Stocker R., Jermiin L.S., Hunt N.H.
      Gene 396:203-213(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    4. Cited for: BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiI23O2_MOUSE
    AccessioniPrimary (citable) accession number: Q8R0V5
    Secondary accession number(s): E9QKA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3