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Protein

Adhesion G protein-coupled receptor G3

Gene

Adgrg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor that regulates migration of lymphatic endothelial cells via the small GTPases RhoA and CDC42 (By similarity). Regulates B-cell development (PubMed:24113187). Seems to signal through G-alpha(q)-proteins (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: UniProtKB
  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • negative regulation of CREB transcription factor activity Source: UniProtKB
  • negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • regulation of cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiP02.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor G3
Alternative name(s):
G-protein coupled receptor 97
Gene namesi
Name:Adgrg3
Synonyms:Gpr97
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1859670. Adgrg3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 267ExtracellularCuratedAdd BLAST249
Transmembranei268 – 288Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini289 – 302CytoplasmicCuratedAdd BLAST14
Transmembranei303 – 323Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini324 – 342ExtracellularCuratedAdd BLAST19
Transmembranei343 – 363Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini364 – 372CytoplasmicCurated9
Transmembranei373 – 393Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini394 – 426ExtracellularCuratedAdd BLAST33
Transmembranei427 – 447Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini448 – 467CytoplasmicCuratedAdd BLAST20
Transmembranei468 – 488Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini489 – 494ExtracellularCurated6
Transmembranei495 – 515Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini516 – 542CytoplasmicCuratedAdd BLAST27

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mutant mice show altered follicular-versus-marginal zone B-lymphocyte fate decision in the spleen and decreased numbers of B220+ lymphocytes in the bone marrow.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001289019 – 542Adhesion G protein-coupled receptor G3Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8R0T6.
PaxDbiQ8R0T6.
PRIDEiQ8R0T6.

PTM databases

iPTMnetiQ8R0T6.
PhosphoSitePlusiQ8R0T6.

Expressioni

Tissue specificityi

Specifically expressed in intestinal lymphatic endothelium.1 Publication

Gene expression databases

BgeeiENSMUSG00000060470.
CleanExiMM_GPR97.
GenevisibleiQ8R0T6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R0T6. 2 interactors.
MINTiMINT-4096549.
STRINGi10090.ENSMUSP00000051079.

Structurei

3D structure databases

ProteinModelPortaliQ8R0T6.
SMRiQ8R0T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 256GPSPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000112795.
HOVERGENiHBG051822.
InParanoidiQ8R0T6.
KOiK08452.
OMAiCVFWDVT.
OrthoDBiEOG091G0FP0.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R0T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATARSLGLL FFLLLTSDEE TTEEPRNVCR RLQEGHEYDT FDLNDTAQCF
60 70 80 90 100
TKCGQSEHSP CDVGNLQRYW LNYESYLLEN SMETVDMPFV KALIQNISTD
110 120 130 140 150
VSEDLLYSLM LSQIPRQVMQ GEDEPADGVR LPKSLFGALP GNRSAVRLAI
160 170 180 190 200
TVLDIGAGNV FKGPKLLEDK GSSVLNNRMV GLSVGQMHAT GLSEPVEITF
210 220 230 240 250
SHERQPPNVI LTCVFWDMAK GDWDSHGCST VPGDGRTVCR CDHLTFFALL
260 270 280 290 300
LRPILDLATA QTLTRISQAG SAVSMIFLAF TMVLYVAFRF SLQRFKSEDA
310 320 330 340 350
PKIHMALSIS LFLLNLTFLI NVGSSSQGPP ASCWVRAAIF HYFLLCVFTW
360 370 380 390 400
MGLEAFHLYL LAIRVFNTYF GHYFLKLSLL AWGLPVLVVI GAGSSNSYGV
410 420 430 440 450
YTIRDQENRT SLELCWFQKE PALYATVHGY FLVTFLFGAV VLALVAWKIF
460 470 480 490 500
TLPSVTAGKG QGPTWKSVLT VLGLSSLVGM TWGLAVLTPL GLSTIYVFTL
510 520 530 540
LNSLQGLFIF CWFIILYFPT QSTTASSSGT ARLDQAHSVS QE
Length:542
Mass (Da):60,072
Last modified:July 27, 2011 - v3
Checksum:iE37A23B108BA1CB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295F → L in AAH64726 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155164 mRNA. Translation: BAE33087.1.
BC026426 mRNA. Translation: AAH26426.1.
BC064726 mRNA. Translation: AAH64726.1.
CCDSiCCDS22554.1.
RefSeqiNP_766624.3. NM_173036.3.
UniGeneiMm.27995.

Genome annotation databases

EnsembliENSMUST00000051259; ENSMUSP00000051079; ENSMUSG00000060470.
GeneIDi54672.
KEGGimmu:54672.
UCSCiuc009mxp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155164 mRNA. Translation: BAE33087.1.
BC026426 mRNA. Translation: AAH26426.1.
BC064726 mRNA. Translation: AAH64726.1.
CCDSiCCDS22554.1.
RefSeqiNP_766624.3. NM_173036.3.
UniGeneiMm.27995.

3D structure databases

ProteinModelPortaliQ8R0T6.
SMRiQ8R0T6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R0T6. 2 interactors.
MINTiMINT-4096549.
STRINGi10090.ENSMUSP00000051079.

Protein family/group databases

MEROPSiP02.024.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8R0T6.
PhosphoSitePlusiQ8R0T6.

Proteomic databases

MaxQBiQ8R0T6.
PaxDbiQ8R0T6.
PRIDEiQ8R0T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051259; ENSMUSP00000051079; ENSMUSG00000060470.
GeneIDi54672.
KEGGimmu:54672.
UCSCiuc009mxp.2. mouse.

Organism-specific databases

CTDi222487.
MGIiMGI:1859670. Adgrg3.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000112795.
HOVERGENiHBG051822.
InParanoidiQ8R0T6.
KOiK08452.
OMAiCVFWDVT.
OrthoDBiEOG091G0FP0.
TreeFamiTF321769.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ8R0T6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060470.
CleanExiMM_GPR97.
GenevisibleiQ8R0T6. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG3_MOUSE
AccessioniPrimary (citable) accession number: Q8R0T6
Secondary accession number(s): Q3U2Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.