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Protein

Zinc finger protein 768

Gene

Znf768

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri289 – 311C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 768
Gene namesi
Name:Znf768
Synonyms:Zfp768
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2384582. Zfp768.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044091 – 568Zinc finger protein 768Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei35PhosphothreonineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei107PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei149PhosphoserineBy similarity1
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R0T2.
PaxDbiQ8R0T2.
PeptideAtlasiQ8R0T2.
PRIDEiQ8R0T2.

PTM databases

iPTMnetiQ8R0T2.
PhosphoSitePlusiQ8R0T2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047371.
CleanExiMM_ZFP768.
ExpressionAtlasiQ8R0T2. baseline and differential.
GenevisibleiQ8R0T2. MM.

Interactioni

Protein-protein interaction databases

BioGridi231467. 4 interactors.
IntActiQ8R0T2. 1 interactor.
MINTiMINT-1577320.
STRINGi10090.ENSMUSP00000055374.

Structurei

3D structure databases

ProteinModelPortaliQ8R0T2.
SMRiQ8R0T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 150Pro-richAdd BLAST93

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri289 – 311C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00880000137903.
HOGENOMiHOG000234617.
HOVERGENiHBG105926.
InParanoidiQ8R0T2.
KOiK09228.
OMAiSRYESQN.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8R0T2.
TreeFamiTF350793.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR000684. RNA_pol_II_repeat_euk.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF05001. RNA_pol_Rpb1_R. 2 hits.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 10 hits.
SUPFAMiSSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.

Sequencei

Sequence statusi: Complete.

Q8R0T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEREASSWGL ESRDVHSPNA VGSPEGSLKD PAGNTSENEE GEISQREGNG
60 70 80 90 100
DYEVEEIPFG LEPQSPEFEP QSPEFESQSP RFEPESPGFE SRSPGFVPPS
110 120 130 140 150
PEFAPRSPES DPQSPEFESQ SPKYEPRSPG CHPRSPGCEP GSPRYEPKSP
160 170 180 190 200
GYGSKSPEFE SQSPGYESQS PGYEPQNSGD GVQNSEFKTH SPEFETQSSK
210 220 230 240 250
FQEGAEMPLS PEEKNPLSIS LGVHPLDSFT QGFGEQPTGA LPPFDMPSGA
260 270 280 290 300
LLAAPQFEML QNPLNLTGTL RGPGRRGGRA RGGQGPRPNI CGICGKSFGR
310 320 330 340 350
GSTLIQHQRI HTGEKPYKCE VCSKAFSQSS DLIKHQRTHT GERPYKCPRC
360 370 380 390 400
GKAFADSSYL LRHQRTHSGQ KPYKCPHCGK AFGDSSYLLR HQRTHSHERP
410 420 430 440 450
YSCPECGKCY SQNSSLRSHQ RVHTGQRPFS CGICGKSFSQ RSALIPHARS
460 470 480 490 500
HAREKPFKCP ECGKRFGQSS VLAIHARTHL PGRTYSCPDC GKTFNRSSTL
510 520 530 540 550
IQHQRSHTGE RPYRCAVCGK GFCRSSTLLQ HHRVHSGERP YKCDDCGKAF
560
SQSSDLIRHQ RTHAAGRR
Length:568
Mass (Da):62,711
Last modified:June 1, 2002 - v1
Checksum:i5CD7C426EE3C10C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155155 mRNA. Translation: BAE33082.1.
BC026432 mRNA. Translation: AAH26432.1.
CCDSiCCDS21864.1.
RefSeqiNP_666314.1. NM_146202.1.
UniGeneiMm.23031.

Genome annotation databases

EnsembliENSMUST00000060783; ENSMUSP00000055374; ENSMUSG00000047371.
GeneIDi233890.
KEGGimmu:233890.
UCSCiuc009jvc.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN768_MOUSE
AccessioniPrimary (citable) accession number: Q8R0T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families