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Protein

Voltage-dependent L-type calcium channel subunit beta-4

Gene

Cacnb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.By similarity

GO - Molecular functioni

  • high voltage-gated calcium channel activity Source: MGI
  • protein kinase binding Source: Ensembl
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  • adult walking behavior Source: MGI
  • calcium ion transport Source: MGI
  • cAMP metabolic process Source: MGI
  • cellular calcium ion homeostasis Source: MGI
  • cellular response to leukemia inhibitory factor Source: MGI
  • detection of light stimulus involved in visual perception Source: MGI
  • gamma-aminobutyric acid secretion Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: MGI
  • muscle fiber development Source: MGI
  • neurological system process Source: MGI
  • neuromuscular junction development Source: MGI
  • neuronal action potential propagation Source: MGI
  • Peyer's patch development Source: MGI
  • regulation of membrane potential Source: MGI
  • regulation of voltage-gated calcium channel activity Source: MGI
  • spleen development Source: MGI
  • synaptic transmission, glutamatergic Source: MGI
  • T cell receptor signaling pathway Source: MGI
  • thymus development Source: MGI

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-112308. Presynaptic depolarization and calcium channel opening.
R-MMU-419037. NCAM1 interactions.
R-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit beta-4Curated
Short name:
CAB4Curated
Alternative name(s):
Calcium channel voltage-dependent subunit beta 4Curated
Gene namesi
Name:Cacnb4Imported
Synonyms:Cacnlb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:103301. Cacnb4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440611 – 519Voltage-dependent L-type calcium channel subunit beta-4Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineBy similarity1
Modified residuei182PhosphoserineCombined sources1
Modified residuei410PhosphothreonineCombined sources1
Modified residuei447PhosphoserineBy similarity1
Modified residuei505Omega-N-methylarginineCombined sources1
Modified residuei507PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R0S4.
PaxDbiQ8R0S4.
PeptideAtlasiQ8R0S4.
PRIDEiQ8R0S4.

PTM databases

iPTMnetiQ8R0S4.
PhosphoSitePlusiQ8R0S4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017412.
ExpressionAtlasiQ8R0S4. baseline and differential.
GenevisibleiQ8R0S4. MM.

Interactioni

Subunit structurei

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG (By similarity). Interacts with CBARP (PubMed:24751537).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198442. 3 interactors.
IntActiQ8R0S4. 9 interactors.
STRINGi10090.ENSMUSP00000077438.

Structurei

3D structure databases

ProteinModelPortaliQ8R0S4.
SMRiQ8R0S4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R0S4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 160SH3PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
GeneTreeiENSGT00390000002740.
HOGENOMiHOG000230979.
HOVERGENiHBG050765.
InParanoidiQ8R0S4.
KOiK04865.
PhylomeDBiQ8R0S4.
TreeFamiTF316195.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR000584. VDCC_L_bsu.
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
PRINTSiPR01626. LCACHANNELB.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q8R0S4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSYGKNGA ADGPHSPSSQ VARGTTTRRS RLKRSDGSTT STSFILRQGS
60 70 80 90 100
ADSYTSRPSD SDVSLEEDRE AIRQEREQQA AIQLERAKSK PVAFAVKTNV
110 120 130 140 150
SYCGALDEDV PVPSTAISFD AKDFLHIKEK YNNDWWIGRL VKEGCEIGFI
160 170 180 190 200
PSPLRLENIR IQQEQKRGRF HGGKSSGNSS SSLGEMVSGT FRATPTTTAK
210 220 230 240 250
QKQKVTEHIP PYDVVPSMRP VVLVGPSLKG YEVTDMMQKA LFDFLKHRFD
260 270 280 290 300
GRISITRVTA DISLAKRSVL NNPSKRAIIE RSNTRSSLAE VQSEIERIFE
310 320 330 340 350
LARSLQLVVL DADTINHPAQ LIKTSLAPII VHVKVSSPKV LQRLIKSRGK
360 370 380 390 400
SQSKHLNVQL VAADKLAQCP PEMFDVILDE NQLEDACEHL GEYLEAYWRA
410 420 430 440 450
THTSSSTPMT PLLGRNVGST ALSPYPTAIS GLQSQRMRHS NHSTENSPIE
460 470 480 490 500
RRSLMTSDEN YHNERARKSR NRLSSSSQHS RDHYPLVEED YPDSYQDTYK
510
PHRNRGSPGG CSHDSRHRL
Length:519
Mass (Da):57,950
Last modified:January 23, 2007 - v2
Checksum:i663A88C7BCF7E90C
GO
Isoform 1 (identifier: Q8R0S4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MSSSYGKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQ → MYDNLYLHGVEDSEA

Show »
Length:486
Mass (Da):54,619
Checksum:iF4FCDD8810D75696
GO
Isoform 2 (identifier: Q8R0S4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MSSSYGKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQ → MA

Note: No experimental confirmation available.
Show »
Length:473
Mass (Da):53,084
Checksum:i1EA0EE1CA4264A65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti492P → A in BAC31681 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225991 – 48MSSSY…FILRQ → MYDNLYLHGVEDSEA in isoform 1. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_0107371 – 48MSSSY…FILRQ → MA in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100402 Genomic DNA. Translation: BAC80139.1.
AK038633 mRNA. Translation: BAC30073.1.
AK043850 mRNA. Translation: BAC31681.1.
AK079616 mRNA. Translation: BAC37703.1.
AK147338 mRNA. Translation: BAE27855.1.
BC026479 mRNA. Translation: AAH26479.1.
CCDSiCCDS16034.1. [Q8R0S4-3]
CCDS16035.1. [Q8R0S4-1]
CCDS71052.1. [Q8R0S4-2]
RefSeqiNP_001032176.1. NM_001037099.2. [Q8R0S4-3]
NP_001272356.1. NM_001285427.1. [Q8R0S4-2]
NP_666235.1. NM_146123.3. [Q8R0S4-1]
XP_006497704.1. XM_006497641.3. [Q8R0S4-2]
XP_011237317.1. XM_011239015.1. [Q8R0S4-2]
XP_017170652.1. XM_017315163.1. [Q8R0S4-2]
UniGeneiMm.330223.

Genome annotation databases

EnsembliENSMUST00000078324; ENSMUSP00000077438; ENSMUSG00000017412. [Q8R0S4-3]
ENSMUST00000102760; ENSMUSP00000099821; ENSMUSG00000017412. [Q8R0S4-1]
ENSMUST00000102761; ENSMUSP00000099822; ENSMUSG00000017412. [Q8R0S4-2]
GeneIDi12298.
KEGGimmu:12298.
UCSCiuc008jra.2. mouse. [Q8R0S4-1]
uc008jrb.2. mouse. [Q8R0S4-2]
uc008jrc.1. mouse. [Q8R0S4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCACB4_MOUSE
AccessioniPrimary (citable) accession number: Q8R0S4
Secondary accession number(s): Q3UHK2, Q8BRN6, Q8CAJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families