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Protein

IQ motif and SEC7 domain-containing protein 1

Gene

Iqsec1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
IQ motif and SEC7 domain-containing protein 1
Gene namesi
Name:Iqsec1
Synonyms:Kiaa0763
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1196356 Iqsec1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002456071 – 961IQ motif and SEC7 domain-containing protein 1Add BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei890PhosphoserineBy similarity1
Modified residuei909PhosphotyrosineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei923PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R0S2
PaxDbiQ8R0S2
PeptideAtlasiQ8R0S2
PRIDEiQ8R0S2

PTM databases

iPTMnetiQ8R0S2
PhosphoSitePlusiQ8R0S2

Expressioni

Gene expression databases

BgeeiENSMUSG00000034312
CleanExiMM_IQSEC1
ExpressionAtlasiQ8R0S2 baseline and differential
GenevisibleiQ8R0S2 MM

Interactioni

Subunit structurei

Interacts with ARF1 and ARF6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231231, 13 interactors
IntActiQ8R0S2, 11 interactors
STRINGi10090.ENSMUSP00000098710

Structurei

3D structure databases

ProteinModelPortaliQ8R0S2
SMRiQ8R0S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 162IQPROSITE-ProRule annotationAdd BLAST30
Domaini515 – 708SEC7PROSITE-ProRule annotationAdd BLAST194
Domaini772 – 864PHAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili846 – 877Sequence analysisAdd BLAST32

Domaini

The PH domain mediates interaction with lipid membranes that contain phosphatidylinositol-4,5-bisphosphate, but does not bind membranes that lack phosphatidylinositol-4,5-bisphosphate.By similarity

Sequence similaritiesi

Belongs to the BRAG family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0931 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00760000119036
HOGENOMiHOG000113099
HOVERGENiHBG056324
InParanoidiQ8R0S2
KOiK12495
PhylomeDBiQ8R0S2
TreeFamiTF323811

Family and domain databases

CDDicd13318 PH_IQSEC, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR030737 IQSEC1
IPR033742 IQSEC_PH
IPR011993 PH-like_dom_sf
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PANTHERiPTHR44233:SF3 PTHR44233:SF3, 1 hit
PfamiView protein in Pfam
PF16453 IQ_SEC7_PH, 1 hit
PF01369 Sec7, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50190 SEC7, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWCLHCNSER TQSLLELELD SGVEGEAPSS ETGTSLDSPS AYHQGPLVPG
60 70 80 90 100
SSLSPDHYEH TSVGAYGLYA GPGPQQRTRR PRLQHSTSVL RKQAEEEAIK
110 120 130 140 150
RSRSLSESYE LSSDLQDKQV EMLERKYGGR LVTRHAARTI QTAFRQYQMN
160 170 180 190 200
KNFERLRSSM SENRMSRRIV LSNMRMQFSF EGPEKVHSSY FEGKQVSVTN
210 220 230 240 250
DGSQLGALVP SECGDLSDPA LKSPAPSSDF ADAITELEDA FSRQVKSLAE
260 270 280 290 300
SIDDALNCRS LHSEEVPASD TARARDTEPK PGLHGMDHRK LDEMTASYSD
310 320 330 340 350
VTLYIDEEEL SPPLPLSQAG DRPSSTESDL RLRSGGAAQD YWALAHKEDK
360 370 380 390 400
ADTDTSCRST PSLERPEPRL RVEHLPLLTI EPPSDSSVEL SDRSDRSSLK
410 420 430 440 450
RQSAYERSLG GQQGSPKHGP HGGPPKGLPR EEPELRPRPP RPLESHLAIN
460 470 480 490 500
GSANRQSKSE SDYSDGDNDS INSTSNSNDT INCSSESSSR DSLREQTLSK
510 520 530 540 550
QTYHKETRNS WDSPAFSNDV IRKRHYRIGL NLFNKKPEKG IQYLIERGFV
560 570 580 590 600
PDTPVGVAHF LLQRKGLSRQ MIGEFLGNRQ KQFNRDVLDC VVDEMDFSAM
610 620 630 640 650
ELDEALRKFQ AHIRVQGEAQ KVERLIEAFS QRYCVCNPGV VRQFRNPDTI
660 670 680 690 700
FILAFAIILL NTDMYSPNVK PERKMKLEDF VKNLRGVDDG EDIPRETLIG
710 720 730 740 750
IYERIRKREL KTNEDHVSQV QKVEKLIVGK KPIGSLHHGL GCVLSLPHRR
760 770 780 790 800
LVCYCRLFEV PDPNKPQKLG LHQREIFLFN DLLVVTKIFQ KKKNSVTYSF
810 820 830 840 850
RQSFSLYGMQ VLLFENQYYP NGIRLTSAVP GADIKVLINF NAPNPQDRKK
860 870 880 890 900
FTDDLRESVA EVQEMEKHRI ESELEKQKGV VRPSMSQCSS LKKESGNGTL
910 920 930 940 950
SRACLDDSYA SGEGLKRSAL SSSLRDLSEA GKRGRRSSAG SLESNVEFQP
960
FQPPQPPVLC S
Length:961
Mass (Da):108,015
Last modified:July 11, 2006 - v2
Checksum:i44E9B61CE2445325
GO
Isoform 2 (identifier: Q8R0S2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MWCLHCNSERTQSLLELELDSG → MKGDGGAVWGLMWKYCISVRTLS

Note: No experimental confirmation available.
Show »
Length:962
Mass (Da):108,009
Checksum:iAB75E35ABE8F5131
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti759E → Q in BAD90418 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0197591 – 22MWCLH…ELDSG → MKGDGGAVWGLMWKYCISVR TLS in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121954 Genomic DNA No translation available.
AK157963 mRNA Translation: BAE34286.1
BC026481 mRNA Translation: AAH26481.1
AK220355 mRNA Translation: BAD90418.1
CCDSiCCDS51850.1 [Q8R0S2-1]
RefSeqiNP_001127855.1, NM_001134383.1 [Q8R0S2-1]
UniGeneiMm.196943
Mm.473438

Genome annotation databases

EnsembliENSMUST00000101153; ENSMUSP00000098712; ENSMUSG00000034312 [Q8R0S2-1]
GeneIDi232227
KEGGimmu:232227
UCSCiuc009cxq.2 mouse [Q8R0S2-1]
uc033itn.1 mouse [Q8R0S2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIQEC1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0S2
Secondary accession number(s): Q3TZC3, Q5DU15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health