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Q8R0S1

- ATF7_MOUSE

UniProt

Q8R0S1 - ATF7_MOUSE

Protein

Cyclic AMP-dependent transcription factor ATF-7

Gene

Atf7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3125C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-7
    Short name:
    cAMP-dependent transcription factor ATF-7
    Alternative name(s):
    Activating transcription factor 7
    Transcription factor ATF-A
    Gene namesi
    Name:Atf7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2443472. Atf7.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Nucleusnucleoplasm By similarity
    Note: Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear peiphery By similarity.By similarity

    GO - Cellular componenti

    1. nuclear periphery Source: UniProtKB
    2. nucleoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Cyclic AMP-dependent transcription factor ATF-7PRO_0000076593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511Phosphothreonine; by MAPK111 Publication
    Modified residuei53 – 531Phosphothreonine1 Publication
    Modified residuei101 – 1011PhosphothreonineBy similarity
    Cross-linki107 – 107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1)By similarity

    Post-translational modificationi

    On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity By similarity.By similarity
    Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase By similarity.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ8R0S1.
    PRIDEiQ8R0S1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R0S1.
    BgeeiQ8R0S1.
    CleanExiMM_ATF7.
    GenevestigatoriQ8R0S1.

    Interactioni

    Subunit structurei

    Homodimer; binds DNA as homodimer By similarity. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members By similarity. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 the interaction potentiates the transactivation activity and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN By similarity.By similarity

    Protein-protein interaction databases

    BioGridi230215. 2 interactions.
    IntActiQ8R0S1. 1 interaction.
    MINTiMINT-7557949.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R0S1.
    SMRiQ8R0S1. Positions 1-38, 334-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini332 – 39564bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 285285Transactivation domainBy similarityAdd
    BLAST
    Regioni334 – 35421Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni360 – 38829Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi118 – 253136Pro-richAdd
    BLAST
    Compositional biasi322 – 3254Poly-Arg

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
    Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3125C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG306955.
    GeneTreeiENSGT00390000020106.
    HOVERGENiHBG004300.
    KOiK09045.
    OMAiTPDVKIK.
    OrthoDBiEOG741Z31.
    PhylomeDBiQ8R0S1.

    Family and domain databases

    Gene3Di3.30.160.60. 1 hit.
    InterProiIPR004827. bZIP.
    IPR016378. TF_cAMP-dep.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
    SMARTiSM00338. BRLZ. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R0S1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDDRPFVCS APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ    50
    TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK ASDDDEKKGA AGPLDMSLPS 100
    TPDIKIKEEE PVEVDSSPPD SPASSPCSPP LKEKEVTTKP VVISTPTPTI 150
    VRPGSLPLHL GYDPLHPTLP SPTSVITQAP PSNRQIGSPT GSLPLVMHLA 200
    NGQTMPMLPG PPVQMPSVIS LARPVSMVPN IPGIPGPPVN NSGSISPSGH 250
    PMPSEAKMRL KATLTHQVSS INGGCGMVVG TASTMVTARP EQNQILIQHP 300
    DAPSPAQPQV SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR 350
    QKRKLWVSSL EKKAEELTSQ NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV 400
    TALQKKTQGY LGK 413
    Length:413
    Mass (Da):44,608
    Last modified:June 1, 2002 - v1
    Checksum:iAFF4D1A7BFE71AF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC026483 mRNA. Translation: AAH26483.1.
    CCDSiCCDS37230.1.
    RefSeqiNP_666177.1. NM_146065.1.
    UniGeneiMm.208714.
    Mm.475149.

    Genome annotation databases

    EnsembliENSMUST00000108828; ENSMUSP00000104456; ENSMUSG00000099083.
    ENSMUST00000169033; ENSMUSP00000130130; ENSMUSG00000099083.
    GeneIDi223922.
    KEGGimmu:223922.
    UCSCiuc007xwo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC026483 mRNA. Translation: AAH26483.1 .
    CCDSi CCDS37230.1.
    RefSeqi NP_666177.1. NM_146065.1.
    UniGenei Mm.208714.
    Mm.475149.

    3D structure databases

    ProteinModelPortali Q8R0S1.
    SMRi Q8R0S1. Positions 1-38, 334-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230215. 2 interactions.
    IntActi Q8R0S1. 1 interaction.
    MINTi MINT-7557949.

    Proteomic databases

    PaxDbi Q8R0S1.
    PRIDEi Q8R0S1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108828 ; ENSMUSP00000104456 ; ENSMUSG00000099083 .
    ENSMUST00000169033 ; ENSMUSP00000130130 ; ENSMUSG00000099083 .
    GeneIDi 223922.
    KEGGi mmu:223922.
    UCSCi uc007xwo.1. mouse.

    Organism-specific databases

    CTDi 11016.
    MGIi MGI:2443472. Atf7.

    Phylogenomic databases

    eggNOGi NOG306955.
    GeneTreei ENSGT00390000020106.
    HOVERGENi HBG004300.
    KOi K09045.
    OMAi TPDVKIK.
    OrthoDBi EOG741Z31.
    PhylomeDBi Q8R0S1.

    Miscellaneous databases

    ChiTaRSi ATF7. mouse.
    NextBioi 376970.
    PROi Q8R0S1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R0S1.
    Bgeei Q8R0S1.
    CleanExi MM_ATF7.
    Genevestigatori Q8R0S1.

    Family and domain databases

    Gene3Di 3.30.160.60. 1 hit.
    InterProi IPR004827. bZIP.
    IPR016378. TF_cAMP-dep.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003153. ATF2_CRE-BP1. 1 hit.
    SMARTi SM00338. BRLZ. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51 AND THR-53, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiATF7_MOUSE
    AccessioniPrimary (citable) accession number: Q8R0S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3