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Protein

Protein ABHD8

Gene

Abhd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei244Charge relay systemBy similarity1
Active sitei362Charge relay systemBy similarity1
Active sitei390Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERimouse-Abhd8. Epoxide_hydrolase.
MEROPSiS33.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD8Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 8Curated
Short name:
Abhydrolase domain-containing protein 8Imported
Gene namesi
Name:Abhd8Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1918946. Abhd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002813841 – 439Protein ABHD8Add BLAST439

Proteomic databases

EPDiQ8R0P8.
PaxDbiQ8R0P8.
PRIDEiQ8R0P8.

PTM databases

iPTMnetiQ8R0P8.
PhosphoSitePlusiQ8R0P8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007950.
CleanExiMM_ABHD8.
GenevisibleiQ8R0P8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R0P8. 1 interactor.
STRINGi10090.ENSMUSP00000008094.

Structurei

3D structure databases

ProteinModelPortaliQ8R0P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 271AB hydrolase-1Sequence analysisAdd BLAST103

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2382. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000007336.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ8R0P8.
KOiK13701.
OMAiFFCCLLG.
OrthoDBiEOG091G09BH.
PhylomeDBiQ8R0P8.
TreeFamiTF331708.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R0P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEHTMLTG VTDGFFCCLL GTPPNAVRPL ESVESSDGYT FVEVKPGRVL
60 70 80 90 100
RVKHAGPAPI PTPPPPPPED DPGVKTGLVR CQRRITVYRN GRLVVENLGR
110 120 130 140 150
APRADLQGRS GSGDPPAALE VELAEPAGGD TRANPGSGRR RRPRRPKRTI
160 170 180 190 200
HIDCEQRITS CKGAQADVVL FFIHGVGGSL AIWKEQLDFF VRLGYEVVAP
210 220 230 240 250
DLAGHGASSA PQVAAAYTFY ALAEDMRAIF TRYAKKRNVL IGHSYGVSFC
260 270 280 290 300
TFLAHEYPDL VHKVIMINGG GPTALEPSLC SIFNMPTCVL HCLSPCLAWS
310 320 330 340 350
FLKAGFARQG AKEKQLLKEG NAFNVSSFVL RAMMSGQYWP EGDEVYHAEL
360 370 380 390 400
TVPVLLVHGM HDKFVPVEED QRMAEILLLA FLKLIEEGSH MVMLECPETV
410 420 430
NTLLHEFLLW EPEPEAEPKL EPKPKPQLLQ PEPAPGEEK
Length:439
Mass (Da):48,229
Last modified:June 1, 2002 - v1
Checksum:iA3FDE2A1174C2481
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84R → P in BAB22558 (PubMed:16141072).Curated1
Sequence conflicti248S → F in BAA92755 (PubMed:10679242).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030191 mRNA. Translation: BAA92755.1.
AK003090 mRNA. Translation: BAB22558.1.
AK155503 mRNA. Translation: BAE33297.1.
BC026540 mRNA. Translation: AAH26540.1.
CCDSiCCDS40382.1.
RefSeqiNP_071864.2. NM_022419.3.
UniGeneiMm.276383.

Genome annotation databases

EnsembliENSMUST00000008094; ENSMUSP00000008094; ENSMUSG00000007950.
GeneIDi64296.
KEGGimmu:64296.
UCSCiuc009mdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030191 mRNA. Translation: BAA92755.1.
AK003090 mRNA. Translation: BAB22558.1.
AK155503 mRNA. Translation: BAE33297.1.
BC026540 mRNA. Translation: AAH26540.1.
CCDSiCCDS40382.1.
RefSeqiNP_071864.2. NM_022419.3.
UniGeneiMm.276383.

3D structure databases

ProteinModelPortaliQ8R0P8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R0P8. 1 interactor.
STRINGi10090.ENSMUSP00000008094.

Protein family/group databases

ESTHERimouse-Abhd8. Epoxide_hydrolase.
MEROPSiS33.011.

PTM databases

iPTMnetiQ8R0P8.
PhosphoSitePlusiQ8R0P8.

Proteomic databases

EPDiQ8R0P8.
PaxDbiQ8R0P8.
PRIDEiQ8R0P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008094; ENSMUSP00000008094; ENSMUSG00000007950.
GeneIDi64296.
KEGGimmu:64296.
UCSCiuc009mdf.2. mouse.

Organism-specific databases

CTDi79575.
MGIiMGI:1918946. Abhd8.

Phylogenomic databases

eggNOGiKOG2382. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000007336.
HOGENOMiHOG000261674.
HOVERGENiHBG080814.
InParanoidiQ8R0P8.
KOiK13701.
OMAiFFCCLLG.
OrthoDBiEOG091G09BH.
PhylomeDBiQ8R0P8.
TreeFamiTF331708.

Miscellaneous databases

ChiTaRSiAbhd8. mouse.
PROiQ8R0P8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007950.
CleanExiMM_ABHD8.
GenevisibleiQ8R0P8. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHD8_MOUSE
AccessioniPrimary (citable) accession number: Q8R0P8
Secondary accession number(s): Q9DC79, Q9JMF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.