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Protein

Mth938 domain-containing protein

Gene

Aamdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in preadipocyte differentiation and adipogenesis.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mth938 domain-containing protein
Alternative name(s):
LI2
Gene namesi
Name:Aamdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913523. Aamdc.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Diffuse distribution with some highly concentrated spots around the nucleus.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122Mth938 domain-containing proteinPRO_0000239815Add
BLAST

Proteomic databases

EPDiQ8R0P4.
MaxQBiQ8R0P4.
PaxDbiQ8R0P4.
PRIDEiQ8R0P4.

PTM databases

iPTMnetiQ8R0P4.
PhosphoSiteiQ8R0P4.

Expressioni

Tissue specificityi

Widely expressed, with high expression in the adipose tissue and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiQ8R0P4.
CleanExiMM_1810020D17RIK.
ExpressionAtlasiQ8R0P4. baseline and differential.
GenevisibleiQ8R0P4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115672.

Structurei

3D structure databases

ProteinModelPortaliQ8R0P4.
SMRiQ8R0P4. Positions 3-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni6 – 122117MTH138-like domainAdd
BLAST

Sequence similaritiesi

Belongs to the AAMDC family.Curated

Phylogenomic databases

eggNOGiENOG410IXVS. Eukaryota.
ENOG41120BN. LUCA.
GeneTreeiENSGT00390000011958.
HOGENOMiHOG000223243.
HOVERGENiHBG081222.
InParanoidiQ8R0P4.
OrthoDBiEOG71RXMQ.
PhylomeDBiQ8R0P4.
TreeFamiTF332083.

Family and domain databases

Gene3Di3.40.1230.10. 1 hit.
InterProiIPR007523. NDUFAF3/AAMDC.
[Graphical view]
PfamiPF04430. DUF498. 1 hit.
[Graphical view]
SUPFAMiSSF64076. SSF64076. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPKIASLS WGQMKVQGST LTYKDCKVWP GGSRAWDWRE TGTEHSPGVQ
60 70 80 90 100
PADVKEVAEK GVQTLVIGRG MSEALKVPPS TVEYLEKQGI DVRVLQTEQA
110 120
VKEYNALVAQ GVRVGGVFHS TC
Length:122
Mass (Da):13,244
Last modified:June 1, 2002 - v1
Checksum:i1E9BFD4770DC03FE
GO
Isoform 2 (identifier: Q8R0P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-76: Missing.

Show »
Length:90
Mass (Da):9,930
Checksum:i45413770571D0B61
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 7632Missing in isoform 2. 2 PublicationsVSP_019270Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007558 mRNA. Translation: BAC25178.1.
AK008195 mRNA. Translation: BAC25205.1.
BC026557 mRNA. Translation: AAH26557.1.
BC062811 mRNA. Translation: AAH62811.1.
CCDSiCCDS21461.1. [Q8R0P4-1]
CCDS52314.1. [Q8R0P4-2]
RefSeqiNP_001171416.1. NM_001177945.1.
NP_001171417.1. NM_001177946.1.
NP_001171418.1. NM_001177947.1. [Q8R0P4-2]
NP_899074.2. NM_183251.3. [Q8R0P4-1]
XP_006508177.1. XM_006508114.2. [Q8R0P4-1]
XP_006508178.1. XM_006508115.2. [Q8R0P4-2]
UniGeneiMm.41583.

Genome annotation databases

EnsembliENSMUST00000136757; ENSMUSP00000121940; ENSMUSG00000035642. [Q8R0P4-1]
ENSMUST00000138060; ENSMUSP00000116214; ENSMUSG00000035642. [Q8R0P4-2]
GeneIDi66273.
KEGGimmu:66273.
UCSCiuc009ijl.2. mouse. [Q8R0P4-2]
uc012fpj.1. mouse. [Q8R0P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007558 mRNA. Translation: BAC25178.1.
AK008195 mRNA. Translation: BAC25205.1.
BC026557 mRNA. Translation: AAH26557.1.
BC062811 mRNA. Translation: AAH62811.1.
CCDSiCCDS21461.1. [Q8R0P4-1]
CCDS52314.1. [Q8R0P4-2]
RefSeqiNP_001171416.1. NM_001177945.1.
NP_001171417.1. NM_001177946.1.
NP_001171418.1. NM_001177947.1. [Q8R0P4-2]
NP_899074.2. NM_183251.3. [Q8R0P4-1]
XP_006508177.1. XM_006508114.2. [Q8R0P4-1]
XP_006508178.1. XM_006508115.2. [Q8R0P4-2]
UniGeneiMm.41583.

3D structure databases

ProteinModelPortaliQ8R0P4.
SMRiQ8R0P4. Positions 3-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115672.

PTM databases

iPTMnetiQ8R0P4.
PhosphoSiteiQ8R0P4.

Proteomic databases

EPDiQ8R0P4.
MaxQBiQ8R0P4.
PaxDbiQ8R0P4.
PRIDEiQ8R0P4.

Protocols and materials databases

DNASUi66273.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000136757; ENSMUSP00000121940; ENSMUSG00000035642. [Q8R0P4-1]
ENSMUST00000138060; ENSMUSP00000116214; ENSMUSG00000035642. [Q8R0P4-2]
GeneIDi66273.
KEGGimmu:66273.
UCSCiuc009ijl.2. mouse. [Q8R0P4-2]
uc012fpj.1. mouse. [Q8R0P4-1]

Organism-specific databases

CTDi28971.
MGIiMGI:1913523. Aamdc.

Phylogenomic databases

eggNOGiENOG410IXVS. Eukaryota.
ENOG41120BN. LUCA.
GeneTreeiENSGT00390000011958.
HOGENOMiHOG000223243.
HOVERGENiHBG081222.
InParanoidiQ8R0P4.
OrthoDBiEOG71RXMQ.
PhylomeDBiQ8R0P4.
TreeFamiTF332083.

Miscellaneous databases

NextBioi321169.
PROiQ8R0P4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R0P4.
CleanExiMM_1810020D17RIK.
ExpressionAtlasiQ8R0P4. baseline and differential.
GenevisibleiQ8R0P4. MM.

Family and domain databases

Gene3Di3.40.1230.10. 1 hit.
InterProiIPR007523. NDUFAF3/AAMDC.
[Graphical view]
PfamiPF04430. DUF498. 1 hit.
[Graphical view]
SUPFAMiSSF64076. SSF64076. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Pancreas and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary cancer and Thymus.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen and Testis.
  4. "Involvement of LOC66273 isoform 2, a novel Mth938 containing protein, in MAPK pathway."
    Wang H., Ma X., Zhang H., Zang J., Hu S., Li D.
    Front. Biosci. 3:1241-1248(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells."
    Ma X., Ding W., Wang J., Wu G., Zhang H., Yin J., Zhou L., Li D.
    J. Nutr. 142:448-455(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAAMDC_MOUSE
AccessioniPrimary (citable) accession number: Q8R0P4
Secondary accession number(s): Q8BH71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.