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Protein

Probable palmitoyltransferase ZDHHC1

Gene

Zdhhc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC1 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 1
Short name:
DHHC-1
Gene namesi
Name:Zdhhc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1918046. Zdhhc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128581 – 484Probable palmitoyltransferase ZDHHC1Add BLAST484

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8R0N9.
PRIDEiQ8R0N9.

PTM databases

PhosphoSitePlusiQ8R0N9.

Expressioni

Tissue specificityi

Expressed at high levels in fetal lung and heart. Expressed at lower levels in fetal liver and brain. Also detected in adult islet cells of pancreas, Leydig cells of testis, retina and molecular layer of cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000039199.
CleanExiMM_ZDHHC1.
GenevisibleiQ8R0N9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 181DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000120122.
HOVERGENiHBG059666.
InParanoidiQ8R0N9.
KOiK20027.
OMAiQEAKGAH.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ8R0N9.
TreeFamiTF317498.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R0N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNICNKPSNK TAPEKSVWTA PSQDSGPSPE LQGQRSRRNG WSWPPHPLQI
60 70 80 90 100
VAWLLYLFFA VIGFGVLVPL LPHHWVPAGY ACMGAIFAGH LVVHLTAVSI
110 120 130 140 150
DPADANVRDK SYSGPLPIFN RSQHAHVIED LHCNLCDVDV SARSKHCSAC
160 170 180 190 200
NKCVCGFDHH CKWLNNCVGE RNYRLFLHSV ASALLGVLLL VLVATYVFVE
210 220 230 240 250
FFVNPMRLRT NQHFEVLKNH TDVWFVFLPA APVETQAPAI LALAALLILL
260 270 280 290 300
GLLSTALLGH LLCFHIYLMW HKLTTYEYIV QHRPAQEAKE THKELESCPR
310 320 330 340 350
KVRSIQEMEF YMRTFSHVRP EPSGQARTAA LNANPSQFLA TQGQVEPPLP
360 370 380 390 400
SSSDTLALPP RIQPQKKRKR RVYRLPRSGV LDRELPLPRL RETGTPSRRS
410 420 430 440 450
SSSSDSTSAS PVHAGGSAGA YYSASAESME EIPVAQTRLG SAALGAPGAR
460 470 480
GRESGLALQA RSPAVFVSPS SGEPGTPGGG DGLP
Length:484
Mass (Da):52,979
Last modified:October 24, 2003 - v2
Checksum:iF80783E2EF8B2E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038593 mRNA. Translation: BAC30059.1.
BC026570 mRNA. Translation: AAH26570.2.
BC119378 mRNA. Translation: AAI19379.1.
CCDSiCCDS22603.1.
RefSeqiNP_780369.1. NM_175160.3.
XP_006531420.1. XM_006531357.3.
XP_011246802.1. XM_011248500.2.
XP_011246803.1. XM_011248501.2.
UniGeneiMm.100917.

Genome annotation databases

EnsembliENSMUST00000044286; ENSMUSP00000036471; ENSMUSG00000039199.
ENSMUST00000212303; ENSMUSP00000148381; ENSMUSG00000039199.
GeneIDi70796.
KEGGimmu:70796.
UCSCiuc009ndd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038593 mRNA. Translation: BAC30059.1.
BC026570 mRNA. Translation: AAH26570.2.
BC119378 mRNA. Translation: AAI19379.1.
CCDSiCCDS22603.1.
RefSeqiNP_780369.1. NM_175160.3.
XP_006531420.1. XM_006531357.3.
XP_011246802.1. XM_011248500.2.
XP_011246803.1. XM_011248501.2.
UniGeneiMm.100917.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036471.

PTM databases

PhosphoSitePlusiQ8R0N9.

Proteomic databases

PaxDbiQ8R0N9.
PRIDEiQ8R0N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044286; ENSMUSP00000036471; ENSMUSG00000039199.
ENSMUST00000212303; ENSMUSP00000148381; ENSMUSG00000039199.
GeneIDi70796.
KEGGimmu:70796.
UCSCiuc009ndd.1. mouse.

Organism-specific databases

CTDi29800.
MGIiMGI:1918046. Zdhhc1.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000120122.
HOVERGENiHBG059666.
InParanoidiQ8R0N9.
KOiK20027.
OMAiQEAKGAH.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ8R0N9.
TreeFamiTF317498.

Miscellaneous databases

PROiPR:Q8R0N9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039199.
CleanExiMM_ZDHHC1.
GenevisibleiQ8R0N9. MM.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0N9
Secondary accession number(s): Q0VE36, Q8BJ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 24, 2003
Last modified: April 12, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.