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Q8R0M8

- MOT5_MOUSE

UniProt

Q8R0M8 - MOT5_MOUSE

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Protein
Monocarboxylate transporter 5
Gene
Slc16a4, Mct5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate By similarity.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 5
Short name:
MCT 5
Gene namesi
Name:Slc16a4
Synonyms:Mct5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2385183. Slc16a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Topological domaini38 – 5821Extracellular Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Topological domaini80 – 878Cytoplasmic Reviewed prediction
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Topological domaini109 – 1091Extracellular Reviewed prediction
Transmembranei110 – 12920Helical; Reviewed prediction
Add
BLAST
Topological domaini130 – 15324Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST
Topological domaini175 – 1751Extracellular Reviewed prediction
Transmembranei176 – 19520Helical; Reviewed prediction
Add
BLAST
Topological domaini196 – 304109Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei305 – 32521Helical; Reviewed prediction
Add
BLAST
Topological domaini326 – 34217Extracellular Reviewed prediction
Add
BLAST
Transmembranei343 – 36321Helical; Reviewed prediction
Add
BLAST
Topological domaini364 – 37411Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei375 – 39521Helical; Reviewed prediction
Add
BLAST
Topological domaini396 – 3961Extracellular Reviewed prediction
Transmembranei397 – 41620Helical; Reviewed prediction
Add
BLAST
Topological domaini417 – 43014Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei431 – 45121Helical; Reviewed prediction
Add
BLAST
Topological domaini452 – 46312Extracellular Reviewed prediction
Add
BLAST
Transmembranei464 – 48421Helical; Reviewed prediction
Add
BLAST
Topological domaini485 – 50016Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Monocarboxylate transporter 5
PRO_0000416125Add
BLAST

Proteomic databases

PRIDEiQ8R0M8.

PTM databases

PhosphoSiteiQ8R0M8.

Expressioni

Gene expression databases

BgeeiQ8R0M8.
GenevestigatoriQ8R0M8.

Structurei

3D structure databases

ProteinModelPortaliQ8R0M8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000114926.
HOGENOMiHOG000059591.
HOVERGENiHBG006385.
InParanoidiQ8R0M8.
KOiK08181.
OMAiAVVITKY.
OrthoDBiEOG7NGQBB.
PhylomeDBiQ8R0M8.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R0M8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVKKEKTPSP YTKPLDGGWG WMVVLHFFLV NVFVMGMTKT FAIFFVVFQE    50
EFEGTSEQIG WIGSIMSSLR FSAGPLAAII CDVLGEKATS ILGTFLVSGG 100
YVISSWATGI PFLCVTMGLL PGLGSAFLYQ VAAVVITKYF KKRLGLSTAI 150
ARSGMGLTFL LAPFTKFLID LYDWTGALIL FGAIILNLVP SSMLLRPIHS 200
QSNNNSDIEN KGSILSATEP EASYKTETSK CKETQEPFIK DSTMKKSEQP 250
TTTLTVLGNQ SEEFSNRPHR NRPLLMSNGK SHKKKFVSWN CKQKLLDISL 300
FRNPFFYIFT WSFLLSQLAY FIPTFHLVAR AKTLGIDVMD ASYLVSVAGI 350
TETVSQLISG WIADQNWIKK YQYHKSYLIL CGVTNLLAPL ATTFPLLMAY 400
TILFAIFAGG YLALILPVLV DLSKNSRVHK FLGYASFFAG IAVLSGPPIA 450
GWIYDYTQTY TGSFYFSGTC YILSSVSLFF VPLAERWKRK QSDLLRTTIK 500
Length:500
Mass (Da):55,678
Last modified:June 1, 2002 - v1
Checksum:i80B0FFF7D0C652E7
GO
Isoform 2 (identifier: Q8R0M8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-500: GWIYDYTQTYTGSFYFSGTCYILSSVSLFFVPLAERWKRKQSDLLRTTIK → DVTHGWTTYLMHMKPLKT

Note: No experimental confirmation available.

Show »
Length:468
Mass (Da):51,899
Checksum:i7FF2E4895F05836F
GO
Isoform 3 (identifier: Q8R0M8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-500: ITETVSQLIS...QSDLLRTTIK → KKNELSLIKVY

Note: No experimental confirmation available.

Show »
Length:360
Mass (Da):40,028
Checksum:i423DCF37A5728068
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei350 – 500151ITETV…RTTIK → KKNELSLIKVY in isoform 3.
VSP_042510Add
BLAST
Alternative sequencei451 – 50050GWIYD…RTTIK → DVTHGWTTYLMHMKPLKT in isoform 2.
VSP_042511Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti366 – 3661N → D in BAC32495. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045797 mRNA. Translation: BAC32495.1.
AK049873 mRNA. Translation: BAC33967.1.
AK052779 mRNA. Translation: BAC35143.1.
AK085492 mRNA. Translation: BAC39456.1.
AK136837 mRNA. Translation: BAE23142.1.
AC132405 Genomic DNA. No translation available.
CH466607 Genomic DNA. Translation: EDL01900.1.
BC025441 mRNA. Translation: AAH25441.1.
BC026596 mRNA. Translation: AAH26596.1.
CCDSiCCDS17736.1. [Q8R0M8-1]
RefSeqiNP_666248.1. NM_146136.1. [Q8R0M8-1]
UniGeneiMm.38384.

Genome annotation databases

EnsembliENSMUST00000029502; ENSMUSP00000029502; ENSMUSG00000027896. [Q8R0M8-1]
ENSMUST00000106723; ENSMUSP00000102334; ENSMUSG00000027896. [Q8R0M8-2]
GeneIDi229699.
KEGGimmu:229699.
UCSCiuc008qwx.1. mouse. [Q8R0M8-3]
uc008qwy.2. mouse. [Q8R0M8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045797 mRNA. Translation: BAC32495.1 .
AK049873 mRNA. Translation: BAC33967.1 .
AK052779 mRNA. Translation: BAC35143.1 .
AK085492 mRNA. Translation: BAC39456.1 .
AK136837 mRNA. Translation: BAE23142.1 .
AC132405 Genomic DNA. No translation available.
CH466607 Genomic DNA. Translation: EDL01900.1 .
BC025441 mRNA. Translation: AAH25441.1 .
BC026596 mRNA. Translation: AAH26596.1 .
CCDSi CCDS17736.1. [Q8R0M8-1 ]
RefSeqi NP_666248.1. NM_146136.1. [Q8R0M8-1 ]
UniGenei Mm.38384.

3D structure databases

ProteinModelPortali Q8R0M8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R0M8.

Proteomic databases

PRIDEi Q8R0M8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029502 ; ENSMUSP00000029502 ; ENSMUSG00000027896 . [Q8R0M8-1 ]
ENSMUST00000106723 ; ENSMUSP00000102334 ; ENSMUSG00000027896 . [Q8R0M8-2 ]
GeneIDi 229699.
KEGGi mmu:229699.
UCSCi uc008qwx.1. mouse. [Q8R0M8-3 ]
uc008qwy.2. mouse. [Q8R0M8-1 ]

Organism-specific databases

CTDi 9122.
MGIi MGI:2385183. Slc16a4.

Phylogenomic databases

GeneTreei ENSGT00740000114926.
HOGENOMi HOG000059591.
HOVERGENi HBG006385.
InParanoidi Q8R0M8.
KOi K08181.
OMAi AVVITKY.
OrthoDBi EOG7NGQBB.
PhylomeDBi Q8R0M8.
TreeFami TF313792.

Miscellaneous databases

NextBioi 379615.
PROi Q8R0M8.
SOURCEi Search...

Gene expression databases

Bgeei Q8R0M8.
Genevestigatori Q8R0M8.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Diencephalon, Hippocampus and Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Kidney.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMOT5_MOUSE
AccessioniPrimary (citable) accession number: Q8R0M8
Secondary accession number(s): Q8BLA5, Q8BWE3, Q8R157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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