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Protein

Transcriptional adapter 3

Gene

Tada3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • histone H3 acetylation Source: MGI
  • histone H4 acetylation Source: GO_Central
  • mitotic cell cycle Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of histone deacetylation Source: MGI
  • regulation of protein phosphorylation Source: MGI
  • regulation of protein stability Source: MGI
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • regulation of tubulin deacetylation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 3
Alternative name(s):
ADA3 homolog
Short name:
mADA3
Transcriptional adapter 3-like
Short name:
ADA3-like protein
Gene namesi
Name:Tada3
Synonyms:Ada3, Tada3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1915724 Tada3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724171 – 432Transcriptional adapter 3Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei280PhosphoserineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei418N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R0L9
PaxDbiQ8R0L9
PeptideAtlasiQ8R0L9
PRIDEiQ8R0L9

PTM databases

iPTMnetiQ8R0L9
PhosphoSitePlusiQ8R0L9

Expressioni

Gene expression databases

BgeeiENSMUSG00000048930
ExpressionAtlasiQ8R0L9 baseline and differential
GenevisibleiQ8R0L9 MM

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex (By similarity). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221609, 5 interactors
IntActiQ8R0L9, 4 interactors
MINTiQ8R0L9
STRINGi10090.ENSMUSP00000032410

Structurei

3D structure databases

ProteinModelPortaliQ8R0L9
SMRiQ8R0L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 69Sequence analysisAdd BLAST30
Coiled coili367 – 407Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the NGG1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4191 Eukaryota
ENOG410XQUH LUCA
GeneTreeiENSGT00390000008947
HOGENOMiHOG000007362
HOVERGENiHBG055283
InParanoidiQ8R0L9
KOiK11315
OMAiPNKFWAS
OrthoDBiEOG091G0DWR
PhylomeDBiQ8R0L9
TreeFamiTF323397

Family and domain databases

InterProiView protein in InterPro
IPR019340 Histone_AcTrfase_su3
PANTHERiPTHR13556 PTHR13556, 2 hits
PfamiView protein in Pfam
PF10198 Ada3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0L9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELKDCPLQ FHDFKSVDHL KVCPRYTAVL ARSEDDGIGI EELDTLQLEL
60 70 80 90 100
ETLLSSASRR LRVLEAETQI LTDWQDKKGD RRFLKLGRDH ELGAPPKHGK
110 120 130 140 150
PKKQKLEGKT GHGPGPGPGR PKSKNVQPKI QEYEFTDDPI DVPRIPKNDA
160 170 180 190 200
PNRFWASVEP YCADITSEEV RTLEELLKPP EDEAEHYKIP PLGKHYSQRW
210 220 230 240 250
AQEDLLEEQK DGARAAAVAD KKKGLIGPLT ELDTKDVDAL LKKSEAQHEQ
260 270 280 290 300
PEDGCPFGAL TQRLLQALVE ENIISPMEDS PIPDMSGKES GADGASTSPR
310 320 330 340 350
NQNKPFSVPH TKSLESRIKE ELIAQGLLES EDRPAEDSED EVLAELRKRQ
360 370 380 390 400
AELKALSAHN RTKKHDLLRL AKEEVSRQEL RQRVRMADNE VMDAFRKIMA
410 420 430
ARQKKRTPTK KEKDQAWKTL KERESILKLL DG
Length:432
Mass (Da):48,900
Last modified:June 1, 2002 - v1
Checksum:i773C73A40B26190A
GO
Isoform 2 (identifier: Q8R0L9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-188: Missing.

Show »
Length:413
Mass (Da):46,622
Checksum:iA9B8A1DC70CDA0D5
GO
Isoform 3 (identifier: Q8R0L9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-432: Missing.

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):17,701
Checksum:i8EDA3FAF362D28A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 200Missing in AAH22707 (PubMed:15489334).CuratedAdd BLAST200
Sequence conflicti201A → M in AAH22707 (PubMed:15489334).Curated1
Sequence conflicti391V → S in BAB22769 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009741157 – 432Missing in isoform 3. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_009740170 – 188Missing in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF383154 mRNA Translation: AAM21463.1
AK003405 mRNA Translation: BAB22769.1
AK078906 mRNA Translation: BAC37451.1
BC022707 mRNA Translation: AAH22707.1
BC023879 mRNA Translation: AAH23879.1
BC026630 mRNA Translation: AAH26630.1
BC032195 mRNA Translation: AAH32195.1
CCDSiCCDS20416.1 [Q8R0L9-1]
RefSeqiNP_598693.1, NM_133932.2 [Q8R0L9-1]
UniGeneiMm.266811

Genome annotation databases

EnsembliENSMUST00000032410; ENSMUSP00000032410; ENSMUSG00000048930 [Q8R0L9-1]
ENSMUST00000043333; ENSMUSP00000043363; ENSMUSG00000048930 [Q8R0L9-2]
GeneIDi101206
KEGGimmu:101206
UCSCiuc009dfn.2 mouse [Q8R0L9-1]
uc009dfp.2 mouse [Q8R0L9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTADA3_MOUSE
AccessioniPrimary (citable) accession number: Q8R0L9
Secondary accession number(s): Q8CIH4
, Q8K289, Q8R5E3, Q9CTJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health