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Protein

Signal-transducing adaptor protein 2

Gene

Stap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transducing adaptor protein 2
Short name:
STAP-2
Gene namesi
Name:Stap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2147039. Stap2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Signal-transducing adaptor protein 2PRO_0000072240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501Phosphotyrosine; by PTK6By similarity

Post-translational modificationi

Phosphorylated on tyrosine. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R0L1.
PaxDbiQ8R0L1.
PRIDEiQ8R0L1.

PTM databases

PhosphoSiteiQ8R0L1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8R0L1.
CleanExiMM_STAP2.
GenevisibleiQ8R0L1. MM.

Interactioni

Subunit structurei

Interacts with PTK6 and CSF1R.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038130.

Structurei

3D structure databases

ProteinModelPortaliQ8R0L1.
SMRiQ8R0L1. Positions 21-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 120101PHAdd
BLAST
Domaini152 – 24897SH2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili390 – 41021Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi278 – 36588Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH2 domain

Phylogenomic databases

eggNOGiNOG43046.
GeneTreeiENSGT00530000063841.
HOGENOMiHOG000063725.
HOVERGENiHBG108516.
InParanoidiQ8R0L1.
OMAiLYMMAEA.
OrthoDBiEOG79KPFP.
PhylomeDBiQ8R0L1.
TreeFamiTF332087.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000980. SH2.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALSPPRG PKLKGAPPSH YYESFLEKKG PCDQDYRKFW AGLQGLAICF
60 70 80 90 100
YNSNRDLQPL EKLDLRLFSK LRDEALLGSS RDTAYHFSLV LRDQEVKFKV
110 120 130 140 150
ESLESCEMWK GFILTVVELR VPSNLTLLPG HLYMMAEVLT KEEVRRAAEV
160 170 180 190 200
PWCFLQVSRL EAQLLLERYP ECGNLLLRPG GDGKDSVSVT TRQILNGSPV
210 220 230 240 250
VKHYKVKRAG SKYVIDVEDP FSCPSLEAVV NYFVTHTKRA LVPFLLDEDY
260 270 280 290 300
EKVLGFVDSD RENGESAWAV PSFRASGPAL PANVLKPLPP VPVSVSSQED
310 320 330 340 350
KLPQLPPLPQ LPDTDENYVT PIEDSPAAEY MNQDVSLSSQ AVPLKPKKPA
360 370 380 390 400
RLPAKPPKPS VVPKPDLKAI TSVWTRKLGG SSSQASSLVT RLGDITAELE
410
EKLQKRRALE H
Length:411
Mass (Da):45,802
Last modified:June 1, 2002 - v1
Checksum:i485C00B703C470A8
GO
Isoform 2 (identifier: Q8R0L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-272: FVDSDRENGESAWAVPS → VCDVGLPGLDRDTLSGG
     273-411: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,644
Checksum:i7F31946967BC55F9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei256 – 27217FVDSD…WAVPS → VCDVGLPGLDRDTLSGG in isoform 2. 1 PublicationVSP_013401Add
BLAST
Alternative sequencei273 – 411139Missing in isoform 2. 1 PublicationVSP_013402Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050131 mRNA. Translation: BAC34083.1.
AK050172 mRNA. Translation: BAC34107.1.
BC026642 mRNA. Translation: AAH26642.1.
CCDSiCCDS28889.1. [Q8R0L1-1]
RefSeqiNP_666046.1. NM_145934.2. [Q8R0L1-1]
UniGeneiMm.204991.

Genome annotation databases

EnsembliENSMUST00000043785; ENSMUSP00000038130; ENSMUSG00000038781. [Q8R0L1-1]
GeneIDi106766.
KEGGimmu:106766.
UCSCiuc008dao.3. mouse. [Q8R0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050131 mRNA. Translation: BAC34083.1.
AK050172 mRNA. Translation: BAC34107.1.
BC026642 mRNA. Translation: AAH26642.1.
CCDSiCCDS28889.1. [Q8R0L1-1]
RefSeqiNP_666046.1. NM_145934.2. [Q8R0L1-1]
UniGeneiMm.204991.

3D structure databases

ProteinModelPortaliQ8R0L1.
SMRiQ8R0L1. Positions 21-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038130.

PTM databases

PhosphoSiteiQ8R0L1.

Proteomic databases

MaxQBiQ8R0L1.
PaxDbiQ8R0L1.
PRIDEiQ8R0L1.

Protocols and materials databases

DNASUi106766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043785; ENSMUSP00000038130; ENSMUSG00000038781. [Q8R0L1-1]
GeneIDi106766.
KEGGimmu:106766.
UCSCiuc008dao.3. mouse. [Q8R0L1-1]

Organism-specific databases

CTDi55620.
MGIiMGI:2147039. Stap2.

Phylogenomic databases

eggNOGiNOG43046.
GeneTreeiENSGT00530000063841.
HOGENOMiHOG000063725.
HOVERGENiHBG108516.
InParanoidiQ8R0L1.
OMAiLYMMAEA.
OrthoDBiEOG79KPFP.
PhylomeDBiQ8R0L1.
TreeFamiTF332087.

Miscellaneous databases

NextBioi358384.
PROiQ8R0L1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R0L1.
CleanExiMM_STAP2.
GenevisibleiQ8R0L1. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR000980. SH2.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif."
    Minoguchi M., Minoguchi S., Aki D., Joo A., Yamamoto T., Yumioka T., Matsuda T., Yoshimura A.
    J. Biol. Chem. 278:11182-11189(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CSF1R, FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, SUBCELLULAR LOCATION.
    Tissue: Fetal liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiSTAP2_MOUSE
AccessioniPrimary (citable) accession number: Q8R0L1
Secondary accession number(s): Q8BWS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.