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Q8R0L1

- STAP2_MOUSE

UniProt

Q8R0L1 - STAP2_MOUSE

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Protein

Signal-transducing adaptor protein 2

Gene

Stap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transducing adaptor protein 2
Short name:
STAP-2
Gene namesi
Name:Stap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2147039. Stap2.

Subcellular locationi

Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: The translocation to the membranes occurs in response to EGF when the protein is overexpressed in fibroblastic cells.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Signal-transducing adaptor protein 2PRO_0000072240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501Phosphotyrosine; by PTK6By similarity

Post-translational modificationi

Phosphorylated on tyrosine. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R0L1.
PaxDbiQ8R0L1.
PRIDEiQ8R0L1.

PTM databases

PhosphoSiteiQ8R0L1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8R0L1.
CleanExiMM_STAP2.
GenevestigatoriQ8R0L1.

Interactioni

Subunit structurei

Interacts with PTK6 and CSF1R.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8R0L1.
SMRiQ8R0L1. Positions 21-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 120101PHAdd
BLAST
Domaini152 – 24897SH2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili390 – 41021Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi278 – 36588Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH2 domain

Phylogenomic databases

eggNOGiNOG43046.
GeneTreeiENSGT00530000063841.
HOGENOMiHOG000063725.
HOVERGENiHBG108516.
InParanoidiQ8R0L1.
OMAiPGHLYMM.
OrthoDBiEOG79KPFP.
PhylomeDBiQ8R0L1.
TreeFamiTF332087.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000980. SH2.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R0L1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALSPPRG PKLKGAPPSH YYESFLEKKG PCDQDYRKFW AGLQGLAICF
60 70 80 90 100
YNSNRDLQPL EKLDLRLFSK LRDEALLGSS RDTAYHFSLV LRDQEVKFKV
110 120 130 140 150
ESLESCEMWK GFILTVVELR VPSNLTLLPG HLYMMAEVLT KEEVRRAAEV
160 170 180 190 200
PWCFLQVSRL EAQLLLERYP ECGNLLLRPG GDGKDSVSVT TRQILNGSPV
210 220 230 240 250
VKHYKVKRAG SKYVIDVEDP FSCPSLEAVV NYFVTHTKRA LVPFLLDEDY
260 270 280 290 300
EKVLGFVDSD RENGESAWAV PSFRASGPAL PANVLKPLPP VPVSVSSQED
310 320 330 340 350
KLPQLPPLPQ LPDTDENYVT PIEDSPAAEY MNQDVSLSSQ AVPLKPKKPA
360 370 380 390 400
RLPAKPPKPS VVPKPDLKAI TSVWTRKLGG SSSQASSLVT RLGDITAELE
410
EKLQKRRALE H
Length:411
Mass (Da):45,802
Last modified:June 1, 2002 - v1
Checksum:i485C00B703C470A8
GO
Isoform 2 (identifier: Q8R0L1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-272: FVDSDRENGESAWAVPS → VCDVGLPGLDRDTLSGG
     273-411: Missing.

Note: No experimental confirmation available.

Show »
Length:272
Mass (Da):30,644
Checksum:i7F31946967BC55F9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei256 – 27217FVDSD…WAVPS → VCDVGLPGLDRDTLSGG in isoform 2. 1 PublicationVSP_013401Add
BLAST
Alternative sequencei273 – 411139Missing in isoform 2. 1 PublicationVSP_013402Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050131 mRNA. Translation: BAC34083.1.
AK050172 mRNA. Translation: BAC34107.1.
BC026642 mRNA. Translation: AAH26642.1.
CCDSiCCDS28889.1. [Q8R0L1-1]
RefSeqiNP_666046.1. NM_145934.2. [Q8R0L1-1]
UniGeneiMm.204991.

Genome annotation databases

EnsembliENSMUST00000043785; ENSMUSP00000038130; ENSMUSG00000038781. [Q8R0L1-1]
GeneIDi106766.
KEGGimmu:106766.
UCSCiuc008dao.2. mouse. [Q8R0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050131 mRNA. Translation: BAC34083.1 .
AK050172 mRNA. Translation: BAC34107.1 .
BC026642 mRNA. Translation: AAH26642.1 .
CCDSi CCDS28889.1. [Q8R0L1-1 ]
RefSeqi NP_666046.1. NM_145934.2. [Q8R0L1-1 ]
UniGenei Mm.204991.

3D structure databases

ProteinModelPortali Q8R0L1.
SMRi Q8R0L1. Positions 21-247.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R0L1.

Proteomic databases

MaxQBi Q8R0L1.
PaxDbi Q8R0L1.
PRIDEi Q8R0L1.

Protocols and materials databases

DNASUi 106766.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043785 ; ENSMUSP00000038130 ; ENSMUSG00000038781 . [Q8R0L1-1 ]
GeneIDi 106766.
KEGGi mmu:106766.
UCSCi uc008dao.2. mouse. [Q8R0L1-1 ]

Organism-specific databases

CTDi 55620.
MGIi MGI:2147039. Stap2.

Phylogenomic databases

eggNOGi NOG43046.
GeneTreei ENSGT00530000063841.
HOGENOMi HOG000063725.
HOVERGENi HBG108516.
InParanoidi Q8R0L1.
OMAi PGHLYMM.
OrthoDBi EOG79KPFP.
PhylomeDBi Q8R0L1.
TreeFami TF332087.

Miscellaneous databases

NextBioi 358384.
PROi Q8R0L1.
SOURCEi Search...

Gene expression databases

Bgeei Q8R0L1.
CleanExi MM_STAP2.
Genevestigatori Q8R0L1.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000980. SH2.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif."
    Minoguchi M., Minoguchi S., Aki D., Joo A., Yamamoto T., Yumioka T., Matsuda T., Yoshimura A.
    J. Biol. Chem. 278:11182-11189(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CSF1R, FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, SUBCELLULAR LOCATION.
    Tissue: Fetal liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiSTAP2_MOUSE
AccessioniPrimary (citable) accession number: Q8R0L1
Secondary accession number(s): Q8BWS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3