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Q8R0L1

- STAP2_MOUSE

UniProt

Q8R0L1 - STAP2_MOUSE

Protein

Signal-transducing adaptor protein 2

Gene

Stap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Substrate of protein kinase PTK6 By similarity. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal-transducing adaptor protein 2
    Short name:
    STAP-2
    Gene namesi
    Name:Stap2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2147039. Stap2.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: The translocation to the membranes occurs in response to EGF when the protein is overexpressed in fibroblastic cells.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Signal-transducing adaptor protein 2PRO_0000072240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei250 – 2501Phosphotyrosine; by PTK6By similarity

    Post-translational modificationi

    Phosphorylated on tyrosine. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8R0L1.
    PaxDbiQ8R0L1.
    PRIDEiQ8R0L1.

    PTM databases

    PhosphoSiteiQ8R0L1.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiQ8R0L1.
    CleanExiMM_STAP2.
    GenevestigatoriQ8R0L1.

    Interactioni

    Subunit structurei

    Interacts with PTK6 and CSF1R.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R0L1.
    SMRiQ8R0L1. Positions 21-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 120101PHAdd
    BLAST
    Domaini152 – 24897SH2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili390 – 41021Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi278 – 36588Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH2 domain

    Phylogenomic databases

    eggNOGiNOG43046.
    GeneTreeiENSGT00530000063841.
    HOGENOMiHOG000063725.
    HOVERGENiHBG108516.
    InParanoidiQ8R0L1.
    OMAiPGHLYMM.
    OrthoDBiEOG79KPFP.
    PhylomeDBiQ8R0L1.
    TreeFamiTF332087.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000980. SH2.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R0L1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATALSPPRG PKLKGAPPSH YYESFLEKKG PCDQDYRKFW AGLQGLAICF    50
    YNSNRDLQPL EKLDLRLFSK LRDEALLGSS RDTAYHFSLV LRDQEVKFKV 100
    ESLESCEMWK GFILTVVELR VPSNLTLLPG HLYMMAEVLT KEEVRRAAEV 150
    PWCFLQVSRL EAQLLLERYP ECGNLLLRPG GDGKDSVSVT TRQILNGSPV 200
    VKHYKVKRAG SKYVIDVEDP FSCPSLEAVV NYFVTHTKRA LVPFLLDEDY 250
    EKVLGFVDSD RENGESAWAV PSFRASGPAL PANVLKPLPP VPVSVSSQED 300
    KLPQLPPLPQ LPDTDENYVT PIEDSPAAEY MNQDVSLSSQ AVPLKPKKPA 350
    RLPAKPPKPS VVPKPDLKAI TSVWTRKLGG SSSQASSLVT RLGDITAELE 400
    EKLQKRRALE H 411
    Length:411
    Mass (Da):45,802
    Last modified:June 1, 2002 - v1
    Checksum:i485C00B703C470A8
    GO
    Isoform 2 (identifier: Q8R0L1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         256-272: FVDSDRENGESAWAVPS → VCDVGLPGLDRDTLSGG
         273-411: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:272
    Mass (Da):30,644
    Checksum:i7F31946967BC55F9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei256 – 27217FVDSD…WAVPS → VCDVGLPGLDRDTLSGG in isoform 2. 1 PublicationVSP_013401Add
    BLAST
    Alternative sequencei273 – 411139Missing in isoform 2. 1 PublicationVSP_013402Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050131 mRNA. Translation: BAC34083.1.
    AK050172 mRNA. Translation: BAC34107.1.
    BC026642 mRNA. Translation: AAH26642.1.
    CCDSiCCDS28889.1. [Q8R0L1-1]
    RefSeqiNP_666046.1. NM_145934.2. [Q8R0L1-1]
    UniGeneiMm.204991.

    Genome annotation databases

    EnsembliENSMUST00000043785; ENSMUSP00000038130; ENSMUSG00000038781. [Q8R0L1-1]
    GeneIDi106766.
    KEGGimmu:106766.
    UCSCiuc008dao.2. mouse. [Q8R0L1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050131 mRNA. Translation: BAC34083.1 .
    AK050172 mRNA. Translation: BAC34107.1 .
    BC026642 mRNA. Translation: AAH26642.1 .
    CCDSi CCDS28889.1. [Q8R0L1-1 ]
    RefSeqi NP_666046.1. NM_145934.2. [Q8R0L1-1 ]
    UniGenei Mm.204991.

    3D structure databases

    ProteinModelPortali Q8R0L1.
    SMRi Q8R0L1. Positions 21-247.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R0L1.

    Proteomic databases

    MaxQBi Q8R0L1.
    PaxDbi Q8R0L1.
    PRIDEi Q8R0L1.

    Protocols and materials databases

    DNASUi 106766.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043785 ; ENSMUSP00000038130 ; ENSMUSG00000038781 . [Q8R0L1-1 ]
    GeneIDi 106766.
    KEGGi mmu:106766.
    UCSCi uc008dao.2. mouse. [Q8R0L1-1 ]

    Organism-specific databases

    CTDi 55620.
    MGIi MGI:2147039. Stap2.

    Phylogenomic databases

    eggNOGi NOG43046.
    GeneTreei ENSGT00530000063841.
    HOGENOMi HOG000063725.
    HOVERGENi HBG108516.
    InParanoidi Q8R0L1.
    OMAi PGHLYMM.
    OrthoDBi EOG79KPFP.
    PhylomeDBi Q8R0L1.
    TreeFami TF332087.

    Miscellaneous databases

    NextBioi 358384.
    PROi Q8R0L1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R0L1.
    CleanExi MM_STAP2.
    Genevestigatori Q8R0L1.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000980. SH2.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif."
      Minoguchi M., Minoguchi S., Aki D., Joo A., Yamamoto T., Yumioka T., Matsuda T., Yoshimura A.
      J. Biol. Chem. 278:11182-11189(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CSF1R, FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, SUBCELLULAR LOCATION.
      Tissue: Fetal liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiSTAP2_MOUSE
    AccessioniPrimary (citable) accession number: Q8R0L1
    Secondary accession number(s): Q8BWS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3