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Protein

Signal-transducing adaptor protein 2

Gene

Stap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.By similarity1 Publication

Enzyme and pathway databases

ReactomeiR-MMU-8849474 PTK6 Activates STAT3

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-transducing adaptor protein 2
Short name:
STAP-2
Gene namesi
Name:Stap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2147039 Stap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722401 – 411Signal-transducing adaptor protein 2Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphotyrosineBy similarity1
Modified residuei250Phosphotyrosine; by PTK6By similarity1
Modified residuei318PhosphotyrosineBy similarity1
Modified residuei330PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine. Phosphorylated by PTK6 at Tyr-250 modulates PTK6-mediated STAT3 activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R0L1
PeptideAtlasiQ8R0L1
PRIDEiQ8R0L1

PTM databases

iPTMnetiQ8R0L1
PhosphoSitePlusiQ8R0L1

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000038781
CleanExiMM_STAP2
GenevisibleiQ8R0L1 MM

Interactioni

Subunit structurei

Interacts with PTK6 and CSF1R.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038130

Structurei

3D structure databases

ProteinModelPortaliQ8R0L1
SMRiQ8R0L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 120PHAdd BLAST101
Domaini152 – 248SH2PROSITE-ProRule annotationAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili390 – 410Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 365Pro-richAdd BLAST88

Keywords - Domaini

Coiled coil, SH2 domain

Phylogenomic databases

eggNOGiENOG410IM0D Eukaryota
ENOG410YHUB LUCA
GeneTreeiENSGT00530000063841
HOGENOMiHOG000063725
HOVERGENiHBG108516
InParanoidiQ8R0L1
OMAiPDCGNML
OrthoDBiEOG091G0929
PhylomeDBiQ8R0L1
TreeFamiTF332087

Family and domain databases

CDDicd10404 SH2_STAP2, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035878 STAP2_SH2
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALSPPRG PKLKGAPPSH YYESFLEKKG PCDQDYRKFW AGLQGLAICF
60 70 80 90 100
YNSNRDLQPL EKLDLRLFSK LRDEALLGSS RDTAYHFSLV LRDQEVKFKV
110 120 130 140 150
ESLESCEMWK GFILTVVELR VPSNLTLLPG HLYMMAEVLT KEEVRRAAEV
160 170 180 190 200
PWCFLQVSRL EAQLLLERYP ECGNLLLRPG GDGKDSVSVT TRQILNGSPV
210 220 230 240 250
VKHYKVKRAG SKYVIDVEDP FSCPSLEAVV NYFVTHTKRA LVPFLLDEDY
260 270 280 290 300
EKVLGFVDSD RENGESAWAV PSFRASGPAL PANVLKPLPP VPVSVSSQED
310 320 330 340 350
KLPQLPPLPQ LPDTDENYVT PIEDSPAAEY MNQDVSLSSQ AVPLKPKKPA
360 370 380 390 400
RLPAKPPKPS VVPKPDLKAI TSVWTRKLGG SSSQASSLVT RLGDITAELE
410
EKLQKRRALE H
Length:411
Mass (Da):45,802
Last modified:June 1, 2002 - v1
Checksum:i485C00B703C470A8
GO
Isoform 2 (identifier: Q8R0L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-272: FVDSDRENGESAWAVPS → VCDVGLPGLDRDTLSGG
     273-411: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,644
Checksum:i7F31946967BC55F9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013401256 – 272FVDSD…WAVPS → VCDVGLPGLDRDTLSGG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_013402273 – 411Missing in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050131 mRNA Translation: BAC34083.1
AK050172 mRNA Translation: BAC34107.1
BC026642 mRNA Translation: AAH26642.1
CCDSiCCDS28889.1 [Q8R0L1-1]
RefSeqiNP_666046.1, NM_145934.2 [Q8R0L1-1]
XP_017172690.1, XM_017317201.1
UniGeneiMm.204991

Genome annotation databases

EnsembliENSMUST00000043785; ENSMUSP00000038130; ENSMUSG00000038781 [Q8R0L1-1]
GeneIDi106766
KEGGimmu:106766
UCSCiuc008dao.3 mouse [Q8R0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTAP2_MOUSE
AccessioniPrimary (citable) accession number: Q8R0L1
Secondary accession number(s): Q8BWS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health