Q8R0J8 (GNTK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable gluconokinase
EC=2.7.1.12

Alternative name(s):
Gluconate kinase

Gene names

Name:

Idnk

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + D-gluconate = ADP + 6-phospho-D-gluconate.
Pathway	Carbohydrate acid metabolism; D-gluconate degradation.
Sequence similarities	Belongs to the gluconokinase GntK/GntV family.
Sequence caution	The sequence AAH26742.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-gluconate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW gluconokinase activity Inferred from electronic annotation. Source: EC shikimate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Probable gluconokinase		PRO_0000327371
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8R0J8 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: ADEA93B8EC453C1A	FASTA	184	19,981
	10 20 30 40 50 60 MEAPGVLLVM GVSGSGKSTV GALLASKLGW KFYDADDYHS EENRIKMAKG VPLSDQDRIP 70 80 90 100 110 120 WLCTLHDILL RDVALGQPVV LACSALKKTY RDILIRGGSD APLKSDDSAK EPLAGGKLLV 130 140 150 160 170 180 VYLCGSFDII YGRLLQRKGH FMPPELLQSQ FSILEPPSAP ENFIQVSVDK SLPEITAAVM EALK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC026742 mRNA. Translation: AAH26742.1. Different initiation.
IPI	IPI00267718.
RefSeq	NP_932121.2. NM_198004.3.
UniGene	Mm.293919.
3D structure databases
HSSP	HSSP built from PDB template 1KO1 based on UniProtKB P46859.
ProteinModelPortal	Q8R0J8.
SMR	Q8R0J8. Positions 4-183.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000060218.
PTM databases
PhosphoSite	Q8R0J8.
Proteomic databases
PaxDb	Q8R0J8.
PRIDE	Q8R0J8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000051490; ENSMUSP00000060218; ENSMUSG00000050002.
GeneID	75731.
KEGG	mmu:75731.
UCSC	uc007qth.2. mouse.
Organism-specific databases
CTD	414328.
MGI	MGI:1922981. Idnk.
Phylogenomic databases
eggNOG	COG3265.
GeneTree	ENSGT00390000003364.
HOGENOM	HOG000032567.
HOVERGEN	HBG107958.
InParanoid	Q8R0J8.
OMA	LRDGNPN.
OrthoDB	EOG4PZJ7R.
Enzyme and pathway databases
UniPathway	UPA00792.
Gene expression databases
ArrayExpress	Q8R0J8.
Bgee	Q8R0J8.
Genevestigator	Q8R0J8.
Family and domain databases
InterPro	IPR000623. Shikimate_kinase. IPR006001. Therm_gnt_kin. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
TIGRFAMs	TIGR01313. therm_gnt_kin. 1 hit.
ProtoNet	Search...
Other
NextBio	343800.
SOURCE	Search...

Entry information

Entry name

GNTK_MOUSE

Accession

Primary (citable) accession number: Q8R0J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program