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Protein

Vacuolar protein sorting-associated protein 37B

Gene

Vps37b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37B
Short name:
Vps37B
Alternative name(s):
ESCRT-I complex subunit VPS37B
Gene namesi
Name:Vps37b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916724 Vps37b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872011 – 285Vacuolar protein sorting-associated protein 37BAdd BLAST285

Proteomic databases

EPDiQ8R0J7
MaxQBiQ8R0J7
PaxDbiQ8R0J7
PeptideAtlasiQ8R0J7
PRIDEiQ8R0J7

PTM databases

iPTMnetiQ8R0J7
PhosphoSitePlusiQ8R0J7

Expressioni

Gene expression databases

BgeeiENSMUSG00000066278
CleanExiMM_VPS37B
GenevisibleiQ8R0J7 MM

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047980

Structurei

3D structure databases

ProteinModelPortaliQ8R0J7
SMRiQ8R0J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 173VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 170Interaction with IST1By similarityAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 280Pro-richAdd BLAST111

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000234744
HOVERGENiHBG073355
InParanoidiQ8R0J7
KOiK12185
OMAiRTMHLRR
OrthoDBiEOG091G0GMF
PhylomeDBiQ8R0J7
TreeFamiTF321840

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR029012 Helix_hairpin_bin_sf
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R0J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAVSEARF AGLSLMQLHE LLEDDAQLGD MVRGMEEAQT VQLNKEMTLA
60 70 80 90 100
SNRSLAEGNL LYQPQLDAQK ARLTQKYQEL QVLFEAYQIK KTKLDKQSNN
110 120 130 140 150
ASLETLLALL QAEGAKIEED TENMAEKFLD GELPLDSFID VYQSKRKLAH
160 170 180 190 200
MRRVKVEKLQ ELVLKGQRHP QAGAPPPPRV PEPSPATALP YPSLEATGLP
210 220 230 240 250
SVVPRRIPPP PPPVPAGHVA TPFAAAMGSG QVSAYPGLQC PPLPPRVGLP
260 270 280
SQQGFSAQLV SPYPPALPQR PPPRMAPHQP GFILQ
Length:285
Mass (Da):31,056
Last modified:June 1, 2002 - v1
Checksum:iD3B8241F206A9425
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40T → N in BAE38730 (PubMed:16141072).Curated1
Sequence conflicti89I → V in BAE29150 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149893 mRNA Translation: BAE29150.1
AK166359 mRNA Translation: BAE38730.1
BC026744 mRNA Translation: AAH26744.1
CCDSiCCDS19670.1
RefSeqiNP_808544.1, NM_177876.4
UniGeneiMm.4079

Genome annotation databases

EnsembliENSMUST00000040967; ENSMUSP00000047980; ENSMUSG00000066278
GeneIDi330192
KEGGimmu:330192
UCSCiuc008zot.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVP37B_MOUSE
AccessioniPrimary (citable) accession number: Q8R0J7
Secondary accession number(s): Q3TLR2, Q3UDW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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