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Q8R0G9 (NU133_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear pore complex protein Nup133
Alternative name(s):
133 kDa nucleoporin
Nucleoporin Nup133
Gene names
Name:Nup133
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1155 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in poly(A)+ RNA transport By similarity. UniProtKB Q8WUM0

Subunit structure

Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus By similarity. UniProtKB Q8WUM0

Subcellular location

Nucleusnuclear pore complex By similarity. Chromosomecentromerekinetochore By similarity. Note: Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores By similarity.

Sequence similarities

Belongs to the nucleoporin Nup133 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11551155Nuclear pore complex protein Nup133
PRO_0000204839

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue71Phosphoserine By similarity
Modified residue271Phosphoserine By similarity
Modified residue281Phosphothreonine By similarity
Modified residue401Phosphoserine By similarity
Modified residue441Phosphoserine By similarity
Modified residue491Phosphoserine By similarity
Modified residue4791Phosphoserine By similarity
Modified residue7861N6-acetyllysine Ref.4

Experimental info

Sequence conflict2141V → E in AAH23915. Ref.2
Sequence conflict2891T → R in AAH23915. Ref.2
Sequence conflict2891T → R in AAH26845. Ref.2
Sequence conflict4731T → I in AAH23915. Ref.2
Sequence conflict4731T → I in AAH26845. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8R0G9 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 2B1967D74FA3D683

FASTA1,155128,620
        10         20         30         40         50         60 
MFPSVSSPRT PGPGTRRGPL VGIGPTSTPR ASRRGLSLGS AVNSPVLFSP AGRRSSVSSR 

        70         80         90        100        110        120 
GTPTRIFPHH SISESVNYDV RVFGSSLPVK IMEALTMAEA DEQLSVHVDE GGWACLVCTE 

       130        140        150        160        170        180 
KLLIWKIAVS PVTKLSVCKE LQLPPSDFHG SADLVALSYA ATSGEVHSVQ AVSVMVATKE 

       190        200        210        220        230        240 
GSIRYWPSLA REDTYSDTCV DLGGEKMCRF LTAVQGGSFI LSSVGSQLVR LIPESSGKIH 

       250        260        270        280        290        300 
QHVLPQGQGM LSGIGRRVSS LFGILSPTSD LMLASVLWDR GGSSFYTLTS SNISKWELDD 

       310        320        330        340        350        360 
SSEKQVHSWD VHRTLKESIT DAVWGSESNY EAIKEGVNIQ YLDLKQNCDG LLILAAAWHL 

       370        380        390        400        410        420 
GDSPCLVYYS VITVEDNGNQ MSDAVTVEVT QYNPPFQSED LIACRLMVPN FSSQMTYLYM 

       430        440        450        460        470        480 
ENAVFVCSTG TGKFSLPQEK IVFDTQGDGI LGAGSCAGVP ILFSRNSGLV SVTPRENVSL 

       490        500        510        520        530        540 
LAEDLEESLT SSVGGRGSES MVFETTTKNE TVAHEDKTKL LKAAFLQYCR KDLGRAQIMA 

       550        560        570        580        590        600 
DELFSSHTDL DSDPELDKAV TQISVDLIDD YPASDPRWAE SVPQEAPGLS NTSLIILHQL 

       610        620        630        640        650        660 
EDKMKAHCLL VDFLHQVGLF RRLSSYPIRG TPMSTRLLLC EHAEKLSAAI TLKNHHSRLP 

       670        680        690        700        710        720 
DLVNSAILLA LNKRECEVPN SLTPADVFFR EVSQVDTICE CLLEHEEQVL REVALVSQEW 

       730        740        750        760        770        780 
AEVAIDVNTV LKDMLQAATH YRLNKSSMYS QEEVLGKEPE YVPWTATSGP SGIRTAVMRQ 

       790        800        810        820        830        840 
HGIILKMVYP QADSKLRNVV MEQLVALIDC FLDSYVSQLK SLEKSSDQER YSSLEVEYLQ 

       850        860        870        880        890        900 
KRSELLSPLL TLGQYPWAAS LAEKYCDFDI LVQMCEQTDN QARLQRYMTQ FADQNFSDFL 

       910        920        930        940        950        960 
FRWYLEKGKR GKLLSQPISQ HGQLANFLQA HEHLSWLHEI NSQELEKAHT TLLGLANMET 

       970        980        990       1000       1010       1020 
RYFAKKKTLL GLSKLAALAS DISEDRLQEK IEAMAEQERF LLHQETLPEQ LLTERQLSLS 

      1030       1040       1050       1060       1070       1080 
AMPVLTAPQL ISLYICDENR RANEYDFKKA LDLLEYIDEE EDVSIDDLKL EILCRALQRD 

      1090       1100       1110       1120       1130       1140 
DWSGSDGKDD PIEVSKDSVF VKILQKLIKD GIQLSEYLPE VTDLLRAEQL GSLKSNSYFE 

      1150 
FVLKANYEYY VQGQM 

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References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Mammary gland.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC123825 Genomic DNA. No translation available.
AC147266 Genomic DNA. No translation available.
BC026845 mRNA. Translation: AAH26845.1.
BC023915 mRNA. Translation: AAH23915.1.
CCDSCCDS22765.1.
RefSeqNP_758492.2. NM_172288.2.
UniGeneMm.267812.

3D structure databases

ProteinModelPortalQ8R0G9.
SMRQ8R0G9. Positions 74-476, 517-1155.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231592. 1 interaction.
IntActQ8R0G9. 2 interactions.
MINTMINT-4104201.

PTM databases

PhosphoSiteQ8R0G9.

Proteomic databases

MaxQBQ8R0G9.
PaxDbQ8R0G9.
PRIDEQ8R0G9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044795; ENSMUSP00000048084; ENSMUSG00000039509.
GeneID234865.
KEGGmmu:234865.
UCSCuc009nws.2. mouse.

Organism-specific databases

CTD55746.
MGIMGI:2442620. Nup133.

Phylogenomic databases

eggNOGNOG312399.
GeneTreeENSGT00390000011529.
HOGENOMHOG000293246.
HOVERGENHBG052678.
InParanoidQ8R0G9.
KOK14300.
OMAMCRLMVP.
OrthoDBEOG7P8P70.
TreeFamTF106141.

Gene expression databases

BgeeQ8R0G9.
CleanExMM_NUP133.
GenevestigatorQ8R0G9.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNUP133. mouse.
NextBio382413.
PROQ8R0G9.
SOURCESearch...

Entry information

Entry nameNU133_MOUSE
AccessionPrimary (citable) accession number: Q8R0G9
Secondary accession number(s): E9QLJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot