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Q8R0G9

- NU133_MOUSE

UniProt

Q8R0G9 - NU133_MOUSE

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Protein

Nuclear pore complex protein Nup133

Gene

Nup133

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in poly(A)+ RNA transport.By similarity

GO - Molecular functioni

  1. nucleocytoplasmic transporter activity Source: UniProtKB

GO - Biological processi

  1. mRNA export from nucleus Source: UniProtKB
  2. nuclear pore organization Source: Ensembl
  3. paraxial mesoderm development Source: MGI
  4. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup133
Alternative name(s):
133 kDa nucleoporin
Nucleoporin Nup133
Gene namesi
Name:Nup133
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2442620. Nup133.

Subcellular locationi

Nucleusnuclear pore complex By similarity. Chromosomecentromerekinetochore By similarity
Note: Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores (By similarity).By similarity

GO - Cellular componenti

  1. condensed chromosome outer kinetochore Source: Ensembl
  2. nuclear pore Source: UniProtKB
  3. nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11551155Nuclear pore complex protein Nup133PRO_0000204839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei28 – 281PhosphothreonineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei479 – 4791PhosphoserineBy similarity
Modified residuei786 – 7861N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R0G9.
PaxDbiQ8R0G9.
PRIDEiQ8R0G9.

PTM databases

PhosphoSiteiQ8R0G9.

Expressioni

Gene expression databases

BgeeiQ8R0G9.
CleanExiMM_NUP133.
GenevestigatoriQ8R0G9.

Interactioni

Subunit structurei

Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus (By similarity).By similarity

Protein-protein interaction databases

BioGridi231592. 1 interaction.
IntActiQ8R0G9. 2 interactions.
MINTiMINT-4104201.

Structurei

3D structure databases

ProteinModelPortaliQ8R0G9.
SMRiQ8R0G9. Positions 74-476, 517-1155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nucleoporin Nup133 family.Curated

Phylogenomic databases

eggNOGiNOG312399.
GeneTreeiENSGT00390000011529.
HOGENOMiHOG000293246.
HOVERGENiHBG052678.
InParanoidiQ8R0G9.
KOiK14300.
OMAiMCRLMVP.
OrthoDBiEOG7P8P70.
TreeFamiTF106141.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R0G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPSVSSPRT PGPGTRRGPL VGIGPTSTPR ASRRGLSLGS AVNSPVLFSP
60 70 80 90 100
AGRRSSVSSR GTPTRIFPHH SISESVNYDV RVFGSSLPVK IMEALTMAEA
110 120 130 140 150
DEQLSVHVDE GGWACLVCTE KLLIWKIAVS PVTKLSVCKE LQLPPSDFHG
160 170 180 190 200
SADLVALSYA ATSGEVHSVQ AVSVMVATKE GSIRYWPSLA REDTYSDTCV
210 220 230 240 250
DLGGEKMCRF LTAVQGGSFI LSSVGSQLVR LIPESSGKIH QHVLPQGQGM
260 270 280 290 300
LSGIGRRVSS LFGILSPTSD LMLASVLWDR GGSSFYTLTS SNISKWELDD
310 320 330 340 350
SSEKQVHSWD VHRTLKESIT DAVWGSESNY EAIKEGVNIQ YLDLKQNCDG
360 370 380 390 400
LLILAAAWHL GDSPCLVYYS VITVEDNGNQ MSDAVTVEVT QYNPPFQSED
410 420 430 440 450
LIACRLMVPN FSSQMTYLYM ENAVFVCSTG TGKFSLPQEK IVFDTQGDGI
460 470 480 490 500
LGAGSCAGVP ILFSRNSGLV SVTPRENVSL LAEDLEESLT SSVGGRGSES
510 520 530 540 550
MVFETTTKNE TVAHEDKTKL LKAAFLQYCR KDLGRAQIMA DELFSSHTDL
560 570 580 590 600
DSDPELDKAV TQISVDLIDD YPASDPRWAE SVPQEAPGLS NTSLIILHQL
610 620 630 640 650
EDKMKAHCLL VDFLHQVGLF RRLSSYPIRG TPMSTRLLLC EHAEKLSAAI
660 670 680 690 700
TLKNHHSRLP DLVNSAILLA LNKRECEVPN SLTPADVFFR EVSQVDTICE
710 720 730 740 750
CLLEHEEQVL REVALVSQEW AEVAIDVNTV LKDMLQAATH YRLNKSSMYS
760 770 780 790 800
QEEVLGKEPE YVPWTATSGP SGIRTAVMRQ HGIILKMVYP QADSKLRNVV
810 820 830 840 850
MEQLVALIDC FLDSYVSQLK SLEKSSDQER YSSLEVEYLQ KRSELLSPLL
860 870 880 890 900
TLGQYPWAAS LAEKYCDFDI LVQMCEQTDN QARLQRYMTQ FADQNFSDFL
910 920 930 940 950
FRWYLEKGKR GKLLSQPISQ HGQLANFLQA HEHLSWLHEI NSQELEKAHT
960 970 980 990 1000
TLLGLANMET RYFAKKKTLL GLSKLAALAS DISEDRLQEK IEAMAEQERF
1010 1020 1030 1040 1050
LLHQETLPEQ LLTERQLSLS AMPVLTAPQL ISLYICDENR RANEYDFKKA
1060 1070 1080 1090 1100
LDLLEYIDEE EDVSIDDLKL EILCRALQRD DWSGSDGKDD PIEVSKDSVF
1110 1120 1130 1140 1150
VKILQKLIKD GIQLSEYLPE VTDLLRAEQL GSLKSNSYFE FVLKANYEYY

VQGQM
Length:1,155
Mass (Da):128,620
Last modified:July 27, 2011 - v2
Checksum:i2B1967D74FA3D683
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti214 – 2141V → E in AAH23915. (PubMed:15489334)Curated
Sequence conflicti289 – 2891T → R in AAH23915. (PubMed:15489334)Curated
Sequence conflicti289 – 2891T → R in AAH26845. (PubMed:15489334)Curated
Sequence conflicti473 – 4731T → I in AAH23915. (PubMed:15489334)Curated
Sequence conflicti473 – 4731T → I in AAH26845. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123825 Genomic DNA. No translation available.
AC147266 Genomic DNA. No translation available.
BC026845 mRNA. Translation: AAH26845.1.
BC023915 mRNA. Translation: AAH23915.1.
CCDSiCCDS22765.1.
RefSeqiNP_758492.2. NM_172288.2.
UniGeneiMm.267812.

Genome annotation databases

EnsembliENSMUST00000044795; ENSMUSP00000048084; ENSMUSG00000039509.
GeneIDi234865.
KEGGimmu:234865.
UCSCiuc009nws.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC123825 Genomic DNA. No translation available.
AC147266 Genomic DNA. No translation available.
BC026845 mRNA. Translation: AAH26845.1 .
BC023915 mRNA. Translation: AAH23915.1 .
CCDSi CCDS22765.1.
RefSeqi NP_758492.2. NM_172288.2.
UniGenei Mm.267812.

3D structure databases

ProteinModelPortali Q8R0G9.
SMRi Q8R0G9. Positions 74-476, 517-1155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231592. 1 interaction.
IntActi Q8R0G9. 2 interactions.
MINTi MINT-4104201.

PTM databases

PhosphoSitei Q8R0G9.

Proteomic databases

MaxQBi Q8R0G9.
PaxDbi Q8R0G9.
PRIDEi Q8R0G9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044795 ; ENSMUSP00000048084 ; ENSMUSG00000039509 .
GeneIDi 234865.
KEGGi mmu:234865.
UCSCi uc009nws.2. mouse.

Organism-specific databases

CTDi 55746.
MGIi MGI:2442620. Nup133.

Phylogenomic databases

eggNOGi NOG312399.
GeneTreei ENSGT00390000011529.
HOGENOMi HOG000293246.
HOVERGENi HBG052678.
InParanoidi Q8R0G9.
KOi K14300.
OMAi MCRLMVP.
OrthoDBi EOG7P8P70.
TreeFami TF106141.

Enzyme and pathway databases

Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

ChiTaRSi NUP133. mouse.
NextBioi 382413.
PROi Q8R0G9.
SOURCEi Search...

Gene expression databases

Bgeei Q8R0G9.
CleanExi MM_NUP133.
Genevestigatori Q8R0G9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiNU133_MOUSE
AccessioniPrimary (citable) accession number: Q8R0G9
Secondary accession number(s): E9QLJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: July 27, 2011
Last modified: October 1, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3