Nuclear pore complex protein Nup133

Preferred order of sections

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup133

Alternative name(s):
133 kDa nucleoporin
Nucleoporin Nup133

Gene names

Name:

Nup133

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1155 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in poly(A)+ RNA transport By similarity. UniProtKB Q8WUM0
Subunit structure	Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus By similarity. UniProtKB Q8WUM0
Subcellular location	Nucleus › nuclear pore complex By similarity. Chromosome › centromere › kinetochore By similarity. Note: Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores By similarity.
Sequence similarities	Belongs to the nucleoporin Nup133 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Centromere Chromosome Kinetochore Nuclear pore complex Nucleus
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA export from nucleus Inferred from sequence or structural similarity PubMed 11684705. Source: UniProtKB nuclear pore organization Inferred from electronic annotation. Source: Compara paraxial mesoderm development Inferred from mutant phenotype PubMed 15755804. Source: MGI protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	condensed chromosome outer kinetochore Inferred from electronic annotation. Source: Compara nuclear pore outer ring Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	nucleocytoplasmic transporter activity Inferred from sequence or structural similarity PubMed 11684705. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1155

1155

Nuclear pore complex protein Nup133

PRO_0000204839

Amino acid modifications

Modified residue

1

N-acetylmethionine By similarity

Modified residue

7

1

Phosphoserine By similarity

Modified residue

27

1

Phosphoserine By similarity

Modified residue

28

1

Phosphothreonine By similarity

Modified residue

40

1

Phosphoserine By similarity

Modified residue

44

1

Phosphoserine By similarity

Modified residue

49

1

Phosphoserine By similarity

Modified residue

479

1

Phosphoserine By similarity

Modified residue

500

1

Phosphoserine Ref.3

Experimental info

Sequence conflict

214

1

V → E in AAH23915. Ref.2

Sequence conflict

289

1

T → R in AAH23915. Ref.2

Sequence conflict

289

1

T → R in AAH26845. Ref.2

Sequence conflict

473

1

T → I in AAH23915. Ref.2

Sequence conflict

473

1

T → I in AAH26845. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q8R0G9 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 2B1967D74FA3D683
Show »

FASTA

1,155

128,620

        10         20         30         40         50         60 
MFPSVSSPRT PGPGTRRGPL VGIGPTSTPR ASRRGLSLGS AVNSPVLFSP AGRRSSVSSR 

        70         80         90        100        110        120 
GTPTRIFPHH SISESVNYDV RVFGSSLPVK IMEALTMAEA DEQLSVHVDE GGWACLVCTE 

       130        140        150        160        170        180 
KLLIWKIAVS PVTKLSVCKE LQLPPSDFHG SADLVALSYA ATSGEVHSVQ AVSVMVATKE 

       190        200        210        220        230        240 
GSIRYWPSLA REDTYSDTCV DLGGEKMCRF LTAVQGGSFI LSSVGSQLVR LIPESSGKIH 

       250        260        270        280        290        300 
QHVLPQGQGM LSGIGRRVSS LFGILSPTSD LMLASVLWDR GGSSFYTLTS SNISKWELDD 

       310        320        330        340        350        360 
SSEKQVHSWD VHRTLKESIT DAVWGSESNY EAIKEGVNIQ YLDLKQNCDG LLILAAAWHL 

       370        380        390        400        410        420 
GDSPCLVYYS VITVEDNGNQ MSDAVTVEVT QYNPPFQSED LIACRLMVPN FSSQMTYLYM 

       430        440        450        460        470        480 
ENAVFVCSTG TGKFSLPQEK IVFDTQGDGI LGAGSCAGVP ILFSRNSGLV SVTPRENVSL 

       490        500        510        520        530        540 
LAEDLEESLT SSVGGRGSES MVFETTTKNE TVAHEDKTKL LKAAFLQYCR KDLGRAQIMA 

       550        560        570        580        590        600 
DELFSSHTDL DSDPELDKAV TQISVDLIDD YPASDPRWAE SVPQEAPGLS NTSLIILHQL 

       610        620        630        640        650        660 
EDKMKAHCLL VDFLHQVGLF RRLSSYPIRG TPMSTRLLLC EHAEKLSAAI TLKNHHSRLP 

       670        680        690        700        710        720 
DLVNSAILLA LNKRECEVPN SLTPADVFFR EVSQVDTICE CLLEHEEQVL REVALVSQEW 

       730        740        750        760        770        780 
AEVAIDVNTV LKDMLQAATH YRLNKSSMYS QEEVLGKEPE YVPWTATSGP SGIRTAVMRQ 

       790        800        810        820        830        840 
HGIILKMVYP QADSKLRNVV MEQLVALIDC FLDSYVSQLK SLEKSSDQER YSSLEVEYLQ 

       850        860        870        880        890        900 
KRSELLSPLL TLGQYPWAAS LAEKYCDFDI LVQMCEQTDN QARLQRYMTQ FADQNFSDFL 

       910        920        930        940        950        960 
FRWYLEKGKR GKLLSQPISQ HGQLANFLQA HEHLSWLHEI NSQELEKAHT TLLGLANMET 

       970        980        990       1000       1010       1020 
RYFAKKKTLL GLSKLAALAS DISEDRLQEK IEAMAEQERF LLHQETLPEQ LLTERQLSLS 

      1030       1040       1050       1060       1070       1080 
AMPVLTAPQL ISLYICDENR RANEYDFKKA LDLLEYIDEE EDVSIDDLKL EILCRALQRD 

      1090       1100       1110       1120       1130       1140 
DWSGSDGKDD PIEVSKDSVF VKILQKLIKD GIQLSEYLPE VTDLLRAEQL GSLKSNSYFE 

      1150 
FVLKANYEYY VQGQM

« Hide

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Mammary gland.
[3]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC123825 Genomic DNA. No translation available. AC147266 Genomic DNA. No translation available. BC026845 mRNA. Translation: AAH26845.1. BC023915 mRNA. Translation: AAH23915.1.
IPI	IPI00320303.
RefSeq	NP_758492.2. NM_172288.2.
UniGene	Mm.267812.
3D structure databases
ProteinModelPortal	Q8R0G9.
SMR	Q8R0G9. Positions 74-476, 517-1155.
ModBase	Search...
PTM databases
PhosphoSite	Q8R0G9.
Proteomic databases
PaxDb	Q8R0G9.
PRIDE	Q8R0G9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044795; ENSMUSP00000048084; ENSMUSG00000039509.
GeneID	234865.
KEGG	mmu:234865.
Organism-specific databases
CTD	55746.
MGI	MGI:2442620. Nup133.
Phylogenomic databases
eggNOG	NOG312399.
GeneTree	ENSGT00390000011529.
HOGENOM	HOG000293246.
HOVERGEN	HBG052678.
InParanoid	Q8R0G9.
KO	K14300.
OMA	YLEKGKR.
OrthoDB	EOG469QT0.
Gene expression databases
Bgee	Q8R0G9.
CleanEx	MM_NUP133.
Genevestigator	Q8R0G9.
GermOnline	ENSMUSG00000039509. Mus musculus.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR007187. Nucleoporin_Nup133/Nup155_C. IPR014908. Nucleoporin_Nup133/Nup155_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Pfam	PF03177. Nucleoporin_C. 1 hit. PF08801. Nucleoporin_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NUP133. mouse.
NextBio	382413.
SOURCE	Search...

Entry information

Entry name

NU133_MOUSE

Accession

Primary (citable) accession number: Q8R0G9
Secondary accession number(s): E9QLJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents