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Q8R0G9

- NU133_MOUSE

UniProt

Q8R0G9 - NU133_MOUSE

Protein

Nuclear pore complex protein Nup133

Gene

Nup133

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in poly(A)+ RNA transport.By similarity

    GO - Molecular functioni

    1. nucleocytoplasmic transporter activity Source: UniProtKB

    GO - Biological processi

    1. mRNA export from nucleus Source: UniProtKB
    2. nuclear pore organization Source: Ensembl
    3. paraxial mesoderm development Source: MGI
    4. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore complex protein Nup133
    Alternative name(s):
    133 kDa nucleoporin
    Nucleoporin Nup133
    Gene namesi
    Name:Nup133
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2442620. Nup133.

    Subcellular locationi

    Nucleusnuclear pore complex By similarity. Chromosomecentromerekinetochore By similarity
    Note: Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores By similarity.By similarity

    GO - Cellular componenti

    1. condensed chromosome outer kinetochore Source: Ensembl
    2. nuclear pore Source: UniProtKB
    3. nuclear pore outer ring Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11551155Nuclear pore complex protein Nup133PRO_0000204839Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei7 – 71PhosphoserineBy similarity
    Modified residuei27 – 271PhosphoserineBy similarity
    Modified residuei28 – 281PhosphothreonineBy similarity
    Modified residuei40 – 401PhosphoserineBy similarity
    Modified residuei44 – 441PhosphoserineBy similarity
    Modified residuei49 – 491PhosphoserineBy similarity
    Modified residuei479 – 4791PhosphoserineBy similarity
    Modified residuei786 – 7861N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8R0G9.
    PaxDbiQ8R0G9.
    PRIDEiQ8R0G9.

    PTM databases

    PhosphoSiteiQ8R0G9.

    Expressioni

    Gene expression databases

    BgeeiQ8R0G9.
    CleanExiMM_NUP133.
    GenevestigatoriQ8R0G9.

    Interactioni

    Subunit structurei

    Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus By similarity.By similarity

    Protein-protein interaction databases

    BioGridi231592. 1 interaction.
    IntActiQ8R0G9. 2 interactions.
    MINTiMINT-4104201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R0G9.
    SMRiQ8R0G9. Positions 74-476, 517-1155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nucleoporin Nup133 family.Curated

    Phylogenomic databases

    eggNOGiNOG312399.
    GeneTreeiENSGT00390000011529.
    HOGENOMiHOG000293246.
    HOVERGENiHBG052678.
    InParanoidiQ8R0G9.
    KOiK14300.
    OMAiMCRLMVP.
    OrthoDBiEOG7P8P70.
    TreeFamiTF106141.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
    IPR014908. Nucleoporin_Nup133/Nup155_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF03177. Nucleoporin_C. 1 hit.
    PF08801. Nucleoporin_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R0G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPSVSSPRT PGPGTRRGPL VGIGPTSTPR ASRRGLSLGS AVNSPVLFSP     50
    AGRRSSVSSR GTPTRIFPHH SISESVNYDV RVFGSSLPVK IMEALTMAEA 100
    DEQLSVHVDE GGWACLVCTE KLLIWKIAVS PVTKLSVCKE LQLPPSDFHG 150
    SADLVALSYA ATSGEVHSVQ AVSVMVATKE GSIRYWPSLA REDTYSDTCV 200
    DLGGEKMCRF LTAVQGGSFI LSSVGSQLVR LIPESSGKIH QHVLPQGQGM 250
    LSGIGRRVSS LFGILSPTSD LMLASVLWDR GGSSFYTLTS SNISKWELDD 300
    SSEKQVHSWD VHRTLKESIT DAVWGSESNY EAIKEGVNIQ YLDLKQNCDG 350
    LLILAAAWHL GDSPCLVYYS VITVEDNGNQ MSDAVTVEVT QYNPPFQSED 400
    LIACRLMVPN FSSQMTYLYM ENAVFVCSTG TGKFSLPQEK IVFDTQGDGI 450
    LGAGSCAGVP ILFSRNSGLV SVTPRENVSL LAEDLEESLT SSVGGRGSES 500
    MVFETTTKNE TVAHEDKTKL LKAAFLQYCR KDLGRAQIMA DELFSSHTDL 550
    DSDPELDKAV TQISVDLIDD YPASDPRWAE SVPQEAPGLS NTSLIILHQL 600
    EDKMKAHCLL VDFLHQVGLF RRLSSYPIRG TPMSTRLLLC EHAEKLSAAI 650
    TLKNHHSRLP DLVNSAILLA LNKRECEVPN SLTPADVFFR EVSQVDTICE 700
    CLLEHEEQVL REVALVSQEW AEVAIDVNTV LKDMLQAATH YRLNKSSMYS 750
    QEEVLGKEPE YVPWTATSGP SGIRTAVMRQ HGIILKMVYP QADSKLRNVV 800
    MEQLVALIDC FLDSYVSQLK SLEKSSDQER YSSLEVEYLQ KRSELLSPLL 850
    TLGQYPWAAS LAEKYCDFDI LVQMCEQTDN QARLQRYMTQ FADQNFSDFL 900
    FRWYLEKGKR GKLLSQPISQ HGQLANFLQA HEHLSWLHEI NSQELEKAHT 950
    TLLGLANMET RYFAKKKTLL GLSKLAALAS DISEDRLQEK IEAMAEQERF 1000
    LLHQETLPEQ LLTERQLSLS AMPVLTAPQL ISLYICDENR RANEYDFKKA 1050
    LDLLEYIDEE EDVSIDDLKL EILCRALQRD DWSGSDGKDD PIEVSKDSVF 1100
    VKILQKLIKD GIQLSEYLPE VTDLLRAEQL GSLKSNSYFE FVLKANYEYY 1150
    VQGQM 1155
    Length:1,155
    Mass (Da):128,620
    Last modified:July 27, 2011 - v2
    Checksum:i2B1967D74FA3D683
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti214 – 2141V → E in AAH23915. (PubMed:15489334)Curated
    Sequence conflicti289 – 2891T → R in AAH23915. (PubMed:15489334)Curated
    Sequence conflicti289 – 2891T → R in AAH26845. (PubMed:15489334)Curated
    Sequence conflicti473 – 4731T → I in AAH23915. (PubMed:15489334)Curated
    Sequence conflicti473 – 4731T → I in AAH26845. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123825 Genomic DNA. No translation available.
    AC147266 Genomic DNA. No translation available.
    BC026845 mRNA. Translation: AAH26845.1.
    BC023915 mRNA. Translation: AAH23915.1.
    CCDSiCCDS22765.1.
    RefSeqiNP_758492.2. NM_172288.2.
    UniGeneiMm.267812.

    Genome annotation databases

    EnsembliENSMUST00000044795; ENSMUSP00000048084; ENSMUSG00000039509.
    GeneIDi234865.
    KEGGimmu:234865.
    UCSCiuc009nws.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123825 Genomic DNA. No translation available.
    AC147266 Genomic DNA. No translation available.
    BC026845 mRNA. Translation: AAH26845.1 .
    BC023915 mRNA. Translation: AAH23915.1 .
    CCDSi CCDS22765.1.
    RefSeqi NP_758492.2. NM_172288.2.
    UniGenei Mm.267812.

    3D structure databases

    ProteinModelPortali Q8R0G9.
    SMRi Q8R0G9. Positions 74-476, 517-1155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231592. 1 interaction.
    IntActi Q8R0G9. 2 interactions.
    MINTi MINT-4104201.

    PTM databases

    PhosphoSitei Q8R0G9.

    Proteomic databases

    MaxQBi Q8R0G9.
    PaxDbi Q8R0G9.
    PRIDEi Q8R0G9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044795 ; ENSMUSP00000048084 ; ENSMUSG00000039509 .
    GeneIDi 234865.
    KEGGi mmu:234865.
    UCSCi uc009nws.2. mouse.

    Organism-specific databases

    CTDi 55746.
    MGIi MGI:2442620. Nup133.

    Phylogenomic databases

    eggNOGi NOG312399.
    GeneTreei ENSGT00390000011529.
    HOGENOMi HOG000293246.
    HOVERGENi HBG052678.
    InParanoidi Q8R0G9.
    KOi K14300.
    OMAi MCRLMVP.
    OrthoDBi EOG7P8P70.
    TreeFami TF106141.

    Enzyme and pathway databases

    Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    ChiTaRSi NUP133. mouse.
    NextBioi 382413.
    PROi Q8R0G9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R0G9.
    CleanExi MM_NUP133.
    Genevestigatori Q8R0G9.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR007187. Nucleoporin_Nup133/Nup155_C.
    IPR014908. Nucleoporin_Nup133/Nup155_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF03177. Nucleoporin_C. 1 hit.
    PF08801. Nucleoporin_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Mammary gland.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiNU133_MOUSE
    AccessioniPrimary (citable) accession number: Q8R0G9
    Secondary accession number(s): E9QLJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3