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Q8R0G7

- SPNS1_MOUSE

UniProt

Q8R0G7 - SPNS1_MOUSE

Protein

Protein spinster homolog 1

Gene

Spns1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Sphingolipid transporter. May be involved in necrotic or autophagic cell death By similarity.By similarity

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein spinster homolog 1
    Gene namesi
    Name:Spns1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1920908. Spns1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: Ensembl
    3. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 528527Protein spinster homolog 1PRO_0000305040Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei518 – 5181PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ8R0G7.
    PRIDEiQ8R0G7.

    PTM databases

    PhosphoSiteiQ8R0G7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8R0G7.
    BgeeiQ8R0G7.
    CleanExiMM_SPNS1.
    GenevestigatoriQ8R0G7.

    Interactioni

    Subunit structurei

    Interacts with BCL2 and BCL2L1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R0G7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00390000005976.
    HOGENOMiHOG000276167.
    HOVERGENiHBG055503.
    InParanoidiQ8R0G7.
    OMAiGPTDDRI.
    OrthoDBiEOG783MVC.
    PhylomeDBiQ8R0G7.
    TreeFamiTF314395.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R0G7-1 [UniParc]FASTAAdd to Basket

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    MAGSDTAPFL SQADDPDDGP APGHPGLPGP MGNPKSGELE VPDCEGLQRI    50
    TGLSRGHSTL IVVVLCYINL LNYMDRFTVA GVLTDIEQFF NIGDGSTGLI 100
    QTVFISSYMV LAPVFGYLGD RYNRKYLMCG GIAFWSLVTL GSSFIPREHF 150
    WLLLLTRGLV GVGEASYSTI APTLIADLFV ADQRSRMLSI FYFAIPVGSG 200
    LGYIAGSKVK DVAGDWHWAL RVTPGLGVLA VLLLFLVVQE PPRGAVERHS 250
    GSPPLSPTSW WADLKALARN PSFVLSSLGF TSVAFVTGSL ALWAPAFLLR 300
    SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRRF 350
    NPRADPLVCA AGLLGSAPFL FLALACARGS IVATYIFIFI GETLLSMNWA 400
    IVADILLYVV IPTRRSTAEA FQIVLSHLLG DAGSPYLIGL ISDRLRRSWP 450
    PSFLSEFRAL QFSLMLCAFV GALGGAAFLG TAMFIEDDRR RAQLHVQGLL 500
    HESGPSDDRI VVPQRGRSTR VPVSSVLI 528
    Length:528
    Mass (Da):56,709
    Last modified:June 1, 2002 - v1
    Checksum:iDDAB448D7D2B9E17
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601L → I in BAE39125. (PubMed:16141072)Curated
    Sequence conflicti121 – 1211R → K in AAH02297. (PubMed:15489334)Curated
    Sequence conflicti127 – 1271L → F in AAG43831. (PubMed:11340170)Curated
    Sequence conflicti154 – 1541L → F in AAG43831. (PubMed:11340170)Curated
    Sequence conflicti159 – 1591L → M in AAG43831. (PubMed:11340170)Curated
    Sequence conflicti178 – 1781L → F in AAG43831. (PubMed:11340170)Curated
    Sequence conflicti341 – 3411V → M in AAG43831. (PubMed:11340170)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212372 mRNA. Translation: AAG43831.1.
    AK166931 mRNA. Translation: BAE39125.1.
    BC002297 mRNA. Translation: AAH02297.1.
    BC026854 mRNA. Translation: AAH26854.1.
    BC085491 mRNA. Translation: AAH85491.1.
    CCDSiCCDS21826.1.
    RefSeqiNP_076201.2. NM_023712.3.
    UniGeneiMm.11112.

    Genome annotation databases

    EnsembliENSMUST00000032994; ENSMUSP00000032994; ENSMUSG00000030741.
    GeneIDi73658.
    KEGGimmu:73658.
    UCSCiuc009jqy.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212372 mRNA. Translation: AAG43831.1 .
    AK166931 mRNA. Translation: BAE39125.1 .
    BC002297 mRNA. Translation: AAH02297.1 .
    BC026854 mRNA. Translation: AAH26854.1 .
    BC085491 mRNA. Translation: AAH85491.1 .
    CCDSi CCDS21826.1.
    RefSeqi NP_076201.2. NM_023712.3.
    UniGenei Mm.11112.

    3D structure databases

    ProteinModelPortali Q8R0G7.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R0G7.

    Proteomic databases

    PaxDbi Q8R0G7.
    PRIDEi Q8R0G7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032994 ; ENSMUSP00000032994 ; ENSMUSG00000030741 .
    GeneIDi 73658.
    KEGGi mmu:73658.
    UCSCi uc009jqy.3. mouse.

    Organism-specific databases

    CTDi 83985.
    MGIi MGI:1920908. Spns1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00390000005976.
    HOGENOMi HOG000276167.
    HOVERGENi HBG055503.
    InParanoidi Q8R0G7.
    OMAi GPTDDRI.
    OrthoDBi EOG783MVC.
    PhylomeDBi Q8R0G7.
    TreeFami TF314395.

    Miscellaneous databases

    ChiTaRSi SPNS1. mouse.
    NextBioi 338727.
    PROi Q8R0G7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R0G7.
    Bgeei Q8R0G7.
    CleanExi MM_SPNS1.
    Genevestigatori Q8R0G7.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster."
      Nakano Y., Fujitani K., Kurihara J., Ragan J., Usui-Aoki K., Shimoda L., Lukacsovich T., Suzuki K., Sezaki M., Sano Y., Ueda R., Awano W., Kaneda M., Umeda M., Yamamoto D.
      Mol. Cell. Biol. 21:3775-3788(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and Czech II.
      Tissue: Mammary tumor.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Kidney.

    Entry informationi

    Entry nameiSPNS1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R0G7
    Secondary accession number(s): Q3TKM0, Q99LN7, Q9EQK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3