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Protein

Protein spinster homolog 1

Gene

Spns1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sphingolipid transporter. May be involved in necrotic or autophagic cell death (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein spinster homolog 1
Gene namesi
Name:Spns1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920908 Spns1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003050402 – 528Protein spinster homolog 1Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei518PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R0G7
PaxDbiQ8R0G7
PRIDEiQ8R0G7

PTM databases

iPTMnetiQ8R0G7
PhosphoSitePlusiQ8R0G7
SwissPalmiQ8R0G7

Expressioni

Gene expression databases

BgeeiENSMUSG00000030741
CleanExiMM_SPNS1
ExpressionAtlasiQ8R0G7 baseline and differential
GenevisibleiQ8R0G7 MM

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032994

Structurei

3D structure databases

ProteinModelPortaliQ8R0G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1330 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00390000005976
HOGENOMiHOG000276167
HOVERGENiHBG055503
InParanoidiQ8R0G7
OMAiFASFPMP
OrthoDBiEOG091G082Q
PhylomeDBiQ8R0G7
TreeFamiTF314395

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R0G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSDTAPFL SQADDPDDGP APGHPGLPGP MGNPKSGELE VPDCEGLQRI
60 70 80 90 100
TGLSRGHSTL IVVVLCYINL LNYMDRFTVA GVLTDIEQFF NIGDGSTGLI
110 120 130 140 150
QTVFISSYMV LAPVFGYLGD RYNRKYLMCG GIAFWSLVTL GSSFIPREHF
160 170 180 190 200
WLLLLTRGLV GVGEASYSTI APTLIADLFV ADQRSRMLSI FYFAIPVGSG
210 220 230 240 250
LGYIAGSKVK DVAGDWHWAL RVTPGLGVLA VLLLFLVVQE PPRGAVERHS
260 270 280 290 300
GSPPLSPTSW WADLKALARN PSFVLSSLGF TSVAFVTGSL ALWAPAFLLR
310 320 330 340 350
SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRRF
360 370 380 390 400
NPRADPLVCA AGLLGSAPFL FLALACARGS IVATYIFIFI GETLLSMNWA
410 420 430 440 450
IVADILLYVV IPTRRSTAEA FQIVLSHLLG DAGSPYLIGL ISDRLRRSWP
460 470 480 490 500
PSFLSEFRAL QFSLMLCAFV GALGGAAFLG TAMFIEDDRR RAQLHVQGLL
510 520
HESGPSDDRI VVPQRGRSTR VPVSSVLI
Length:528
Mass (Da):56,709
Last modified:June 1, 2002 - v1
Checksum:iDDAB448D7D2B9E17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60L → I in BAE39125 (PubMed:16141072).Curated1
Sequence conflicti121R → K in AAH02297 (PubMed:15489334).Curated1
Sequence conflicti127L → F in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti154L → F in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti159L → M in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti178L → F in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti341V → M in AAG43831 (PubMed:11340170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212372 mRNA Translation: AAG43831.1
AK166931 mRNA Translation: BAE39125.1
BC002297 mRNA Translation: AAH02297.1
BC026854 mRNA Translation: AAH26854.1
BC085491 mRNA Translation: AAH85491.1
CCDSiCCDS21826.1
RefSeqiNP_076201.2, NM_023712.3
UniGeneiMm.11112

Genome annotation databases

EnsembliENSMUST00000032994; ENSMUSP00000032994; ENSMUSG00000030741
GeneIDi73658
KEGGimmu:73658
UCSCiuc009jqy.3 mouse

Similar proteinsi

Entry informationi

Entry nameiSPNS1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0G7
Secondary accession number(s): Q3TKM0, Q99LN7, Q9EQK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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