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Q8R0G7 (SPNS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein spinster homolog 1
Gene names
Name:Spns1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sphingolipid transporter. May be involved in necrotic or autophagic cell death By similarity.

Subunit structure

Interacts with BCL2 and BCL2L1 By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Spinster (TC 2.A.1.49) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Protein spinster homolog 1
PRO_0000305040

Regions

Transmembrane60 – 8021Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane381 – 40121Helical; Potential
Transmembrane421 – 44121Helical; Potential
Transmembrane465 – 48521Helical; Potential

Amino acid modifications

Modified residue5181Phosphoserine By similarity

Experimental info

Sequence conflict601L → I in BAE39125. Ref.2
Sequence conflict1211R → K in AAH02297. Ref.3
Sequence conflict1271L → F in AAG43831. Ref.1
Sequence conflict1541L → F in AAG43831. Ref.1
Sequence conflict1591L → M in AAG43831. Ref.1
Sequence conflict1781L → F in AAG43831. Ref.1
Sequence conflict3411V → M in AAG43831. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8R0G7 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: DDAB448D7D2B9E17

FASTA52856,709
        10         20         30         40         50         60 
MAGSDTAPFL SQADDPDDGP APGHPGLPGP MGNPKSGELE VPDCEGLQRI TGLSRGHSTL 

        70         80         90        100        110        120 
IVVVLCYINL LNYMDRFTVA GVLTDIEQFF NIGDGSTGLI QTVFISSYMV LAPVFGYLGD 

       130        140        150        160        170        180 
RYNRKYLMCG GIAFWSLVTL GSSFIPREHF WLLLLTRGLV GVGEASYSTI APTLIADLFV 

       190        200        210        220        230        240 
ADQRSRMLSI FYFAIPVGSG LGYIAGSKVK DVAGDWHWAL RVTPGLGVLA VLLLFLVVQE 

       250        260        270        280        290        300 
PPRGAVERHS GSPPLSPTSW WADLKALARN PSFVLSSLGF TSVAFVTGSL ALWAPAFLLR 

       310        320        330        340        350        360 
SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRRF NPRADPLVCA 

       370        380        390        400        410        420 
AGLLGSAPFL FLALACARGS IVATYIFIFI GETLLSMNWA IVADILLYVV IPTRRSTAEA 

       430        440        450        460        470        480 
FQIVLSHLLG DAGSPYLIGL ISDRLRRSWP PSFLSEFRAL QFSLMLCAFV GALGGAAFLG 

       490        500        510        520 
TAMFIEDDRR RAQLHVQGLL HESGPSDDRI VVPQRGRSTR VPVSSVLI

« Hide

References

« Hide 'large scale' references
[1]"Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster."
Nakano Y., Fujitani K., Kurihara J., Ragan J., Usui-Aoki K., Shimoda L., Lukacsovich T., Suzuki K., Sezaki M., Sano Y., Ueda R., Awano W., Kaneda M., Umeda M., Yamamoto D.
Mol. Cell. Biol. 21:3775-3788(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and Czech II.
Tissue: Mammary tumor.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF212372 mRNA. Translation: AAG43831.1.
AK166931 mRNA. Translation: BAE39125.1.
BC002297 mRNA. Translation: AAH02297.1.
BC026854 mRNA. Translation: AAH26854.1.
BC085491 mRNA. Translation: AAH85491.1.
IPIIPI00111254.
RefSeqNP_076201.2. NM_023712.3.
UniGeneMm.11112.

3D structure databases

ProteinModelPortalQ8R0G7.
ModBaseSearch...

PTM databases

PhosphoSiteQ8R0G7.

Proteomic databases

PaxDbQ8R0G7.
PRIDEQ8R0G7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032994; ENSMUSP00000032994; ENSMUSG00000030741.
GeneID73658.
KEGGmmu:73658.
UCSCuc009jqy.2. mouse.

Organism-specific databases

CTD83985.
MGIMGI:1920908. Spns1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00390000005976.
HOGENOMHOG000276167.
HOVERGENHBG055503.
InParanoidQ8R0G7.
OMAFLVVQEP.
OrthoDBEOG451DQM.

Gene expression databases

ArrayExpressQ8R0G7.
BgeeQ8R0G7.
CleanExMM_SPNS1.
GenevestigatorQ8R0G7.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSPNS1. mouse.
NextBio338727.
SOURCESearch...

Entry information

Entry nameSPNS1_MOUSE
AccessionPrimary (citable) accession number: Q8R0G7
Secondary accession number(s): Q3TKM0, Q99LN7, Q9EQK0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2002
Last modified: April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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