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Protein

Protein spinster homolog 1

Gene

Spns1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sphingolipid transporter. May be involved in necrotic or autophagic cell death (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein spinster homolog 1
Gene namesi
Name:Spns1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920908. Spns1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003050402 – 528Protein spinster homolog 1Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei518PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R0G7.
PaxDbiQ8R0G7.
PRIDEiQ8R0G7.

PTM databases

iPTMnetiQ8R0G7.
PhosphoSitePlusiQ8R0G7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030741.
CleanExiMM_SPNS1.
ExpressionAtlasiQ8R0G7. baseline and differential.
GenevisibleiQ8R0G7. MM.

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032994.

Structurei

3D structure databases

ProteinModelPortaliQ8R0G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1330. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00390000005976.
HOGENOMiHOG000276167.
HOVERGENiHBG055503.
InParanoidiQ8R0G7.
OMAiGPTDDRI.
OrthoDBiEOG091G082Q.
PhylomeDBiQ8R0G7.
TreeFamiTF314395.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R0G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSDTAPFL SQADDPDDGP APGHPGLPGP MGNPKSGELE VPDCEGLQRI
60 70 80 90 100
TGLSRGHSTL IVVVLCYINL LNYMDRFTVA GVLTDIEQFF NIGDGSTGLI
110 120 130 140 150
QTVFISSYMV LAPVFGYLGD RYNRKYLMCG GIAFWSLVTL GSSFIPREHF
160 170 180 190 200
WLLLLTRGLV GVGEASYSTI APTLIADLFV ADQRSRMLSI FYFAIPVGSG
210 220 230 240 250
LGYIAGSKVK DVAGDWHWAL RVTPGLGVLA VLLLFLVVQE PPRGAVERHS
260 270 280 290 300
GSPPLSPTSW WADLKALARN PSFVLSSLGF TSVAFVTGSL ALWAPAFLLR
310 320 330 340 350
SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRRF
360 370 380 390 400
NPRADPLVCA AGLLGSAPFL FLALACARGS IVATYIFIFI GETLLSMNWA
410 420 430 440 450
IVADILLYVV IPTRRSTAEA FQIVLSHLLG DAGSPYLIGL ISDRLRRSWP
460 470 480 490 500
PSFLSEFRAL QFSLMLCAFV GALGGAAFLG TAMFIEDDRR RAQLHVQGLL
510 520
HESGPSDDRI VVPQRGRSTR VPVSSVLI
Length:528
Mass (Da):56,709
Last modified:June 1, 2002 - v1
Checksum:iDDAB448D7D2B9E17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60L → I in BAE39125 (PubMed:16141072).Curated1
Sequence conflicti121R → K in AAH02297 (PubMed:15489334).Curated1
Sequence conflicti127L → F in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti154L → F in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti159L → M in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti178L → F in AAG43831 (PubMed:11340170).Curated1
Sequence conflicti341V → M in AAG43831 (PubMed:11340170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212372 mRNA. Translation: AAG43831.1.
AK166931 mRNA. Translation: BAE39125.1.
BC002297 mRNA. Translation: AAH02297.1.
BC026854 mRNA. Translation: AAH26854.1.
BC085491 mRNA. Translation: AAH85491.1.
CCDSiCCDS21826.1.
RefSeqiNP_076201.2. NM_023712.3.
UniGeneiMm.11112.

Genome annotation databases

EnsembliENSMUST00000032994; ENSMUSP00000032994; ENSMUSG00000030741.
GeneIDi73658.
KEGGimmu:73658.
UCSCiuc009jqy.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212372 mRNA. Translation: AAG43831.1.
AK166931 mRNA. Translation: BAE39125.1.
BC002297 mRNA. Translation: AAH02297.1.
BC026854 mRNA. Translation: AAH26854.1.
BC085491 mRNA. Translation: AAH85491.1.
CCDSiCCDS21826.1.
RefSeqiNP_076201.2. NM_023712.3.
UniGeneiMm.11112.

3D structure databases

ProteinModelPortaliQ8R0G7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032994.

PTM databases

iPTMnetiQ8R0G7.
PhosphoSitePlusiQ8R0G7.

Proteomic databases

MaxQBiQ8R0G7.
PaxDbiQ8R0G7.
PRIDEiQ8R0G7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032994; ENSMUSP00000032994; ENSMUSG00000030741.
GeneIDi73658.
KEGGimmu:73658.
UCSCiuc009jqy.3. mouse.

Organism-specific databases

CTDi83985.
MGIiMGI:1920908. Spns1.

Phylogenomic databases

eggNOGiKOG1330. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00390000005976.
HOGENOMiHOG000276167.
HOVERGENiHBG055503.
InParanoidiQ8R0G7.
OMAiGPTDDRI.
OrthoDBiEOG091G082Q.
PhylomeDBiQ8R0G7.
TreeFamiTF314395.

Miscellaneous databases

ChiTaRSiSpns1. mouse.
PROiQ8R0G7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030741.
CleanExiMM_SPNS1.
ExpressionAtlasiQ8R0G7. baseline and differential.
GenevisibleiQ8R0G7. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPNS1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0G7
Secondary accession number(s): Q3TKM0, Q99LN7, Q9EQK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.