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Protein

Acylpyruvase FAHD1, mitochondrial

Gene

Fahd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity (PubMed:25575590).By similarity1 Publication

Catalytic activityi

A 3-acylpyruvate + H2O = a carboxylate + pyruvate.By similarity
Oxaloacetate = pyruvate + CO2.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Divalent metal cationBy similarity1
Metal bindingi76Divalent metal cationBy similarity1
Metal bindingi105Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Lyase

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acylpyruvase FAHD1, mitochondrial (EC:3.7.1.5)
Alternative name(s):
Fumarylacetoacetate hydrolase domain-containing protein 1
Oxaloacetate decarboxylaseBy similarity (EC:4.1.1.3By similarity)
Short name:
OAA decarboxylaseBy similarity
Gene namesi
Name:Fahd1
ORF Names:MNCb-4134
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1915886. Fahd1.

Subcellular locationi

  • Mitochondrion By similarity
  • Cytoplasmcytosol By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Elevated oxaloacetate levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000015683031 – 227Acylpyruvase FAHD1, mitochondrialAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei118N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R0F8.
PaxDbiQ8R0F8.
PeptideAtlasiQ8R0F8.
PRIDEiQ8R0F8.

PTM databases

iPTMnetiQ8R0F8.
PhosphoSitePlusiQ8R0F8.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in the liver and the kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000045316.
CleanExiMM_FAHD1.
GenevisibleiQ8R0F8. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8R0F8. 4 interactors.
MINTiMINT-1849538.
STRINGi10090.ENSMUSP00000055827.

Structurei

3D structure databases

ProteinModelPortaliQ8R0F8.
SMRiQ8R0F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1535. Eukaryota.
COG0179. LUCA.
GeneTreeiENSGT00530000063832.
HOGENOMiHOG000063753.
HOVERGENiHBG057495.
InParanoidiQ8R0F8.
KOiK01557.
OMAiVVSMRFK.
OrthoDBiEOG091G0I6G.
TreeFamiTF300911.

Family and domain databases

Gene3Di3.90.850.10. 1 hit.
InterProiIPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R0F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSCTMAST KPLSRFWEWG KNIVCVGRNY ADHVKEMRST VLSEPVLFLK
60 70 80 90 100
PSTAYAPEGS PVLMPAYCRN LHHEVELGVL LGKRGEAIPE AAAMDYVAGY
110 120 130 140 150
ALCLDMTARD VQEECKKKGL PWTLAKSFTS SCPVSAFVPK EKIPDPHALR
160 170 180 190 200
LWLKVNGELR QEGKTSSMIF SIPYIISYVS KIITLEEGDL ILTGTPKGVG
210 220
PIKENDEIEA GIDGVVSMRF KVKRSEY
Length:227
Mass (Da):25,172
Last modified:October 3, 2012 - v2
Checksum:i62C5AEA14F8F38C5
GO

Sequence cautioni

The sequence BAC32142 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → R in BAC32142 (PubMed:16141072).Curated1
Sequence conflicti202I → V in BAE34035 (PubMed:16141072).Curated1
Sequence conflicti202I → V in AAH26949 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041600 mRNA. Translation: BAA95083.1.
AK044920 mRNA. Translation: BAC32142.1. Different initiation.
AK157292 mRNA. Translation: BAE34035.1.
AK141973 mRNA. Translation: BAE24904.1.
AC166102 Genomic DNA. No translation available.
BC026949 mRNA. Translation: AAH26949.1.
CCDSiCCDS37496.1.
RefSeqiNP_075969.1. NM_023480.2.
UniGeneiMm.347964.

Genome annotation databases

EnsembliENSMUST00000049642; ENSMUSP00000055827; ENSMUSG00000045316.
GeneIDi68636.
KEGGimmu:68636.
UCSCiuc008ayl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041600 mRNA. Translation: BAA95083.1.
AK044920 mRNA. Translation: BAC32142.1. Different initiation.
AK157292 mRNA. Translation: BAE34035.1.
AK141973 mRNA. Translation: BAE24904.1.
AC166102 Genomic DNA. No translation available.
BC026949 mRNA. Translation: AAH26949.1.
CCDSiCCDS37496.1.
RefSeqiNP_075969.1. NM_023480.2.
UniGeneiMm.347964.

3D structure databases

ProteinModelPortaliQ8R0F8.
SMRiQ8R0F8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R0F8. 4 interactors.
MINTiMINT-1849538.
STRINGi10090.ENSMUSP00000055827.

PTM databases

iPTMnetiQ8R0F8.
PhosphoSitePlusiQ8R0F8.

Proteomic databases

MaxQBiQ8R0F8.
PaxDbiQ8R0F8.
PeptideAtlasiQ8R0F8.
PRIDEiQ8R0F8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049642; ENSMUSP00000055827; ENSMUSG00000045316.
GeneIDi68636.
KEGGimmu:68636.
UCSCiuc008ayl.1. mouse.

Organism-specific databases

CTDi81889.
MGIiMGI:1915886. Fahd1.

Phylogenomic databases

eggNOGiKOG1535. Eukaryota.
COG0179. LUCA.
GeneTreeiENSGT00530000063832.
HOGENOMiHOG000063753.
HOVERGENiHBG057495.
InParanoidiQ8R0F8.
KOiK01557.
OMAiVVSMRFK.
OrthoDBiEOG091G0I6G.
TreeFamiTF300911.

Miscellaneous databases

PROiQ8R0F8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045316.
CleanExiMM_FAHD1.
GenevisibleiQ8R0F8. MM.

Family and domain databases

Gene3Di3.90.850.10. 1 hit.
InterProiIPR011234. Fumarylacetoacetase_C-rel.
[Graphical view]
PfamiPF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFAHD1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0F8
Secondary accession number(s): Q3U020
, Q3UQY4, Q8BLJ7, Q9JJB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.