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Protein

Zinc finger and BTB domain-containing protein 44

Gene

Zbtb44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri399 – 421C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 44
Alternative name(s):
BTB/POZ domain-containing protein 15
Gene namesi
Name:Zbtb44
Synonyms:Btbd15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1925123 Zbtb44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746091 – 453Zinc finger and BTB domain-containing protein 44Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei135PhosphoserineBy similarity1
Modified residuei159PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei200PhosphothreonineCombined sources1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8R0A2
PeptideAtlasiQ8R0A2
PRIDEiQ8R0A2

PTM databases

iPTMnetiQ8R0A2
PhosphoSitePlusiQ8R0A2

Expressioni

Gene expression databases

BgeeiENSMUSG00000047412
CleanExiMM_ZBTB44
ExpressionAtlasiQ8R0A2 baseline and differential
GenevisibleiQ8R0A2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110877

Structurei

3D structure databases

ProteinModelPortaliQ8R0A2
SMRiQ8R0A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 98BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 14Poly-Ser6
Compositional biasi364 – 367Poly-Asp4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri399 – 421C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149041
HOGENOMiHOG000155763
HOVERGENiHBG061797
InParanoidiQ8R0A2
KOiK10515
OMAiTFTHNSP
OrthoDBiEOG091G037M
PhylomeDBiQ8R0A2
TreeFamiTF332673

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA
60 70 80 90 100
ACSDFFRTKL VGQTEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN
110 120 130 140 150
IIDVLAAASY MQMFSVASTC SEFMKSSILW NTPNSQPEKS LDAGQENSSN
160 170 180 190 200
CNFTSRDGSI SPVSSECSAV ERTIPVCRES RRKRKSYIVM SPESPVKCST
210 220 230 240 250
QTSSPQVLNS SASYAENRSQ PVDSSLAFPW TFPFGIDRRI QPEKAKQAEN
260 270 280 290 300
TRTLELPGPS EAGRRVADYV TCESTKPTLP LGTEEDVRVK VERLSDEEVH
310 320 330 340 350
EEVSQPVSAS QSSLSDQQTV PGSEPVQEDL LISPQSSSIG SVDEGVTEGL
360 370 380 390 400
PTLQSTSSTN AHADDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ
410 420 430 440 450
CPTCGVRFTR IQNLKQHMLI HSGIKPFQCD CCGKKFTRAY SLKMHRLKHE

VIS
Length:453
Mass (Da):50,175
Last modified:February 6, 2007 - v2
Checksum:i314AEAFFD1F9AC9C
GO
Isoform 2 (identifier: Q8R0A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-385: Missing.

Note: No experimental confirmation available.
Show »
Length:435
Mass (Da):48,051
Checksum:i46A8F116FDA25575
GO

Sequence cautioni

The sequence BAC29628 differs from that shown. Reason: Erroneous termination at position 348. Translated as Glu.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022838368 – 385Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036895 mRNA Translation: BAC29628.1 Sequence problems.
CT025653 Genomic DNA No translation available.
BG243783 Genomic DNA No translation available.
CCDSiCCDS40568.1 [Q8R0A2-2]
CCDS52747.1 [Q8R0A2-1]
RefSeqiNP_001108602.1, NM_001115130.1 [Q8R0A2-1]
NP_766353.2, NM_172765.3 [Q8R0A2-2]
UniGeneiMm.239355
Mm.393131

Genome annotation databases

EnsembliENSMUST00000115222; ENSMUSP00000110877; ENSMUSG00000047412 [Q8R0A2-1]
ENSMUST00000167346; ENSMUSP00000133109; ENSMUSG00000047412 [Q8R0A2-2]
ENSMUST00000216649; ENSMUSP00000149386; ENSMUSG00000047412 [Q8R0A2-2]
GeneIDi235132
KEGGimmu:235132
UCSCiuc009ord.2 mouse [Q8R0A2-2]
uc009org.2 mouse [Q8R0A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZBT44_MOUSE
AccessioniPrimary (citable) accession number: Q8R0A2
Secondary accession number(s): Q8CB31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 20, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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