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Protein

Zinc finger and BTB domain-containing protein 44

Gene

Zbtb44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri399 – 42123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 44
Alternative name(s):
BTB/POZ domain-containing protein 15
Gene namesi
Name:Zbtb44
Synonyms:Btbd15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1925123. Zbtb44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Zinc finger and BTB domain-containing protein 44PRO_0000274609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei159 – 1591PhosphoserineCombined sources
Modified residuei161 – 1611PhosphoserineCombined sources
Modified residuei165 – 1651PhosphoserineCombined sources
Modified residuei191 – 1911PhosphoserineCombined sources
Modified residuei194 – 1941PhosphoserineCombined sources
Modified residuei199 – 1991PhosphoserineCombined sources
Modified residuei200 – 2001PhosphothreonineCombined sources
Cross-linki290 – 290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R0A2.
MaxQBiQ8R0A2.
PaxDbiQ8R0A2.
PRIDEiQ8R0A2.

PTM databases

iPTMnetiQ8R0A2.
PhosphoSiteiQ8R0A2.

Expressioni

Gene expression databases

BgeeiQ8R0A2.
CleanExiMM_ZBTB44.
GenevisibleiQ8R0A2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110877.

Structurei

3D structure databases

ProteinModelPortaliQ8R0A2.
SMRiQ8R0A2. Positions 6-116, 397-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9868BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 146Poly-Ser
Compositional biasi364 – 3674Poly-Asp

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri399 – 42123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000155763.
HOVERGENiHBG061797.
InParanoidiQ8R0A2.
KOiK10515.
OMAiTFTHNSP.
OrthoDBiEOG7K6PTG.
PhylomeDBiQ8R0A2.
TreeFamiTF332673.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA
60 70 80 90 100
ACSDFFRTKL VGQTEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN
110 120 130 140 150
IIDVLAAASY MQMFSVASTC SEFMKSSILW NTPNSQPEKS LDAGQENSSN
160 170 180 190 200
CNFTSRDGSI SPVSSECSAV ERTIPVCRES RRKRKSYIVM SPESPVKCST
210 220 230 240 250
QTSSPQVLNS SASYAENRSQ PVDSSLAFPW TFPFGIDRRI QPEKAKQAEN
260 270 280 290 300
TRTLELPGPS EAGRRVADYV TCESTKPTLP LGTEEDVRVK VERLSDEEVH
310 320 330 340 350
EEVSQPVSAS QSSLSDQQTV PGSEPVQEDL LISPQSSSIG SVDEGVTEGL
360 370 380 390 400
PTLQSTSSTN AHADDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ
410 420 430 440 450
CPTCGVRFTR IQNLKQHMLI HSGIKPFQCD CCGKKFTRAY SLKMHRLKHE

VIS
Length:453
Mass (Da):50,175
Last modified:February 6, 2007 - v2
Checksum:i314AEAFFD1F9AC9C
GO
Isoform 2 (identifier: Q8R0A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-385: Missing.

Note: No experimental confirmation available.
Show »
Length:435
Mass (Da):48,051
Checksum:i46A8F116FDA25575
GO

Sequence cautioni

The sequence BAC29628.1 differs from that shown. Reason: Erroneous termination at position 348. Translated as Glu.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei368 – 38518Missing in isoform 2. 1 PublicationVSP_022838Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036895 mRNA. Translation: BAC29628.1. Sequence problems.
CT025653 Genomic DNA. No translation available.
BG243783 Genomic DNA. No translation available.
CCDSiCCDS40568.1. [Q8R0A2-2]
CCDS52747.1. [Q8R0A2-1]
RefSeqiNP_001108602.1. NM_001115130.1. [Q8R0A2-1]
NP_766353.2. NM_172765.3. [Q8R0A2-2]
UniGeneiMm.239355.
Mm.393131.

Genome annotation databases

EnsembliENSMUST00000115222; ENSMUSP00000110877; ENSMUSG00000047412. [Q8R0A2-1]
ENSMUST00000167346; ENSMUSP00000133109; ENSMUSG00000047412. [Q8R0A2-2]
GeneIDi235132.
KEGGimmu:235132.
UCSCiuc009ord.2. mouse. [Q8R0A2-2]
uc009org.2. mouse. [Q8R0A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036895 mRNA. Translation: BAC29628.1. Sequence problems.
CT025653 Genomic DNA. No translation available.
BG243783 Genomic DNA. No translation available.
CCDSiCCDS40568.1. [Q8R0A2-2]
CCDS52747.1. [Q8R0A2-1]
RefSeqiNP_001108602.1. NM_001115130.1. [Q8R0A2-1]
NP_766353.2. NM_172765.3. [Q8R0A2-2]
UniGeneiMm.239355.
Mm.393131.

3D structure databases

ProteinModelPortaliQ8R0A2.
SMRiQ8R0A2. Positions 6-116, 397-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110877.

PTM databases

iPTMnetiQ8R0A2.
PhosphoSiteiQ8R0A2.

Proteomic databases

EPDiQ8R0A2.
MaxQBiQ8R0A2.
PaxDbiQ8R0A2.
PRIDEiQ8R0A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115222; ENSMUSP00000110877; ENSMUSG00000047412. [Q8R0A2-1]
ENSMUST00000167346; ENSMUSP00000133109; ENSMUSG00000047412. [Q8R0A2-2]
GeneIDi235132.
KEGGimmu:235132.
UCSCiuc009ord.2. mouse. [Q8R0A2-2]
uc009org.2. mouse. [Q8R0A2-1]

Organism-specific databases

CTDi29068.
MGIiMGI:1925123. Zbtb44.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000155763.
HOVERGENiHBG061797.
InParanoidiQ8R0A2.
KOiK10515.
OMAiTFTHNSP.
OrthoDBiEOG7K6PTG.
PhylomeDBiQ8R0A2.
TreeFamiTF332673.

Miscellaneous databases

ChiTaRSiZbtb44. mouse.
PROiQ8R0A2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R0A2.
CleanExiMM_ZBTB44.
GenevisibleiQ8R0A2. MM.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Vagina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 287-453 (ISOFORM 1).
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159; SER-161; SER-165; SER-191; SER-194; SER-199 AND THR-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiZBT44_MOUSE
AccessioniPrimary (citable) accession number: Q8R0A2
Secondary accession number(s): Q8CB31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.