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Protein

Chromaffin granule amine transporter

Gene

Slc18a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromaffin granule amine transporter
Alternative name(s):
Solute carrier family 18 member 1
Vesicular amine transporter 1
Short name:
VAT1
Gene namesi
Name:Slc18a1
Synonyms:Vmat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106684. Slc18a1.

Subcellular locationi

  • Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence analysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Topological domaini43 – 13593Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei136 – 15520HelicalSequence analysisAdd
BLAST
Topological domaini156 – 1649CytoplasmicSequence analysis
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Topological domaini186 – 1949Lumenal, vesicleSequence analysis
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 2249CytoplasmicSequence analysis
Transmembranei225 – 24723HelicalSequence analysisAdd
BLAST
Topological domaini248 – 2536Lumenal, vesicleSequence analysis
Transmembranei254 – 27623HelicalSequence analysisAdd
BLAST
Topological domaini277 – 29620CytoplasmicSequence analysisAdd
BLAST
Transmembranei297 – 31620HelicalSequence analysisAdd
BLAST
Topological domaini317 – 33216Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei333 – 35725HelicalSequence analysisAdd
BLAST
Topological domaini358 – 3625CytoplasmicSequence analysis
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Topological domaini384 – 39411Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST
Topological domaini416 – 4194CytoplasmicSequence analysis
Transmembranei420 – 44021HelicalSequence analysisAdd
BLAST
Topological domaini441 – 4455Lumenal, vesicleSequence analysis
Transmembranei446 – 46722HelicalSequence analysisAdd
BLAST
Topological domaini468 – 52154CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Chromaffin granule amine transporterPRO_0000127511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R090.
PRIDEiQ8R090.

PTM databases

iPTMnetiQ8R090.
PhosphoSiteiQ8R090.
SwissPalmiQ8R090.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036330.
ExpressionAtlasiQ8R090. baseline and differential.
GenevisibleiQ8R090. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046924.

Structurei

3D structure databases

ProteinModelPortaliQ8R090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3764. Eukaryota.
ENOG410XW69. LUCA.
GeneTreeiENSGT00390000003851.
HOGENOMiHOG000018545.
HOVERGENiHBG055082.
InParanoidiQ8R090.
KOiK08155.
OMAiNNCLQGT.
OrthoDBiEOG091G0534.
PhylomeDBiQ8R090.
TreeFamiTF313494.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQVVLGAPQ RLLKEGRQSR KLVLVVVFVA LLLDNMLLTV VVPIVPTFLY
60 70 80 90 100
ATEFKDINSS LLRGPSVSSQ QALTSPAFST TFSFFDNTTM TVEEHVPFRV
110 120 130 140 150
AWINGTIPPP VTEAGSVPKN NCLQGIEFLE EENVRIGILF ASKALMQLLV
160 170 180 190 200
NPFVGPLTNR IGYHIPMFVG FMIMFLSTLM FAFSGTYALL FVARTLQGIG
210 220 230 240 250
SSFSSVAGLG MLASVYTDNY ERGRAMGIAL GGLALGLLVG APFGSVMYEF
260 270 280 290 300
VGKSSPFLIL AFLALLDGAL QFCILWPSKV SPESAMGTPL LTLLKDPYIL
310 320 330 340 350
VAAGSICLAN MGVAILEPTL PIWMMQTMCS PEWQLGLAFL PASVAYLIGT
360 370 380 390 400
NLFGVLANKM GRWLCSLVGM VAVGISLLCV PLAHNIFGLI GPNAGLGFAI
410 420 430 440 450
GMVDSSLMPI MGYLVDLRHT SVYGSVYAIA DVAFCVGFAI GPSTGGVIVP
460 470 480 490 500
VIGFPWLMVI IGTINIIYAP LCCFLQNPPA KEEELAILNQ ECPTETQMYT
510 520
IQRPTKEFPL GENSDDPGSE E
Length:521
Mass (Da):56,033
Last modified:June 1, 2002 - v1
Checksum:i2258D64F5F3D15DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027192 mRNA. Translation: AAH27192.1.
BC031146 mRNA. Translation: AAH31146.1.
CCDSiCCDS22344.1.
RefSeqiNP_694694.1. NM_153054.2.
XP_006509597.1. XM_006509534.2.
UniGeneiMm.19301.

Genome annotation databases

EnsembliENSMUST00000037478; ENSMUSP00000046924; ENSMUSG00000036330.
GeneIDi110877.
KEGGimmu:110877.
UCSCiuc009lwt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027192 mRNA. Translation: AAH27192.1.
BC031146 mRNA. Translation: AAH31146.1.
CCDSiCCDS22344.1.
RefSeqiNP_694694.1. NM_153054.2.
XP_006509597.1. XM_006509534.2.
UniGeneiMm.19301.

3D structure databases

ProteinModelPortaliQ8R090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046924.

PTM databases

iPTMnetiQ8R090.
PhosphoSiteiQ8R090.
SwissPalmiQ8R090.

Proteomic databases

PaxDbiQ8R090.
PRIDEiQ8R090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037478; ENSMUSP00000046924; ENSMUSG00000036330.
GeneIDi110877.
KEGGimmu:110877.
UCSCiuc009lwt.1. mouse.

Organism-specific databases

CTDi6570.
MGIiMGI:106684. Slc18a1.

Phylogenomic databases

eggNOGiKOG3764. Eukaryota.
ENOG410XW69. LUCA.
GeneTreeiENSGT00390000003851.
HOGENOMiHOG000018545.
HOVERGENiHBG055082.
InParanoidiQ8R090.
KOiK08155.
OMAiNNCLQGT.
OrthoDBiEOG091G0534.
PhylomeDBiQ8R090.
TreeFamiTF313494.

Enzyme and pathway databases

ReactomeiR-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiQ8R090.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036330.
ExpressionAtlasiQ8R090. baseline and differential.
GenevisibleiQ8R090. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMAT1_MOUSE
AccessioniPrimary (citable) accession number: Q8R090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.