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Protein

Probable fibrosin-1

Gene

Fbrs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • growth factor activity Source: MGI

GO - Biological processi

  • positive regulation of fibroblast proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fibrosin-1
Gene namesi
Name:Fbrs
Synonyms:Fbs, Fbs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104648. Fbrs.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872071 – 466Probable fibrosin-1Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229Asymmetric dimethylarginineCombined sources1
Modified residuei239Asymmetric dimethylarginineBy similarity1
Modified residuei281PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R089.
PaxDbiQ8R089.
PRIDEiQ8R089.

PTM databases

iPTMnetiQ8R089.
PhosphoSitePlusiQ8R089.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042423.
CleanExiMM_FBRS.
ExpressionAtlasiQ8R089. baseline and differential.
GenevisibleiQ8R089. MM.

Interactioni

GO - Molecular functioni

  • growth factor activity Source: MGI

Structurei

3D structure databases

ProteinModelPortaliQ8R089.
SMRiQ8R089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 334Ala-richAdd BLAST24
Compositional biasi348 – 461Pro-richAdd BLAST114

Phylogenomic databases

eggNOGiENOG410IK36. Eukaryota.
ENOG4111ADK. LUCA.
GeneTreeiENSGT00390000001466.
HOVERGENiHBG051563.
InParanoidiQ8R089.
OMAiSERCPGF.
OrthoDBiEOG091G01SH.
TreeFamiTF331929.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.

Sequencei

Sequence statusi: Complete.

Q8R089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKYPGKME GLFRHNPYMA FPPAVPGLPP GLPPAVSFGS LQGAFQPKNT
60 70 80 90 100
NPELPPRLGP VLSGLPQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH
110 120 130 140 150
QEKMKGDSHK LDFRNDLLPC LPGPYGALPP GQELSHPASL FTATGAVHAA
160 170 180 190 200
ANPFTTAPGA HGPFLSPSTH IDPFGRPTSF ASLAALSNGA FGGLGSPTFN
210 220 230 240 250
SSAVFAQKES PGAPPAFASP PDPWGRLHRS PLAFPAWVRP PETARTPGSD
260 270 280 290 300
KERPMERREP SVTKEEKDRD LPFSRPQLRV SPATPKARAG EEGARPAKES
310 320 330 340 350
VRVKEERKEE AAAAAAAAAA AAAAAAAAAA AAAATTGPQG LHLLLERPRP
360 370 380 390 400
PPFLGPSLPE RCAGFPEPTW LAGPPRLARP PRFYEAGEEL TGPGAMAAAR
410 420 430 440 450
LYSLDPAHPL LYSRLAPPPP PTATPGTPHL LSKTPPGALL GAPPPLVPAP
460
RPSSPPRAPG PARADR
Length:466
Mass (Da):49,038
Last modified:May 3, 2011 - v2
Checksum:i9852DF3F13B97FAE
GO

Sequence cautioni

The sequence AAH27193 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AK037952 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AK037952 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283A → T in AK037952 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136146 Genomic DNA. No translation available.
BC027193 mRNA. Translation: AAH27193.1. Different initiation.
AK037952 mRNA. No translation available.
CCDSiCCDS52408.1.
RefSeqiNP_034313.1. NM_010183.1.
UniGeneiMm.323505.

Genome annotation databases

EnsembliENSMUST00000048896; ENSMUSP00000043682; ENSMUSG00000042423.
ENSMUST00000205432; ENSMUSP00000145783; ENSMUSG00000042423.
GeneIDi14123.
KEGGimmu:14123.
UCSCiuc009jvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136146 Genomic DNA. No translation available.
BC027193 mRNA. Translation: AAH27193.1. Different initiation.
AK037952 mRNA. No translation available.
CCDSiCCDS52408.1.
RefSeqiNP_034313.1. NM_010183.1.
UniGeneiMm.323505.

3D structure databases

ProteinModelPortaliQ8R089.
SMRiQ8R089.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8R089.
PhosphoSitePlusiQ8R089.

Proteomic databases

MaxQBiQ8R089.
PaxDbiQ8R089.
PRIDEiQ8R089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048896; ENSMUSP00000043682; ENSMUSG00000042423.
ENSMUST00000205432; ENSMUSP00000145783; ENSMUSG00000042423.
GeneIDi14123.
KEGGimmu:14123.
UCSCiuc009jvs.2. mouse.

Organism-specific databases

CTDi64319.
MGIiMGI:104648. Fbrs.

Phylogenomic databases

eggNOGiENOG410IK36. Eukaryota.
ENOG4111ADK. LUCA.
GeneTreeiENSGT00390000001466.
HOVERGENiHBG051563.
InParanoidiQ8R089.
OMAiSERCPGF.
OrthoDBiEOG091G01SH.
TreeFamiTF331929.

Miscellaneous databases

PROiQ8R089.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042423.
CleanExiMM_FBRS.
ExpressionAtlasiQ8R089. baseline and differential.
GenevisibleiQ8R089. MM.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.
ProtoNetiSearch...

Entry informationi

Entry nameiFBRS_MOUSE
AccessioniPrimary (citable) accession number: Q8R089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 3, 2011
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Prakash et al. cloned a partial cDNA corresponding to the 3'UTR of the last exon of the gene (PubMed:7892239). They have shown that a synthetic peptide derived from this sequence could stimulate fibroblasts growth in vitro, and that this protein could be a fibrogenic lymphokine, that could stimulate several biological activities related to scarring. It would be expressed several cell types including CD4+ lymphocytes and fibroblasts. However, it was not confirmed by in vivo data.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.