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Protein

Sulfite oxidase, mitochondrial

Gene

Suox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.By similarity
  • Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Pathway:isulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi119 – 1191Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi144 – 1441Iron (heme axial ligand)PROSITE-ProRule annotation
Binding sitei146 – 1461Heme bBy similarity
Binding sitei148 – 1481Heme bBy similarity
Metal bindingi265 – 2651MolybdenumBy similarity
Binding sitei323 – 3231MolybdopterinBy similarity
Binding sitei362 – 3621MolybdopterinBy similarity
Binding sitei367 – 3671MolybdopterinBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

ReactomeiREACT_273024. Sulfide oxidation to sulfate.
UniPathwayiUPA00096.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase, mitochondrial (EC:1.8.3.1)
Gene namesi
Name:Suox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2446117. Suox.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • mitochondrial intermembrane space Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8080MitochondrionBy similarityAdd
BLAST
Chaini81 – 546466Sulfite oxidase, mitochondrialPRO_0000006483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R086.
PaxDbiQ8R086.
PRIDEiQ8R086.

2D gel databases

REPRODUCTION-2DPAGEQ8R086.

PTM databases

PhosphoSiteiQ8R086.

Expressioni

Gene expression databases

BgeeiQ8R086.
CleanExiMM_SUOX.
GenevisibleiQ8R086. MM.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiQ8R086. 5 interactions.
MINTiMINT-1860734.
STRINGi10090.ENSMUSP00000056195.

Structurei

3D structure databases

ProteinModelPortaliQ8R086.
SMRiQ8R086. Positions 82-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 16280Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 17510HingeBy similarity
Regioni176 – 402227Moco domainBy similarityAdd
BLAST
Regioni216 – 2205Molybdopterin-bindingBy similarity
Regioni378 – 3803Molybdopterin-bindingBy similarity
Regioni403 – 539137HomodimerizationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG2041.
GeneTreeiENSGT00390000003749.
HOGENOMiHOG000252609.
HOVERGENiHBG017865.
InParanoidiQ8R086.
KOiK00387.
OMAiAVHNQSH.
OrthoDBiEOG7P8P7Z.
PhylomeDBiQ8R086.
TreeFamiTF300905.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLQLYRSVV VRLPQAIRVK STPLRLCIQA CSTNDSLEPQ HPSLTFSDDN
60 70 80 90 100
SRTRRWKVMG TLLGLGVVLV YHEHRCRASQ ESPRMYSKED VRSHNNPKTG
110 120 130 140 150
VWVTLGSEVF DVTKFVDLHP GGPSKLMLAA GGPLEPFWAL YAVHNQPHVR
160 170 180 190 200
ELLAEYKIGE LNPEDSMSPS VEASDPYADD PIRHPALRIN SQRPFNAEPP
210 220 230 240 250
PELLTEGYIT PNPIFFTRNH LPVPNLDPHT YRLHVVGAPG GQSLSLSLDD
260 270 280 290 300
LHKFPKHEVT VTLQCAGNRR SEMSKVKEVK GLEWRTGAIS TARWAGARLC
310 320 330 340 350
DVLAQAGHRL CDSEAHVCFE GLDSDPTGTA YGASIPLARA MDPEAEVLLA
360 370 380 390 400
YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD
410 420 430 440 450
YKGFSPSVDW DTVNFDLAPS IQELPIQSAI TQPQDGAIVE SGEVTIKGYA
460 470 480 490 500
WSGGGRAVIR VDVSVDGGLT WQEAELEGEE QCPRKAWAWR IWQLKAQVPA
510 520 530 540
EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP
Length:546
Mass (Da):60,756
Last modified:July 10, 2007 - v2
Checksum:iA10ADF73FFA8DE51
GO

Sequence cautioni

The sequence BAE32710.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti455 – 4551G → S in BAE28865 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149422 mRNA. Translation: BAE28865.1.
AK154608 mRNA. Translation: BAE32710.1. Different initiation.
BC027197 mRNA. Translation: AAH27197.2.
CCDSiCCDS24285.1.
RefSeqiNP_776094.2. NM_173733.3.
UniGeneiMm.23352.

Genome annotation databases

EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858.
GeneIDi211389.
KEGGimmu:211389.
UCSCiuc007hnt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149422 mRNA. Translation: BAE28865.1.
AK154608 mRNA. Translation: BAE32710.1. Different initiation.
BC027197 mRNA. Translation: AAH27197.2.
CCDSiCCDS24285.1.
RefSeqiNP_776094.2. NM_173733.3.
UniGeneiMm.23352.

3D structure databases

ProteinModelPortaliQ8R086.
SMRiQ8R086. Positions 82-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R086. 5 interactions.
MINTiMINT-1860734.
STRINGi10090.ENSMUSP00000056195.

PTM databases

PhosphoSiteiQ8R086.

2D gel databases

REPRODUCTION-2DPAGEQ8R086.

Proteomic databases

MaxQBiQ8R086.
PaxDbiQ8R086.
PRIDEiQ8R086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858.
GeneIDi211389.
KEGGimmu:211389.
UCSCiuc007hnt.2. mouse.

Organism-specific databases

CTDi6821.
MGIiMGI:2446117. Suox.

Phylogenomic databases

eggNOGiCOG2041.
GeneTreeiENSGT00390000003749.
HOGENOMiHOG000252609.
HOVERGENiHBG017865.
InParanoidiQ8R086.
KOiK00387.
OMAiAVHNQSH.
OrthoDBiEOG7P8P7Z.
PhylomeDBiQ8R086.
TreeFamiTF300905.

Enzyme and pathway databases

UniPathwayiUPA00096.
ReactomeiREACT_273024. Sulfide oxidation to sulfate.

Miscellaneous databases

NextBioi373222.
PROiQ8R086.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R086.
CleanExiMM_SUOX.
GenevisibleiQ8R086. MM.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSUOX_MOUSE
AccessioniPrimary (citable) accession number: Q8R086
Secondary accession number(s): Q3U3S5, Q3UEP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: July 10, 2007
Last modified: July 22, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.