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Protein

Sulfite oxidase, mitochondrial

Gene

Suox

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.By similarity
  • Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Pathwayi: sulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi119Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi144Iron (heme axial ligand)PROSITE-ProRule annotation1
Binding sitei146Heme bBy similarity1
Binding sitei148Heme bBy similarity1
Metal bindingi265MolybdenumBy similarity1
Binding sitei323MolybdopterinBy similarity1
Binding sitei362MolybdopterinBy similarity1
Binding sitei367MolybdopterinBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

ReactomeiR-MMU-1614517. Sulfide oxidation to sulfate.
UniPathwayiUPA00096.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase, mitochondrial (EC:1.8.3.1)
Gene namesi
Name:Suox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2446117. Suox.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 80MitochondrionBy similarityAdd BLAST80
ChainiPRO_000000648381 – 546Sulfite oxidase, mitochondrialAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R086.
MaxQBiQ8R086.
PaxDbiQ8R086.
PeptideAtlasiQ8R086.
PRIDEiQ8R086.

2D gel databases

REPRODUCTION-2DPAGEQ8R086.

PTM databases

iPTMnetiQ8R086.
PhosphoSitePlusiQ8R086.
SwissPalmiQ8R086.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049858.
CleanExiMM_SUOX.
GenevisibleiQ8R086. MM.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi229229. 1 interactor.
IntActiQ8R086. 5 interactors.
MINTiMINT-1860734.
STRINGi10090.ENSMUSP00000056195.

Structurei

3D structure databases

ProteinModelPortaliQ8R086.
SMRiQ8R086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 162Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 175HingeBy similarity10
Regioni176 – 402Moco domainBy similarityAdd BLAST227
Regioni216 – 220Molybdopterin-bindingBy similarity5
Regioni378 – 380Molybdopterin-bindingBy similarity3
Regioni403 – 539HomodimerizationBy similarityAdd BLAST137

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0535. Eukaryota.
KOG4576. Eukaryota.
COG2041. LUCA.
GeneTreeiENSGT00390000003749.
HOGENOMiHOG000252609.
HOVERGENiHBG017865.
InParanoidiQ8R086.
KOiK00387.
OMAiAVHNQSH.
OrthoDBiEOG091G0DBF.
PhylomeDBiQ8R086.
TreeFamiTF300905.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLQLYRSVV VRLPQAIRVK STPLRLCIQA CSTNDSLEPQ HPSLTFSDDN
60 70 80 90 100
SRTRRWKVMG TLLGLGVVLV YHEHRCRASQ ESPRMYSKED VRSHNNPKTG
110 120 130 140 150
VWVTLGSEVF DVTKFVDLHP GGPSKLMLAA GGPLEPFWAL YAVHNQPHVR
160 170 180 190 200
ELLAEYKIGE LNPEDSMSPS VEASDPYADD PIRHPALRIN SQRPFNAEPP
210 220 230 240 250
PELLTEGYIT PNPIFFTRNH LPVPNLDPHT YRLHVVGAPG GQSLSLSLDD
260 270 280 290 300
LHKFPKHEVT VTLQCAGNRR SEMSKVKEVK GLEWRTGAIS TARWAGARLC
310 320 330 340 350
DVLAQAGHRL CDSEAHVCFE GLDSDPTGTA YGASIPLARA MDPEAEVLLA
360 370 380 390 400
YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD
410 420 430 440 450
YKGFSPSVDW DTVNFDLAPS IQELPIQSAI TQPQDGAIVE SGEVTIKGYA
460 470 480 490 500
WSGGGRAVIR VDVSVDGGLT WQEAELEGEE QCPRKAWAWR IWQLKAQVPA
510 520 530 540
EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP
Length:546
Mass (Da):60,756
Last modified:July 10, 2007 - v2
Checksum:iA10ADF73FFA8DE51
GO

Sequence cautioni

The sequence BAE32710 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455G → S in BAE28865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149422 mRNA. Translation: BAE28865.1.
AK154608 mRNA. Translation: BAE32710.1. Different initiation.
BC027197 mRNA. Translation: AAH27197.2.
CCDSiCCDS24285.1.
RefSeqiNP_776094.2. NM_173733.3.
UniGeneiMm.23352.

Genome annotation databases

EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858.
GeneIDi211389.
KEGGimmu:211389.
UCSCiuc007hnt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149422 mRNA. Translation: BAE28865.1.
AK154608 mRNA. Translation: BAE32710.1. Different initiation.
BC027197 mRNA. Translation: AAH27197.2.
CCDSiCCDS24285.1.
RefSeqiNP_776094.2. NM_173733.3.
UniGeneiMm.23352.

3D structure databases

ProteinModelPortaliQ8R086.
SMRiQ8R086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229229. 1 interactor.
IntActiQ8R086. 5 interactors.
MINTiMINT-1860734.
STRINGi10090.ENSMUSP00000056195.

PTM databases

iPTMnetiQ8R086.
PhosphoSitePlusiQ8R086.
SwissPalmiQ8R086.

2D gel databases

REPRODUCTION-2DPAGEQ8R086.

Proteomic databases

EPDiQ8R086.
MaxQBiQ8R086.
PaxDbiQ8R086.
PeptideAtlasiQ8R086.
PRIDEiQ8R086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858.
GeneIDi211389.
KEGGimmu:211389.
UCSCiuc007hnt.2. mouse.

Organism-specific databases

CTDi6821.
MGIiMGI:2446117. Suox.

Phylogenomic databases

eggNOGiKOG0535. Eukaryota.
KOG4576. Eukaryota.
COG2041. LUCA.
GeneTreeiENSGT00390000003749.
HOGENOMiHOG000252609.
HOVERGENiHBG017865.
InParanoidiQ8R086.
KOiK00387.
OMAiAVHNQSH.
OrthoDBiEOG091G0DBF.
PhylomeDBiQ8R086.
TreeFamiTF300905.

Enzyme and pathway databases

UniPathwayiUPA00096.
ReactomeiR-MMU-1614517. Sulfide oxidation to sulfate.

Miscellaneous databases

PROiQ8R086.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049858.
CleanExiMM_SUOX.
GenevisibleiQ8R086. MM.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUOX_MOUSE
AccessioniPrimary (citable) accession number: Q8R086
Secondary accession number(s): Q3U3S5, Q3UEP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.