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Q8R086

- SUOX_MOUSE

UniProt

Q8R086 - SUOX_MOUSE

Protein

Sulfite oxidase, mitochondrial

Gene

Suox

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Sulfite + O2 + H2O = sulfate + H2O2.

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group non-covalently per subunit.By similarity
    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi119 – 1191Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi144 – 1441Iron (heme axial ligand)PROSITE-ProRule annotation
    Binding sitei146 – 1461Heme bBy similarity
    Binding sitei148 – 1481Heme bBy similarity
    Metal bindingi265 – 2651MolybdenumBy similarity
    Binding sitei323 – 3231MolybdopterinBy similarity
    Binding sitei362 – 3621MolybdopterinBy similarity
    Binding sitei367 – 3671MolybdopterinBy similarity

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: InterPro
    3. molybdenum ion binding Source: InterPro
    4. molybdopterin cofactor binding Source: InterPro
    5. sulfite oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sulfur compound metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, Molybdenum

    Enzyme and pathway databases

    ReactomeiREACT_198963. Sulfide oxidation to sulfate.
    UniPathwayiUPA00096.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfite oxidase, mitochondrial (EC:1.8.3.1)
    Gene namesi
    Name:Suox
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2446117. Suox.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 8080MitochondrionBy similarityAdd
    BLAST
    Chaini81 – 546466Sulfite oxidase, mitochondrialPRO_0000006483Add
    BLAST

    Proteomic databases

    MaxQBiQ8R086.
    PaxDbiQ8R086.
    PRIDEiQ8R086.

    2D gel databases

    REPRODUCTION-2DPAGEQ8R086.

    PTM databases

    PhosphoSiteiQ8R086.

    Expressioni

    Gene expression databases

    BgeeiQ8R086.
    CleanExiMM_SUOX.
    GenevestigatoriQ8R086.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiQ8R086. 5 interactions.
    MINTiMINT-1860734.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R086.
    SMRiQ8R086. Positions 82-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 16280Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni166 – 17510HingeBy similarity
    Regioni176 – 402227Moco domainBy similarityAdd
    BLAST
    Regioni216 – 2205Molybdopterin-bindingBy similarity
    Regioni378 – 3803Molybdopterin-bindingBy similarity
    Regioni403 – 539137HomodimerizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2041.
    GeneTreeiENSGT00390000003749.
    HOGENOMiHOG000252609.
    HOVERGENiHBG017865.
    InParanoidiQ8R086.
    KOiK00387.
    OMAiAVHNQSH.
    OrthoDBiEOG7P8P7Z.
    PhylomeDBiQ8R086.
    TreeFamiTF300905.

    Family and domain databases

    Gene3Di2.60.40.650. 1 hit.
    3.10.120.10. 1 hit.
    3.90.420.10. 1 hit.
    InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
    IPR018506. Cyt_B5_heme-BS.
    IPR014756. Ig_E-set.
    IPR005066. MoCF_OxRdtse_dimer.
    IPR008335. Mopterin_OxRdtase_euk.
    IPR000572. OxRdtase_Mopterin-bd_dom.
    IPR022407. OxRdtase_Mopterin_BS.
    [Graphical view]
    PfamiPF00173. Cyt-b5. 1 hit.
    PF03404. Mo-co_dimer. 1 hit.
    PF00174. Oxidored_molyb. 1 hit.
    [Graphical view]
    PRINTSiPR00363. CYTOCHROMEB5.
    PR00407. EUMOPTERIN.
    SUPFAMiSSF55856. SSF55856. 1 hit.
    SSF56524. SSF56524. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
    PS50255. CYTOCHROME_B5_2. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R086-1 [UniParc]FASTAAdd to Basket

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    MLLQLYRSVV VRLPQAIRVK STPLRLCIQA CSTNDSLEPQ HPSLTFSDDN    50
    SRTRRWKVMG TLLGLGVVLV YHEHRCRASQ ESPRMYSKED VRSHNNPKTG 100
    VWVTLGSEVF DVTKFVDLHP GGPSKLMLAA GGPLEPFWAL YAVHNQPHVR 150
    ELLAEYKIGE LNPEDSMSPS VEASDPYADD PIRHPALRIN SQRPFNAEPP 200
    PELLTEGYIT PNPIFFTRNH LPVPNLDPHT YRLHVVGAPG GQSLSLSLDD 250
    LHKFPKHEVT VTLQCAGNRR SEMSKVKEVK GLEWRTGAIS TARWAGARLC 300
    DVLAQAGHRL CDSEAHVCFE GLDSDPTGTA YGASIPLARA MDPEAEVLLA 350
    YEMNGQPLPR DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD 400
    YKGFSPSVDW DTVNFDLAPS IQELPIQSAI TQPQDGAIVE SGEVTIKGYA 450
    WSGGGRAVIR VDVSVDGGLT WQEAELEGEE QCPRKAWAWR IWQLKAQVPA 500
    EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV HVQVVP 546
    Length:546
    Mass (Da):60,756
    Last modified:July 10, 2007 - v2
    Checksum:iA10ADF73FFA8DE51
    GO

    Sequence cautioni

    The sequence BAE32710.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti455 – 4551G → S in BAE28865. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK149422 mRNA. Translation: BAE28865.1.
    AK154608 mRNA. Translation: BAE32710.1. Different initiation.
    BC027197 mRNA. Translation: AAH27197.2.
    CCDSiCCDS24285.1.
    RefSeqiNP_776094.2. NM_173733.3.
    UniGeneiMm.23352.

    Genome annotation databases

    EnsembliENSMUST00000054764; ENSMUSP00000056195; ENSMUSG00000049858.
    GeneIDi211389.
    KEGGimmu:211389.
    UCSCiuc007hnt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK149422 mRNA. Translation: BAE28865.1 .
    AK154608 mRNA. Translation: BAE32710.1 . Different initiation.
    BC027197 mRNA. Translation: AAH27197.2 .
    CCDSi CCDS24285.1.
    RefSeqi NP_776094.2. NM_173733.3.
    UniGenei Mm.23352.

    3D structure databases

    ProteinModelPortali Q8R086.
    SMRi Q8R086. Positions 82-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R086. 5 interactions.
    MINTi MINT-1860734.

    PTM databases

    PhosphoSitei Q8R086.

    2D gel databases

    REPRODUCTION-2DPAGE Q8R086.

    Proteomic databases

    MaxQBi Q8R086.
    PaxDbi Q8R086.
    PRIDEi Q8R086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054764 ; ENSMUSP00000056195 ; ENSMUSG00000049858 .
    GeneIDi 211389.
    KEGGi mmu:211389.
    UCSCi uc007hnt.2. mouse.

    Organism-specific databases

    CTDi 6821.
    MGIi MGI:2446117. Suox.

    Phylogenomic databases

    eggNOGi COG2041.
    GeneTreei ENSGT00390000003749.
    HOGENOMi HOG000252609.
    HOVERGENi HBG017865.
    InParanoidi Q8R086.
    KOi K00387.
    OMAi AVHNQSH.
    OrthoDBi EOG7P8P7Z.
    PhylomeDBi Q8R086.
    TreeFami TF300905.

    Enzyme and pathway databases

    UniPathwayi UPA00096 .
    Reactomei REACT_198963. Sulfide oxidation to sulfate.

    Miscellaneous databases

    NextBioi 373222.
    PROi Q8R086.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R086.
    CleanExi MM_SUOX.
    Genevestigatori Q8R086.

    Family and domain databases

    Gene3Di 2.60.40.650. 1 hit.
    3.10.120.10. 1 hit.
    3.90.420.10. 1 hit.
    InterProi IPR001199. Cyt_B5-like_heme/steroid-bd.
    IPR018506. Cyt_B5_heme-BS.
    IPR014756. Ig_E-set.
    IPR005066. MoCF_OxRdtse_dimer.
    IPR008335. Mopterin_OxRdtase_euk.
    IPR000572. OxRdtase_Mopterin-bd_dom.
    IPR022407. OxRdtase_Mopterin_BS.
    [Graphical view ]
    Pfami PF00173. Cyt-b5. 1 hit.
    PF03404. Mo-co_dimer. 1 hit.
    PF00174. Oxidored_molyb. 1 hit.
    [Graphical view ]
    PRINTSi PR00363. CYTOCHROMEB5.
    PR00407. EUMOPTERIN.
    SUPFAMi SSF55856. SSF55856. 1 hit.
    SSF56524. SSF56524. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00191. CYTOCHROME_B5_1. 1 hit.
    PS50255. CYTOCHROME_B5_2. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiSUOX_MOUSE
    AccessioniPrimary (citable) accession number: Q8R086
    Secondary accession number(s): Q3U3S5, Q3UEP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3