Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional apoptosis regulator

Gene

Bfar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 7441RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional apoptosis regulator
Gene namesi
Name:Bfar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1914368. Bfar.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 140140CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 331170ExtracellularSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 3608CytoplasmicSequence analysis
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Topological domaini382 – 40423ExtracellularSequence analysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence analysisAdd
BLAST
Topological domaini426 – 45025CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Bifunctional apoptosis regulatorPRO_0000055823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8R079.
MaxQBiQ8R079.
PaxDbiQ8R079.
PRIDEiQ8R079.

PTM databases

iPTMnetiQ8R079.
PhosphoSiteiQ8R079.

Expressioni

Gene expression databases

BgeeiQ8R079.
CleanExiMM_BFAR.
ExpressionAtlasiQ8R079. baseline and differential.
GenevisibleiQ8R079. MM.

Interactioni

Subunit structurei

Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211952. 1 interaction.
STRINGi10090.ENSMUSP00000023365.

Structurei

Secondary structure

1
450
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi173 – 1764Combined sources
Helixi179 – 1813Combined sources
Helixi184 – 19411Combined sources
Helixi196 – 1983Combined sources
Helixi199 – 2079Combined sources
Helixi212 – 2176Combined sources
Helixi220 – 2245Combined sources
Turni226 – 2283Combined sources
Helixi233 – 24715Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V85NMR-A170-247[»]
ProteinModelPortaliQ8R079.
SMRiQ8R079. Positions 1-94, 170-248.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R079.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 24968SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 7441RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ8R079.
KOiK15684.
OrthoDBiEOG7PP56P.
PhylomeDBiQ8R079.
TreeFamiTF332303.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPQKNDLS MREQEEEHPV RSSGPQISVS EFSCHCCYDT LVNPTTLNCG
60 70 80 90 100
HSFCRHCLAL WWMSSKKTEC PECREKWEGF PKVNILLRDA IEKLFPDAIR
110 120 130 140 150
MRVEDIQQNN DVVQSLAAFQ KYGNDQNPLA PSTGRVNPQR GGGFFSGVLT
160 170 180 190 200
ALTGVAVILL VYHWRSRESE HGLLVHKAVD KWTMEEVVLW LEQLGPWASL
210 220 230 240 250
YRDRFLSERV NGRLLLTLTE EEFSRAPYTI ENSSHRRVIL TELERVRALG
260 270 280 290 300
VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LGLLYLYLFD YTDCFLPFIH
310 320 330 340 350
TICPLQENSS GEDIFTKLLD LREPTWKQWR EFLVKYSFLP YQLIAEFAWD
360 370 380 390 400
WLEVHYWTSR FLIVNAVLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV
410 420 430 440 450
STQGLFMAMF WPLIPQFVCN CLFYWALYFN PIINIDLVVK EVRRLETQVL
Length:450
Mass (Da):52,968
Last modified:June 1, 2002 - v1
Checksum:i07B1122FAA9EF2BC
GO
Isoform 2 (identifier: Q8R079-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-213: Missing.

Show »
Length:325
Mass (Da):38,794
Checksum:i0FAF89270C1AD700
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841M → T in BAB29029 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 213125Missing in isoform 2. 1 PublicationVSP_016651Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013874 mRNA. Translation: BAB29029.1.
AK028592 mRNA. Translation: BAC26022.1.
BC027221 mRNA. Translation: AAH27221.1.
CCDSiCCDS27966.1. [Q8R079-1]
CCDS49769.1. [Q8R079-2]
RefSeqiNP_001171023.1. NM_001177552.1. [Q8R079-2]
NP_080252.1. NM_025976.5.
UniGeneiMm.223689.

Genome annotation databases

EnsembliENSMUST00000069281; ENSMUSP00000063371; ENSMUSG00000022684. [Q8R079-2]
GeneIDi67118.
KEGGimmu:67118.
UCSCiuc007ygf.2. mouse. [Q8R079-1]
uc007ygg.2. mouse. [Q8R079-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013874 mRNA. Translation: BAB29029.1.
AK028592 mRNA. Translation: BAC26022.1.
BC027221 mRNA. Translation: AAH27221.1.
CCDSiCCDS27966.1. [Q8R079-1]
CCDS49769.1. [Q8R079-2]
RefSeqiNP_001171023.1. NM_001177552.1. [Q8R079-2]
NP_080252.1. NM_025976.5.
UniGeneiMm.223689.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V85NMR-A170-247[»]
ProteinModelPortaliQ8R079.
SMRiQ8R079. Positions 1-94, 170-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211952. 1 interaction.
STRINGi10090.ENSMUSP00000023365.

PTM databases

iPTMnetiQ8R079.
PhosphoSiteiQ8R079.

Proteomic databases

EPDiQ8R079.
MaxQBiQ8R079.
PaxDbiQ8R079.
PRIDEiQ8R079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069281; ENSMUSP00000063371; ENSMUSG00000022684. [Q8R079-2]
GeneIDi67118.
KEGGimmu:67118.
UCSCiuc007ygf.2. mouse. [Q8R079-1]
uc007ygg.2. mouse. [Q8R079-2]

Organism-specific databases

CTDi51283.
MGIiMGI:1914368. Bfar.

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ8R079.
KOiK15684.
OrthoDBiEOG7PP56P.
PhylomeDBiQ8R079.
TreeFamiTF332303.

Miscellaneous databases

ChiTaRSiBfar. mouse.
EvolutionaryTraceiQ8R079.
PROiQ8R079.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R079.
CleanExiMM_BFAR.
ExpressionAtlasiQ8R079. baseline and differential.
GenevisibleiQ8R079. MM.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Head and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.
  3. "Sterile alpha motif (SAM) domain of mouse bifunctional apoptosis regulator."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 170-247.

Entry informationi

Entry nameiBFAR_MOUSE
AccessioniPrimary (citable) accession number: Q8R079
Secondary accession number(s): Q8C1A7, Q9CXY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.