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Protein

Bifunctional apoptosis regulator

Gene

Bfar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 74RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional apoptosis regulator
Gene namesi
Name:Bfar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1914368. Bfar.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 140CytoplasmicSequence analysisAdd BLAST140
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 331ExtracellularSequence analysisAdd BLAST170
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Topological domaini353 – 360CytoplasmicSequence analysis8
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 404ExtracellularSequence analysisAdd BLAST23
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 450CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000558231 – 450Bifunctional apoptosis regulatorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8R079.
PaxDbiQ8R079.
PRIDEiQ8R079.

PTM databases

iPTMnetiQ8R079.
PhosphoSitePlusiQ8R079.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022684.
CleanExiMM_BFAR.
ExpressionAtlasiQ8R079. baseline and differential.
GenevisibleiQ8R079. MM.

Interactioni

Subunit structurei

Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211952. 1 interactor.
STRINGi10090.ENSMUSP00000023365.

Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi173 – 176Combined sources4
Helixi179 – 181Combined sources3
Helixi184 – 194Combined sources11
Helixi196 – 198Combined sources3
Helixi199 – 207Combined sources9
Helixi212 – 217Combined sources6
Helixi220 – 224Combined sources5
Turni226 – 228Combined sources3
Helixi233 – 247Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V85NMR-A170-247[»]
ProteinModelPortaliQ8R079.
SMRiQ8R079.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R079.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 249SAMPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 74RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ8R079.
KOiK15684.
PhylomeDBiQ8R079.
TreeFamiTF332303.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R079-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPQKNDLS MREQEEEHPV RSSGPQISVS EFSCHCCYDT LVNPTTLNCG
60 70 80 90 100
HSFCRHCLAL WWMSSKKTEC PECREKWEGF PKVNILLRDA IEKLFPDAIR
110 120 130 140 150
MRVEDIQQNN DVVQSLAAFQ KYGNDQNPLA PSTGRVNPQR GGGFFSGVLT
160 170 180 190 200
ALTGVAVILL VYHWRSRESE HGLLVHKAVD KWTMEEVVLW LEQLGPWASL
210 220 230 240 250
YRDRFLSERV NGRLLLTLTE EEFSRAPYTI ENSSHRRVIL TELERVRALG
260 270 280 290 300
VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LGLLYLYLFD YTDCFLPFIH
310 320 330 340 350
TICPLQENSS GEDIFTKLLD LREPTWKQWR EFLVKYSFLP YQLIAEFAWD
360 370 380 390 400
WLEVHYWTSR FLIVNAVLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV
410 420 430 440 450
STQGLFMAMF WPLIPQFVCN CLFYWALYFN PIINIDLVVK EVRRLETQVL
Length:450
Mass (Da):52,968
Last modified:June 1, 2002 - v1
Checksum:i07B1122FAA9EF2BC
GO
Isoform 2 (identifier: Q8R079-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-213: Missing.

Show »
Length:325
Mass (Da):38,794
Checksum:i0FAF89270C1AD700
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184M → T in BAB29029 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01665189 – 213Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013874 mRNA. Translation: BAB29029.1.
AK028592 mRNA. Translation: BAC26022.1.
BC027221 mRNA. Translation: AAH27221.1.
CCDSiCCDS27966.1. [Q8R079-1]
CCDS49769.1. [Q8R079-2]
RefSeqiNP_001171023.1. NM_001177552.1. [Q8R079-2]
NP_080252.1. NM_025976.5.
UniGeneiMm.223689.

Genome annotation databases

EnsembliENSMUST00000069281; ENSMUSP00000063371; ENSMUSG00000022684. [Q8R079-2]
GeneIDi67118.
KEGGimmu:67118.
UCSCiuc007ygf.2. mouse. [Q8R079-1]
uc007ygg.2. mouse. [Q8R079-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013874 mRNA. Translation: BAB29029.1.
AK028592 mRNA. Translation: BAC26022.1.
BC027221 mRNA. Translation: AAH27221.1.
CCDSiCCDS27966.1. [Q8R079-1]
CCDS49769.1. [Q8R079-2]
RefSeqiNP_001171023.1. NM_001177552.1. [Q8R079-2]
NP_080252.1. NM_025976.5.
UniGeneiMm.223689.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V85NMR-A170-247[»]
ProteinModelPortaliQ8R079.
SMRiQ8R079.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211952. 1 interactor.
STRINGi10090.ENSMUSP00000023365.

PTM databases

iPTMnetiQ8R079.
PhosphoSitePlusiQ8R079.

Proteomic databases

EPDiQ8R079.
PaxDbiQ8R079.
PRIDEiQ8R079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069281; ENSMUSP00000063371; ENSMUSG00000022684. [Q8R079-2]
GeneIDi67118.
KEGGimmu:67118.
UCSCiuc007ygf.2. mouse. [Q8R079-1]
uc007ygg.2. mouse. [Q8R079-2]

Organism-specific databases

CTDi51283.
MGIiMGI:1914368. Bfar.

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ8R079.
KOiK15684.
PhylomeDBiQ8R079.
TreeFamiTF332303.

Miscellaneous databases

ChiTaRSiBfar. mouse.
EvolutionaryTraceiQ8R079.
PROiQ8R079.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022684.
CleanExiMM_BFAR.
ExpressionAtlasiQ8R079. baseline and differential.
GenevisibleiQ8R079. MM.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBFAR_MOUSE
AccessioniPrimary (citable) accession number: Q8R079
Secondary accession number(s): Q8C1A7, Q9CXY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.