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Protein

Inositol-trisphosphate 3-kinase A

Gene

Itpka

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulationi

IP3K is activated by calmodulin.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei195 – 1951ATPBy similarity
Binding sitei207 – 2071ATPBy similarity
Binding sitei260 – 2601ATPBy similarity
Binding sitei262 – 2621SubstrateBy similarity
Binding sitei283 – 2831SubstrateBy similarity
Binding sitei334 – 3341ATPBy similarity
Binding sitei414 – 4141ATPBy similarity
Binding sitei417 – 4171SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2493ATPBy similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • dendritic spine maintenance Source: MGI
  • inositol metabolic process Source: MGI
  • positive regulation of dendritic spine morphogenesis Source: MGI
  • regulation of synaptic plasticity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase A
Short name:
IP3 3-kinase A
Short name:
IP3K A
Short name:
InsP 3-kinase A
Gene namesi
Name:Itpka
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1333822. Itpka.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Inositol-trisphosphate 3-kinase APRO_0000066866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R071.
PaxDbiQ8R071.
PeptideAtlasiQ8R071.
PRIDEiQ8R071.

PTM databases

iPTMnetiQ8R071.
PhosphoSiteiQ8R071.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027296.
CleanExiMM_ITPKA.
GenevisibleiQ8R071. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230741. 1 interaction.
IntActiQ8R071. 3 interactions.
MINTiMINT-4098679.
STRINGi10090.ENSMUSP00000028758.

Structurei

3D structure databases

ProteinModelPortaliQ8R071.
SMRiQ8R071. Positions 185-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni285 – 2939Calmodulin-bindingBy similarity
Regioni310 – 3178Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000231765.
HOVERGENiHBG052138.
InParanoidiQ8R071.
KOiK00911.
OMAiWLPAVGS.
OrthoDBiEOG091G03J3.
PhylomeDBiQ8R071.
TreeFamiTF318394.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPGRPTGM ARPRGAGPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA
60 70 80 90 100
AGEPRARGAK RRGGQVPNGL PRAAPAPVIP QLTVTSEEDV TPASPGPPDQ
110 120 130 140 150
EGNWLPAAGS HLQQPRRLST SSLSSTGSSS LLEDSEDDLL SDSESRSRGN
160 170 180 190 200
VQLETSEDVG QKSHWQKIRT MVNLPVMSPF RKRYSWVQLA GHTGSFKAAG
210 220 230 240 250
TSGLILKRSS EPEHYCLVRL MADVLRGCVP AFHGIVERDG ESYLQLQDLL
260 270 280 290 300
DGFDGPCVLD CKMGVRTYLE EELTKARERP KLRKDMYKKM LAVDPEAPTE
310 320 330 340 350
EEHAQRAVTK PRYMQWREGI SSSTTLGFRI EGIKKADGSC STDFKTTRSR
360 370 380 390 400
EQVTRVFEEF MQGDAEVLRR YLNRLQQIRD TLEISDFFRR HEVIGSSLLF
410 420 430 440 450
VHDHCHRAGV WLIDFGKTTP LPDGQILDHR RPWEEGNRED GYLLGLDNLI

GILASLAER
Length:459
Mass (Da):50,935
Last modified:June 1, 2002 - v1
Checksum:i3CDA79DD267A1A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844536 Genomic DNA. Translation: CAM18079.1.
BC027291 mRNA. Translation: AAH27291.1.
CCDSiCCDS16607.1.
RefSeqiNP_666237.1. NM_146125.2.
UniGeneiMm.65337.

Genome annotation databases

EnsembliENSMUST00000028758; ENSMUSP00000028758; ENSMUSG00000027296.
GeneIDi228550.
KEGGimmu:228550.
UCSCiuc008luf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844536 Genomic DNA. Translation: CAM18079.1.
BC027291 mRNA. Translation: AAH27291.1.
CCDSiCCDS16607.1.
RefSeqiNP_666237.1. NM_146125.2.
UniGeneiMm.65337.

3D structure databases

ProteinModelPortaliQ8R071.
SMRiQ8R071. Positions 185-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230741. 1 interaction.
IntActiQ8R071. 3 interactions.
MINTiMINT-4098679.
STRINGi10090.ENSMUSP00000028758.

PTM databases

iPTMnetiQ8R071.
PhosphoSiteiQ8R071.

Proteomic databases

MaxQBiQ8R071.
PaxDbiQ8R071.
PeptideAtlasiQ8R071.
PRIDEiQ8R071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028758; ENSMUSP00000028758; ENSMUSG00000027296.
GeneIDi228550.
KEGGimmu:228550.
UCSCiuc008luf.1. mouse.

Organism-specific databases

CTDi3706.
MGIiMGI:1333822. Itpka.

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000231765.
HOVERGENiHBG052138.
InParanoidiQ8R071.
KOiK00911.
OMAiWLPAVGS.
OrthoDBiEOG091G03J3.
PhylomeDBiQ8R071.
TreeFamiTF318394.

Enzyme and pathway databases

ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

PROiQ8R071.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027296.
CleanExiMM_ITPKA.
GenevisibleiQ8R071. MM.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIP3KA_MOUSE
AccessioniPrimary (citable) accession number: Q8R071
Secondary accession number(s): A2AQ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.