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Protein

Inositol-trisphosphate 3-kinase A

Gene

Itpka

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulationi

IP3K is activated by calmodulin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei195ATPBy similarity1
Binding sitei207ATPBy similarity1
Binding sitei260ATPBy similarity1
Binding sitei262SubstrateBy similarity1
Binding sitei283SubstrateBy similarity1
Binding sitei334ATPBy similarity1
Binding sitei414ATPBy similarity1
Binding sitei417SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi247 – 249ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • dendritic spine maintenance Source: MGI
  • inositol metabolic process Source: MGI
  • inositol phosphate biosynthetic process Source: InterPro
  • positive regulation of dendritic spine morphogenesis Source: MGI
  • regulation of synaptic plasticity Source: MGI

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase A
Short name:
IP3 3-kinase A
Short name:
IP3K A
Short name:
InsP 3-kinase A
Gene namesi
Name:Itpka
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1333822 Itpka

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668661 – 459Inositol-trisphosphate 3-kinase AAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35Omega-N-methylarginineCombined sources1
Modified residuei55Omega-N-methylarginineCombined sources1
Modified residuei62Omega-N-methylarginineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei195PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R071
PaxDbiQ8R071
PeptideAtlasiQ8R071
PRIDEiQ8R071

PTM databases

iPTMnetiQ8R071
PhosphoSitePlusiQ8R071

Expressioni

Gene expression databases

BgeeiENSMUSG00000027296
CleanExiMM_ITPKA
GenevisibleiQ8R071 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230741, 2 interactors
IntActiQ8R071, 4 interactors
MINTiQ8R071
STRINGi10090.ENSMUSP00000028758

Structurei

3D structure databases

ProteinModelPortaliQ8R071
SMRiQ8R071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni285 – 293Calmodulin-bindingBy similarity9
Regioni310 – 317Substrate bindingBy similarity8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00390000017438
HOGENOMiHOG000231765
HOVERGENiHBG052138
InParanoidiQ8R071
KOiK00911
OMAiNVMDCKM
OrthoDBiEOG091G03J3
PhylomeDBiQ8R071
TreeFamiTF318394

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPGRPTGM ARPRGAGPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA
60 70 80 90 100
AGEPRARGAK RRGGQVPNGL PRAAPAPVIP QLTVTSEEDV TPASPGPPDQ
110 120 130 140 150
EGNWLPAAGS HLQQPRRLST SSLSSTGSSS LLEDSEDDLL SDSESRSRGN
160 170 180 190 200
VQLETSEDVG QKSHWQKIRT MVNLPVMSPF RKRYSWVQLA GHTGSFKAAG
210 220 230 240 250
TSGLILKRSS EPEHYCLVRL MADVLRGCVP AFHGIVERDG ESYLQLQDLL
260 270 280 290 300
DGFDGPCVLD CKMGVRTYLE EELTKARERP KLRKDMYKKM LAVDPEAPTE
310 320 330 340 350
EEHAQRAVTK PRYMQWREGI SSSTTLGFRI EGIKKADGSC STDFKTTRSR
360 370 380 390 400
EQVTRVFEEF MQGDAEVLRR YLNRLQQIRD TLEISDFFRR HEVIGSSLLF
410 420 430 440 450
VHDHCHRAGV WLIDFGKTTP LPDGQILDHR RPWEEGNRED GYLLGLDNLI

GILASLAER
Length:459
Mass (Da):50,935
Last modified:June 1, 2002 - v1
Checksum:i3CDA79DD267A1A5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844536 Genomic DNA No translation available.
BC027291 mRNA Translation: AAH27291.1
CCDSiCCDS16607.1
RefSeqiNP_666237.1, NM_146125.2
UniGeneiMm.65337

Genome annotation databases

EnsembliENSMUST00000028758; ENSMUSP00000028758; ENSMUSG00000027296
GeneIDi228550
KEGGimmu:228550
UCSCiuc008luf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIP3KA_MOUSE
AccessioniPrimary (citable) accession number: Q8R071
Secondary accession number(s): A2AQ20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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