Reviewed, UniProtKB/Swiss-Prot Q8R071 (IP3KA_MOUSE)

Names and origin

Protein names

Recommended name:
    Inositol-trisphosphate 3-kinase A
    EC=2.7.1.127
Alternative name(s):
    Inositol 1,4,5-trisphosphate 3-kinase A
    IP3 3-kinase A
      Short name=IP3K A

Gene names

Name:

Itpka

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme regulation	IP3K is activated by calmodulin By similarity.
Sequence similarities	Belongs to the inositol phosphokinase (IPK) family.

Ontologies

Keywords
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	inositol metabolic process Inferred from mutant phenotype. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW inositol trisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	Inositol-trisphosphate 3-kinase A		PRO_0000066866
Regions
	Nucleotide binding	247 – 249	3	ATP By similarity
	Region	285 – 293	9	Calmodulin-binding By similarity
	Region	310 – 317	8	Substrate binding By similarity
Sites
	Binding site	195	1	ATP By similarity
	Binding site	207	1	ATP By similarity
	Binding site	260	1	ATP By similarity
	Binding site	262	1	Substrate By similarity
	Binding site	283	1	Substrate By similarity
	Binding site	334	1	ATP By similarity
	Binding site	414	1	ATP By similarity
	Binding site	417	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R071-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3CDA79DD267A1A5D	FASTA	459	50,935
	10 20 30 40 50 60 MTLPGRPTGM ARPRGAGPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA AGEPRARGAK 70 80 90 100 110 120 RRGGQVPNGL PRAAPAPVIP QLTVTSEEDV TPASPGPPDQ EGNWLPAAGS HLQQPRRLST 130 140 150 160 170 180 SSLSSTGSSS LLEDSEDDLL SDSESRSRGN VQLETSEDVG QKSHWQKIRT MVNLPVMSPF 190 200 210 220 230 240 RKRYSWVQLA GHTGSFKAAG TSGLILKRSS EPEHYCLVRL MADVLRGCVP AFHGIVERDG 250 260 270 280 290 300 ESYLQLQDLL DGFDGPCVLD CKMGVRTYLE EELTKARERP KLRKDMYKKM LAVDPEAPTE 310 320 330 340 350 360 EEHAQRAVTK PRYMQWREGI SSSTTLGFRI EGIKKADGSC STDFKTTRSR EQVTRVFEEF 370 380 390 400 410 420 MQGDAEVLRR YLNRLQQIRD TLEISDFFRR HEVIGSSLLF VHDHCHRAGV WLIDFGKTTP 430 440 450 LPDGQILDHR RPWEEGNRED GYLLGLDNLI GILASLAER

References

[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL844536 Genomic DNA. Translation: CAM18079.1. BC027291 mRNA. Translation: AAH27291.1.
IPI	IPI00153136.
RefSeq	NP_666237.1.
UniGene	Mm.65337
3D structure databases
SMR	Q8R071. Positions 185-459.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8R071.
PTM databases
PhosphoSite	Q8R071.
Proteomic databases
PRIDE	Q8R071.
Genome annotation databases
Ensembl	ENSMUST00000028758; ENSMUSP00000028758; ENSMUSG00000027296; Mus musculus. [Genome view]
GeneID	228550.
KEGG	mmu:228550.
UCSC	uc008luf.1. mouse.
Organism-specific databases
CTD	228550.
MGI	MGI:1333822. Itpka.
Phylogenomic databases
HOGENOM	Q8R071.
HOVERGEN	Q8R071.
OMA	YSWVQLA.
Enzyme and pathway databases
BRENDA	2.7.1.127. 244.
Gene expression databases
ArrayExpress	Q8R071.
Bgee	Q8R071.
CleanEx	MM_ITPKA.
Genevestigator	Q8R071.
GermOnline	ENSMUSG00000027296. Mus musculus.
Family and domain databases
InterPro	IPR005522. IPK. [Graphical view]
PANTHER	PTHR12400. IPK. 1 hit.
Pfam	PF03770. IPK. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	379032.
SOURCE	Search...

Entry information

Entry name

IP3KA_MOUSE

Accession

Primary (citable) accession number: Q8R071
Secondary accession number(s): A2AQ20

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)