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Protein

Protein zwilch homolog

Gene

Zwilch

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zwilch homolog
Gene namesi
Name:Zwilch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915264. Zwilch.

Subcellular locationi

  • Chromosomecentromerekinetochore By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Protein zwilch homologPRO_0000314801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R060.
MaxQBiQ8R060.
PaxDbiQ8R060.
PRIDEiQ8R060.

PTM databases

iPTMnetiQ8R060.
PhosphoSiteiQ8R060.

Expressioni

Gene expression databases

BgeeiQ8R060.

Interactioni

Subunit structurei

Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH; in the complex interacts directly with KNTC1/ROD (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8R060. 2 interactions.
STRINGi10090.ENSMUSP00000112790.

Structurei

3D structure databases

ProteinModelPortaliQ8R060.
SMRiQ8R060. Positions 1-309, 337-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZWILCH family.Curated

Phylogenomic databases

eggNOGiKOG4803. Eukaryota.
ENOG410Y8MB. LUCA.
HOGENOMiHOG000155813.
HOVERGENiHBG108779.
InParanoidiQ8R060.
KOiK11579.
PhylomeDBiQ8R060.

Family and domain databases

InterProiIPR018630. RZZ-complex_zwilch.
[Graphical view]
PfamiPF09817. DUF2352. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSRMNRAAE EFYARLRQEF NEEKKGASKD PFIYEADVQV QLISKGQPSL
60 70 80 90 100
LKTILNENDS VFLVEKVVLE KEETSQVEEL QSEETAISDL SAGENIRPLA
110 120 130 140 150
LPVGRARQLI GLYTMAHNPN MTHLKIKQPV TALPPLWVRC DGSDPEGTCW
160 170 180 190 200
LGAELITTND IIAGVILYVL TCKADKNYSE DLENLKTSHK KRHHVSAVTA
210 220 230 240 250
RGFAQYELFK SDDLDDTVAP SQTTVTLDLS WSPVDEMLQT PPLSSTAALN
260 270 280 290 300
IRVQSGESRG CLSHLHRELK FLLVLADGIR TGVTEWLEPL ETKSALEFVQ
310 320 330 340 350
EFLNDLNKLD EFDDSTKKDK QKEAVNHDAA AVVRSMLLTV RGDLDFAEQL
360 370 380 390 400
WCRMSSSVVS YQDLVKCFTL ILQSLQRGDI QPWLHSGSNS LLSKLIHQSY
410 420 430 440 450
HGAMDSVPLS GTTPLQMLLE IGLDKLKKDY ISFFVSQELA SLNHLEYFIS
460 470 480 490 500
PSVSTQEQVC RVQKLHHILE ILVICMLFIK PQHELLFSLT QSCIKYYKQN
510 520 530 540 550
PLDEQHIFQL PVRPAAVKNL YQSEKPQKWR VELSNSQKRV KTVWQLSDSS
560 570 580
PVDHSSFHRP EFPELTLNGS LEERTAFVNM LTCSQVHFK
Length:589
Mass (Da):66,839
Last modified:June 1, 2002 - v1
Checksum:iD4CF69E0E818A988
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191E → G in BAB26358 (PubMed:16141072).Curated
Sequence conflicti215 – 2151D → V in BAB26358 (PubMed:16141072).Curated
Sequence conflicti285 – 2851E → G in BAB26358 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009559 mRNA. Translation: BAB26358.2.
AK019825 mRNA. Translation: BAB31869.2.
BC027435 mRNA. Translation: AAH27435.1.
RefSeqiNP_080783.3. NM_026507.4.
UniGeneiMm.335237.

Genome annotation databases

GeneIDi68014.
KEGGimmu:68014.
UCSCiuc012gva.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009559 mRNA. Translation: BAB26358.2.
AK019825 mRNA. Translation: BAB31869.2.
BC027435 mRNA. Translation: AAH27435.1.
RefSeqiNP_080783.3. NM_026507.4.
UniGeneiMm.335237.

3D structure databases

ProteinModelPortaliQ8R060.
SMRiQ8R060. Positions 1-309, 337-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R060. 2 interactions.
STRINGi10090.ENSMUSP00000112790.

PTM databases

iPTMnetiQ8R060.
PhosphoSiteiQ8R060.

Proteomic databases

EPDiQ8R060.
MaxQBiQ8R060.
PaxDbiQ8R060.
PRIDEiQ8R060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi68014.
KEGGimmu:68014.
UCSCiuc012gva.1. mouse.

Organism-specific databases

CTDi55055.
MGIiMGI:1915264. Zwilch.

Phylogenomic databases

eggNOGiKOG4803. Eukaryota.
ENOG410Y8MB. LUCA.
HOGENOMiHOG000155813.
HOVERGENiHBG108779.
InParanoidiQ8R060.
KOiK11579.
PhylomeDBiQ8R060.

Miscellaneous databases

ChiTaRSiZwilch. mouse.
PROiQ8R060.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R060.

Family and domain databases

InterProiIPR018630. RZZ-complex_zwilch.
[Graphical view]
PfamiPF09817. DUF2352. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiZWILC_MOUSE
AccessioniPrimary (citable) accession number: Q8R060
Secondary accession number(s): Q9D2E4, Q9D761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.