Reviewed, UniProtKB/Swiss-Prot Q8R059 (GALE_MOUSE)

Names and origin

Protein names

Recommended name:
    UDP-glucose 4-epimerase
    EC=5.1.3.2
Alternative name(s):
    UDP-galactose 4-epimerase
    Galactowaldenase

Gene names

Name:

Gale

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
Catalytic activity	UDP-glucose = UDP-galactose.
Cofactor	NAD.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the sugar epimerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	NAD
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	cellular metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	UDP-glucose 4-epimerase activity Inferred from direct assay. Source: MGI coenzyme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	UDP-glucose 4-epimerase		PRO_0000183190
Regions
	Nucleotide binding	4 – 35	32	NAD By similarity
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	131	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R059-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 8EAE03B38040CED5	FASTA	347	38,225
	10 20 30 40 50 60 MEKVLVTGGA GYIGSHTVLE LLEAGYSPVV IDNFHNAIRG EDSMPESLRR VQELTGRSVE 70 80 90 100 110 120 FEEMDILDQA ALQHLFKKHS FKAVIHFAGL KAVGESVQKP LDYYRVNLTG TIQLLEIMRA 130 140 150 160 170 180 HGVKNLVFSS SATVYGNPQY LPLDEAHPTG GCTNPYGKSK FFIEEMIRDL CRADTAWNAV 190 200 210 220 230 240 LLRYFNPIGA HASGRIGEDP QGIPNNLMPY VSQVAIGRRE ALNVFGDDYA TEDGTGVRDY 250 260 270 280 290 300 IHVVDLAKGH IAALKKLKEQ CGCRTYNLGT GTGYSVLQMV QAMEKASGKK IPYKVVARRE 310 320 330 340 GDVAACYANP SLAHEELGWT AALGLDRMCE DLWRWQKQNP SGFGAQA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC027438 mRNA. Translation: AAH27438.1.
IPI	IPI00153129.
RefSeq	NP_848476.1.
UniGene	Mm.247946
3D structure databases
SMR	Q8R059. Positions 2-347.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8R059.
Proteomic databases
PRIDE	Q8R059.
Genome annotation databases
Ensembl	ENSMUST00000102540; ENSMUSP00000099599; ENSMUSG00000028671; Mus musculus. [Genome view] ENSMUST00000102541; ENSMUSP00000099600; ENSMUSG00000028671; Mus musculus. [Genome view] ENSMUST00000116275; ENSMUSP00000111979; ENSMUSG00000028671; Mus musculus. [Genome view]
GeneID	74246.
KEGG	mmu:74246.
UCSC	uc008vhk.1. mouse.
Organism-specific databases
CTD	74246.
MGI	MGI:1921496. Gale.
Phylogenomic databases
HOGENOM	Q8R059.
HOVERGEN	Q8R059.
OMA	CIDNFAN
OrthoDB	EOG9X0QBM
Enzyme and pathway databases
BRENDA	5.1.3.2. 244.
Gene expression databases
ArrayExpress	Q8R059.
Bgee	Q8R059.
CleanEx	MM_GALE.
Genevestigator	Q8R059.
GermOnline	ENSMUSG00000028671. Mus musculus.
Family and domain databases
InterPro	IPR001509. Epimerase_deHydtase. IPR005886. GalE. IPR016040. NAD(P)-bd_dom. IPR008089. Nuc_sugar_epim. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR10366:SF39. GalE. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
PRINTS	PR01713. NUCEPIMERASE.
TIGRFAMs	TIGR01179. galE. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	340230.
SOURCE	Search...

Entry information

Entry name

GALE_MOUSE

Accession

Primary (citable) accession number: Q8R059

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2002
Last modified:	November 24, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)