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Q8R040 (RPP21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p21

Short name=RNaseP protein p21
EC=3.1.26.5
Alternative name(s):
Ribonucleoprotein V
Gene names
Name:Rpp21
Synonyms:Cat60
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40 By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentNucleus
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to drug

Inferred from electronic annotation. Source: Ensembl

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 150149Ribonuclease P protein subunit p21
PRO_0000153846

Sites

Metal binding621Zinc By similarity
Metal binding651Zinc By similarity
Metal binding921Zinc By similarity
Metal binding951Zinc By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Experimental info

Sequence conflict181Y → C in AAP03887. Ref.1
Sequence conflict47 – 537KRLVLRQ → NAGPPA in CAD44293. Ref.2
Sequence conflict1411I → M in AAH28491. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8R040 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: EDB5C52A6F2FF519

FASTA15017,243
        10         20         30         40         50         60 
MAGPVKDREA FQRLSFLYQA AHCVLSQNPE NQALARFYCH TEKTIAKRLV LRQDPSVKRT 

        70         80         90        100        110        120 
LCRSCSSLLI PGLTCTQRQR RRKGQRWTVQ TCLTCQRSQR FLNDPKHLLW GDRPEAQLEN 

       130        140        150 
QADINPSEPL PNIADLPKEN IQTQALNTSE 

« Hide

References

« Hide 'large scale' references
[1]"Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex."
Takada T., Kumanovics A., Amadou C., Yoshino M., Jones E.P., Athanasiou M., Evans G.A., Lindahl K.F.
Genome Res. 13:589-600(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
Tissue: Testis.
[2]"Genes from major histocompatibility complex (MHC) class I region from HLA-C to HLA-A."
Raha-Chowdhury R., Andrews S.R., Gruen J.R., Weissman S.M.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Spleen.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY251016 mRNA. Translation: AAP03887.1.
AJ504717 mRNA. Translation: CAD44293.1.
AK002780 mRNA. Translation: BAB22353.1.
AK003455 mRNA. Translation: BAB22800.1.
BC028491 mRNA. Translation: AAH28491.1.
CCDSCCDS28719.1.
RefSeqNP_080584.1. NM_026308.2.
UniGeneMm.27131.

3D structure databases

ProteinModelPortalQ8R040.
SMRQ8R040. Positions 4-103.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R040.

Proteomic databases

PaxDbQ8R040.
PRIDEQ8R040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025319; ENSMUSP00000025319; ENSMUSG00000024446.
GeneID67676.
KEGGmmu:67676.
UCSCuc008ckq.1. mouse.

Organism-specific databases

CTD79897.
MGIMGI:1914926. Rpp21.

Phylogenomic databases

eggNOGCOG2023.
GeneTreeENSGT00390000003020.
HOGENOMHOG000231207.
HOVERGENHBG055987.
InParanoidQ8R040.
KOK03540.
OMANYLYQAA.
PhylomeDBQ8R040.
TreeFamTF323865.

Gene expression databases

BgeeQ8R040.
CleanExMM_RPP21.
GenevestigatorQ8R040.

Family and domain databases

InterProIPR007175. Rpr2.
[Graphical view]
PANTHERPTHR14742. PTHR14742. 1 hit.
PfamPF04032. Rpr2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio325229.
PROQ8R040.
SOURCESearch...

Entry information

Entry nameRPP21_MOUSE
AccessionPrimary (citable) accession number: Q8R040
Secondary accession number(s): Q80XY3, Q811B7, Q9CPX1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot