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Q8R040

- RPP21_MOUSE

UniProt

Q8R040 - RPP21_MOUSE

Protein

Ribonuclease P protein subunit p21

Gene

Rpp21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi62 – 621ZincBy similarity
    Metal bindingi65 – 651ZincBy similarity
    Metal bindingi92 – 921ZincBy similarity
    Metal bindingi95 – 951ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to drug Source: Ensembl
    2. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p21 (EC:3.1.26.5)
    Short name:
    RNaseP protein p21
    Alternative name(s):
    Ribonucleoprotein V
    Gene namesi
    Name:Rpp21
    Synonyms:Cat60
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1914926. Rpp21.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 150149Ribonuclease P protein subunit p21PRO_0000153846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ8R040.
    PRIDEiQ8R040.

    PTM databases

    PhosphoSiteiQ8R040.

    Expressioni

    Gene expression databases

    BgeeiQ8R040.
    CleanExiMM_RPP21.
    GenevestigatoriQ8R040.

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R040.
    SMRiQ8R040. Positions 4-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2023.
    GeneTreeiENSGT00390000003020.
    HOGENOMiHOG000231207.
    HOVERGENiHBG055987.
    InParanoidiQ8R040.
    KOiK03540.
    OMAiNYLYQAA.
    PhylomeDBiQ8R040.
    TreeFamiTF323865.

    Family and domain databases

    InterProiIPR007175. Rpr2.
    [Graphical view]
    PANTHERiPTHR14742. PTHR14742. 1 hit.
    PfamiPF04032. Rpr2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R040-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPVKDREA FQRLSFLYQA AHCVLSQNPE NQALARFYCH TEKTIAKRLV    50
    LRQDPSVKRT LCRSCSSLLI PGLTCTQRQR RRKGQRWTVQ TCLTCQRSQR 100
    FLNDPKHLLW GDRPEAQLEN QADINPSEPL PNIADLPKEN IQTQALNTSE 150
    Length:150
    Mass (Da):17,243
    Last modified:July 5, 2004 - v2
    Checksum:iEDB5C52A6F2FF519
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181Y → C in AAP03887. (PubMed:12671000)Curated
    Sequence conflicti47 – 537KRLVLRQ → NAGPPA in CAD44293. 1 PublicationCurated
    Sequence conflicti141 – 1411I → M in AAH28491. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY251016 mRNA. Translation: AAP03887.1.
    AJ504717 mRNA. Translation: CAD44293.1.
    AK002780 mRNA. Translation: BAB22353.1.
    AK003455 mRNA. Translation: BAB22800.1.
    BC028491 mRNA. Translation: AAH28491.1.
    CCDSiCCDS28719.1.
    RefSeqiNP_080584.1. NM_026308.2.
    UniGeneiMm.27131.

    Genome annotation databases

    EnsembliENSMUST00000025319; ENSMUSP00000025319; ENSMUSG00000024446.
    GeneIDi67676.
    KEGGimmu:67676.
    UCSCiuc008ckq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY251016 mRNA. Translation: AAP03887.1 .
    AJ504717 mRNA. Translation: CAD44293.1 .
    AK002780 mRNA. Translation: BAB22353.1 .
    AK003455 mRNA. Translation: BAB22800.1 .
    BC028491 mRNA. Translation: AAH28491.1 .
    CCDSi CCDS28719.1.
    RefSeqi NP_080584.1. NM_026308.2.
    UniGenei Mm.27131.

    3D structure databases

    ProteinModelPortali Q8R040.
    SMRi Q8R040. Positions 4-103.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R040.

    Proteomic databases

    PaxDbi Q8R040.
    PRIDEi Q8R040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025319 ; ENSMUSP00000025319 ; ENSMUSG00000024446 .
    GeneIDi 67676.
    KEGGi mmu:67676.
    UCSCi uc008ckq.1. mouse.

    Organism-specific databases

    CTDi 79897.
    MGIi MGI:1914926. Rpp21.

    Phylogenomic databases

    eggNOGi COG2023.
    GeneTreei ENSGT00390000003020.
    HOGENOMi HOG000231207.
    HOVERGENi HBG055987.
    InParanoidi Q8R040.
    KOi K03540.
    OMAi NYLYQAA.
    PhylomeDBi Q8R040.
    TreeFami TF323865.

    Miscellaneous databases

    NextBioi 325229.
    PROi Q8R040.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R040.
    CleanExi MM_RPP21.
    Genevestigatori Q8R040.

    Family and domain databases

    InterProi IPR007175. Rpr2.
    [Graphical view ]
    PANTHERi PTHR14742. PTHR14742. 1 hit.
    Pfami PF04032. Rpr2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex."
      Takada T., Kumanovics A., Amadou C., Yoshino M., Jones E.P., Athanasiou M., Evans G.A., Lindahl K.F.
      Genome Res. 13:589-600(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
      Tissue: Testis.
    2. "Genes from major histocompatibility complex (MHC) class I region from HLA-C to HLA-A."
      Raha-Chowdhury R., Andrews S.R., Gruen J.R., Weissman S.M.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Spleen.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiRPP21_MOUSE
    AccessioniPrimary (citable) accession number: Q8R040
    Secondary accession number(s): Q80XY3, Q811B7, Q9CPX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3