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Q8R040

- RPP21_MOUSE

UniProt

Q8R040 - RPP21_MOUSE

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Protein

Ribonuclease P protein subunit p21

Gene

Rpp21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621ZincBy similarity
Metal bindingi65 – 651ZincBy similarity
Metal bindingi92 – 921ZincBy similarity
Metal bindingi95 – 951ZincBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. response to drug Source: Ensembl
  2. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p21 (EC:3.1.26.5)
Short name:
RNaseP protein p21
Alternative name(s):
Ribonucleoprotein V
Gene namesi
Name:Rpp21
Synonyms:Cat60
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1914926. Rpp21.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 150149Ribonuclease P protein subunit p21PRO_0000153846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8R040.
PRIDEiQ8R040.

PTM databases

PhosphoSiteiQ8R040.

Expressioni

Gene expression databases

BgeeiQ8R040.
CleanExiMM_RPP21.
ExpressionAtlasiQ8R040. baseline and differential.
GenevestigatoriQ8R040.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP21, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8R040.
SMRiQ8R040. Positions 4-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2023.
GeneTreeiENSGT00390000003020.
HOGENOMiHOG000231207.
HOVERGENiHBG055987.
InParanoidiQ8R040.
KOiK03540.
OMAiNYLYQAA.
PhylomeDBiQ8R040.
TreeFamiTF323865.

Family and domain databases

InterProiIPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R040-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPVKDREA FQRLSFLYQA AHCVLSQNPE NQALARFYCH TEKTIAKRLV
60 70 80 90 100
LRQDPSVKRT LCRSCSSLLI PGLTCTQRQR RRKGQRWTVQ TCLTCQRSQR
110 120 130 140 150
FLNDPKHLLW GDRPEAQLEN QADINPSEPL PNIADLPKEN IQTQALNTSE
Length:150
Mass (Da):17,243
Last modified:July 5, 2004 - v2
Checksum:iEDB5C52A6F2FF519
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181Y → C in AAP03887. (PubMed:12671000)Curated
Sequence conflicti47 – 537KRLVLRQ → NAGPPA in CAD44293. 1 PublicationCurated
Sequence conflicti141 – 1411I → M in AAH28491. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY251016 mRNA. Translation: AAP03887.1.
AJ504717 mRNA. Translation: CAD44293.1.
AK002780 mRNA. Translation: BAB22353.1.
AK003455 mRNA. Translation: BAB22800.1.
BC028491 mRNA. Translation: AAH28491.1.
CCDSiCCDS28719.1.
RefSeqiNP_080584.1. NM_026308.2.
UniGeneiMm.27131.

Genome annotation databases

EnsembliENSMUST00000025319; ENSMUSP00000025319; ENSMUSG00000024446.
GeneIDi67676.
KEGGimmu:67676.
UCSCiuc008ckq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY251016 mRNA. Translation: AAP03887.1 .
AJ504717 mRNA. Translation: CAD44293.1 .
AK002780 mRNA. Translation: BAB22353.1 .
AK003455 mRNA. Translation: BAB22800.1 .
BC028491 mRNA. Translation: AAH28491.1 .
CCDSi CCDS28719.1.
RefSeqi NP_080584.1. NM_026308.2.
UniGenei Mm.27131.

3D structure databases

ProteinModelPortali Q8R040.
SMRi Q8R040. Positions 4-103.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R040.

Proteomic databases

PaxDbi Q8R040.
PRIDEi Q8R040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025319 ; ENSMUSP00000025319 ; ENSMUSG00000024446 .
GeneIDi 67676.
KEGGi mmu:67676.
UCSCi uc008ckq.1. mouse.

Organism-specific databases

CTDi 79897.
MGIi MGI:1914926. Rpp21.

Phylogenomic databases

eggNOGi COG2023.
GeneTreei ENSGT00390000003020.
HOGENOMi HOG000231207.
HOVERGENi HBG055987.
InParanoidi Q8R040.
KOi K03540.
OMAi NYLYQAA.
PhylomeDBi Q8R040.
TreeFami TF323865.

Miscellaneous databases

NextBioi 325229.
PROi Q8R040.
SOURCEi Search...

Gene expression databases

Bgeei Q8R040.
CleanExi MM_RPP21.
ExpressionAtlasi Q8R040. baseline and differential.
Genevestigatori Q8R040.

Family and domain databases

InterProi IPR007175. Rpr2.
[Graphical view ]
PANTHERi PTHR14742. PTHR14742. 1 hit.
Pfami PF04032. Rpr2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex."
    Takada T., Kumanovics A., Amadou C., Yoshino M., Jones E.P., Athanasiou M., Evans G.A., Lindahl K.F.
    Genome Res. 13:589-600(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Testis.
  2. "Genes from major histocompatibility complex (MHC) class I region from HLA-C to HLA-A."
    Raha-Chowdhury R., Andrews S.R., Gruen J.R., Weissman S.M.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiRPP21_MOUSE
AccessioniPrimary (citable) accession number: Q8R040
Secondary accession number(s): Q80XY3, Q811B7, Q9CPX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3