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Protein

Polycomb group RING finger protein 1

Gene

Pcgf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri47 – 8640RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 1
Alternative name(s):
Nervous system Polycomb-1
Short name:
NSPc1
RING finger protein 68
Gene namesi
Name:Pcgf1
Synonyms:Nspc1, Rnf68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917087. Pcgf1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 259258Polycomb group RING finger protein 1PRO_0000277856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei3 – 31PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8R023.
MaxQBiQ8R023.
PaxDbiQ8R023.
PRIDEiQ8R023.

PTM databases

PhosphoSiteiQ8R023.

Expressioni

Developmental stagei

Expressed in the otic vesicle, urogenital bud and dorsal root ganglia at 10.5 dpc, in the neural tube and neural crest cell derivatives of the peripheral nervous system at 11.5 dpc.1 Publication

Gene expression databases

BgeeiQ8R023.
CleanExiMM_PCGF1.
ExpressionAtlasiQ8R023. baseline and differential.
GenevisibleiQ8R023. MM.

Interactioni

Subunit structurei

Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2. Specifically interacts with BCOR, RING1 and RNF2/RING2. Also interacts with BCORL1, the interaction is direct (By similarity). Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. Interacts with DPPA4, NANOG, POU5F1 and RYBP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213711. 31 interactions.
IntActiQ8R023. 29 interactions.
STRINGi10090.ENSMUSP00000090277.

Structurei

3D structure databases

ProteinModelPortaliQ8R023.
SMRiQ8R023. Positions 35-129, 167-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 247162Necessary for repressor activityBy similarityAdd
BLAST
Regioni167 – 25589Sufficient for interaction with BCOR and BCORL1By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri47 – 8640RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ8R023.
KOiK11487.
OMAiFVRCSVR.
PhylomeDBiQ8R023.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC
60 70 80 90 100
AGYFVDATTI TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL
110 120 130 140 150
DRVMQDIVYK LVPGLQDSEE KRIREFYQSR GLDRVSQPSG EEPALSNLGL
160 170 180 190 200
PFSSFDHSKA HYYRYDEQLS LCLERLSSGK DKNKNVLQNK YVRCSVRAEV
210 220 230 240 250
RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQLWLSR WFGKPSPLLL

QYSVKEKRR
Length:259
Mass (Da):30,318
Last modified:February 10, 2009 - v2
Checksum:iB631543B0DEA2954
GO

Sequence cautioni

The sequence AAH28560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104324 Genomic DNA. No translation available.
BC028560 mRNA. Translation: AAH28560.1. Different initiation.
RefSeqiNP_932109.1. NM_197992.1.
UniGeneiMm.12261.

Genome annotation databases

EnsembliENSMUST00000165164; ENSMUSP00000130614; ENSMUSG00000069678.
GeneIDi69837.
KEGGimmu:69837.
UCSCiuc009cmg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104324 Genomic DNA. No translation available.
BC028560 mRNA. Translation: AAH28560.1. Different initiation.
RefSeqiNP_932109.1. NM_197992.1.
UniGeneiMm.12261.

3D structure databases

ProteinModelPortaliQ8R023.
SMRiQ8R023. Positions 35-129, 167-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213711. 31 interactions.
IntActiQ8R023. 29 interactions.
STRINGi10090.ENSMUSP00000090277.

PTM databases

PhosphoSiteiQ8R023.

Proteomic databases

EPDiQ8R023.
MaxQBiQ8R023.
PaxDbiQ8R023.
PRIDEiQ8R023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165164; ENSMUSP00000130614; ENSMUSG00000069678.
GeneIDi69837.
KEGGimmu:69837.
UCSCiuc009cmg.1. mouse.

Organism-specific databases

CTDi84759.
MGIiMGI:1917087. Pcgf1.

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ8R023.
KOiK11487.
OMAiFVRCSVR.
PhylomeDBiQ8R023.
TreeFamiTF324206.

Miscellaneous databases

NextBioi330455.
PROiQ8R023.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R023.
CleanExiMM_PCGF1.
ExpressionAtlasiQ8R023. baseline and differential.
GenevisibleiQ8R023. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-259.
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system."
    Nunes M., Blanc I., Maes J., Fellous M., Robert B., McElreavey K.
    Mech. Dev. 102:219-222(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPCGF1_MOUSE
AccessioniPrimary (citable) accession number: Q8R023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 10, 2009
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.