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Protein

Nectin-4

Gene

Nectin4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-420597. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Nectin-4
Alternative name(s):
Ig superfamily receptor LNIR
Nectin cell adhesion molecule 4By similarity
Poliovirus receptor-related protein 4
Gene namesi
Name:Nectin4By similarity
Synonyms:Lnir, Prr4, Pvrl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918990. Pvrl4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 347317ExtracellularSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 508140CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 508478Nectin-4PRO_0000297674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 126PROSITE-ProRule annotation
Disulfide bondi170 ↔ 222PROSITE-ProRule annotation
Disulfide bondi269 ↔ 314PROSITE-ProRule annotation
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8R007.
PaxDbiQ8R007.
PRIDEiQ8R007.

PTM databases

iPTMnetiQ8R007.
PhosphoSiteiQ8R007.

Expressioni

Tissue specificityi

Expressed in brain, lung, testis and embryo.1 Publication

Developmental stagei

Detected at embryonic days 11, 15 and 17.1 Publication

Gene expression databases

BgeeiQ8R007.
CleanExiMM_PVRL4.
GenevisibleiQ8R007. MM.

Interactioni

Subunit structurei

Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-59965N.
STRINGi10090.ENSMUSP00000006578.

Structurei

3D structure databases

ProteinModelPortaliQ8R007.
SMRiQ8R007. Positions 31-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 143113Ig-like V-typeAdd
BLAST
Domaini147 – 23690Ig-like C2-type 1Add
BLAST
Domaini247 – 33084Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPI. Eukaryota.
ENOG4111HYP. LUCA.
GeneTreeiENSGT00770000120512.
HOGENOMiHOG000115806.
HOVERGENiHBG108310.
InParanoidiQ8R007.
KOiK06593.
OMAiHSKYGLH.
PhylomeDBiQ8R007.
TreeFamiTF338610.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR033320. Nectin-4.
[Graphical view]
PANTHERiPTHR23277:SF11. PTHR23277:SF11. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSLGAEMW GPEAWLRLLF LASFTGQYSA GELETSDVVT VVLGQDAKLP
60 70 80 90 100
CFYRGDPDEQ VGQVAWARVD PNEGIRELAL LHSKYGLHVN PAYEDRVEQP
110 120 130 140 150
PPPRDPLDGS VLLRNAVQAD EGEYECRVST FPAGSFQARM RLRVLVPPLP
160 170 180 190 200
SLNPGPPLEE GQGLTLAASC TAEGSPAPSV TWDTEVKGTQ SSRSFTHPRS
210 220 230 240 250
AAVTSEFHLV PSRSMNGQPL TCVVSHPGLL QDRRITHTLQ VAFLAEASVR
260 270 280 290 300
GLEDQNLWQV GREGATLKCL SEGQPPPKYN WTRLDGPLPS GVRVKGDTLG
310 320 330 340 350
FPPLTTEHSG VYVCHVSNEL SSRDSQVTVE VLDPEDPGKQ VDLVSASVII
360 370 380 390 400
VGVIAALLFC LLVVVVVLMS RYHRRKAQQM TQKYEEELTL TRENSIRRLH
410 420 430 440 450
SHHSDPRSQP EESVGLRAEG HPDSLKDNSS CSVMSEEPEG RSYSTLTTVR
460 470 480 490 500
EIETQTELLS PGSGRTEEDD DQDEGIKQAM NHFVQENGTL RAKPTGNGIY

INGRGHLV
Length:508
Mass (Da):55,657
Last modified:June 1, 2002 - v1
Checksum:i24DAEBD21F22E376
GO
Isoform 2 (identifier: Q8R007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-434: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,031
Checksum:iF8F0466C000852E8
GO

Sequence cautioni

The sequence BAE32972.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21P → S in BAE32972 (PubMed:16141072).Curated
Sequence conflicti159 – 1591E → Q in BAC25972 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei410 – 43425Missing in isoform 2. 1 PublicationVSP_027336Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF472510 mRNA. Translation: AAL79833.1.
AK004821 mRNA. Translation: BAB23592.1.
AK154983 mRNA. Translation: BAE32972.1. Different initiation.
AK028479 mRNA. Translation: BAC25972.1.
BC024948 mRNA. Translation: AAH24948.1.
CCDSiCCDS15493.1. [Q8R007-1]
CCDS48442.1. [Q8R007-2]
RefSeqiNP_001116152.1. NM_001122680.1. [Q8R007-2]
NP_082169.2. NM_027893.3. [Q8R007-1]
UniGeneiMm.263414.

Genome annotation databases

EnsembliENSMUST00000006578; ENSMUSP00000006578; ENSMUSG00000006411. [Q8R007-1]
ENSMUST00000094325; ENSMUSP00000091883; ENSMUSG00000006411. [Q8R007-2]
ENSMUST00000111286; ENSMUSP00000106917; ENSMUSG00000006411. [Q8R007-1]
GeneIDi71740.
KEGGimmu:71740.
UCSCiuc007dof.2. mouse. [Q8R007-1]
uc011wwc.1. mouse. [Q8R007-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF472510 mRNA. Translation: AAL79833.1.
AK004821 mRNA. Translation: BAB23592.1.
AK154983 mRNA. Translation: BAE32972.1. Different initiation.
AK028479 mRNA. Translation: BAC25972.1.
BC024948 mRNA. Translation: AAH24948.1.
CCDSiCCDS15493.1. [Q8R007-1]
CCDS48442.1. [Q8R007-2]
RefSeqiNP_001116152.1. NM_001122680.1. [Q8R007-2]
NP_082169.2. NM_027893.3. [Q8R007-1]
UniGeneiMm.263414.

3D structure databases

ProteinModelPortaliQ8R007.
SMRiQ8R007. Positions 31-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59965N.
STRINGi10090.ENSMUSP00000006578.

PTM databases

iPTMnetiQ8R007.
PhosphoSiteiQ8R007.

Proteomic databases

MaxQBiQ8R007.
PaxDbiQ8R007.
PRIDEiQ8R007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006578; ENSMUSP00000006578; ENSMUSG00000006411. [Q8R007-1]
ENSMUST00000094325; ENSMUSP00000091883; ENSMUSG00000006411. [Q8R007-2]
ENSMUST00000111286; ENSMUSP00000106917; ENSMUSG00000006411. [Q8R007-1]
GeneIDi71740.
KEGGimmu:71740.
UCSCiuc007dof.2. mouse. [Q8R007-1]
uc011wwc.1. mouse. [Q8R007-2]

Organism-specific databases

CTDi71740.
MGIiMGI:1918990. Pvrl4.

Phylogenomic databases

eggNOGiENOG410IFPI. Eukaryota.
ENOG4111HYP. LUCA.
GeneTreeiENSGT00770000120512.
HOGENOMiHOG000115806.
HOVERGENiHBG108310.
InParanoidiQ8R007.
KOiK06593.
OMAiHSKYGLH.
PhylomeDBiQ8R007.
TreeFamiTF338610.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.
R-MMU-420597. Nectin/Necl trans heterodimerization.

Miscellaneous databases

PROiQ8R007.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R007.
CleanExiMM_PVRL4.
GenevisibleiQ8R007. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR033320. Nectin-4.
[Graphical view]
PANTHERiPTHR23277:SF11. PTHR23277:SF11. 1 hit.
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."
    Reymond N., Fabre S., Lecocq E., Adelaide J., Dubreuil P., Lopez M.
    J. Biol. Chem. 276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Lung and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiNECT4_MOUSE
AccessioniPrimary (citable) accession number: Q8R007
Secondary accession number(s): Q3U318, Q8CED8, Q9DBP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.