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Protein

Nectin-4

Gene

Nectin4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions
R-MMU-420597 Nectin/Necl trans heterodimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Nectin-4
Alternative name(s):
Ig superfamily receptor LNIR
Nectin cell adhesion molecule 4By similarity
Poliovirus receptor-related protein 4
Gene namesi
Name:Nectin4By similarity
Synonyms:Lnir, Prr4, Pvrl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1918990 Nectin4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 347ExtracellularSequence analysisAdd BLAST317
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 508CytoplasmicSequence analysisAdd BLAST140

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000029767431 – 508Nectin-4Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 126PROSITE-ProRule annotation
Disulfide bondi170 ↔ 222PROSITE-ProRule annotation
Disulfide bondi269 ↔ 314PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R007
PRIDEiQ8R007

PTM databases

iPTMnetiQ8R007
PhosphoSitePlusiQ8R007

Expressioni

Tissue specificityi

Expressed in brain, lung, testis and embryo.1 Publication

Developmental stagei

Detected at embryonic days 11, 15 and 17.1 Publication

Gene expression databases

BgeeiENSMUSG00000006411
CleanExiMM_PVRL4
GenevisibleiQ8R007 MM

Interactioni

Subunit structurei

Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214892, 2 interactors
DIPiDIP-59965N
STRINGi10090.ENSMUSP00000006578

Structurei

3D structure databases

ProteinModelPortaliQ8R007
SMRiQ8R007
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 143Ig-like V-typeAdd BLAST113
Domaini147 – 236Ig-like C2-type 1Add BLAST90
Domaini247 – 330Ig-like C2-type 2Add BLAST84

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPI Eukaryota
ENOG4111HYP LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000115806
HOVERGENiHBG108310
InParanoidiQ8R007
KOiK06593
OMAiHSKYGLH
OrthoDBiEOG091G0BLQ
PhylomeDBiQ8R007
TreeFamiTF338610

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR033320 Nectin-4
PANTHERiPTHR23277:SF11 PTHR23277:SF11, 1 hit
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSLGAEMW GPEAWLRLLF LASFTGQYSA GELETSDVVT VVLGQDAKLP
60 70 80 90 100
CFYRGDPDEQ VGQVAWARVD PNEGIRELAL LHSKYGLHVN PAYEDRVEQP
110 120 130 140 150
PPPRDPLDGS VLLRNAVQAD EGEYECRVST FPAGSFQARM RLRVLVPPLP
160 170 180 190 200
SLNPGPPLEE GQGLTLAASC TAEGSPAPSV TWDTEVKGTQ SSRSFTHPRS
210 220 230 240 250
AAVTSEFHLV PSRSMNGQPL TCVVSHPGLL QDRRITHTLQ VAFLAEASVR
260 270 280 290 300
GLEDQNLWQV GREGATLKCL SEGQPPPKYN WTRLDGPLPS GVRVKGDTLG
310 320 330 340 350
FPPLTTEHSG VYVCHVSNEL SSRDSQVTVE VLDPEDPGKQ VDLVSASVII
360 370 380 390 400
VGVIAALLFC LLVVVVVLMS RYHRRKAQQM TQKYEEELTL TRENSIRRLH
410 420 430 440 450
SHHSDPRSQP EESVGLRAEG HPDSLKDNSS CSVMSEEPEG RSYSTLTTVR
460 470 480 490 500
EIETQTELLS PGSGRTEEDD DQDEGIKQAM NHFVQENGTL RAKPTGNGIY

INGRGHLV
Length:508
Mass (Da):55,657
Last modified:June 1, 2002 - v1
Checksum:i24DAEBD21F22E376
GO
Isoform 2 (identifier: Q8R007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-434: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,031
Checksum:iF8F0466C000852E8
GO

Sequence cautioni

The sequence BAE32972 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2P → S in BAE32972 (PubMed:16141072).Curated1
Sequence conflicti159E → Q in BAC25972 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027336410 – 434Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF472510 mRNA Translation: AAL79833.1
AK004821 mRNA Translation: BAB23592.1
AK154983 mRNA Translation: BAE32972.1 Different initiation.
AK028479 mRNA Translation: BAC25972.1
BC024948 mRNA Translation: AAH24948.1
CCDSiCCDS15493.1 [Q8R007-1]
CCDS48442.1 [Q8R007-2]
RefSeqiNP_001116152.1, NM_001122680.1 [Q8R007-2]
NP_082169.2, NM_027893.3 [Q8R007-1]
UniGeneiMm.263414

Genome annotation databases

EnsembliENSMUST00000006578; ENSMUSP00000006578; ENSMUSG00000006411 [Q8R007-1]
ENSMUST00000094325; ENSMUSP00000091883; ENSMUSG00000006411 [Q8R007-2]
ENSMUST00000111286; ENSMUSP00000106917; ENSMUSG00000006411 [Q8R007-1]
GeneIDi71740
KEGGimmu:71740
UCSCiuc007dof.2 mouse [Q8R007-1]
uc011wwc.1 mouse [Q8R007-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNECT4_MOUSE
AccessioniPrimary (citable) accession number: Q8R007
Secondary accession number(s): Q3U318, Q8CED8, Q9DBP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health