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Protein

Organic solute transporter subunit alpha

Gene

Slc51a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.4 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transporter activity Source: MGI

GO - Biological processi

  • bile acid and bile salt transport Source: UniProtKB
  • transport Source: MGI

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Organic solute transporter subunit alpha
Short name:
OST-alpha
Alternative name(s):
Solute carrier family 51 subunit alpha
Gene namesi
Name:Slc51a
Synonyms:Osta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146634. Slc51a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 87CytoplasmicSequence analysisAdd BLAST18
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 114ExtracellularSequence analysis6
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 181CytoplasmicSequence analysisAdd BLAST46
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 219ExtracellularSequence analysisAdd BLAST17
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 255CytoplasmicSequence analysisAdd BLAST15
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 297ExtracellularSequence analysisAdd BLAST21
Transmembranei298 – 317HelicalSequence analysisAdd BLAST20
Topological domaini318 – 340CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • protein complex Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are physically indistinguishable from wild-type mice but display strongly reduced transileal transport of taurocholate. Moreover, the bile acid pool size is significantly reduced, but fecal bile acid excretion is not elevated.1 Publication

Chemistry databases

ChEMBLiCHEMBL2073723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315441 – 340Organic solute transporter subunit alphaAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei330PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R000.
PRIDEiQ8R000.

PTM databases

iPTMnetiQ8R000.
PhosphoSitePlusiQ8R000.

Expressioni

Tissue specificityi

Present at high levels in ileum. In ileum, it is restricted to the apical domain on the mature villus enterocytes with little detectable expression in the goblet cells or crypt enterocytes (at protein level). Expressed in kidney but not in heart, brain, liver, spleen, embryo, lung, thymus, ovary nor testis.2 Publications

Inductioni

Positively regulated via the bile acid-activated nuclear receptor farnesoid X receptor (NR1H4/FXR). Up-regulated in mice lacking Mrp4, but it is unable to compensate for the absence of Mrp4.2 Publications

Gene expression databases

BgeeiENSMUSG00000035699.
GenevisibleiQ8R000. MM.

Interactioni

Subunit structurei

Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046286.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 167Poly-Cys8

Sequence similaritiesi

Belongs to the OST-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKZG. Eukaryota.
ENOG410XW07. LUCA.
GeneTreeiENSGT00640000091510.
HOGENOMiHOG000115297.
HOVERGENiHBG098275.
InParanoidiQ8R000.
KOiK14360.
OMAiLNTPPCC.
OrthoDBiEOG091G0CFZ.
PhylomeDBiQ8R000.
TreeFamiTF316050.

Family and domain databases

InterProiView protein in InterPro
IPR005178. Ostalpha/TMEM184C.
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiView protein in Pfam
PF03619. Solute_trans_a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGRTHIKL DPRYTAELLE LLETNYSISP ACFSHPPTAA QLLRALGPVD
60 70 80 90 100
IALTIILTFL TTGSVAIFLE DAVYLYKNTL CPIKKRTLIW SSSAPTVVSV
110 120 130 140 150
FCCFGLWIPR ALTLVEMAIT SFYAVCFYLL MMVMVEGFGG KKAVLRTLKD
160 170 180 190 200
TPMRVHTGPC CCCCPCCPPL ILTRKKLQLL LLGPFQYAFF KITLSIVGLF
210 220 230 240 250
LIPDGIYDPG EISEKSAALW INNLLAVSTL LALWSLAILF RQAKMHLGEQ
260 270 280 290 300
NMGSKFALFQ VLVILTALQP AIFSILANSG QIACSPPYSS KIRSQVMNCH
310 320 330 340
MLILETFLMT VLTRMYYRRK DDKVGYEACS LPDLDSALKA
Length:340
Mass (Da):37,759
Last modified:June 1, 2002 - v1
Checksum:i5A072346AB5402F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052725 mRNA. Translation: BAC35116.1.
AK147155 mRNA. Translation: BAE27722.1.
BC024441 mRNA. Translation: AAH24441.1.
BC025912 mRNA. Translation: AAH25912.1.
BC031178 mRNA. Translation: AAH31178.1.
CCDSiCCDS28121.1.
RefSeqiNP_666044.1. NM_145932.3.
UniGeneiMm.476915.

Genome annotation databases

EnsembliENSMUST00000042042; ENSMUSP00000046286; ENSMUSG00000035699.
GeneIDi106407.
KEGGimmu:106407.
UCSCiuc007yyx.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiOSTA_MOUSE
AccessioniPrimary (citable) accession number: Q8R000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families