Reviewed,
UniProtKB/Swiss-Prot Q8QZY2 (GLCTK_MOUSE)
Last modified
June 16, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glycerate kinase EC=2.7.1.31 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 523 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate. |
| Subcellular location | Cytoplasm By similarity. |
| Tissue specificity | Expressed in the hippocampus, callus, brain, cerebellum, renal cortex interstitial cells, epithelium of interlobular bile duct and skeletal muscle. Ref.4 |
| Sequence similarities | Belongs to the glycerate kinase type-2 family. |
| Sequence caution | The sequence AAP97704.1 differs from that shown. Reason: Frameshift at several positions. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerate kinase activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8QZY2-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8QZY2-2) The sequence of this isoform differs from the canonical sequence as follows: 1-127: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 523 | 523 | Glycerate kinase | PRO_0000287194 | |||||
Regions | |||||||||
| Compositional bias | 94 – 97 | 4 | Poly-Ala | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 127 | 127 | Missing in isoform 2. | VSP_025366 | |||||
Experimental info | |||||||||
| Sequence conflict | 136 | 1 | V → I in BAC33747. Ref.2 | ||||||
| Sequence conflict | 136 | 1 | V → I in BAC34112. Ref.2 | ||||||
| Sequence conflict | 136 | 1 | V → I in BAC35110. Ref.2 | ||||||
| Sequence conflict | 139 | 1 | F → Y in AAP97704. Ref.1 | ||||||
| Sequence conflict | 235 | 1 | Q → H in BAC33747. Ref.2 | ||||||
| Sequence conflict | 261 | 1 | A → T in BAC33747. Ref.2 | ||||||
| Sequence conflict | 261 | 1 | A → T in BAC34112. Ref.2 | ||||||
| Sequence conflict | 261 | 1 | A → T in BAC35110. Ref.2 | ||||||
| Sequence conflict | 338 | 1 | Q → R in BAC34112. Ref.2 | ||||||
| Sequence conflict | 396 | 1 | A → V in BAC33747. Ref.2 | ||||||
| Sequence conflict | 396 | 1 | A → V in BAC34112. Ref.2 | ||||||
| Sequence conflict | 396 | 1 | A → V in BAC35110. Ref.2 | ||||||
| Sequence conflict | 485 | 1 | T → A in BAC33747. Ref.2 | ||||||
| Sequence conflict | 485 | 1 | T → A in BAC34112. Ref.2 | ||||||
| Sequence conflict | 485 | 1 | T → A in BAC35110. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Zan Q., Guo J.H., Yu L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Kidney and Liver. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: FVB/N. Tissue: Kidney and Liver. |
| [4] | "Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2." Guo J.-H., Hexige S., Chen L., Zhou G.-J., Wang X., Jiang J.-M., Kong Y.-H., Ji G.-Q., Wu C.-Q., Zhao S.-Y., Yu L. DNA Seq. 17:1-7(2006) [PubMed: 16753811] [Abstract] Cited for: TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| AF455785 mRNA. Translation: AAP97704.1. Frameshift. AK049425 mRNA. Translation: BAC33747.1. AK050182 mRNA. Translation: BAC34112.1. AK052709 mRNA. Translation: BAC35110.1. BC025834 mRNA. Translation: AAH25834.1. BC025935 mRNA. Translation: AAH25935.1. BC030732 mRNA. Translation: AAH30732.1. BC033063 mRNA. Translation: AAH33063.1. BC036136 mRNA. Translation: AAH36136.1. Different initiation. | |
| IPI | IPI00453581. IPI00845645. |
| RefSeq | NP_001034675.1. NP_777271.3. |
| UniGene | Mm.335420 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1O0U based on UniProtKB Q9X1S1. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8QZY2. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000020258. Mus musculus. [Contig view] |
| GeneID | 235582. |
| KEGG | mmu:235582. |
Organism-specific databases | |
| MGI | MGI:2444085. Glyctk. |
Phylogenomic databases | |
| HOVERGEN | Q8QZY2. |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.31. 244. |
Gene expression databases | |
| ArrayExpress | Q8QZY2. |
| Bgee | Q8QZY2. |
| CleanEx | MM_GLYCTK. |
Family and domain databases | |
| InterPro | IPR007835. MOFRL. [Graphical view] |
| Pfam | PF05161. MOFRL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 382759. |
| SOURCE | Search... |
Entry information
| Entry name | GLCTK_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8QZY2 Secondary accession number(s): Q7TNX6 Q8K0R7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


