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Q8QZY2 (GLCTK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerate kinase
EC=2.7.1.31
Gene names
Name:Glyctk
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in the hippocampus, callus, brain, cerebellum, renal cortex interstitial cells, epithelium of interlobular bile duct and skeletal muscle. Ref.4

Sequence similarities

Belongs to the glycerate kinase type-2 family.

Sequence caution

The sequence AAH36136.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAP97704.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processprotein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular componentmitochondrion

Inferred from direct assay. Source: MGI

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerate kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8QZY2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8QZY2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Glycerate kinase
PRO_0000287194

Regions

Compositional bias94 – 974Poly-Ala

Natural variations

Alternative sequence1 – 127127Missing in isoform 2.
VSP_025366

Experimental info

Sequence conflict1361V → I in BAC33747. Ref.2
Sequence conflict1361V → I in BAC34112. Ref.2
Sequence conflict1361V → I in BAC35110. Ref.2
Sequence conflict1391F → Y in AAP97704. Ref.1
Sequence conflict2351Q → H in BAC33747. Ref.2
Sequence conflict2611A → T in BAC33747. Ref.2
Sequence conflict2611A → T in BAC34112. Ref.2
Sequence conflict2611A → T in BAC35110. Ref.2
Sequence conflict3381Q → R in BAC34112. Ref.2
Sequence conflict3961A → V in BAC33747. Ref.2
Sequence conflict3961A → V in BAC34112. Ref.2
Sequence conflict3961A → V in BAC35110. Ref.2
Sequence conflict4851T → A in BAC33747. Ref.2
Sequence conflict4851T → A in BAC34112. Ref.2
Sequence conflict4851T → A in BAC35110. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 8EECD09476764FF2

FASTA52355,293
        10         20         30         40         50         60 
MAAALQVLPC LLRAPSRPLL WGPPVARMTS GMALAEQARQ LFDSAVGAVQ PGPMLQRTLS 

        70         80         90        100        110        120 
LDPSGRQLKV RDRTFQLREN LYLVGFGKAV LGMAAAAEEL LAQHLVQGVI SVPKGIRAAM 

       130        140        150        160        170        180 
EHAGKKEMLL KPHSRVQVFE GAEDNLPDRD ALRAALTIQQ LAEGLTADDL LLVLISGGGS 

       190        200        210        220        230        240 
ALLPAPIPPV TLEEKQMLTK LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVISLI 

       250        260        270        280        290        300 
LSDVIGDPLE VIASGPTVAS AHSVQDCLHI LNHYGLRAAL PRSVKTVLSR ADSDPHGPHT 

       310        320        330        340        350        360 
CGHVLNVIIG SNSLALAEAQ RQAEVLGYHA MVLSTAMQGD VKRVARFYGL LARVAAAHLT 

       370        380        390        400        410        420 
PSLAERPLEE EAELHQLAAE LQLPDLQLEE ALEAVAKAKG PVCLLAGGEP TVQLQGSGKG 

       430        440        450        460        470        480 
GRNQELALHV GVELGRQPLG PIDVLFLSGG TDGQDGPTKV AGAWVMSDLI SQASAESLDI 

       490        500        510        520 
ATSLTNNDSY TFFCRFRGGT HLLHTGLTGT NVMDVHLLIL HPQ

« Hide

Isoform 2 [UniParc].

Checksum: 0B97A395C5202E15
Show »

FASTA39641,702

References

« Hide 'large scale' references
[1]Zan Q., Guo J.H., Yu L.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Kidney and Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: FVB/N.
Tissue: Kidney and Liver.
[4]"Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2."
Guo J.-H., Hexige S., Chen L., Zhou G.-J., Wang X., Jiang J.-M., Kong Y.-H., Ji G.-Q., Wu C.-Q., Zhao S.-Y., Yu L.
DNA Seq. 17:1-7(2006) [PubMed: 16753811] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF455785 mRNA. Translation: AAP97704.1. Frameshift.
AK049425 mRNA. Translation: BAC33747.1.
AK050182 mRNA. Translation: BAC34112.1.
AK052709 mRNA. Translation: BAC35110.1.
BC025834 mRNA. Translation: AAH25834.1.
BC025935 mRNA. Translation: AAH25935.1.
BC030732 mRNA. Translation: AAH30732.1.
BC033063 mRNA. Translation: AAH33063.1.
BC036136 mRNA. Translation: AAH36136.1. Different initiation.
IPIIPI00453581.
IPI00845645.
RefSeqNP_001034675.1. NM_001039586.1.
NP_777271.3. NM_174846.4.
UniGeneMm.335420.

3D structure databases

HSSPHSSP built from PDB template 1X3L based on UniProtKB O58231.
ProteinModelPortalQ8QZY2.
SMRQ8QZY2. Positions 32-521.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8QZY2.

PTM databases

PhosphoSiteQ8QZY2.

Proteomic databases

PRIDEQ8QZY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036382; ENSMUSP00000047761; ENSMUSG00000020258.
ENSMUST00000112543; ENSMUSP00000108162; ENSMUSG00000020258.
GeneID235582.
KEGGmmu:235582.
UCSCuc009riz.1. mouse.

Organism-specific databases

CTD132158.
MGIMGI:2444085. Glyctk.

Phylogenomic databases

eggNOGroNOG04858.
GeneTreeENSGT00390000014365.
HOVERGENHBG098351.
InParanoidQ8QZY2.
OrthoDBEOG4SBDXX.

Gene expression databases

ArrayExpressQ8QZY2.
BgeeQ8QZY2.
CleanExMM_GLYCTK.
GenevestigatorQ8QZY2.

Family and domain databases

InterProIPR007835. MOFRL.
[Graphical view]
Gene3DG3DSA:3.40.1480.10. G3DSA:3.40.1480.10. 2 hits.
KOK00865.
PfamPF05161. MOFRL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio382759.
SOURCESearch...

Entry information

Entry nameGLCTK_MOUSE
AccessionPrimary (citable) accession number: Q8QZY2
Secondary accession number(s): Q7TNX6 expand/collapse secondary AC list , Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2002
Last modified: November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents