Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerate kinase

Gene

Glyctk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-glycerate = ADP + 3-phospho-D-glycerate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerate kinase (EC:2.7.1.31)
Gene namesi
Name:Glyctk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444085. Glyctk.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871941 – 523Glycerate kinaseAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Modified residuei200N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8QZY2.
PRIDEiQ8QZY2.

PTM databases

iPTMnetiQ8QZY2.
PhosphoSitePlusiQ8QZY2.
SwissPalmiQ8QZY2.

Expressioni

Tissue specificityi

Expressed in the hippocampus, callus, brain, cerebellum, renal cortex interstitial cells, epithelium of interlobular bile duct and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000020258.
CleanExiMM_GLYCTK.

Interactioni

Protein-protein interaction databases

IntActiQ8QZY2. 3 interactors.
MINTiMINT-4118160.
STRINGi10090.ENSMUSP00000047761.

Structurei

3D structure databases

ProteinModelPortaliQ8QZY2.
SMRiQ8QZY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 97Poly-Ala4

Sequence similaritiesi

Belongs to the glycerate kinase type-2 family.Curated

Phylogenomic databases

eggNOGiKOG3935. Eukaryota.
COG2379. LUCA.
HOVERGENiHBG098351.
InParanoidiQ8QZY2.
KOiK11529.
PhylomeDBiQ8QZY2.
TreeFamiTF313770.

Family and domain databases

Gene3Di3.40.1480.10. 2 hits.
InterProiIPR007835. MOFRL.
IPR025286. MOFRL_assoc_dom.
[Graphical view]
PfamiPF13660. DUF4147. 1 hit.
PF05161. MOFRL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8QZY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALQVLPC LLRAPSRPLL WGPPVARMTS GMALAEQARQ LFDSAVGAVQ
60 70 80 90 100
PGPMLQRTLS LDPSGRQLKV RDRTFQLREN LYLVGFGKAV LGMAAAAEEL
110 120 130 140 150
LAQHLVQGVI SVPKGIRAAM EHAGKKEMLL KPHSRVQVFE GAEDNLPDRD
160 170 180 190 200
ALRAALTIQQ LAEGLTADDL LLVLISGGGS ALLPAPIPPV TLEEKQMLTK
210 220 230 240 250
LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVISLI LSDVIGDPLE
260 270 280 290 300
VIASGPTVAS AHSVQDCLHI LNHYGLRAAL PRSVKTVLSR ADSDPHGPHT
310 320 330 340 350
CGHVLNVIIG SNSLALAEAQ RQAEVLGYHA MVLSTAMQGD VKRVARFYGL
360 370 380 390 400
LARVAAAHLT PSLAERPLEE EAELHQLAAE LQLPDLQLEE ALEAVAKAKG
410 420 430 440 450
PVCLLAGGEP TVQLQGSGKG GRNQELALHV GVELGRQPLG PIDVLFLSGG
460 470 480 490 500
TDGQDGPTKV AGAWVMSDLI SQASAESLDI ATSLTNNDSY TFFCRFRGGT
510 520
HLLHTGLTGT NVMDVHLLIL HPQ
Length:523
Mass (Da):55,293
Last modified:June 1, 2002 - v1
Checksum:i8EECD09476764FF2
GO
Isoform 2 (identifier: Q8QZY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Show »
Length:396
Mass (Da):41,702
Checksum:i0B97A395C5202E15
GO

Sequence cautioni

The sequence AAH36136 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP97704 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136V → I in BAC33747 (PubMed:16141072).Curated1
Sequence conflicti136V → I in BAC34112 (PubMed:16141072).Curated1
Sequence conflicti136V → I in BAC35110 (PubMed:16141072).Curated1
Sequence conflicti139F → Y in AAP97704 (Ref. 1) Curated1
Sequence conflicti235Q → H in BAC33747 (PubMed:16141072).Curated1
Sequence conflicti261A → T in BAC33747 (PubMed:16141072).Curated1
Sequence conflicti261A → T in BAC34112 (PubMed:16141072).Curated1
Sequence conflicti261A → T in BAC35110 (PubMed:16141072).Curated1
Sequence conflicti338Q → R in BAC34112 (PubMed:16141072).Curated1
Sequence conflicti396A → V in BAC33747 (PubMed:16141072).Curated1
Sequence conflicti396A → V in BAC34112 (PubMed:16141072).Curated1
Sequence conflicti396A → V in BAC35110 (PubMed:16141072).Curated1
Sequence conflicti485T → A in BAC33747 (PubMed:16141072).Curated1
Sequence conflicti485T → A in BAC34112 (PubMed:16141072).Curated1
Sequence conflicti485T → A in BAC35110 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253661 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455785 mRNA. Translation: AAP97704.1. Frameshift.
AK049425 mRNA. Translation: BAC33747.1.
AK050182 mRNA. Translation: BAC34112.1.
AK052709 mRNA. Translation: BAC35110.1.
BC025834 mRNA. Translation: AAH25834.1.
BC025935 mRNA. Translation: AAH25935.1.
BC030732 mRNA. Translation: AAH30732.1.
BC033063 mRNA. Translation: AAH33063.1.
BC036136 mRNA. Translation: AAH36136.1. Different initiation.
CCDSiCCDS23469.1. [Q8QZY2-1]
RefSeqiNP_001034675.1. NM_001039586.1.
NP_777271.3. NM_174846.4.
XP_006511778.1. XM_006511715.3.
XP_011241181.1. XM_011242879.2.
XP_011241182.1. XM_011242880.2.
UniGeneiMm.335420.

Genome annotation databases

GeneIDi235582.
KEGGimmu:235582.
UCSCiuc009riz.1. mouse. [Q8QZY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF455785 mRNA. Translation: AAP97704.1. Frameshift.
AK049425 mRNA. Translation: BAC33747.1.
AK050182 mRNA. Translation: BAC34112.1.
AK052709 mRNA. Translation: BAC35110.1.
BC025834 mRNA. Translation: AAH25834.1.
BC025935 mRNA. Translation: AAH25935.1.
BC030732 mRNA. Translation: AAH30732.1.
BC033063 mRNA. Translation: AAH33063.1.
BC036136 mRNA. Translation: AAH36136.1. Different initiation.
CCDSiCCDS23469.1. [Q8QZY2-1]
RefSeqiNP_001034675.1. NM_001039586.1.
NP_777271.3. NM_174846.4.
XP_006511778.1. XM_006511715.3.
XP_011241181.1. XM_011242879.2.
XP_011241182.1. XM_011242880.2.
UniGeneiMm.335420.

3D structure databases

ProteinModelPortaliQ8QZY2.
SMRiQ8QZY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8QZY2. 3 interactors.
MINTiMINT-4118160.
STRINGi10090.ENSMUSP00000047761.

PTM databases

iPTMnetiQ8QZY2.
PhosphoSitePlusiQ8QZY2.
SwissPalmiQ8QZY2.

Proteomic databases

PaxDbiQ8QZY2.
PRIDEiQ8QZY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi235582.
KEGGimmu:235582.
UCSCiuc009riz.1. mouse. [Q8QZY2-1]

Organism-specific databases

CTDi132158.
MGIiMGI:2444085. Glyctk.

Phylogenomic databases

eggNOGiKOG3935. Eukaryota.
COG2379. LUCA.
HOVERGENiHBG098351.
InParanoidiQ8QZY2.
KOiK11529.
PhylomeDBiQ8QZY2.
TreeFamiTF313770.

Miscellaneous databases

PROiQ8QZY2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020258.
CleanExiMM_GLYCTK.

Family and domain databases

Gene3Di3.40.1480.10. 2 hits.
InterProiIPR007835. MOFRL.
IPR025286. MOFRL_assoc_dom.
[Graphical view]
PfamiPF13660. DUF4147. 1 hit.
PF05161. MOFRL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLCTK_MOUSE
AccessioniPrimary (citable) accession number: Q8QZY2
Secondary accession number(s): Q7TNX6
, Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.