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Q8QZX5

- LSM10_MOUSE

UniProt

Q8QZX5 - LSM10_MOUSE

Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

Lsm10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing By similarity. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed By similarity. Required for cell cycle progression from G1 to S phases By similarity. Binds specifically to U7 snRNA By similarity. Binds specifically to U7 snRNA By similarity. Binds to the downstream cleavage product (DCP) of histone pre-mRNA.By similarity

    GO - Molecular functioni

    1. histone pre-mRNA DCP binding Source: UniProtKB
    2. snRNA binding Source: MGI

    GO - Biological processi

    1. mitotic S phase Source: UniProtKB
    2. mRNA processing Source: UniProtKB-KW
    3. RNA splicing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_215668. SLBP independent Processing of Histone Pre-mRNAs.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U7 snRNA-associated Sm-like protein LSm10
    Gene namesi
    Name:Lsm10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2151045. Lsm10.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Cajal body Source: UniProtKB
    2. U7 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 122122U7 snRNA-associated Sm-like protein LSm10PRO_0000125586Add
    BLAST

    Post-translational modificationi

    Not methylated. Methylation is not necessary for interaction with SMN By similarity.By similarity

    Proteomic databases

    PRIDEiQ8QZX5.

    PTM databases

    PhosphoSiteiQ8QZX5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8QZX5.
    BgeeiQ8QZX5.
    CleanExiMM_LSM10.
    GenevestigatoriQ8QZX5.

    Interactioni

    Subunit structurei

    Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000061913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8QZX5.
    SMRiQ8QZX5. Positions 20-84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP Sm proteins family.Curated

    Phylogenomic databases

    eggNOGiNOG146625.
    GeneTreeiENSGT00510000048364.
    HOGENOMiHOG000230640.
    HOVERGENiHBG052366.
    InParanoidiQ8QZX5.
    OMAiRNFGSEG.
    OrthoDBiEOG7TF7CV.
    PhylomeDBiQ8QZX5.
    TreeFamiTF332356.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8QZX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSHSVKER TISENSLIIL LQGLQGQITT VDLRDESVAR GRIDNVDAFM    50
    NIRLANVTYT DRWGHQVELD DLFVTGRNVR YVHIPDGVDI TATIEQQLQI 100
    IHRVRNFGGK GQGRREFPSK RP 122
    Length:122
    Mass (Da):13,881
    Last modified:June 1, 2002 - v1
    Checksum:iB4614D960896B828
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024543 mRNA. Translation: AAH24543.1.
    BC026476 mRNA. Translation: AAH26476.1.
    CCDSiCCDS18642.1.
    RefSeqiNP_001156738.1. NM_001163266.1.
    NP_620046.1. NM_138721.2.
    XP_006502749.1. XM_006502686.1.
    XP_006502750.1. XM_006502687.1.
    UniGeneiMm.41865.

    Genome annotation databases

    EnsembliENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188.
    ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188.
    GeneIDi116748.
    KEGGimmu:116748.
    UCSCiuc008usk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC024543 mRNA. Translation: AAH24543.1 .
    BC026476 mRNA. Translation: AAH26476.1 .
    CCDSi CCDS18642.1.
    RefSeqi NP_001156738.1. NM_001163266.1.
    NP_620046.1. NM_138721.2.
    XP_006502749.1. XM_006502686.1.
    XP_006502750.1. XM_006502687.1.
    UniGenei Mm.41865.

    3D structure databases

    ProteinModelPortali Q8QZX5.
    SMRi Q8QZX5. Positions 20-84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000061913.

    PTM databases

    PhosphoSitei Q8QZX5.

    Proteomic databases

    PRIDEi Q8QZX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055575 ; ENSMUSP00000061913 ; ENSMUSG00000050188 .
    ENSMUST00000179323 ; ENSMUSP00000136585 ; ENSMUSG00000050188 .
    GeneIDi 116748.
    KEGGi mmu:116748.
    UCSCi uc008usk.2. mouse.

    Organism-specific databases

    CTDi 84967.
    MGIi MGI:2151045. Lsm10.

    Phylogenomic databases

    eggNOGi NOG146625.
    GeneTreei ENSGT00510000048364.
    HOGENOMi HOG000230640.
    HOVERGENi HBG052366.
    InParanoidi Q8QZX5.
    OMAi RNFGSEG.
    OrthoDBi EOG7TF7CV.
    PhylomeDBi Q8QZX5.
    TreeFami TF332356.

    Enzyme and pathway databases

    Reactomei REACT_215668. SLBP independent Processing of Histone Pre-mRNAs.

    Miscellaneous databases

    NextBioi 369080.
    PROi Q8QZX5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8QZX5.
    Bgeei Q8QZX5.
    CleanExi MM_LSM10.
    Genevestigatori Q8QZX5.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Mammary tumor.
    2. "Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA."
      Yang X.-C., Torres M.P., Marzluff W.F., Dominski Z.
      Mol. Cell. Biol. 29:4045-4056(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA-BINDING.

    Entry informationi

    Entry nameiLSM10_MOUSE
    AccessioniPrimary (citable) accession number: Q8QZX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3