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Q8QZX5

- LSM10_MOUSE

UniProt

Q8QZX5 - LSM10_MOUSE

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Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

Lsm10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA.By similarity

GO - Molecular functioni

  1. histone pre-mRNA DCP binding Source: UniProtKB
  2. snRNA binding Source: MGI

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. positive regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
  3. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_215668. SLBP independent Processing of Histone Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene namesi
Name:Lsm10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2151045. Lsm10.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Cajal body Source: UniProtKB
  2. U7 snRNP Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122U7 snRNA-associated Sm-like protein LSm10PRO_0000125586Add
BLAST

Post-translational modificationi

Not methylated. Methylation is not necessary for interaction with SMN (By similarity).By similarity

Proteomic databases

MaxQBiQ8QZX5.
PRIDEiQ8QZX5.

PTM databases

PhosphoSiteiQ8QZX5.

Expressioni

Gene expression databases

BgeeiQ8QZX5.
CleanExiMM_LSM10.
ExpressionAtlasiQ8QZX5. baseline and differential.
GenevestigatoriQ8QZX5.

Interactioni

Subunit structurei

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061913.

Structurei

3D structure databases

ProteinModelPortaliQ8QZX5.
SMRiQ8QZX5. Positions 20-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiNOG146625.
GeneTreeiENSGT00510000048364.
HOGENOMiHOG000230640.
HOVERGENiHBG052366.
InParanoidiQ8QZX5.
OMAiRNFGSEG.
OrthoDBiEOG7TF7CV.
PhylomeDBiQ8QZX5.
TreeFamiTF332356.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8QZX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSHSVKER TISENSLIIL LQGLQGQITT VDLRDESVAR GRIDNVDAFM
60 70 80 90 100
NIRLANVTYT DRWGHQVELD DLFVTGRNVR YVHIPDGVDI TATIEQQLQI
110 120
IHRVRNFGGK GQGRREFPSK RP
Length:122
Mass (Da):13,881
Last modified:June 1, 2002 - v1
Checksum:iB4614D960896B828
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024543 mRNA. Translation: AAH24543.1.
BC026476 mRNA. Translation: AAH26476.1.
CCDSiCCDS18642.1.
RefSeqiNP_001156738.1. NM_001163266.1.
NP_620046.1. NM_138721.2.
XP_006502749.1. XM_006502686.1.
XP_006502750.1. XM_006502687.1.
UniGeneiMm.41865.

Genome annotation databases

EnsembliENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188.
ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188.
GeneIDi116748.
KEGGimmu:116748.
UCSCiuc008usk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024543 mRNA. Translation: AAH24543.1 .
BC026476 mRNA. Translation: AAH26476.1 .
CCDSi CCDS18642.1.
RefSeqi NP_001156738.1. NM_001163266.1.
NP_620046.1. NM_138721.2.
XP_006502749.1. XM_006502686.1.
XP_006502750.1. XM_006502687.1.
UniGenei Mm.41865.

3D structure databases

ProteinModelPortali Q8QZX5.
SMRi Q8QZX5. Positions 20-84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000061913.

PTM databases

PhosphoSitei Q8QZX5.

Proteomic databases

MaxQBi Q8QZX5.
PRIDEi Q8QZX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055575 ; ENSMUSP00000061913 ; ENSMUSG00000050188 .
ENSMUST00000179323 ; ENSMUSP00000136585 ; ENSMUSG00000050188 .
GeneIDi 116748.
KEGGi mmu:116748.
UCSCi uc008usk.2. mouse.

Organism-specific databases

CTDi 84967.
MGIi MGI:2151045. Lsm10.

Phylogenomic databases

eggNOGi NOG146625.
GeneTreei ENSGT00510000048364.
HOGENOMi HOG000230640.
HOVERGENi HBG052366.
InParanoidi Q8QZX5.
OMAi RNFGSEG.
OrthoDBi EOG7TF7CV.
PhylomeDBi Q8QZX5.
TreeFami TF332356.

Enzyme and pathway databases

Reactomei REACT_215668. SLBP independent Processing of Histone Pre-mRNAs.

Miscellaneous databases

NextBioi 369080.
PROi Q8QZX5.
SOURCEi Search...

Gene expression databases

Bgeei Q8QZX5.
CleanExi MM_LSM10.
ExpressionAtlasi Q8QZX5. baseline and differential.
Genevestigatori Q8QZX5.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view ]
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
SMARTi SM00651. Sm. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  2. "Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA."
    Yang X.-C., Torres M.P., Marzluff W.F., Dominski Z.
    Mol. Cell. Biol. 29:4045-4056(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING.

Entry informationi

Entry nameiLSM10_MOUSE
AccessioniPrimary (citable) accession number: Q8QZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3