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Q8QZX5 (LSM10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene names
Name:Lsm10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length122 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing By similarity. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed By similarity. Required for cell cycle progression from G1 to S phases By similarity. Binds specifically to U7 snRNA By similarity. Binds specifically to U7 snRNA By similarity. Binds to the downstream cleavage product (DCP) of histone pre-mRNA.

Subunit structure

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Not methylated. Methylation is not necessary for interaction with SMN By similarity.

Sequence similarities

Belongs to the snRNP Sm proteins family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 122122U7 snRNA-associated Sm-like protein LSm10
PRO_0000125586

Sequences

Sequence LengthMass (Da)Tools
Q8QZX5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B4614D960896B828

FASTA12213,881
        10         20         30         40         50         60 
MALSHSVKER TISENSLIIL LQGLQGQITT VDLRDESVAR GRIDNVDAFM NIRLANVTYT 

        70         80         90        100        110        120 
DRWGHQVELD DLFVTGRNVR YVHIPDGVDI TATIEQQLQI IHRVRNFGGK GQGRREFPSK 


RP 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon and Mammary tumor.
[2]"Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA."
Yang X.-C., Torres M.P., Marzluff W.F., Dominski Z.
Mol. Cell. Biol. 29:4045-4056(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC024543 mRNA. Translation: AAH24543.1.
BC026476 mRNA. Translation: AAH26476.1.
CCDSCCDS18642.1.
RefSeqNP_001156738.1. NM_001163266.1.
NP_620046.1. NM_138721.2.
XP_006502749.1. XM_006502686.1.
XP_006502750.1. XM_006502687.1.
UniGeneMm.41865.

3D structure databases

ProteinModelPortalQ8QZX5.
SMRQ8QZX5. Positions 20-84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000061913.

PTM databases

PhosphoSiteQ8QZX5.

Proteomic databases

PRIDEQ8QZX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188.
ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188.
GeneID116748.
KEGGmmu:116748.
UCSCuc008usk.2. mouse.

Organism-specific databases

CTD84967.
MGIMGI:2151045. Lsm10.

Phylogenomic databases

eggNOGNOG146625.
GeneTreeENSGT00510000048364.
HOGENOMHOG000230640.
HOVERGENHBG052366.
InParanoidQ8QZX5.
OMARNFGSEG.
OrthoDBEOG7TF7CV.
PhylomeDBQ8QZX5.
TreeFamTF332356.

Gene expression databases

ArrayExpressQ8QZX5.
BgeeQ8QZX5.
CleanExMM_LSM10.
GenevestigatorQ8QZX5.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

NextBio369080.
PROQ8QZX5.
SOURCESearch...

Entry information

Entry nameLSM10_MOUSE
AccessionPrimary (citable) accession number: Q8QZX5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot