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Protein

U7 snRNA-associated Sm-like protein LSm10

Gene

Lsm10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA.By similarity

GO - Molecular functioni

  • histone pre-mRNA DCP binding Source: UniProtKB
  • snRNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_278946. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_343355. SLBP independent Processing of Histone Pre-mRNAs.
REACT_351784. Cleavage of Growing Transcript in the Termination Region.

Names & Taxonomyi

Protein namesi
Recommended name:
U7 snRNA-associated Sm-like protein LSm10
Gene namesi
Name:Lsm10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2151045. Lsm10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122U7 snRNA-associated Sm-like protein LSm10PRO_0000125586Add
BLAST

Post-translational modificationi

Not methylated. Methylation is not necessary for interaction with SMN (By similarity).By similarity

Proteomic databases

MaxQBiQ8QZX5.
PRIDEiQ8QZX5.

PTM databases

PhosphoSiteiQ8QZX5.

Expressioni

Gene expression databases

BgeeiQ8QZX5.
CleanExiMM_LSM10.
ExpressionAtlasiQ8QZX5. baseline and differential.
GenevisibleiQ8QZX5. MM.

Interactioni

Subunit structurei

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061913.

Structurei

3D structure databases

ProteinModelPortaliQ8QZX5.
SMRiQ8QZX5. Positions 20-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiNOG146625.
GeneTreeiENSGT00510000048364.
HOGENOMiHOG000230640.
HOVERGENiHBG052366.
InParanoidiQ8QZX5.
OMAiRNFGSEG.
OrthoDBiEOG7TF7CV.
PhylomeDBiQ8QZX5.
TreeFamiTF332356.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8QZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSHSVKER TISENSLIIL LQGLQGQITT VDLRDESVAR GRIDNVDAFM
60 70 80 90 100
NIRLANVTYT DRWGHQVELD DLFVTGRNVR YVHIPDGVDI TATIEQQLQI
110 120
IHRVRNFGGK GQGRREFPSK RP
Length:122
Mass (Da):13,881
Last modified:June 1, 2002 - v1
Checksum:iB4614D960896B828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024543 mRNA. Translation: AAH24543.1.
BC026476 mRNA. Translation: AAH26476.1.
CCDSiCCDS18642.1.
RefSeqiNP_001156738.1. NM_001163266.1.
NP_620046.1. NM_138721.2.
XP_006502749.1. XM_006502686.2.
XP_006502750.1. XM_006502687.1.
UniGeneiMm.41865.

Genome annotation databases

EnsembliENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188.
ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188.
GeneIDi116748.
KEGGimmu:116748.
UCSCiuc008usk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024543 mRNA. Translation: AAH24543.1.
BC026476 mRNA. Translation: AAH26476.1.
CCDSiCCDS18642.1.
RefSeqiNP_001156738.1. NM_001163266.1.
NP_620046.1. NM_138721.2.
XP_006502749.1. XM_006502686.2.
XP_006502750.1. XM_006502687.1.
UniGeneiMm.41865.

3D structure databases

ProteinModelPortaliQ8QZX5.
SMRiQ8QZX5. Positions 20-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061913.

PTM databases

PhosphoSiteiQ8QZX5.

Proteomic databases

MaxQBiQ8QZX5.
PRIDEiQ8QZX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055575; ENSMUSP00000061913; ENSMUSG00000050188.
ENSMUST00000179323; ENSMUSP00000136585; ENSMUSG00000050188.
GeneIDi116748.
KEGGimmu:116748.
UCSCiuc008usk.2. mouse.

Organism-specific databases

CTDi84967.
MGIiMGI:2151045. Lsm10.

Phylogenomic databases

eggNOGiNOG146625.
GeneTreeiENSGT00510000048364.
HOGENOMiHOG000230640.
HOVERGENiHBG052366.
InParanoidiQ8QZX5.
OMAiRNFGSEG.
OrthoDBiEOG7TF7CV.
PhylomeDBiQ8QZX5.
TreeFamiTF332356.

Enzyme and pathway databases

ReactomeiREACT_278946. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_343355. SLBP independent Processing of Histone Pre-mRNAs.
REACT_351784. Cleavage of Growing Transcript in the Termination Region.

Miscellaneous databases

NextBioi369080.
PROiQ8QZX5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8QZX5.
CleanExiMM_LSM10.
ExpressionAtlasiQ8QZX5. baseline and differential.
GenevisibleiQ8QZX5. MM.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  2. "Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA."
    Yang X.-C., Torres M.P., Marzluff W.F., Dominski Z.
    Mol. Cell. Biol. 29:4045-4056(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING.

Entry informationi

Entry nameiLSM10_MOUSE
AccessioniPrimary (citable) accession number: Q8QZX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.