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Protein

Serine/threonine-protein kinase SBK1

Gene

Sbk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in signal-transduction pathways related to the control of brain development.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82ATPPROSITE-ProRule annotation1
Active sitei174Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)
Alternative name(s):
SH3-binding kinase 1
Gene namesi
Name:Sbk1
Synonyms:Sbk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2135937. Sbk1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384521 – 417Serine/threonine-protein kinase SBK1Add BLAST417

Proteomic databases

MaxQBiQ8QZX0.
PaxDbiQ8QZX0.
PRIDEiQ8QZX0.

PTM databases

PhosphoSitePlusiQ8QZX0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042978.
CleanExiMM_SBK1.
ExpressionAtlasiQ8QZX0. baseline and differential.
GenevisibleiQ8QZX0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060907.

Structurei

3D structure databases

ProteinModelPortaliQ8QZX0.
SMRiQ8QZX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 318Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi363 – 393Pro-richAdd BLAST31

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiQ8QZX0.
KOiK08858.
OMAiLVAHRTQ.
OrthoDBiEOG091G0QNH.
PhylomeDBiQ8QZX0.
TreeFamiTF326736.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR016234. Ser/Thr_kinase_Sbk1.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000566. Ser/Thr_PK_Sbk1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGCPEPEP LHSLPCCGPG AAPVPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV AYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EECYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHSRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGFAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRLPGS LRLEAPGPLK
360 370 380 390 400
RTVLTESGSG SRPSPPSVGP VVPVPVPVPV PVPEAGLAPP APPGRTDGRT
410
DKSKGQVVLA TAIEICV
Length:417
Mass (Da):45,696
Last modified:June 1, 2002 - v1
Checksum:iC6A79A28EE6D2EC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024114 mRNA. Translation: AAH24114.1.
BC025837 mRNA. Translation: AAH25837.1.
BC031759 mRNA. Translation: AAH31759.1.
CCDSiCCDS21824.1.
RefSeqiNP_663562.1. NM_145587.2.
XP_017177409.1. XM_017321920.1.
UniGeneiMm.29660.

Genome annotation databases

EnsembliENSMUST00000056028; ENSMUSP00000060907; ENSMUSG00000042978.
GeneIDi104175.
KEGGimmu:104175.
UCSCiuc009jqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024114 mRNA. Translation: AAH24114.1.
BC025837 mRNA. Translation: AAH25837.1.
BC031759 mRNA. Translation: AAH31759.1.
CCDSiCCDS21824.1.
RefSeqiNP_663562.1. NM_145587.2.
XP_017177409.1. XM_017321920.1.
UniGeneiMm.29660.

3D structure databases

ProteinModelPortaliQ8QZX0.
SMRiQ8QZX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060907.

PTM databases

PhosphoSitePlusiQ8QZX0.

Proteomic databases

MaxQBiQ8QZX0.
PaxDbiQ8QZX0.
PRIDEiQ8QZX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056028; ENSMUSP00000060907; ENSMUSG00000042978.
GeneIDi104175.
KEGGimmu:104175.
UCSCiuc009jqw.1. mouse.

Organism-specific databases

CTDi388228.
MGIiMGI:2135937. Sbk1.

Phylogenomic databases

eggNOGiKOG1345. Eukaryota.
ENOG41112JR. LUCA.
GeneTreeiENSGT00680000099954.
HOGENOMiHOG000063666.
HOVERGENiHBG108481.
InParanoidiQ8QZX0.
KOiK08858.
OMAiLVAHRTQ.
OrthoDBiEOG091G0QNH.
PhylomeDBiQ8QZX0.
TreeFamiTF326736.

Miscellaneous databases

ChiTaRSiSbk1. mouse.
PROiQ8QZX0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042978.
CleanExiMM_SBK1.
ExpressionAtlasiQ8QZX0. baseline and differential.
GenevisibleiQ8QZX0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR016234. Ser/Thr_kinase_Sbk1.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000566. Ser/Thr_PK_Sbk1. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSBK1_MOUSE
AccessioniPrimary (citable) accession number: Q8QZX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.