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Q8QZW7

- GBRP_MOUSE

UniProt

Q8QZW7 - GBRP_MOUSE

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Protein

Gamma-aminobutyric acid receptor subunit pi

Gene
Gabrp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone By similarity.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW
  2. extracellular ligand-gated ion channel activity Source: InterPro
  3. GABA-A receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit pi
Alternative name(s):
GABA(A) receptor subunit pi
Gene namesi
Name:Gabrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2387597. Gabrp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 242221Extracellular Reviewed predictionAdd
BLAST
Transmembranei243 – 26624Helical; Reviewed predictionAdd
BLAST
Transmembranei270 – 29223Helical; Reviewed predictionAdd
BLAST
Transmembranei305 – 32723Helical; Reviewed predictionAdd
BLAST
Topological domaini328 – 41689Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei417 – 43822Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 440419Gamma-aminobutyric acid receptor subunit piPRO_0000000493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi160 ↔ 174 By similarity
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8QZW7.

PTM databases

PhosphoSiteiQ8QZW7.

Expressioni

Gene expression databases

BgeeiQ8QZW7.
CleanExiMM_GABRP.
GenevestigatoriQ8QZW7.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020366.

Structurei

3D structure databases

ProteinModelPortaliQ8QZW7.
SMRiQ8QZW7. Positions 44-334.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255582.
GeneTreeiENSGT00630000089571.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiQ8QZW7.
KOiK05189.
OMAiNDVEFSW.
OrthoDBiEOG712TVZ.
PhylomeDBiQ8QZW7.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008100. GABAAp_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01724. GABAARPI.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QZW7-1 [UniParc]FASTAAdd to Basket

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MSYSLYLAFL CLSLLTQRTC IQGNQVNVEV SRSDKLSLPG FENLTAGYNK    50
FLRPNFGGDP VRIALTLDIA SISSISESNM DYTATIYLRQ RWTDPRLVFE 100
GNKSFTLDAR LVEFLWVPDT YIVESKKSFL HEVTVGNRLI RLFSNGTVLY 150
ALRITTTVTC NMDLSKYPMD TQTCKLQLES WGYDGNDVEF SWLRGNDSVR 200
GLENLRLAQY TIQQYFTLVT VSQQETGNYT RLVLQFELRR NVLYFILETY 250
VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN 300
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAVKDR GPAKDSEEVN 350
ITNIINSSIS SFKRKISFAS IEISGDNVNY SDLTMKASDK FKFVFREKIS 400
RIIDYFTIQN PSNVDRYSKL LFPLIFMLAN VFYWAYYMYF 440
Length:440
Mass (Da):50,436
Last modified:June 1, 2002 - v1
Checksum:iDF8D2AAB3300D445
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028946 mRNA. Translation: BAC26209.1.
AK160577 mRNA. Translation: BAE35885.1.
AL669814 Genomic DNA. Translation: CAI25681.1.
BC023693 mRNA. Translation: AAH23693.1.
BC025550 mRNA. Translation: AAH25550.1.
BC027245 mRNA. Translation: AAH27245.1.
BC031196 mRNA. Translation: AAH31196.1.
CCDSiCCDS24535.1.
RefSeqiNP_666129.1. NM_146017.3.
UniGeneiMm.99989.

Genome annotation databases

EnsembliENSMUST00000020366; ENSMUSP00000020366; ENSMUSG00000020159.
GeneIDi216643.
KEGGimmu:216643.
UCSCiuc007ikm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK028946 mRNA. Translation: BAC26209.1 .
AK160577 mRNA. Translation: BAE35885.1 .
AL669814 Genomic DNA. Translation: CAI25681.1 .
BC023693 mRNA. Translation: AAH23693.1 .
BC025550 mRNA. Translation: AAH25550.1 .
BC027245 mRNA. Translation: AAH27245.1 .
BC031196 mRNA. Translation: AAH31196.1 .
CCDSi CCDS24535.1.
RefSeqi NP_666129.1. NM_146017.3.
UniGenei Mm.99989.

3D structure databases

ProteinModelPortali Q8QZW7.
SMRi Q8QZW7. Positions 44-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020366.

Chemistry

BindingDBi Q8QZW7.
ChEMBLi CHEMBL2094133.
GuidetoPHARMACOLOGYi 419.

PTM databases

PhosphoSitei Q8QZW7.

Proteomic databases

PRIDEi Q8QZW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020366 ; ENSMUSP00000020366 ; ENSMUSG00000020159 .
GeneIDi 216643.
KEGGi mmu:216643.
UCSCi uc007ikm.1. mouse.

Organism-specific databases

CTDi 2568.
MGIi MGI:2387597. Gabrp.

Phylogenomic databases

eggNOGi NOG255582.
GeneTreei ENSGT00630000089571.
HOGENOMi HOG000231335.
HOVERGENi HBG051707.
InParanoidi Q8QZW7.
KOi K05189.
OMAi NDVEFSW.
OrthoDBi EOG712TVZ.
PhylomeDBi Q8QZW7.
TreeFami TF315453.

Miscellaneous databases

NextBioi 375250.
PROi Q8QZW7.
SOURCEi Search...

Gene expression databases

Bgeei Q8QZW7.
CleanExi MM_GABRP.
Genevestigatori Q8QZW7.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008100. GABAAp_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR01724. GABAARPI.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  2. Brown J.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGBRP_MOUSE
AccessioniPrimary (citable) accession number: Q8QZW7
Secondary accession number(s): Q3TUT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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