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Protein

Protein asunder homolog

Gene

Asun

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Crucial regulator of the mitotic cell cycle and development (By similarity). At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein asunder homolog
Alternative name(s):
Cell cycle regulator Mat89Bb homolog
Spermatogenesis-associated protein 30
Gene namesi
Name:Asun
Synonyms:Spata30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918427. Asun.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Protein asunder homologPRO_0000089846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei623 – 6231PhosphoserineBy similarity
Modified residuei626 – 6261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8QZV7.
MaxQBiQ8QZV7.
PaxDbiQ8QZV7.
PeptideAtlasiQ8QZV7.
PRIDEiQ8QZV7.

PTM databases

iPTMnetiQ8QZV7.
PhosphoSiteiQ8QZV7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040250.
CleanExiMM_4933424B01RIK.
ExpressionAtlasiQ8QZV7. baseline and differential.
GenevisibleiQ8QZV7. MM.

Interactioni

Subunit structurei

Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase.1 Publication

Protein-protein interaction databases

BioGridi214533. 3 interactions.
IntActiQ8QZV7. 1 interaction.
STRINGi10090.ENSMUSP00000032427.

Structurei

3D structure databases

ProteinModelPortaliQ8QZV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the asunder family.Curated

Phylogenomic databases

eggNOGiKOG3711. Eukaryota.
ENOG410XS4B. LUCA.
GeneTreeiENSGT00390000002793.
HOGENOMiHOG000046389.
InParanoidiQ8QZV7.
OMAiKQDEVRC.
OrthoDBiEOG091G03Z1.
TreeFamiTF105815.

Family and domain databases

InterProiIPR019355. Cell_cycle_regulator_Mat89Bb.
[Graphical view]
PfamiPF10221. DUF2151. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIFSESHKT VFVVDHCPYM AESCRQHVEF DMLVKNRTQG IIPLAPISKS
60 70 80 90 100
LWTCSVESSM EYCRIMYDIF PFKKLVNFIV SDSGAHVLNS WTQEDQNLQE
110 120 130 140 150
LMAALATVGP PNPRADPECC SILHGLVAAV ETLCKITEYQ HEARTLLMEN
160 170 180 190 200
AERVGNRGRI ICITNAKSDS HVRMLEDCVQ ETIHEHNKLA ANSDHLMQIQ
210 220 230 240 250
KCELVLIHTY PVGEDSLVSD RPKKELSPVL TSEVHSVRAG RHLATKLNVL
260 270 280 290 300
VQQHFDLAST TITNIPMKEE QHANTSANYD VELLHHKDAH VDFLRSGDSH
310 320 330 340 350
SGSSSREGPF KETVTLKWCT PRTNSIELHY CTGAYRISPV DVNSRPSSCL
360 370 380 390 400
TNFLLNGRSV LLEQPRKSGS KVISHMLSSH GGEIFLHVLS SSRSILEDPP
410 420 430 440 450
SISEGCGGRV TDYRITDFGE FMRENRLTPF LDPRYKIDAS LEIPLERAKD
460 470 480 490 500
QLEKHTRYWP MIISQTTIFN MQAVVPLAGV IVKESLTEED VLNCQKTIYN
510 520 530 540 550
LVDMERKNDP LPVSTVGTRG KGPKRDEQYR IMWNELETLV RAHISNSEKH
560 570 580 590 600
QRVLECLMAC RSKPPEEEER KKRGRKREDR EDKSEQAGKE HGTEKARPDA
610 620 630 640 650
DRLKGILERG KEELAEAEVI KDSPDSPEPP NKKPLVETDE TPHMEKSKGP
660 670 680 690 700
VSLLSLWSNR INTANSRKHQ EFAGRLNSVN NRAELYQHLK EENGEEVGLT
710 720 730
GGPRTAIPFL KCPRSPVVNR METTENGKAS RQ
Length:732
Mass (Da):82,780
Last modified:July 27, 2011 - v2
Checksum:i36E92DC5C00D77F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031S → G in AAH26851 (PubMed:15489334).Curated
Sequence conflicti303 – 3031S → G in AAH27229 (PubMed:15489334).Curated
Sequence conflicti605 – 6051G → R in AAH05696 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124128 Genomic DNA. No translation available.
BC005696 mRNA. Translation: AAH05696.1.
BC026851 mRNA. Translation: AAH26851.1.
BC027229 mRNA. Translation: AAH27229.1.
CCDSiCCDS39710.1.
RefSeqiNP_620096.2. NM_138757.2.
UniGeneiMm.271774.

Genome annotation databases

EnsembliENSMUST00000032427; ENSMUSP00000032427; ENSMUSG00000040250.
GeneIDi71177.
KEGGimmu:71177.
UCSCiuc009esb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124128 Genomic DNA. No translation available.
BC005696 mRNA. Translation: AAH05696.1.
BC026851 mRNA. Translation: AAH26851.1.
BC027229 mRNA. Translation: AAH27229.1.
CCDSiCCDS39710.1.
RefSeqiNP_620096.2. NM_138757.2.
UniGeneiMm.271774.

3D structure databases

ProteinModelPortaliQ8QZV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214533. 3 interactions.
IntActiQ8QZV7. 1 interaction.
STRINGi10090.ENSMUSP00000032427.

PTM databases

iPTMnetiQ8QZV7.
PhosphoSiteiQ8QZV7.

Proteomic databases

EPDiQ8QZV7.
MaxQBiQ8QZV7.
PaxDbiQ8QZV7.
PeptideAtlasiQ8QZV7.
PRIDEiQ8QZV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032427; ENSMUSP00000032427; ENSMUSG00000040250.
GeneIDi71177.
KEGGimmu:71177.
UCSCiuc009esb.1. mouse.

Organism-specific databases

CTDi55726.
MGIiMGI:1918427. Asun.

Phylogenomic databases

eggNOGiKOG3711. Eukaryota.
ENOG410XS4B. LUCA.
GeneTreeiENSGT00390000002793.
HOGENOMiHOG000046389.
InParanoidiQ8QZV7.
OMAiKQDEVRC.
OrthoDBiEOG091G03Z1.
TreeFamiTF105815.

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

PROiQ8QZV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040250.
CleanExiMM_4933424B01RIK.
ExpressionAtlasiQ8QZV7. baseline and differential.
GenevisibleiQ8QZV7. MM.

Family and domain databases

InterProiIPR019355. Cell_cycle_regulator_Mat89Bb.
[Graphical view]
PfamiPF10221. DUF2151. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASUN_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV7
Secondary accession number(s): E9QLV7, Q99JT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.