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Protein

Protein FAM161A

Gene

Fam161a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • cilium organization Source: MGI

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM161A
Gene namesi
Name:Fam161a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921123. Fam161a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290531 – 448Protein FAM161AAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8QZV6.
PaxDbiQ8QZV6.
PRIDEiQ8QZV6.

PTM databases

PhosphoSitePlusiQ8QZV6.

Expressioni

Tissue specificityi

Expressed in the retina.2 Publications

Developmental stagei

Expressed at low levels from 12.5 to 16.5 dpc in the retinal progenitor cells of the optic cup, as well as in the posterior compartment of the lens. Expression drops in the retina at birth. At P5, highly expressed in the postmigratory photoreceptor precursors at the apical side of the outer nuclear layer. At P10, present in the outer nuclear layer and in the inner segments of photoreceptors and in the outer plexiform layer (at protein level). In adult animals, at P30, reaches a well-defined localization in the inner segment of photoreceptors, as well as in the outer plexiform layer (at protein level). Completely absent from the outer segment of photoreceptors (at protein level).2 Publications

Interactioni

Subunit structurei

Interacts (via C-terminus) with microtubules. Interacts with LCA5, CEP290 and SDCCAG8. Interacts with FAM161B. Interacts with POC1B. Interacts with CEP78.By similarity

GO - Molecular functioni

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 207Sequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 61Ser-richAdd BLAST35

Sequence similaritiesi

Belongs to the FAM161 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKK. Eukaryota.
ENOG4111HTJ. LUCA.
HOVERGENiHBG107870.
InParanoidiQ8QZV6.
KOiK16772.

Family and domain databases

InterProiView protein in InterPro
IPR019579. UPF0564.
PfamiView protein in Pfam
PF10595. UPF0564. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8QZV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLEKMYQD KLNIKDIQAG FIRDGISDSS SSSASEKSCS HPALSVTSLS
60 70 80 90 100
EPDLDGSSSL STTTDEGLPD LEEKTPGESS AMVHAQELIN NMWNDFSVED
110 120 130 140 150
YIQYDSDSRT AKKKRKKAKS LTPKITVPVP FEMTVREQNR REKALSARSD
160 170 180 190 200
LETKLLKRDE DDAECKKKFR ANPVPSCVLL PLYEDLVKQS EERRKKARER
210 220 230 240 250
NRAALLASLK PFKFIAREEQ KQAVREKKLR DLFRAKRKTN QFKAKPVPRF
260 270 280 290 300
IYRPAASDKP KEEELYGDSR MLPKVRDLLQ NSPWPSRSAC RRFRDPRSPA
310 320 330 340 350
KPRGKHRRRC LRRDGDLEKW KEPFSEYSFL KCPMLCEECC LHESPCDSDK
360 370 380 390 400
RQKLLADIRA DEEILRETRR PGRSPRRKSP GRSSNPKPRP HECSPPMPTA
410 420 430 440
SSRGREQAIR RSEKARMREY WQELEEQEEK LQKRPMLFER VTQVVFIG
Length:448
Mass (Da):52,029
Last modified:June 1, 2002 - v1
Checksum:iFFADA9805D1CD115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024460 mRNA. Translation: AAH24460.1.
BC026495 mRNA. Translation: AAH26495.1.
RefSeqiNP_082948.2. NM_028672.2.
UniGeneiMm.252406.

Genome annotation databases

GeneIDi73873.
KEGGimmu:73873.
UCSCiuc007ies.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiF161A_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families