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Protein

Protein FAM161A

Gene

Fam161a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ciliogenesis.By similarity

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • cilium organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM161A
Gene namesi
Name:Fam161a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921123. Fam161a.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • ciliary basal body Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • photoreceptor connecting cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Protein FAM161APRO_0000329053Add
BLAST

Proteomic databases

MaxQBiQ8QZV6.
PaxDbiQ8QZV6.
PRIDEiQ8QZV6.

Expressioni

Tissue specificityi

Expressed in the retina.2 Publications

Developmental stagei

Expressed at low levels from 12.5 to 16.5 dpc in the retinal progenitor cells of the optic cup, as well as in the posterior compartment of the lens. Expression drops in the retina at birth. At P5, highly expressed in the postmigratory photoreceptor precursors at the apical side of the outer nuclear layer. At P10, present in the outer nuclear layer and in the inner segments of photoreceptors and in the outer plexiform layer (at protein level). In adult animals, at P30, reaches a well-defined localization in the inner segment of photoreceptors, as well as in the outer plexiform layer (at protein level). Completely absent from the outer segment of photoreceptors (at protein level).2 Publications

Gene expression databases

BgeeiQ8QZV6.

Interactioni

Subunit structurei

Interacts (via C-terminus) with microtubules. Interacts with LCA5, CEP290 and SDCCAG8. Interacts with FAM161B. Interacts with POC1B.By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili135 – 20773Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 6135Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM161 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKK. Eukaryota.
ENOG4111HTJ. LUCA.
HOVERGENiHBG107870.
InParanoidiQ8QZV6.
KOiK16772.

Family and domain databases

InterProiIPR019579. UPF0564.
[Graphical view]
PfamiPF10595. UPF0564. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLEKMYQD KLNIKDIQAG FIRDGISDSS SSSASEKSCS HPALSVTSLS
60 70 80 90 100
EPDLDGSSSL STTTDEGLPD LEEKTPGESS AMVHAQELIN NMWNDFSVED
110 120 130 140 150
YIQYDSDSRT AKKKRKKAKS LTPKITVPVP FEMTVREQNR REKALSARSD
160 170 180 190 200
LETKLLKRDE DDAECKKKFR ANPVPSCVLL PLYEDLVKQS EERRKKARER
210 220 230 240 250
NRAALLASLK PFKFIAREEQ KQAVREKKLR DLFRAKRKTN QFKAKPVPRF
260 270 280 290 300
IYRPAASDKP KEEELYGDSR MLPKVRDLLQ NSPWPSRSAC RRFRDPRSPA
310 320 330 340 350
KPRGKHRRRC LRRDGDLEKW KEPFSEYSFL KCPMLCEECC LHESPCDSDK
360 370 380 390 400
RQKLLADIRA DEEILRETRR PGRSPRRKSP GRSSNPKPRP HECSPPMPTA
410 420 430 440
SSRGREQAIR RSEKARMREY WQELEEQEEK LQKRPMLFER VTQVVFIG
Length:448
Mass (Da):52,029
Last modified:June 1, 2002 - v1
Checksum:iFFADA9805D1CD115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024460 mRNA. Translation: AAH24460.1.
BC026495 mRNA. Translation: AAH26495.1.
RefSeqiNP_082948.2. NM_028672.2.
UniGeneiMm.252406.

Genome annotation databases

GeneIDi73873.
KEGGimmu:73873.
UCSCiuc007ies.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024460 mRNA. Translation: AAH24460.1.
BC026495 mRNA. Translation: AAH26495.1.
RefSeqiNP_082948.2. NM_028672.2.
UniGeneiMm.252406.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ8QZV6.
PaxDbiQ8QZV6.
PRIDEiQ8QZV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi73873.
KEGGimmu:73873.
UCSCiuc007ies.1. mouse.

Organism-specific databases

CTDi84140.
MGIiMGI:1921123. Fam161a.

Phylogenomic databases

eggNOGiENOG410IEKK. Eukaryota.
ENOG4111HTJ. LUCA.
HOVERGENiHBG107870.
InParanoidiQ8QZV6.
KOiK16772.

Miscellaneous databases

PROiQ8QZV6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8QZV6.

Family and domain databases

InterProiIPR019579. UPF0564.
[Graphical view]
PfamiPF10595. UPF0564. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye and Kidney.
  2. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa."
    Bandah-Rozenfeld D., Mizrahi-Meissonnier L., Farhy C., Obolensky A., Chowers I., Pe'er J., Merin S., Ben-Yosef T., Ashery-Padan R., Banin E., Sharon D.
    Am. J. Hum. Genet. 87:382-391(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies."
    Di Gioia S.A., Letteboer S.J., Kostic C., Bandah-Rozenfeld D., Hetterschijt L., Sharon D., Arsenijevic Y., Roepman R., Rivolta C.
    Hum. Mol. Genet. 21:5174-5184(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association."
    Zach F., Grassmann F., Langmann T., Sorusch N., Wolfrum U., Stohr H.
    Hum. Mol. Genet. 21:4573-4586(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiF161A_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.