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Protein

Serine/threonine-protein kinase 32C

Gene

Stk32c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123ATPPROSITE-ProRule annotationBy similarity1
Active sitei217Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 108ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32C (EC:2.7.11.1)
Gene namesi
Name:Stk32cImported
Synonyms:PkekImported
ORF Names:MNCb-1563
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2385336. Stk32c.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324161 – 488Serine/threonine-protein kinase 32CAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei18PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8QZV4.
PaxDbiQ8QZV4.
PeptideAtlasiQ8QZV4.
PRIDEiQ8QZV4.

PTM databases

iPTMnetiQ8QZV4.
PhosphoSitePlusiQ8QZV4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015981.
CleanExiMM_STK32C.
ExpressionAtlasiQ8QZV4. baseline and differential.
GenevisibleiQ8QZV4. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8QZV4. 4 interactors.
MINTiMINT-4118093.
STRINGi10090.ENSMUSP00000016125.

Structurei

3D structure databases

ProteinModelPortaliQ8QZV4.
SMRiQ8QZV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 354Protein kinasePROSITE-ProRule annotationAdd BLAST261

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi398 – 401Poly-LysBy similarity4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00890000139415.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ8QZV4.
KOiK08793.
OMAiWSKEMVA.
OrthoDBiEOG091G0XV4.
PhylomeDBiQ8QZV4.
TreeFamiTF313395.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8QZV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGAERRGS SAAAPPSSPP PGRARPAGSD VSPALPPPAA SQPRARDAGD
60 70 80 90 100
ARAQPRPLFQ WSKWKKRMSM SSISSGSARR PVFDDKEDVN FDHFQILRAI
110 120 130 140 150
GKGSFGKVCI VQKRDTEKMY AMKYMNKQQC IERDEVRNVF RELEILQEIE
160 170 180 190 200
HVFLVNLWYS FQDEEDMFMV VDLLLGGDLR YHLQQNVQFS EDTVRLYICE
210 220 230 240 250
MALALDYLRS QHIIHRDVKP DNILLDEQGH AHLTDFNIAT IIKDGERATA
260 270 280 290 300
LAGTKPYMAP EIFHSFVNGG TGYSFEVDWW SVGVMAYELL RGWRPYDIHS
310 320 330 340 350
SNAVESLVQL FSTVSVQYVP TWSKEMVALL RKLLTVNPEH RFSSLQDMQT
360 370 380 390 400
APSLAHVLWD DLSEKKVEPG FVPNKGRLHC DPTFELEEMI LESRPLHKKK
410 420 430 440 450
KRLAKNKSRD SSRDSSQSEN DYLQDCLDAI QQDFVIFNRE KLKRSQELMS
460 470 480
EPPPGPETSD MTDSTADSEA EPTALPMCGS ICPSSGSS
Length:488
Mass (Da):55,263
Last modified:June 1, 2002 - v1
Checksum:i2B6A927BE6B78EF2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30D → E in BAA95027 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041542 mRNA. Translation: BAA95027.1.
AK046439 mRNA. Translation: BAC32730.1.
BC026457 mRNA. Translation: AAH26457.1.
CCDSiCCDS21952.1.
RefSeqiNP_001156012.1. NM_001162540.1.
NP_067277.2. NM_021302.3.
UniGeneiMm.65336.

Genome annotation databases

EnsembliENSMUST00000016125; ENSMUSP00000016125; ENSMUSG00000015981.
ENSMUST00000215797; ENSMUSP00000150403; ENSMUSG00000111536.
GeneIDi57740.
KEGGimmu:57740.
UCSCiuc009kfl.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiST32C_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV4
Secondary accession number(s): Q9JJG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families