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Q8QZV1 (Q8QZV1_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
CGMP phosphodiesterase EMBL AAL99404.1
Submitted name:
Phosphodiesterase 9A EMBL AAI61837.1
Submitted name:
Phosphodiesterase type 9 EMBL AAN64274.1
Gene names
Name:Pde9a RGD 621035 EMBL AAI61837.1
Synonyms:PDE9A EMBL AAL99404.1
OrganismRattus norvegicus (Rat) EMBL AAL99404.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity. SAAS SAAS023174

Sequences

Sequence LengthMass (Da)Tools
Q8QZV1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4AB9382BA2D2CB54

FASTA53461,756
        10         20         30         40         50         60 
MGAGSSSYRP KAIYLDIDGR IQKVVFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM 

        70         80         90        100        110        120 
VSIDPTMPAN SERTPYKVRP VAVKQVSERE ELVQGVLAQV AEQFSRAFKI NELKAEVANH 

       130        140        150        160        170        180 
LAMLEKRVEL EGLKVVEIEK CKSDIKKMRE ELAARNNRTN CPCKYSFLDN KKLTPRRDVP 

       190        200        210        220        230        240 
TYPKYLLSPE TIEALRKPTF DVWLWEPNEM LSCLEHMYHD LGLVRDFSIN PITLRRWLLC 

       250        260        270        280        290        300 
VHDNYRSNPF HNFRHCFCVT QMMYSMVWLC GLQEKFSQMD ILVLMTAAIC HDLDHPGYNN 

       310        320        330        340        350        360 
TYQINARTEL AVRYNDISPL ENHHCAIAFQ ILARPECNIF ASVPPEGFRQ IRQGMITLIL 

       370        380        390        400        410        420 
ATDMARHAEI MDSFKEKMEN FDYSNEEHLT LLKMILIKCC DISNEVRPME VAEPWVDCLL 

       430        440        450        460        470        480 
EEYFMQSDRE KSEGLPVAPF MDRDKVTKAT AQIGFIKFVL IPMFETVTKL FPIVEETMLR 

       490        500        510        520        530 
PLWESREHYE ELKQLDDAMK ELQKKTENLT SGATENAPEK TRDAKDNEDR SPPN

« Hide

References

« Hide 'large scale' references
[1]"Characterization of PDE9A in the rat brain."
Andreeva S.G., Rosenberg P.A.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague Dawley EMBL AAL99404.1.
[2]"Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain."
van Staveren W.C., Glick J., Markerink-van Ittersum M., Shimizu M., Steinbusch H.W., Beavo J.A., de Vente J.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAN64274.1.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung EMBL AAI61837.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC161837 mRNA. Translation: AAI61837.1.
AF372654 mRNA. Translation: AAL99404.1.
AY145898 mRNA. Translation: AAN64274.1.
IPIIPI00206249.
RefSeqNP_612552.1. NM_138543.1.
UniGeneRn.20981.

3D structure databases

HSSPHSSP built from PDB template 1OYN based on UniProtKB Q08499.
SMRQ8QZV1. Positions 180-505.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000001559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID191569.
KEGGrno:191569.
UCSCRGD:621035. rat.

Organism-specific databases

CTD5152.
RGD621035. Pde9a.

Phylogenomic databases

eggNOGNOG268427.
HOGENOMHOG000008058.
HOVERGENHBG053545.
InParanoidQ8QZV1.
KOK13761.
OrthoDBEOG4G4GQ5.

Enzyme and pathway databases

BRENDA3.1.4.35. 248.

Gene expression databases

GenevestigatorQ8QZV1.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622626.

Entry information

Entry nameQ8QZV1_RAT
AccessionPrimary (citable) accession number: Q8QZV1
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info