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Protein
Submitted name:

CGMP phosphodiesterase

Gene

Pde9a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

a divalent metal cationSAAS annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.SAAS annotation

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: RGD
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP-mediated signaling Source: RGD
  2. metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingSAAS annotation

Enzyme and pathway databases

BRENDAi3.1.4.35. 248.

Names & Taxonomyi

Protein namesi
Submitted name:
CGMP phosphodiesteraseImported
Submitted name:
Phosphodiesterase 9AImported
Submitted name:
Phosphodiesterase type 9Imported
Gene namesi
Name:Pde9aImported
Synonyms:PDE9AImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621035. Pde9a.

Subcellular locationi

GO - Cellular componenti

  1. perikaryon Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8QZV1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001559.

Structurei

3D structure databases

ProteinModelPortaliQ8QZV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG268427.
HOGENOMiHOG000008058.
HOVERGENiHBG053545.
KOiK13761.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAGSSSYRP KAIYLDIDGR IQKVVFSKYC NSSDIMDLFC IATGLPRNTT
60 70 80 90 100
ISLLTTDDAM VSIDPTMPAN SERTPYKVRP VAVKQVSERE ELVQGVLAQV
110 120 130 140 150
AEQFSRAFKI NELKAEVANH LAMLEKRVEL EGLKVVEIEK CKSDIKKMRE
160 170 180 190 200
ELAARNNRTN CPCKYSFLDN KKLTPRRDVP TYPKYLLSPE TIEALRKPTF
210 220 230 240 250
DVWLWEPNEM LSCLEHMYHD LGLVRDFSIN PITLRRWLLC VHDNYRSNPF
260 270 280 290 300
HNFRHCFCVT QMMYSMVWLC GLQEKFSQMD ILVLMTAAIC HDLDHPGYNN
310 320 330 340 350
TYQINARTEL AVRYNDISPL ENHHCAIAFQ ILARPECNIF ASVPPEGFRQ
360 370 380 390 400
IRQGMITLIL ATDMARHAEI MDSFKEKMEN FDYSNEEHLT LLKMILIKCC
410 420 430 440 450
DISNEVRPME VAEPWVDCLL EEYFMQSDRE KSEGLPVAPF MDRDKVTKAT
460 470 480 490 500
AQIGFIKFVL IPMFETVTKL FPIVEETMLR PLWESREHYE ELKQLDDAMK
510 520 530
ELQKKTENLT SGATENAPEK TRDAKDNEDR SPPN
Length:534
Mass (Da):61,756
Last modified:June 1, 2002 - v1
Checksum:i4AB9382BA2D2CB54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161837 mRNA. Translation: AAI61837.1.
AF372654 mRNA. Translation: AAL99404.1.
AY145898 mRNA. Translation: AAN64274.1.
RefSeqiNP_612552.1. NM_138543.1.
XP_008771015.1. XM_008772793.1.
XP_008771016.1. XM_008772794.1.
XP_008771017.1. XM_008772795.1.
UniGeneiRn.20981.

Genome annotation databases

GeneIDi191569.
KEGGirno:191569.
UCSCiRGD:621035. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161837 mRNA. Translation: AAI61837.1.
AF372654 mRNA. Translation: AAL99404.1.
AY145898 mRNA. Translation: AAN64274.1.
RefSeqiNP_612552.1. NM_138543.1.
XP_008771015.1. XM_008772793.1.
XP_008771016.1. XM_008772794.1.
XP_008771017.1. XM_008772795.1.
UniGeneiRn.20981.

3D structure databases

ProteinModelPortaliQ8QZV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi191569.
KEGGirno:191569.
UCSCiRGD:621035. rat.

Organism-specific databases

CTDi5152.
RGDi621035. Pde9a.

Phylogenomic databases

eggNOGiNOG268427.
HOGENOMiHOG000008058.
HOVERGENiHBG053545.
KOiK13761.

Enzyme and pathway databases

BRENDAi3.1.4.35. 248.

Miscellaneous databases

NextBioi622626.

Gene expression databases

GenevestigatoriQ8QZV1.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of PDE9A in the rat brain."
    Andreeva S.G., Rosenberg P.A.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
  2. "Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain."
    van Staveren W.C., Glick J., Markerink-van Ittersum M., Shimizu M., Steinbusch H.W., Beavo J.A., de Vente J.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.

Entry informationi

Entry nameiQ8QZV1_RAT
AccessioniPrimary (citable) accession number: Q8QZV1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.