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Q8QZV1

- Q8QZV1_RAT

UniProt

Q8QZV1 - Q8QZV1_RAT

Protein
Submitted name:

CGMP phosphodiesterase

Gene

Pde9a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: RGD
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP-mediated signaling Source: RGD
    2. metabolic process Source: GOC

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Keywords - Ligandi

    Metal-bindingSAAS annotation

    Enzyme and pathway databases

    BRENDAi3.1.4.35. 248.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CGMP phosphodiesteraseImported
    Submitted name:
    Phosphodiesterase 9AImported
    Submitted name:
    Phosphodiesterase type 9Imported
    Gene namesi
    Name:Pde9aImported
    Synonyms:PDE9AImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621035. Pde9a.

    Subcellular locationi

    GO - Cellular componenti

    1. perikaryon Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ8QZV1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000001559.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG268427.
    HOGENOMiHOG000008058.
    HOVERGENiHBG053545.
    InParanoidiQ8QZV1.
    KOiK13761.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8QZV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAGSSSYRP KAIYLDIDGR IQKVVFSKYC NSSDIMDLFC IATGLPRNTT    50
    ISLLTTDDAM VSIDPTMPAN SERTPYKVRP VAVKQVSERE ELVQGVLAQV 100
    AEQFSRAFKI NELKAEVANH LAMLEKRVEL EGLKVVEIEK CKSDIKKMRE 150
    ELAARNNRTN CPCKYSFLDN KKLTPRRDVP TYPKYLLSPE TIEALRKPTF 200
    DVWLWEPNEM LSCLEHMYHD LGLVRDFSIN PITLRRWLLC VHDNYRSNPF 250
    HNFRHCFCVT QMMYSMVWLC GLQEKFSQMD ILVLMTAAIC HDLDHPGYNN 300
    TYQINARTEL AVRYNDISPL ENHHCAIAFQ ILARPECNIF ASVPPEGFRQ 350
    IRQGMITLIL ATDMARHAEI MDSFKEKMEN FDYSNEEHLT LLKMILIKCC 400
    DISNEVRPME VAEPWVDCLL EEYFMQSDRE KSEGLPVAPF MDRDKVTKAT 450
    AQIGFIKFVL IPMFETVTKL FPIVEETMLR PLWESREHYE ELKQLDDAMK 500
    ELQKKTENLT SGATENAPEK TRDAKDNEDR SPPN 534
    Length:534
    Mass (Da):61,756
    Last modified:June 1, 2002 - v1
    Checksum:i4AB9382BA2D2CB54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161837 mRNA. Translation: AAI61837.1.
    AF372654 mRNA. Translation: AAL99404.1.
    AY145898 mRNA. Translation: AAN64274.1.
    RefSeqiNP_612552.1. NM_138543.1.
    UniGeneiRn.20981.

    Genome annotation databases

    GeneIDi191569.
    KEGGirno:191569.
    UCSCiRGD:621035. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC161837 mRNA. Translation: AAI61837.1 .
    AF372654 mRNA. Translation: AAL99404.1 .
    AY145898 mRNA. Translation: AAN64274.1 .
    RefSeqi NP_612552.1. NM_138543.1.
    UniGenei Rn.20981.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000001559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 191569.
    KEGGi rno:191569.
    UCSCi RGD:621035. rat.

    Organism-specific databases

    CTDi 5152.
    RGDi 621035. Pde9a.

    Phylogenomic databases

    eggNOGi NOG268427.
    HOGENOMi HOG000008058.
    HOVERGENi HBG053545.
    InParanoidi Q8QZV1.
    KOi K13761.

    Enzyme and pathway databases

    BRENDAi 3.1.4.35. 248.

    Miscellaneous databases

    NextBioi 622626.

    Gene expression databases

    Genevestigatori Q8QZV1.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of PDE9A in the rat brain."
      Andreeva S.G., Rosenberg P.A.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague DawleyImported.
    2. "Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain."
      van Staveren W.C., Glick J., Markerink-van Ittersum M., Shimizu M., Steinbusch H.W., Beavo J.A., de Vente J.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.

    Entry informationi

    Entry nameiQ8QZV1_RAT
    AccessioniPrimary (citable) accession number: Q8QZV1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)