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Protein

DNA-binding death effector domain-containing protein 2

Gene

Dedd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding death effector domain-containing protein 2
Alternative name(s):
DED-containing protein FLAME-3
FADD-like anti-apoptotic molecule 3
Gene namesi
Name:Dedd2
Synonyms:Flame3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914629. Dedd2.

Subcellular locationi

  • Nucleusnucleolus By similarity

  • Note: Nuclear, accumulated in subnuclear structures resembling nucleoli.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330DNA-binding death effector domain-containing protein 2PRO_0000191278Add
BLAST

Proteomic databases

PaxDbiQ8QZV0.
PRIDEiQ8QZV0.

PTM databases

iPTMnetiQ8QZV0.
PhosphoSiteiQ8QZV0.

Expressioni

Tissue specificityi

Expression is high in liver, heart, kidney, and testis but low in brain, spleen, lung, and skeleton muscle.

Gene expression databases

BgeeiQ8QZV0.
GenevisibleiQ8QZV0. MM.

Interactioni

Subunit structurei

Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049763.

Structurei

3D structure databases

ProteinModelPortaliQ8QZV0.
SMRiQ8QZV0. Positions 26-102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10480DEDPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi104 – 1096Nuclear localization signalSequence analysis
Motifi156 – 17419Bipartite nuclear localization signalSequence analysisAdd
BLAST

Domaini

Interactions with CASP8 and CASP10 are mediated by the DED domain.By similarity

Sequence similaritiesi

Contains 1 DED (death effector) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGDZ. Eukaryota.
ENOG410XV3E. LUCA.
GeneTreeiENSGT00390000008714.
HOGENOMiHOG000049120.
HOVERGENiHBG007220.
InParanoidiQ8QZV0.
OMAiAPCWEED.
OrthoDBiEOG7BCNBW.
PhylomeDBiQ8QZV0.
TreeFamiTF331807.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGSTPAP SWEEDECLDY YGMLSLHRMF EVVGGQLTEC ELELLAFLLD
60 70 80 90 100
EAPGAPGGLA RARSGLELLL ELERRGQCDE SNLRLLSQLL RVLARHDLLP
110 120 130 140 150
HLARKRRRPV SPERYSYGNP SSSSKRTEDS CRRRRQASSS SDSPQSQWDT
160 170 180 190 200
GSPPTKRQRR SRGRPSSGAR QRRRAGLAAS QQHQQHQELG RPSSEGKVTC
210 220 230 240 250
DIRLRVRAEY CEHGPALEQG VASRRPQALA RQLDVFGQAT AVLRSRDLGS
260 270 280 290 300
VVCDIKFSEL SYLDAFWGDY LSGALLQALR GVFLTEALRE AVGREAVRLL
310 320 330
VSVDEADYEA GRRRLLLMEE EGGRRGTEAS
Length:330
Mass (Da):36,786
Last modified:June 1, 2002 - v1
Checksum:i889BC4F9E01304B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457576 mRNA. Translation: AAM10836.1.
AF543541 mRNA. Translation: AAN33179.1.
BC092250 mRNA. Translation: AAH92250.1.
CCDSiCCDS20973.1.
RefSeqiNP_997560.3. NM_207677.3.
XP_006540385.1. XM_006540322.1.
UniGeneiMm.280594.

Genome annotation databases

EnsembliENSMUST00000058702; ENSMUSP00000049763; ENSMUSG00000054499.
ENSMUST00000205271; ENSMUSP00000146052; ENSMUSG00000054499.
GeneIDi67379.
KEGGimmu:67379.
UCSCiuc009fru.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457576 mRNA. Translation: AAM10836.1.
AF543541 mRNA. Translation: AAN33179.1.
BC092250 mRNA. Translation: AAH92250.1.
CCDSiCCDS20973.1.
RefSeqiNP_997560.3. NM_207677.3.
XP_006540385.1. XM_006540322.1.
UniGeneiMm.280594.

3D structure databases

ProteinModelPortaliQ8QZV0.
SMRiQ8QZV0. Positions 26-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049763.

PTM databases

iPTMnetiQ8QZV0.
PhosphoSiteiQ8QZV0.

Proteomic databases

PaxDbiQ8QZV0.
PRIDEiQ8QZV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058702; ENSMUSP00000049763; ENSMUSG00000054499.
ENSMUST00000205271; ENSMUSP00000146052; ENSMUSG00000054499.
GeneIDi67379.
KEGGimmu:67379.
UCSCiuc009fru.1. mouse.

Organism-specific databases

CTDi162989.
MGIiMGI:1914629. Dedd2.

Phylogenomic databases

eggNOGiENOG410IGDZ. Eukaryota.
ENOG410XV3E. LUCA.
GeneTreeiENSGT00390000008714.
HOGENOMiHOG000049120.
HOVERGENiHBG007220.
InParanoidiQ8QZV0.
OMAiAPCWEED.
OrthoDBiEOG7BCNBW.
PhylomeDBiQ8QZV0.
TreeFamiTF331807.

Miscellaneous databases

PROiQ8QZV0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8QZV0.
GenevisibleiQ8QZV0. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC."
    Zhan Y., Hegde R., Srinivasula S.M., Fernandes-Alnemri T., Alnemri E.S.
    Cell Death Differ. 9:439-447(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "DEDD and DEDD2 associate with caspase-8/10 and signal cell death."
    Alcivar A., Hu S., Tang J., Yang X.
    Oncogene 22:291-297(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiDEDD2_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV0
Secondary accession number(s): Q569Y9, Q8JZV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.