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Protein

DNA-binding death effector domain-containing protein 2

Gene

Dedd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding death effector domain-containing protein 2
Alternative name(s):
DED-containing protein FLAME-3
FADD-like anti-apoptotic molecule 3
Gene namesi
Name:Dedd2
Synonyms:Flame3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914629 Dedd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912781 – 330DNA-binding death effector domain-containing protein 2Add BLAST330

Proteomic databases

PaxDbiQ8QZV0
PRIDEiQ8QZV0

PTM databases

iPTMnetiQ8QZV0
PhosphoSitePlusiQ8QZV0

Expressioni

Tissue specificityi

Expression is high in liver, heart, kidney, and testis but low in brain, spleen, lung, and skeleton muscle.

Gene expression databases

BgeeiENSMUSG00000054499
GenevisibleiQ8QZV0 MM

Interactioni

Subunit structurei

Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8QZV0
SMRiQ8QZV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 104DEDPROSITE-ProRule annotationAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi104 – 109Nuclear localization signalSequence analysis6
Motifi156 – 174Bipartite nuclear localization signalSequence analysisAdd BLAST19

Domaini

Interactions with CASP8 and CASP10 are mediated by the DED domain.By similarity

Phylogenomic databases

eggNOGiENOG410IGDZ Eukaryota
ENOG410XV3E LUCA
GeneTreeiENSGT00390000008714
HOGENOMiHOG000049120
HOVERGENiHBG007220
InParanoidiQ8QZV0
OMAiAPCWEED
OrthoDBiEOG091G0DX2
PhylomeDBiQ8QZV0
TreeFamiTF331807

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit

Sequencei

Sequence statusi: Complete.

Q8QZV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSGSTPAP SWEEDECLDY YGMLSLHRMF EVVGGQLTEC ELELLAFLLD
60 70 80 90 100
EAPGAPGGLA RARSGLELLL ELERRGQCDE SNLRLLSQLL RVLARHDLLP
110 120 130 140 150
HLARKRRRPV SPERYSYGNP SSSSKRTEDS CRRRRQASSS SDSPQSQWDT
160 170 180 190 200
GSPPTKRQRR SRGRPSSGAR QRRRAGLAAS QQHQQHQELG RPSSEGKVTC
210 220 230 240 250
DIRLRVRAEY CEHGPALEQG VASRRPQALA RQLDVFGQAT AVLRSRDLGS
260 270 280 290 300
VVCDIKFSEL SYLDAFWGDY LSGALLQALR GVFLTEALRE AVGREAVRLL
310 320 330
VSVDEADYEA GRRRLLLMEE EGGRRGTEAS
Length:330
Mass (Da):36,786
Last modified:June 1, 2002 - v1
Checksum:i889BC4F9E01304B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457576 mRNA Translation: AAM10836.1
AF543541 mRNA Translation: AAN33179.1
BC092250 mRNA Translation: AAH92250.1
CCDSiCCDS20973.1
RefSeqiNP_997560.3, NM_207677.3
XP_006540385.1, XM_006540322.1
UniGeneiMm.280594

Genome annotation databases

EnsembliENSMUST00000058702; ENSMUSP00000049763; ENSMUSG00000054499
ENSMUST00000205271; ENSMUSP00000146052; ENSMUSG00000054499
GeneIDi67379
KEGGimmu:67379
UCSCiuc009fru.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDEDD2_MOUSE
AccessioniPrimary (citable) accession number: Q8QZV0
Secondary accession number(s): Q569Y9, Q8JZV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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