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Protein

Folliculin

Gene

Flcn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell-cell junction assembly Source: UniProtKB
  • hemopoiesis Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of ATP biosynthetic process Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation involved in kidney development Source: MGI
  • negative regulation of cellular respiration Source: UniProtKB
  • negative regulation of energy homeostasis Source: UniProtKB
  • negative regulation of ERK1 and ERK2 cascade Source: MGI
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of mitochondrial DNA metabolic process Source: UniProtKB
  • negative regulation of mitochondrion organization Source: UniProtKB
  • negative regulation of muscle tissue development Source: UniProtKB
  • negative regulation of post-translational protein modification Source: UniProtKB
  • negative regulation of protein kinase B signaling Source: MGI
  • negative regulation of protein localization to nucleus Source: UniProtKB
  • negative regulation of Rho protein signal transduction Source: UniProtKB
  • negative regulation of TOR signaling Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of TOR signaling Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • regulation of cytokinesis Source: UniProtKB
  • regulation of histone acetylation Source: MGI
  • regulation of pro-B cell differentiation Source: MGI
  • regulation of protein phosphorylation Source: UniProtKB
  • regulation of TOR signaling Source: MGI
  • TOR signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Folliculin
Gene namesi
Name:Flcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442184. Flcn.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579FolliculinPRO_0000223941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621Phosphoserine1 Publication
Modified residuei73 – 731Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8QZS3.
PaxDbiQ8QZS3.
PRIDEiQ8QZS3.

PTM databases

PhosphoSiteiQ8QZS3.

Expressioni

Gene expression databases

BgeeiQ8QZS3.
CleanExiMM_FLCN.
ExpressionAtlasiQ8QZS3. baseline and differential.
GenevisibleiQ8QZS3. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Fnip1Q68FD73EBI-6911093,EBI-6911068

Protein-protein interaction databases

IntActiQ8QZS3. 1 interaction.
STRINGi10090.ENSMUSP00000091696.

Structurei

3D structure databases

ProteinModelPortaliQ8QZS3.
SMRiQ8QZS3. Positions 346-558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili287 – 31024Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the folliculin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG319853.
GeneTreeiENSGT00390000009864.
HOVERGENiHBG081531.
InParanoidiQ8QZS3.
KOiK09594.
OMAiEEDNVKL.
OrthoDBiEOG7PS1FX.
PhylomeDBiQ8QZS3.
TreeFamiTF315084.

Family and domain databases

InterProiIPR021713. Folliculin.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8QZS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGAGSGDSPD QVEQAEEEEG
60 70 80 90 100
GIQMSSRVRA HSPAEGASSE SSSPGPKKSD MCEGCRSLAV GHPGYISHDK
110 120 130 140 150
ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF
160 170 180 190 200
VFSHTFFIKD SLARGFQRWY SIIAIMMDRI YLINSWPFLL GRIRGIISEL
210 220 230 240 250
QAKAFKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS LTSLTSDDNL
260 270 280 290 300
WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD
310 320 330 340 350
NSEAEEEEKA PVTPEGAEGR ELTSCPTESS FLSACGSWQP PKLTGFKSLR
360 370 380 390 400
HMRQVLGAPS FRMLAWHVLM GNQVIWKSRD VNLVHSAFEV LRTMLPVGCV
410 420 430 440 450
RIIPYSSQYE EAYRCNFLGL SPPVPIPAHV LASEFVVVVE VHTATRSNLH
460 470 480 490 500
PAGCEDDQSL SKYEFVVTSG SPVAADRVGP TILNKIEAAL TNQNLSVDVV
510 520 530 540 550
DQCLICLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSVLG ASEEDNVKLL
560 570
KFWMTGLSKT YKSHLMSTVR SPTATESRS
Length:579
Mass (Da):64,327
Last modified:June 1, 2002 - v1
Checksum:iDD20DB9F7AFAC81C
GO

Sequence cautioni

The sequence BAC30240.1 differs from that shown. Reason: Frameshift at position 42. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291L → M in BAE28418 (PubMed:16141072).Curated
Sequence conflicti240 – 2401S → Y in BAE28418 (PubMed:16141072).Curated
Sequence conflicti328 – 3281E → G in BAE32332 (PubMed:16141072).Curated
Sequence conflicti377 – 3771K → R in BAC30240 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039106 mRNA. Translation: BAC30240.1. Frameshift.
AK080933 mRNA. Translation: BAC38084.1.
AK136071 mRNA. Translation: BAE22806.1.
AK148216 mRNA. Translation: BAE28418.1.
AK154040 mRNA. Translation: BAE32332.1.
AL596204 Genomic DNA. Translation: CAI24295.1.
AL596204 Genomic DNA. Translation: CAI24297.1.
BC025820 mRNA. Translation: AAH25820.1.
CCDSiCCDS24777.1.
RefSeqiNP_001258285.1. NM_001271356.1.
NP_001258286.1. NM_001271357.1.
NP_666130.1. NM_146018.2.
XP_011247207.1. XM_011248905.1.
UniGeneiMm.339640.
Mm.401724.
Mm.491488.

Genome annotation databases

EnsembliENSMUST00000091246; ENSMUSP00000091696; ENSMUSG00000032633.
ENSMUST00000102697; ENSMUSP00000099758; ENSMUSG00000032633.
GeneIDi216805.
KEGGimmu:216805.
UCSCiuc007jew.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039106 mRNA. Translation: BAC30240.1. Frameshift.
AK080933 mRNA. Translation: BAC38084.1.
AK136071 mRNA. Translation: BAE22806.1.
AK148216 mRNA. Translation: BAE28418.1.
AK154040 mRNA. Translation: BAE32332.1.
AL596204 Genomic DNA. Translation: CAI24295.1.
AL596204 Genomic DNA. Translation: CAI24297.1.
BC025820 mRNA. Translation: AAH25820.1.
CCDSiCCDS24777.1.
RefSeqiNP_001258285.1. NM_001271356.1.
NP_001258286.1. NM_001271357.1.
NP_666130.1. NM_146018.2.
XP_011247207.1. XM_011248905.1.
UniGeneiMm.339640.
Mm.401724.
Mm.491488.

3D structure databases

ProteinModelPortaliQ8QZS3.
SMRiQ8QZS3. Positions 346-558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8QZS3. 1 interaction.
STRINGi10090.ENSMUSP00000091696.

PTM databases

PhosphoSiteiQ8QZS3.

Proteomic databases

MaxQBiQ8QZS3.
PaxDbiQ8QZS3.
PRIDEiQ8QZS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091246; ENSMUSP00000091696; ENSMUSG00000032633.
ENSMUST00000102697; ENSMUSP00000099758; ENSMUSG00000032633.
GeneIDi216805.
KEGGimmu:216805.
UCSCiuc007jew.2. mouse.

Organism-specific databases

CTDi201163.
MGIiMGI:2442184. Flcn.

Phylogenomic databases

eggNOGiNOG319853.
GeneTreeiENSGT00390000009864.
HOVERGENiHBG081531.
InParanoidiQ8QZS3.
KOiK09594.
OMAiEEDNVKL.
OrthoDBiEOG7PS1FX.
PhylomeDBiQ8QZS3.
TreeFamiTF315084.

Miscellaneous databases

NextBioi375332.
PROiQ8QZS3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8QZS3.
CleanExiMM_FLCN.
ExpressionAtlasiQ8QZS3. baseline and differential.
GenevisibleiQ8QZS3. MM.

Family and domain databases

InterProiIPR021713. Folliculin.
[Graphical view]
PANTHERiPTHR31441. PTHR31441. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Egg, Hypothalamus and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFLCN_MOUSE
AccessioniPrimary (citable) accession number: Q8QZS3
Secondary accession number(s): Q3U4U8
, Q3UFZ1, Q5SWZ2, Q5SX01, Q5SX02, Q8CAC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: June 1, 2002
Last modified: July 22, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.