Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8QZS3

- FLCN_MOUSE

UniProt

Q8QZS3 - FLCN_MOUSE

Protein

Folliculin

Gene

Flcn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein complex binding Source: UniProtKB

    GO - Biological processi

    1. cell-cell junction assembly Source: UniProtKB
    2. hemopoiesis Source: MGI
    3. in utero embryonic development Source: MGI
    4. negative regulation of angiogenesis Source: UniProtKB
    5. negative regulation of ATP biosynthetic process Source: UniProtKB
    6. negative regulation of cell growth Source: UniProtKB
    7. negative regulation of cell migration Source: UniProtKB
    8. negative regulation of cell proliferation involved in kidney development Source: MGI
    9. negative regulation of cellular respiration Source: UniProtKB
    10. negative regulation of energy homeostasis Source: UniProtKB
    11. negative regulation of ERK1 and ERK2 cascade Source: MGI
    12. negative regulation of gene expression Source: UniProtKB
    13. negative regulation of mitochondrial DNA metabolic process Source: UniProtKB
    14. negative regulation of mitochondrion organization Source: UniProtKB
    15. negative regulation of muscle tissue development Source: UniProtKB
    16. negative regulation of post-translational protein modification Source: UniProtKB
    17. negative regulation of protein kinase B signaling Source: MGI
    18. negative regulation of protein localization to nucleus Source: UniProtKB
    19. negative regulation of Rho protein signal transduction Source: UniProtKB
    20. negative regulation of TOR signaling Source: MGI
    21. negative regulation of transcription, DNA-templated Source: UniProtKB
    22. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    23. positive regulation of cell adhesion Source: UniProtKB
    24. positive regulation of gene expression Source: UniProtKB
    25. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
    26. positive regulation of protein phosphorylation Source: UniProtKB
    27. positive regulation of TOR signaling Source: MGI
    28. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    29. positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
    30. regulation of cytokinesis Source: UniProtKB
    31. regulation of histone acetylation Source: MGI
    32. regulation of pro-B cell differentiation Source: MGI
    33. regulation of protein phosphorylation Source: UniProtKB
    34. regulation of TOR signaling Source: MGI
    35. TOR signaling Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folliculin
    Gene namesi
    Name:Flcn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2442184. Flcn.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579FolliculinPRO_0000223941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621Phosphoserine1 Publication
    Modified residuei73 – 731Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8QZS3.
    PRIDEiQ8QZS3.

    PTM databases

    PhosphoSiteiQ8QZS3.

    Expressioni

    Gene expression databases

    BgeeiQ8QZS3.
    CleanExiMM_FLCN.
    GenevestigatoriQ8QZS3.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Fnip1Q68FD73EBI-6911093,EBI-6911068

    Protein-protein interaction databases

    IntActiQ8QZS3. 1 interaction.
    STRINGi10090.ENSMUSP00000091696.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8QZS3.
    SMRiQ8QZS3. Positions 346-558.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili287 – 31024Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the folliculin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG319853.
    GeneTreeiENSGT00390000009864.
    HOVERGENiHBG081531.
    InParanoidiQ8QZS3.
    KOiK09594.
    OMAiDENLWAC.
    OrthoDBiEOG7PS1FX.
    PhylomeDBiQ8QZS3.
    TreeFamiTF315084.

    Family and domain databases

    InterProiIPR021713. Folliculin.
    [Graphical view]
    PANTHERiPTHR31441. PTHR31441. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8QZS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGAGSGDSPD QVEQAEEEEG    50
    GIQMSSRVRA HSPAEGASSE SSSPGPKKSD MCEGCRSLAV GHPGYISHDK 100
    ETSIKYVSHQ HPNHPQLFSI VRQACVRSLS CEVCPGREGP IFFGDEQHGF 150
    VFSHTFFIKD SLARGFQRWY SIIAIMMDRI YLINSWPFLL GRIRGIISEL 200
    QAKAFKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS LTSLTSDDNL 250
    WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD 300
    NSEAEEEEKA PVTPEGAEGR ELTSCPTESS FLSACGSWQP PKLTGFKSLR 350
    HMRQVLGAPS FRMLAWHVLM GNQVIWKSRD VNLVHSAFEV LRTMLPVGCV 400
    RIIPYSSQYE EAYRCNFLGL SPPVPIPAHV LASEFVVVVE VHTATRSNLH 450
    PAGCEDDQSL SKYEFVVTSG SPVAADRVGP TILNKIEAAL TNQNLSVDVV 500
    DQCLICLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSVLG ASEEDNVKLL 550
    KFWMTGLSKT YKSHLMSTVR SPTATESRS 579
    Length:579
    Mass (Da):64,327
    Last modified:June 1, 2002 - v1
    Checksum:iDD20DB9F7AFAC81C
    GO

    Sequence cautioni

    The sequence BAC30240.1 differs from that shown. Reason: Frameshift at position 42.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291L → M in BAE28418. (PubMed:16141072)Curated
    Sequence conflicti240 – 2401S → Y in BAE28418. (PubMed:16141072)Curated
    Sequence conflicti328 – 3281E → G in BAE32332. (PubMed:16141072)Curated
    Sequence conflicti377 – 3771K → R in BAC30240. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039106 mRNA. Translation: BAC30240.1. Frameshift.
    AK080933 mRNA. Translation: BAC38084.1.
    AK136071 mRNA. Translation: BAE22806.1.
    AK148216 mRNA. Translation: BAE28418.1.
    AK154040 mRNA. Translation: BAE32332.1.
    AL596204 Genomic DNA. Translation: CAI24295.1.
    AL596204 Genomic DNA. Translation: CAI24297.1.
    BC025820 mRNA. Translation: AAH25820.1.
    CCDSiCCDS24777.1.
    RefSeqiNP_001258285.1. NM_001271356.1.
    NP_001258286.1. NM_001271357.1.
    NP_666130.1. NM_146018.2.
    UniGeneiMm.339640.
    Mm.401724.
    Mm.491488.

    Genome annotation databases

    EnsembliENSMUST00000091246; ENSMUSP00000091696; ENSMUSG00000032633.
    ENSMUST00000102697; ENSMUSP00000099758; ENSMUSG00000032633.
    GeneIDi216805.
    KEGGimmu:216805.
    UCSCiuc007jew.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039106 mRNA. Translation: BAC30240.1 . Frameshift.
    AK080933 mRNA. Translation: BAC38084.1 .
    AK136071 mRNA. Translation: BAE22806.1 .
    AK148216 mRNA. Translation: BAE28418.1 .
    AK154040 mRNA. Translation: BAE32332.1 .
    AL596204 Genomic DNA. Translation: CAI24295.1 .
    AL596204 Genomic DNA. Translation: CAI24297.1 .
    BC025820 mRNA. Translation: AAH25820.1 .
    CCDSi CCDS24777.1.
    RefSeqi NP_001258285.1. NM_001271356.1.
    NP_001258286.1. NM_001271357.1.
    NP_666130.1. NM_146018.2.
    UniGenei Mm.339640.
    Mm.401724.
    Mm.491488.

    3D structure databases

    ProteinModelPortali Q8QZS3.
    SMRi Q8QZS3. Positions 346-558.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8QZS3. 1 interaction.
    STRINGi 10090.ENSMUSP00000091696.

    PTM databases

    PhosphoSitei Q8QZS3.

    Proteomic databases

    PaxDbi Q8QZS3.
    PRIDEi Q8QZS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000091246 ; ENSMUSP00000091696 ; ENSMUSG00000032633 .
    ENSMUST00000102697 ; ENSMUSP00000099758 ; ENSMUSG00000032633 .
    GeneIDi 216805.
    KEGGi mmu:216805.
    UCSCi uc007jew.1. mouse.

    Organism-specific databases

    CTDi 201163.
    MGIi MGI:2442184. Flcn.

    Phylogenomic databases

    eggNOGi NOG319853.
    GeneTreei ENSGT00390000009864.
    HOVERGENi HBG081531.
    InParanoidi Q8QZS3.
    KOi K09594.
    OMAi DENLWAC.
    OrthoDBi EOG7PS1FX.
    PhylomeDBi Q8QZS3.
    TreeFami TF315084.

    Miscellaneous databases

    NextBioi 375332.
    PROi Q8QZS3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8QZS3.
    CleanExi MM_FLCN.
    Genevestigatori Q8QZS3.

    Family and domain databases

    InterProi IPR021713. Folliculin.
    [Graphical view ]
    PANTHERi PTHR31441. PTHR31441. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Adipose tissue, Egg, Hypothalamus and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFLCN_MOUSE
    AccessioniPrimary (citable) accession number: Q8QZS3
    Secondary accession number(s): Q3U4U8
    , Q3UFZ1, Q5SWZ2, Q5SX01, Q5SX02, Q8CAC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3