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Protein

Serine/threonine-protein kinase PDIK1L

Gene

Pdik1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATPPROSITE-ProRule annotation
Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)
Alternative name(s):
PDLIM1-interacting kinase 1-like
Gene namesi
Name:Pdik1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2385213. Pdik1l.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Serine/threonine-protein kinase PDIK1LPRO_0000086495Add
BLAST

Proteomic databases

PRIDEiQ8QZR7.

PTM databases

PhosphoSiteiQ8QZR7.

Expressioni

Gene expression databases

BgeeiQ8QZR7.
CleanExiMM_PDIK1L.
ExpressionAtlasiQ8QZR7. baseline and differential.
GenevestigatoriQ8QZR7.

Structurei

3D structure databases

ProteinModelPortaliQ8QZR7.
SMRiQ8QZR7. Positions 7-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 334327Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121956.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ8QZR7.
KOiK17539.
OrthoDBiEOG76DTSN.
TreeFamiTF105336.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA
60 70 80 90 100
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS
110 120 130 140 150
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS
160 170 180 190 200
ALAFLHKNQI IHRDLKPDNI LISQSRMDTS DLEPTLKVAD FGLSKVCSAS
210 220 230 240 250
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM
260 270 280 290 300
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM
310 320 330 340
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T
Length:341
Mass (Da):38,550
Last modified:June 1, 2002 - v1
Checksum:iDEBB705C8F9394E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 1005LVETS → VCVTA in BAC35506 (PubMed:16141072).Curated
Sequence conflicti331 – 3311Q → P in BAE24738 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053750 mRNA. Translation: BAC35506.1.
AK139413 mRNA. Translation: BAE24001.1.
AK141566 mRNA. Translation: BAE24738.1.
AK141823 mRNA. Translation: BAE24845.1.
AK157013 mRNA. Translation: BAE33930.1.
AK164975 mRNA. Translation: BAE37986.1.
AL627314 Genomic DNA. Translation: CAM21945.1.
BC027088 mRNA. Translation: AAH27088.1.
BC058514 mRNA. Translation: AAH58514.1.
CCDSiCCDS18768.1.
RefSeqiNP_001157266.1. NM_001163794.1.
NP_666268.1. NM_146156.3.
UniGeneiMm.22778.

Genome annotation databases

EnsembliENSMUST00000061234; ENSMUSP00000060381; ENSMUSG00000050890.
ENSMUST00000105876; ENSMUSP00000101502; ENSMUSG00000050890.
GeneIDi230809.
KEGGimmu:230809.
UCSCiuc008vep.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053750 mRNA. Translation: BAC35506.1.
AK139413 mRNA. Translation: BAE24001.1.
AK141566 mRNA. Translation: BAE24738.1.
AK141823 mRNA. Translation: BAE24845.1.
AK157013 mRNA. Translation: BAE33930.1.
AK164975 mRNA. Translation: BAE37986.1.
AL627314 Genomic DNA. Translation: CAM21945.1.
BC027088 mRNA. Translation: AAH27088.1.
BC058514 mRNA. Translation: AAH58514.1.
CCDSiCCDS18768.1.
RefSeqiNP_001157266.1. NM_001163794.1.
NP_666268.1. NM_146156.3.
UniGeneiMm.22778.

3D structure databases

ProteinModelPortaliQ8QZR7.
SMRiQ8QZR7. Positions 7-323.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8QZR7.

Proteomic databases

PRIDEiQ8QZR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061234; ENSMUSP00000060381; ENSMUSG00000050890.
ENSMUST00000105876; ENSMUSP00000101502; ENSMUSG00000050890.
GeneIDi230809.
KEGGimmu:230809.
UCSCiuc008vep.2. mouse.

Organism-specific databases

CTDi149420.
MGIiMGI:2385213. Pdik1l.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121956.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ8QZR7.
KOiK17539.
OrthoDBiEOG76DTSN.
TreeFamiTF105336.

Miscellaneous databases

NextBioi380182.
PROiQ8QZR7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8QZR7.
CleanExiMM_PDIK1L.
ExpressionAtlasiQ8QZR7. baseline and differential.
GenevestigatoriQ8QZR7.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Brain cortex, Eye, Hippocampus, Spinal ganglion and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiPDK1L_MOUSE
AccessioniPrimary (citable) accession number: Q8QZR7
Secondary accession number(s): A2A9L0, Q3URF0, Q8BKB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.