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Q8QZR7

- PDK1L_MOUSE

UniProt

Q8QZR7 - PDK1L_MOUSE

Protein

Serine/threonine-protein kinase PDIK1L

Gene

Pdik1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATPPROSITE-ProRule annotation
    Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)
    Alternative name(s):
    PDLIM1-interacting kinase 1-like
    Gene namesi
    Name:Pdik1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2385213. Pdik1l.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Serine/threonine-protein kinase PDIK1LPRO_0000086495Add
    BLAST

    Proteomic databases

    PRIDEiQ8QZR7.

    PTM databases

    PhosphoSiteiQ8QZR7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8QZR7.
    BgeeiQ8QZR7.
    CleanExiMM_PDIK1L.
    GenevestigatoriQ8QZR7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8QZR7.
    SMRiQ8QZR7. Positions 7-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 334327Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117533.
    HOGENOMiHOG000231155.
    HOVERGENiHBG056829.
    InParanoidiA2A9L0.
    KOiK17539.
    OrthoDBiEOG76DTSN.
    TreeFamiTF105336.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8QZR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA    50
    LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS 100
    LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS 150
    ALAFLHKNQI IHRDLKPDNI LISQSRMDTS DLEPTLKVAD FGLSKVCSAS 200
    GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM 250
    LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM 300
    NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T 341
    Length:341
    Mass (Da):38,550
    Last modified:June 1, 2002 - v1
    Checksum:iDEBB705C8F9394E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 1005LVETS → VCVTA in BAC35506. (PubMed:16141072)Curated
    Sequence conflicti331 – 3311Q → P in BAE24738. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053750 mRNA. Translation: BAC35506.1.
    AK139413 mRNA. Translation: BAE24001.1.
    AK141566 mRNA. Translation: BAE24738.1.
    AK141823 mRNA. Translation: BAE24845.1.
    AK157013 mRNA. Translation: BAE33930.1.
    AK164975 mRNA. Translation: BAE37986.1.
    AL627314 Genomic DNA. Translation: CAM21945.1.
    BC027088 mRNA. Translation: AAH27088.1.
    BC058514 mRNA. Translation: AAH58514.1.
    CCDSiCCDS18768.1.
    RefSeqiNP_001157266.1. NM_001163794.1.
    NP_666268.1. NM_146156.3.
    UniGeneiMm.22778.

    Genome annotation databases

    EnsembliENSMUST00000061234; ENSMUSP00000060381; ENSMUSG00000050890.
    ENSMUST00000105876; ENSMUSP00000101502; ENSMUSG00000050890.
    GeneIDi230809.
    KEGGimmu:230809.
    UCSCiuc008vep.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK053750 mRNA. Translation: BAC35506.1 .
    AK139413 mRNA. Translation: BAE24001.1 .
    AK141566 mRNA. Translation: BAE24738.1 .
    AK141823 mRNA. Translation: BAE24845.1 .
    AK157013 mRNA. Translation: BAE33930.1 .
    AK164975 mRNA. Translation: BAE37986.1 .
    AL627314 Genomic DNA. Translation: CAM21945.1 .
    BC027088 mRNA. Translation: AAH27088.1 .
    BC058514 mRNA. Translation: AAH58514.1 .
    CCDSi CCDS18768.1.
    RefSeqi NP_001157266.1. NM_001163794.1.
    NP_666268.1. NM_146156.3.
    UniGenei Mm.22778.

    3D structure databases

    ProteinModelPortali Q8QZR7.
    SMRi Q8QZR7. Positions 7-323.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8QZR7.

    Proteomic databases

    PRIDEi Q8QZR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061234 ; ENSMUSP00000060381 ; ENSMUSG00000050890 .
    ENSMUST00000105876 ; ENSMUSP00000101502 ; ENSMUSG00000050890 .
    GeneIDi 230809.
    KEGGi mmu:230809.
    UCSCi uc008vep.2. mouse.

    Organism-specific databases

    CTDi 149420.
    MGIi MGI:2385213. Pdik1l.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117533.
    HOGENOMi HOG000231155.
    HOVERGENi HBG056829.
    InParanoidi A2A9L0.
    KOi K17539.
    OrthoDBi EOG76DTSN.
    TreeFami TF105336.

    Miscellaneous databases

    NextBioi 380182.
    PROi Q8QZR7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8QZR7.
    Bgeei Q8QZR7.
    CleanExi MM_PDIK1L.
    Genevestigatori Q8QZR7.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Brain cortex, Eye, Hippocampus, Spinal ganglion and Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Eye.

    Entry informationi

    Entry nameiPDK1L_MOUSE
    AccessioniPrimary (citable) accession number: Q8QZR7
    Secondary accession number(s): A2A9L0, Q3URF0, Q8BKB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3