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Protein

Serine/threonine-protein kinase PDIK1L

Gene

Pdik1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)
Alternative name(s):
PDLIM1-interacting kinase 1-like
Gene namesi
Name:Pdik1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385213. Pdik1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864951 – 341Serine/threonine-protein kinase PDIK1LAdd BLAST341

Proteomic databases

PaxDbiQ8QZR7.
PRIDEiQ8QZR7.

PTM databases

iPTMnetiQ8QZR7.
PhosphoSitePlusiQ8QZR7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050890.
CleanExiMM_PDIK1L.
ExpressionAtlasiQ8QZR7. baseline and differential.
GenevisibleiQ8QZR7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060381.

Structurei

3D structure databases

ProteinModelPortaliQ8QZR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 334Protein kinasePROSITE-ProRule annotationAdd BLAST327

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0595. Eukaryota.
ENOG410XR01. LUCA.
GeneTreeiENSGT00860000133779.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ8QZR7.
KOiK17539.
TreeFamiTF105336.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA
60 70 80 90 100
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS
110 120 130 140 150
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS
160 170 180 190 200
ALAFLHKNQI IHRDLKPDNI LISQSRMDTS DLEPTLKVAD FGLSKVCSAS
210 220 230 240 250
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM
260 270 280 290 300
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM
310 320 330 340
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T
Length:341
Mass (Da):38,550
Last modified:June 1, 2002 - v1
Checksum:iDEBB705C8F9394E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96 – 100LVETS → VCVTA in BAC35506 (PubMed:16141072).Curated5
Sequence conflicti331Q → P in BAE24738 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053750 mRNA. Translation: BAC35506.1.
AK139413 mRNA. Translation: BAE24001.1.
AK141566 mRNA. Translation: BAE24738.1.
AK141823 mRNA. Translation: BAE24845.1.
AK157013 mRNA. Translation: BAE33930.1.
AK164975 mRNA. Translation: BAE37986.1.
AL627314 Genomic DNA. Translation: CAM21945.1.
BC027088 mRNA. Translation: AAH27088.1.
BC058514 mRNA. Translation: AAH58514.1.
CCDSiCCDS18768.1.
RefSeqiNP_001157266.1. NM_001163794.1.
NP_666268.1. NM_146156.3.
UniGeneiMm.22778.

Genome annotation databases

EnsembliENSMUST00000061234; ENSMUSP00000060381; ENSMUSG00000050890.
ENSMUST00000105876; ENSMUSP00000101502; ENSMUSG00000050890.
GeneIDi230809.
KEGGimmu:230809.
UCSCiuc008vep.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053750 mRNA. Translation: BAC35506.1.
AK139413 mRNA. Translation: BAE24001.1.
AK141566 mRNA. Translation: BAE24738.1.
AK141823 mRNA. Translation: BAE24845.1.
AK157013 mRNA. Translation: BAE33930.1.
AK164975 mRNA. Translation: BAE37986.1.
AL627314 Genomic DNA. Translation: CAM21945.1.
BC027088 mRNA. Translation: AAH27088.1.
BC058514 mRNA. Translation: AAH58514.1.
CCDSiCCDS18768.1.
RefSeqiNP_001157266.1. NM_001163794.1.
NP_666268.1. NM_146156.3.
UniGeneiMm.22778.

3D structure databases

ProteinModelPortaliQ8QZR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060381.

PTM databases

iPTMnetiQ8QZR7.
PhosphoSitePlusiQ8QZR7.

Proteomic databases

PaxDbiQ8QZR7.
PRIDEiQ8QZR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061234; ENSMUSP00000060381; ENSMUSG00000050890.
ENSMUST00000105876; ENSMUSP00000101502; ENSMUSG00000050890.
GeneIDi230809.
KEGGimmu:230809.
UCSCiuc008vep.2. mouse.

Organism-specific databases

CTDi149420.
MGIiMGI:2385213. Pdik1l.

Phylogenomic databases

eggNOGiKOG0595. Eukaryota.
ENOG410XR01. LUCA.
GeneTreeiENSGT00860000133779.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiQ8QZR7.
KOiK17539.
TreeFamiTF105336.

Miscellaneous databases

PROiQ8QZR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050890.
CleanExiMM_PDIK1L.
ExpressionAtlasiQ8QZR7. baseline and differential.
GenevisibleiQ8QZR7. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDK1L_MOUSE
AccessioniPrimary (citable) accession number: Q8QZR7
Secondary accession number(s): A2A9L0, Q3URF0, Q8BKB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.