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Q8QZR7

- PDK1L_MOUSE

UniProt

Q8QZR7 - PDK1L_MOUSE

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Protein

Serine/threonine-protein kinase PDIK1L

Gene
Pdik1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP By similarity
Active sitei164 – 1641Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PDIK1L (EC:2.7.11.1)
Alternative name(s):
PDLIM1-interacting kinase 1-like
Gene namesi
Name:Pdik1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2385213. Pdik1l.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Serine/threonine-protein kinase PDIK1LPRO_0000086495Add
BLAST

Proteomic databases

PRIDEiQ8QZR7.

PTM databases

PhosphoSiteiQ8QZR7.

Expressioni

Gene expression databases

ArrayExpressiQ8QZR7.
BgeeiQ8QZR7.
CleanExiMM_PDIK1L.
GenevestigatoriQ8QZR7.

Structurei

3D structure databases

ProteinModelPortaliQ8QZR7.
SMRiQ8QZR7. Positions 7-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 334327Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117533.
HOGENOMiHOG000231155.
HOVERGENiHBG056829.
InParanoidiA2A9L0.
KOiK17539.
OrthoDBiEOG76DTSN.
TreeFamiTF105336.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QZR7-1 [UniParc]FASTAAdd to Basket

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MVSSQPKYDL IREVGRGSYG VVYEAVIRKT SARVAVKKIR CHAPENVELA    50
LREFWALSSI KSQHPNVIHL EECILQKDGM VQKMSHGSNS SLYLQLVETS 100
LKGEIAFDPR SAYYLWFVMD FCDGGDMNEY LLSRKPNRKT NTSFMLQLSS 150
ALAFLHKNQI IHRDLKPDNI LISQSRMDTS DLEPTLKVAD FGLSKVCSAS 200
GQNPEEPVSV NKCFLSTACG TDFYMAPEVW EGHYTAKADI FALGIIIWAM 250
LERITFIDTE TKKELLGSYV KQGTEIVPVG EALLENPKME LLIPVKKKSM 300
NGRMKQLIKE MLAANPQDRP DAFELELRLV QIAFKDSSWE T 341
Length:341
Mass (Da):38,550
Last modified:June 1, 2002 - v1
Checksum:iDEBB705C8F9394E6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 1005LVETS → VCVTA in BAC35506. 1 Publication
Sequence conflicti331 – 3311Q → P in BAE24738. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053750 mRNA. Translation: BAC35506.1.
AK139413 mRNA. Translation: BAE24001.1.
AK141566 mRNA. Translation: BAE24738.1.
AK141823 mRNA. Translation: BAE24845.1.
AK157013 mRNA. Translation: BAE33930.1.
AK164975 mRNA. Translation: BAE37986.1.
AL627314 Genomic DNA. Translation: CAM21945.1.
BC027088 mRNA. Translation: AAH27088.1.
BC058514 mRNA. Translation: AAH58514.1.
CCDSiCCDS18768.1.
RefSeqiNP_001157266.1. NM_001163794.1.
NP_666268.1. NM_146156.3.
UniGeneiMm.22778.

Genome annotation databases

EnsembliENSMUST00000061234; ENSMUSP00000060381; ENSMUSG00000050890.
ENSMUST00000105876; ENSMUSP00000101502; ENSMUSG00000050890.
GeneIDi230809.
KEGGimmu:230809.
UCSCiuc008vep.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053750 mRNA. Translation: BAC35506.1 .
AK139413 mRNA. Translation: BAE24001.1 .
AK141566 mRNA. Translation: BAE24738.1 .
AK141823 mRNA. Translation: BAE24845.1 .
AK157013 mRNA. Translation: BAE33930.1 .
AK164975 mRNA. Translation: BAE37986.1 .
AL627314 Genomic DNA. Translation: CAM21945.1 .
BC027088 mRNA. Translation: AAH27088.1 .
BC058514 mRNA. Translation: AAH58514.1 .
CCDSi CCDS18768.1.
RefSeqi NP_001157266.1. NM_001163794.1.
NP_666268.1. NM_146156.3.
UniGenei Mm.22778.

3D structure databases

ProteinModelPortali Q8QZR7.
SMRi Q8QZR7. Positions 7-323.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8QZR7.

Proteomic databases

PRIDEi Q8QZR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061234 ; ENSMUSP00000060381 ; ENSMUSG00000050890 .
ENSMUST00000105876 ; ENSMUSP00000101502 ; ENSMUSG00000050890 .
GeneIDi 230809.
KEGGi mmu:230809.
UCSCi uc008vep.2. mouse.

Organism-specific databases

CTDi 149420.
MGIi MGI:2385213. Pdik1l.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117533.
HOGENOMi HOG000231155.
HOVERGENi HBG056829.
InParanoidi A2A9L0.
KOi K17539.
OrthoDBi EOG76DTSN.
TreeFami TF105336.

Miscellaneous databases

NextBioi 380182.
PROi Q8QZR7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8QZR7.
Bgeei Q8QZR7.
CleanExi MM_PDIK1L.
Genevestigatori Q8QZR7.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Brain cortex, Eye, Hippocampus, Spinal ganglion and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.

Entry informationi

Entry nameiPDK1L_MOUSE
AccessioniPrimary (citable) accession number: Q8QZR7
Secondary accession number(s): A2A9L0, Q3URF0, Q8BKB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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