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Q8QZR5

- ALAT1_MOUSE

UniProt

Q8QZR5 - ALAT1_MOUSE

Protein

Alanine aminotransferase 1

Gene

Gpt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles By similarity.By similarity

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. L-alanine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00528; UER00586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine aminotransferase 1 (EC:2.6.1.2)
    Short name:
    ALT1
    Alternative name(s):
    Glutamate pyruvate transaminase 1
    Short name:
    GPT 1
    Glutamic--alanine transaminase 1
    Glutamic--pyruvic transaminase 1
    Gene namesi
    Name:Gpt
    Synonyms:Gpt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:95802. Gpt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 496495Alanine aminotransferase 1PRO_0000123934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei314 – 3141N6-(pyridoxal phosphate)lysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8QZR5.
    PaxDbiQ8QZR5.
    PRIDEiQ8QZR5.

    Expressioni

    Tissue specificityi

    Mainly expressed in liver, intestine, colon and white adipose tissue.1 Publication

    Gene expression databases

    ArrayExpressiQ8QZR5.
    BgeeiQ8QZR5.
    CleanExiMM_GPT.
    GenevestigatoriQ8QZR5.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ8QZR5. 2 interactions.
    MINTiMINT-1869747.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8QZR5.
    SMRiQ8QZR5. Positions 21-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    GeneTreeiENSGT00650000093331.
    HOGENOMiHOG000215020.
    HOVERGENiHBG026148.
    InParanoidiQ8QZR5.
    KOiK00814.
    OMAiHAKFTLE.
    OrthoDBiEOG76HQ18.
    PhylomeDBiQ8QZR5.
    TreeFamiTF300839.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8QZR5-1 [UniParc]FASTAAdd to Basket

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    MASQRNDRIQ ASRNGLKGKV LTLDTMNPCV RRVEYAVRGP IVQRALELEQ    50
    ELRQGVKKPF TEVIRANIGD AQAMGQRPIT FFRQVLALCV YPNLLSSPDF 100
    PEDAKRRAER ILQACGGHSL GAYSISSGIQ PIREDVAQYI ERRDGGIPAD 150
    PNNIFLSTGA SDAIVTMLKL LVAGEGRART GVLIPIPQYP LYSAALAELD 200
    AVQVDYYLDE ERAWALDIAE LRRALCQARD RCCPRVLCVI NPGNPTGQVQ 250
    TRECIEAVIR FAFEEGLFLM ADEVYQDNVY AEGSQFHSFK KVLTEMGPPY 300
    ATQQELASFH SVSKGYMGEC GFRGGYVEVV NMDAEVQKQM AKLMSVRLCP 350
    PVPGQALMGM VVSPPTPSEP SFKQFQAERQ EVLAELAAKA KLTEQVFNEA 400
    PGIRCNPVQG AMYSFPQIQL PLKAVQRAQD LGLAPDMFFC LCLLEETGIC 450
    VVPGSGFGQQ EGTYHFRMTI LPPMEKLRVL LEKLRHFHAK FTHEYS 496
    Length:496
    Mass (Da):55,143
    Last modified:January 23, 2007 - v3
    Checksum:i386AD33881DC7083
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC022625 mRNA. Translation: AAH22625.1.
    BC026846 mRNA. Translation: AAH26846.1.
    CCDSiCCDS27586.1.
    RefSeqiNP_877957.1. NM_182805.2.
    UniGeneiMm.30130.

    Genome annotation databases

    EnsembliENSMUST00000023203; ENSMUSP00000023203; ENSMUSG00000022546.
    GeneIDi76282.
    KEGGimmu:76282.
    UCSCiuc007wls.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC022625 mRNA. Translation: AAH22625.1 .
    BC026846 mRNA. Translation: AAH26846.1 .
    CCDSi CCDS27586.1.
    RefSeqi NP_877957.1. NM_182805.2.
    UniGenei Mm.30130.

    3D structure databases

    ProteinModelPortali Q8QZR5.
    SMRi Q8QZR5. Positions 21-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8QZR5. 2 interactions.
    MINTi MINT-1869747.

    Proteomic databases

    MaxQBi Q8QZR5.
    PaxDbi Q8QZR5.
    PRIDEi Q8QZR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023203 ; ENSMUSP00000023203 ; ENSMUSG00000022546 .
    GeneIDi 76282.
    KEGGi mmu:76282.
    UCSCi uc007wls.1. mouse.

    Organism-specific databases

    CTDi 2875.
    MGIi MGI:95802. Gpt.

    Phylogenomic databases

    eggNOGi COG0436.
    GeneTreei ENSGT00650000093331.
    HOGENOMi HOG000215020.
    HOVERGENi HBG026148.
    InParanoidi Q8QZR5.
    KOi K00814.
    OMAi HAKFTLE.
    OrthoDBi EOG76HQ18.
    PhylomeDBi Q8QZR5.
    TreeFami TF300839.

    Enzyme and pathway databases

    UniPathwayi UPA00528 ; UER00586 .

    Miscellaneous databases

    NextBioi 344903.
    PROi Q8QZR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8QZR5.
    Bgeei Q8QZR5.
    CleanExi MM_GPT.
    Genevestigatori Q8QZR5.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver."
      Jadhao S.B., Yang R.-Z., Lin Q., Hu H., Anania F.A., Shuldiner A.R., Gong D.-W.
      Hepatology 39:1297-1302(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Erratum
      Jadhao S.B., Yang R.-Z., Lin Q., Hu H., Anania F.A., Shuldiner A.R., Gong D.-W.
      Hepatology 40:269-269(2004)
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiALAT1_MOUSE
    AccessioniPrimary (citable) accession number: Q8QZR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3