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Q8QZR5

- ALAT1_MOUSE

UniProt

Q8QZR5 - ALAT1_MOUSE

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Protein

Alanine aminotransferase 1

Gene

Gpt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).By similarity

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. L-alanine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_239550. Amino acid synthesis and interconversion (transamination).
UniPathwayiUPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine aminotransferase 1 (EC:2.6.1.2)
Short name:
ALT1
Alternative name(s):
Glutamate pyruvate transaminase 1
Short name:
GPT 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1
Gene namesi
Name:Gpt
Synonyms:Gpt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:95802. Gpt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 496495Alanine aminotransferase 1PRO_0000123934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei314 – 3141N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8QZR5.
PaxDbiQ8QZR5.
PRIDEiQ8QZR5.

Expressioni

Tissue specificityi

Mainly expressed in liver, intestine, colon and white adipose tissue.1 Publication

Gene expression databases

BgeeiQ8QZR5.
CleanExiMM_GPT.
ExpressionAtlasiQ8QZR5. baseline and differential.
GenevestigatoriQ8QZR5.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8QZR5. 2 interactions.
MINTiMINT-1869747.

Structurei

3D structure databases

ProteinModelPortaliQ8QZR5.
SMRiQ8QZR5. Positions 21-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
GeneTreeiENSGT00650000093331.
HOGENOMiHOG000215020.
HOVERGENiHBG026148.
InParanoidiQ8QZR5.
KOiK00814.
OMAiHAKFTLE.
OrthoDBiEOG76HQ18.
PhylomeDBiQ8QZR5.
TreeFamiTF300839.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QZR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASQRNDRIQ ASRNGLKGKV LTLDTMNPCV RRVEYAVRGP IVQRALELEQ
60 70 80 90 100
ELRQGVKKPF TEVIRANIGD AQAMGQRPIT FFRQVLALCV YPNLLSSPDF
110 120 130 140 150
PEDAKRRAER ILQACGGHSL GAYSISSGIQ PIREDVAQYI ERRDGGIPAD
160 170 180 190 200
PNNIFLSTGA SDAIVTMLKL LVAGEGRART GVLIPIPQYP LYSAALAELD
210 220 230 240 250
AVQVDYYLDE ERAWALDIAE LRRALCQARD RCCPRVLCVI NPGNPTGQVQ
260 270 280 290 300
TRECIEAVIR FAFEEGLFLM ADEVYQDNVY AEGSQFHSFK KVLTEMGPPY
310 320 330 340 350
ATQQELASFH SVSKGYMGEC GFRGGYVEVV NMDAEVQKQM AKLMSVRLCP
360 370 380 390 400
PVPGQALMGM VVSPPTPSEP SFKQFQAERQ EVLAELAAKA KLTEQVFNEA
410 420 430 440 450
PGIRCNPVQG AMYSFPQIQL PLKAVQRAQD LGLAPDMFFC LCLLEETGIC
460 470 480 490
VVPGSGFGQQ EGTYHFRMTI LPPMEKLRVL LEKLRHFHAK FTHEYS
Length:496
Mass (Da):55,143
Last modified:January 23, 2007 - v3
Checksum:i386AD33881DC7083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022625 mRNA. Translation: AAH22625.1.
BC026846 mRNA. Translation: AAH26846.1.
CCDSiCCDS27586.1.
RefSeqiNP_877957.1. NM_182805.2.
UniGeneiMm.30130.

Genome annotation databases

EnsembliENSMUST00000023203; ENSMUSP00000023203; ENSMUSG00000022546.
GeneIDi76282.
KEGGimmu:76282.
UCSCiuc007wls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022625 mRNA. Translation: AAH22625.1 .
BC026846 mRNA. Translation: AAH26846.1 .
CCDSi CCDS27586.1.
RefSeqi NP_877957.1. NM_182805.2.
UniGenei Mm.30130.

3D structure databases

ProteinModelPortali Q8QZR5.
SMRi Q8QZR5. Positions 21-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8QZR5. 2 interactions.
MINTi MINT-1869747.

Proteomic databases

MaxQBi Q8QZR5.
PaxDbi Q8QZR5.
PRIDEi Q8QZR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023203 ; ENSMUSP00000023203 ; ENSMUSG00000022546 .
GeneIDi 76282.
KEGGi mmu:76282.
UCSCi uc007wls.1. mouse.

Organism-specific databases

CTDi 2875.
MGIi MGI:95802. Gpt.

Phylogenomic databases

eggNOGi COG0436.
GeneTreei ENSGT00650000093331.
HOGENOMi HOG000215020.
HOVERGENi HBG026148.
InParanoidi Q8QZR5.
KOi K00814.
OMAi HAKFTLE.
OrthoDBi EOG76HQ18.
PhylomeDBi Q8QZR5.
TreeFami TF300839.

Enzyme and pathway databases

UniPathwayi UPA00528 ; UER00586 .
Reactomei REACT_239550. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

NextBioi 344903.
PROi Q8QZR5.
SOURCEi Search...

Gene expression databases

Bgeei Q8QZR5.
CleanExi MM_GPT.
ExpressionAtlasi Q8QZR5. baseline and differential.
Genevestigatori Q8QZR5.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver."
    Jadhao S.B., Yang R.-Z., Lin Q., Hu H., Anania F.A., Shuldiner A.R., Gong D.-W.
    Hepatology 39:1297-1302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Erratum
    Jadhao S.B., Yang R.-Z., Lin Q., Hu H., Anania F.A., Shuldiner A.R., Gong D.-W.
    Hepatology 40:269-269(2004)
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiALAT1_MOUSE
AccessioniPrimary (citable) accession number: Q8QZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3