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Protein

Pyrethroid hydrolase Ces2a

Gene

Ces2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin.1 Publication

Catalytic activityi

Trans-permethrin + H2O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei344Charge relay systemBy similarity1
Active sitei456Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: MGI
  • trans-permethrin hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  • protein glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-211945. Phase 1 - Functionalization of compounds.

Protein family/group databases

ESTHERimouse-Ces2a. Carb_B_Chordata.
MEROPSiS09.997.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrethroid hydrolase Ces2a (EC:3.1.1.88)
Alternative name(s):
carboxylesterase 2A
Gene namesi
Name:Ces2a
Synonyms:Ces6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142491. Ces2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000042421027 – 558Pyrethroid hydrolase Ces2aAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi95 ↔ 122By similarity
Modified residuei209N6-succinyllysineCombined sources1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi279 ↔ 290By similarity
Modified residuei296N6-succinyllysineCombined sources1
Glycosylationi361N-linked (GlcNAc...)Sequence analysis1
Modified residuei551PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ8QZR3.
PeptideAtlasiQ8QZR3.
PRIDEiQ8QZR3.

PTM databases

iPTMnetiQ8QZR3.
PhosphoSitePlusiQ8QZR3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055730.
GenevisibleiQ8QZR3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8QZR3. 3 interactors.
MINTiMINT-4118069.
STRINGi10090.ENSMUSP00000034346.

Structurei

3D structure databases

ProteinModelPortaliQ8QZR3.
SMRiQ8QZR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
InParanoidiQ8QZR3.
KOiK03927.
OMAiFMGLDHI.
OrthoDBiEOG091G03ZC.
PhylomeDBiQ8QZR3.
TreeFamiTF315470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8QZR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLARLPGWL CVVACGLLLL LQHVHGQDSA SPIRNTHRGQ VRGSFVHVKD
60 70 80 90 100
TKSGVHAFLG IPFAKPPVGL LRFAPPEDPE PWSGVRDGTS QPAMCLQPDI
110 120 130 140 150
MNLEDAKEMN LILPPISMSE DCLYLNIYTP THAQEGSNLP VMVWIHGGGL
160 170 180 190 200
VVGSASMNDV SKLAATEEIV IVAIQYRLGV LGFFSTGDQH ARGNWGYLDQ
210 220 230 240 250
VAALRWVQKN IAYFGGNRDR VTIFGVSAGG TSVSSHILSP MSKGLFHGAI
260 270 280 290 300
MQSGVALLPD LISDTSEVVY KTVANLSGCE ATDSEALIHC LRAKSKQEIL
310 320 330 340 350
AINQVFKMIP AVVDGEFLPK HPQELLTSMD FHPVPSIIGV NTDECGWGVP
360 370 380 390 400
MFMGLDHIIK NITRETLPAV LKNTAARMML PPECSHLLVE EYMGDTEDPE
410 420 430 440 450
TLQAQFREML GDFMFVIPAL QVAHFQRSQA PVYFYEFQHL SSFIKHVRPS
460 470 480 490 500
HVKADHGDDV AFVFGSYLWD MNLDLTEEEE LLKRMMMKYW ANFARNGNPN
510 520 530 540 550
SEGLPSWPVL DHDEQYLQLD TQPAVGRALK ARRLQFWTKT LPQKIQELKG

SQDKHAEL
Length:558
Mass (Da):61,940
Last modified:June 1, 2002 - v1
Checksum:i961AD6BDC892E3FD
GO
Isoform 2 (identifier: Q8QZR3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-304: Missing.

Show »
Length:525
Mass (Da):58,430
Checksum:i6A7BFF2F1FF75C6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200Q → K in BAE38379 (PubMed:16141072).Curated1
Sequence conflicti223I → V in BAE38379 (PubMed:16141072).Curated1
Sequence conflicti371 – 373LKN → VKD in BAE38379 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053352272 – 304Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078953 mRNA. Translation: BAC37476.1.
AK165784 mRNA. Translation: BAE38379.1.
AC156564 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11232.1.
BC024082 mRNA. Translation: AAH24082.1.
BC024491 mRNA. Translation: AAH24491.1.
BC024517 mRNA. Translation: AAH24517.1.
BC025537 mRNA. Translation: AAH25537.1.
BC025812 mRNA. Translation: AAH25812.1.
BC026643 mRNA. Translation: AAH26643.1.
BC031295 mRNA. Translation: AAH31295.1.
CCDSiCCDS22585.1. [Q8QZR3-1]
CCDS52650.1. [Q8QZR3-2]
RefSeqiNP_001177259.1. NM_001190330.1. [Q8QZR3-2]
NP_598721.1. NM_133960.5. [Q8QZR3-1]
UniGeneiMm.212983.

Genome annotation databases

EnsembliENSMUST00000034346; ENSMUSP00000034346; ENSMUSG00000055730. [Q8QZR3-1]
ENSMUST00000164182; ENSMUSP00000127346; ENSMUSG00000055730. [Q8QZR3-2]
GeneIDi102022.
KEGGimmu:102022.
UCSCiuc009nbc.2. mouse. [Q8QZR3-1]
uc012giz.1. mouse. [Q8QZR3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078953 mRNA. Translation: BAC37476.1.
AK165784 mRNA. Translation: BAE38379.1.
AC156564 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11232.1.
BC024082 mRNA. Translation: AAH24082.1.
BC024491 mRNA. Translation: AAH24491.1.
BC024517 mRNA. Translation: AAH24517.1.
BC025537 mRNA. Translation: AAH25537.1.
BC025812 mRNA. Translation: AAH25812.1.
BC026643 mRNA. Translation: AAH26643.1.
BC031295 mRNA. Translation: AAH31295.1.
CCDSiCCDS22585.1. [Q8QZR3-1]
CCDS52650.1. [Q8QZR3-2]
RefSeqiNP_001177259.1. NM_001190330.1. [Q8QZR3-2]
NP_598721.1. NM_133960.5. [Q8QZR3-1]
UniGeneiMm.212983.

3D structure databases

ProteinModelPortaliQ8QZR3.
SMRiQ8QZR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8QZR3. 3 interactors.
MINTiMINT-4118069.
STRINGi10090.ENSMUSP00000034346.

Protein family/group databases

ESTHERimouse-Ces2a. Carb_B_Chordata.
MEROPSiS09.997.

PTM databases

iPTMnetiQ8QZR3.
PhosphoSitePlusiQ8QZR3.

Proteomic databases

PaxDbiQ8QZR3.
PeptideAtlasiQ8QZR3.
PRIDEiQ8QZR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034346; ENSMUSP00000034346; ENSMUSG00000055730. [Q8QZR3-1]
ENSMUST00000164182; ENSMUSP00000127346; ENSMUSG00000055730. [Q8QZR3-2]
GeneIDi102022.
KEGGimmu:102022.
UCSCiuc009nbc.2. mouse. [Q8QZR3-1]
uc012giz.1. mouse. [Q8QZR3-2]

Organism-specific databases

CTDi102022.
MGIiMGI:2142491. Ces2a.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000091866.
HOVERGENiHBG008839.
InParanoidiQ8QZR3.
KOiK03927.
OMAiFMGLDHI.
OrthoDBiEOG091G03ZC.
PhylomeDBiQ8QZR3.
TreeFamiTF315470.

Enzyme and pathway databases

ReactomeiR-MMU-211945. Phase 1 - Functionalization of compounds.

Miscellaneous databases

PROiQ8QZR3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055730.
GenevisibleiQ8QZR3. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEST2A_MOUSE
AccessioniPrimary (citable) accession number: Q8QZR3
Secondary accession number(s): E9Q3D0, Q3TMR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.