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Protein

Pyrethroid hydrolase Ces2a

Gene

Ces2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin.1 Publication

Catalytic activityi

Trans-permethrin + H2O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei344Charge relay systemBy similarity1
Active sitei456Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: MGI
  • trans-permethrin hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  • protein glycosylation Source: MGI

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Protein family/group databases

ESTHERimouse-Ces2a Carb_B_Chordata
MEROPSiS09.997

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrethroid hydrolase Ces2a (EC:3.1.1.88)
Alternative name(s):
carboxylesterase 2A
Gene namesi
Name:Ces2a
Synonyms:Ces6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142491 Ces2a

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000042421027 – 558Pyrethroid hydrolase Ces2aAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi95 ↔ 122By similarity
Modified residuei209N6-succinyllysineCombined sources1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi279 ↔ 290By similarity
Modified residuei296N6-succinyllysineCombined sources1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei551PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ8QZR3
PeptideAtlasiQ8QZR3
PRIDEiQ8QZR3

PTM databases

iPTMnetiQ8QZR3
PhosphoSitePlusiQ8QZR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000055730
ExpressionAtlasiQ8QZR3 baseline and differential
GenevisibleiQ8QZR3 MM

Interactioni

Protein-protein interaction databases

IntActiQ8QZR3, 3 interactors
MINTiQ8QZR3
STRINGi10090.ENSMUSP00000034346

Structurei

3D structure databases

ProteinModelPortaliQ8QZR3
SMRiQ8QZR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
InParanoidiQ8QZR3
KOiK03927
OMAiEYGPACA
OrthoDBiEOG091G03ZC
PhylomeDBiQ8QZR3
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8QZR3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLARLPGWL CVVACGLLLL LQHVHGQDSA SPIRNTHRGQ VRGSFVHVKD
60 70 80 90 100
TKSGVHAFLG IPFAKPPVGL LRFAPPEDPE PWSGVRDGTS QPAMCLQPDI
110 120 130 140 150
MNLEDAKEMN LILPPISMSE DCLYLNIYTP THAQEGSNLP VMVWIHGGGL
160 170 180 190 200
VVGSASMNDV SKLAATEEIV IVAIQYRLGV LGFFSTGDQH ARGNWGYLDQ
210 220 230 240 250
VAALRWVQKN IAYFGGNRDR VTIFGVSAGG TSVSSHILSP MSKGLFHGAI
260 270 280 290 300
MQSGVALLPD LISDTSEVVY KTVANLSGCE ATDSEALIHC LRAKSKQEIL
310 320 330 340 350
AINQVFKMIP AVVDGEFLPK HPQELLTSMD FHPVPSIIGV NTDECGWGVP
360 370 380 390 400
MFMGLDHIIK NITRETLPAV LKNTAARMML PPECSHLLVE EYMGDTEDPE
410 420 430 440 450
TLQAQFREML GDFMFVIPAL QVAHFQRSQA PVYFYEFQHL SSFIKHVRPS
460 470 480 490 500
HVKADHGDDV AFVFGSYLWD MNLDLTEEEE LLKRMMMKYW ANFARNGNPN
510 520 530 540 550
SEGLPSWPVL DHDEQYLQLD TQPAVGRALK ARRLQFWTKT LPQKIQELKG

SQDKHAEL
Length:558
Mass (Da):61,940
Last modified:June 1, 2002 - v1
Checksum:i961AD6BDC892E3FD
GO
Isoform 2 (identifier: Q8QZR3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-304: Missing.

Show »
Length:525
Mass (Da):58,430
Checksum:i6A7BFF2F1FF75C6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200Q → K in BAE38379 (PubMed:16141072).Curated1
Sequence conflicti223I → V in BAE38379 (PubMed:16141072).Curated1
Sequence conflicti371 – 373LKN → VKD in BAE38379 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053352272 – 304Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078953 mRNA Translation: BAC37476.1
AK165784 mRNA Translation: BAE38379.1
AC156564 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11232.1
BC024082 mRNA Translation: AAH24082.1
BC024491 mRNA Translation: AAH24491.1
BC024517 mRNA Translation: AAH24517.1
BC025537 mRNA Translation: AAH25537.1
BC025812 mRNA Translation: AAH25812.1
BC026643 mRNA Translation: AAH26643.1
BC031295 mRNA Translation: AAH31295.1
CCDSiCCDS22585.1 [Q8QZR3-1]
CCDS52650.1 [Q8QZR3-2]
RefSeqiNP_001177259.1, NM_001190330.1 [Q8QZR3-2]
NP_598721.1, NM_133960.5 [Q8QZR3-1]
UniGeneiMm.212983

Genome annotation databases

EnsembliENSMUST00000034346; ENSMUSP00000034346; ENSMUSG00000055730 [Q8QZR3-1]
ENSMUST00000164182; ENSMUSP00000127346; ENSMUSG00000055730 [Q8QZR3-2]
GeneIDi102022
KEGGimmu:102022
UCSCiuc009nbc.2 mouse [Q8QZR3-1]
uc012giz.1 mouse [Q8QZR3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEST2A_MOUSE
AccessioniPrimary (citable) accession number: Q8QZR3
Secondary accession number(s): E9Q3D0, Q3TMR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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