Q8QMY9 (GLRX1_CWPXB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaredoxin-1

Gene names

Ordered Locus Names:

CPXV079

Organism

Cowpox virus (strain Brighton Red) (CPV)

Taxonomic identifier

265872 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Loxodonta africana (African elephant) [TaxID: 9785]
Bos taurus (Bovine) [TaxID: 9913]
Mus musculus (Mouse) [TaxID: 10090]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has thioltransferase and dehydroascorbate reductase activities By similarity.
Subcellular location	Virion. Note: Localizes to the virion core By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Virion
Domain	Redox-active center
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 108	108	Glutaredoxin-1		PRO_0000141622
Regions
	Domain	3 – 106	104	Glutaredoxin
Amino acid modifications
	Disulfide bond	23 ↔ 26		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8QMY9 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: DA72BB137A9054C2	FASTA	108	12,367
	10 20 30 40 50 60 MAEEFVQQRL ANNKVTIFVK FTCPFCRNAL DILNKFSFKR GAYEIVDIKE FRPENELRDY 70 80 90 100 FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC

References

[1]	Dietrich F.S., Ray C.A., Sharma A.D., Allen A., Pickup D.J. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF482758 Genomic DNA. Translation: AAM13524.1.
RefSeq	NP_619866.1. NC_003663.2.
3D structure databases
ProteinModelPortal	Q8QMY9.
SMR	Q8QMY9. Positions 1-107.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1485956.
Phylogenomic databases
ProtClustDB	PHA3050.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR011899. Glutaredoxin_euk/vir. IPR014025. Glutaredoxin_subgr. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_CWPXB

Accession

Primary (citable) accession number: Q8QMY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program