Reviewed, UniProtKB/Swiss-Prot Q8QLK1 (CATV_NPVMC)

Names and origin

Protein names

Recommended name:
    Viral cathepsin
      Short name=V-cath
    EC=3.4.22.50
Alternative name(s):
    Cysteine proteinase
      Short name=CP

Gene names

Name:

VCATH

Organism

Mamestra configurata nucleopolyhedrovirus (MacoNPV)

Taxonomic identifier

191492 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Alphabaculovirus

Virus host

Mamestra configurata (bertha armyworm) [TaxID: 174822]

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.
Catalytic activity	Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.
Post-translational modification	Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 126	110	Activation peptide Potential		PRO_0000322213
	Chain	127 – 337	211	Viral cathepsin		PRO_0000050583
Sites
	Active site	150	1	By similarity
	Active site	283	1	By similarity
	Active site	303	1	By similarity
Amino acid modifications
	Disulfide bond	147 ↔ 188		By similarity
	Disulfide bond	181 ↔ 221		By similarity
	Disulfide bond	276 ↔ 324		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8QLK1-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 2437696EAA2A1AAC	FASTA	337	37,890
	10 20 30 40 50 60 MNKILILLLL VSAVLTSHDQ VVAVTIKPNL YNINSAPLYF EKFISQYNKQ YSSEDEKKYR 70 80 90 100 110 120 YNIFRHNIES INAKNSRNDS AVYKINRFAD MTKNEVVNRH TGLASGDIGA NFCETIVVDG 130 140 150 160 170 180 PGQRQRPANF DWRNYNKVTS VKDQGMCGAC WAFAGLGALE SQYAIKYDRL IDLAEQQLVD 190 200 210 220 230 240 CDFVDMGCDG GLIHTAYEQI MHIGGVEQEY DYPYKAVRLP CAVKPHKFAV GVRNCYRYVL 250 260 270 280 290 300 LSEERLEDLL RHVGPIAIAV DAVDLTDYYG GVISFCENNG LNHAVLLVGY GIENNVPYWT 310 320 330 IKNSWGSDYG ENGYVRIRRG VNSCGMINEL ASSAQIA

References

[1]	"Sequence and organization of the Mamestra configurata nucleopolyhedrovirus genome." Li Q., Donly C., Li L., Willis L.G., Theilmann D.A., Erlandson M. Virology 294:106-121(2002) [PubMed: 11886270] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 90/2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U59461 Genomic DNA. Translation: AAM09141.1.
3D structure databases
HSSP	HSSP built from PDB template 1JQP based on UniProtKB P80067.
ModBase	Search...
Protein family/group databases
MEROPS	C01.083.
Enzyme and pathway databases
BRENDA	3.4.22.50. 298760.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
ProDom	PD000158. Peptidase_C1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATV_NPVMC

Accession

Primary (citable) accession number: Q8QLK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	June 1, 2002
Last modified:	March 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)