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Q8QHJ9

- I17RD_DANRE

UniProt

Q8QHJ9 - I17RD_DANRE

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Protein

Interleukin-17 receptor D

Gene
il17rd, cb208, sef
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation.2 Publications

GO - Biological processi

  1. dorsal/ventral pattern formation Source: ZFIN
  2. inactivation of MAPK activity Source: ZFIN
  3. negative regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor D
Short name:
IL-17 receptor D
Short name:
IL-17RD
Alternative name(s):
Similar expression to FGF genes protein
Short name:
Sef
Gene namesi
Name:il17rd
Synonyms:cb208, sef
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020320-5. il17rd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 298272Extracellular Reviewed predictionAdd
BLAST
Transmembranei299 – 31921Helical; Reviewed predictionAdd
BLAST
Topological domaini320 – 745426Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 745719Interleukin-17 receptor DPRO_0000041874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with fgfr1 and fgfr2.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini354 – 518165SEFIRAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi448 – 4569Poly-Ser
Compositional biasi698 – 7036Poly-Ser

Sequence similaritiesi

Contains 1 SEFIR domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45649.
HOGENOMiHOG000060160.
HOVERGENiHBG081777.
InParanoidiQ8QHJ9.
KOiK05167.
PhylomeDBiQ8QHJ9.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QHJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MAGSRRLAHF FMASCLFLCY TASVNGGKRG NSDKCSYKQG TQTSSMDEGA    50
RKLGVTFRYD NCSVNWSPLG KHAIHEVNNI SFSHLSCDSQ AAVVVHWMAS 100
PLGIEHVKGF RVYLEDKNPE RKQCQHLILK DPRQLNFSYK TIRMSSQPFS 150
SLAFETDYMV RIVPFPTFLN DSFFPPSFLR TNSCEVLLGP DNLVCKPFWK 200
PKMLNVSQLG SNLHVVFDHA PSTFGFSIYY LYYKLRQEGP FRLKRCKPEQ 250
NGPKTTCVLQ DVTPGTYAIE LRDDSNNTRR QTQYHVSQVH SPWAGPIRAM 300
AITVPLVIMS AFATLFTVMC RKKQQENIYS HLDEESSESS SQTTALSADR 350
PWPRPKIFIC YSSRDGAKHL AVIQSFAFFL QDFCGCEVSL DLWEHLEICK 400
EGQMSWLSRR IDEAHFIITV CSKGLKHFVE KRHRKGKATS KEKNREPSAS 450
DSSSSSRDLF IVASAIISEK LKEVHQKSSD LSRFMSVYFD YSHETDVPTS 500
LSLAPKFKLM DQLPQLFARL HSRQLSLTDR EPQPPNVSKR NYFCSKSGRS 550
LYVAIYNMHQ HVTQEPDWLE KELMPPPLPN KRTIPEKVDS GLVLNEVKLK 600
HGSESECPPV RSNVLILPQT PQVGVSLSLS REDLGEGSSS QDAGSCRPVL 650
HTDGSASPPE MPRDSGIYDS SVPSSELSIP LMDGLSPDHA DNSSLADSVS 700
SSSGLGDEEP PAVSSLHCTA HTICKADLHH QHLHPSEGLI AAAST 745
Length:745
Mass (Da):83,391
Last modified:September 13, 2005 - v2
Checksum:i6F8998D63D9DA24F
GO

Sequence cautioni

The sequence AAH94998.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → N in AAL76112. 1 Publication
Sequence conflicti81 – 811S → T in AAL76112. 1 Publication
Sequence conflicti167 – 1671T → N in AAL78817. 1 Publication
Sequence conflicti739 – 7391L → F in AAL78817. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF364103 mRNA. Translation: AAL76112.1.
AF401232 mRNA. Translation: AAL78817.1.
BC094998 mRNA. Translation: AAH94998.1. Sequence problems.
RefSeqiNP_705946.1. NM_153660.1.
UniGeneiDr.12379.

Genome annotation databases

GeneIDi171474.
KEGGidre:171474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF364103 mRNA. Translation: AAL76112.1 .
AF401232 mRNA. Translation: AAL78817.1 .
BC094998 mRNA. Translation: AAH94998.1 . Sequence problems.
RefSeqi NP_705946.1. NM_153660.1.
UniGenei Dr.12379.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171474.
KEGGi dre:171474.

Organism-specific databases

CTDi 54756.
ZFINi ZDB-GENE-020320-5. il17rd.

Phylogenomic databases

eggNOGi NOG45649.
HOGENOMi HOG000060160.
HOVERGENi HBG081777.
InParanoidi Q8QHJ9.
KOi K05167.
PhylomeDBi Q8QHJ9.

Miscellaneous databases

NextBioi 20797123.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Sef, a novel modulator of FGF signalling."
    Tsang M., Friesel R., Kudoh T., Dawid I.
    Nat. Cell Biol. 4:165-169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FGFR1 AND FGFR2.
  2. "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling."
    Fuerthauer M., Lin W., Ang S.-L., Thisse B., Thisse C.
    Nat. Cell Biol. 4:170-174(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441.
    Tissue: Larva.

Entry informationi

Entry nameiI17RD_DANRE
AccessioniPrimary (citable) accession number: Q8QHJ9
Secondary accession number(s): Q4VBV6, Q8QHJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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