Interleukin-17 receptor D precursor - Danio rerio (Zebrafish)

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Q8QHJ9 (I17RD_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Interleukin-17 receptor D
Short name=IL-17 receptor D
Short name=IL-17RD

Alternative name(s):
Similar expression to FGF genes protein
Short name=Sef

Gene names

Name:	il17rd
Synonyms:	cb208, sef

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Ref.1 Ref.2
Subunit structure	Interacts with fgfr1 and fgfr2. Ref.1
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 SEFIR domain.
Sequence caution	The sequence AAH94998.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dorsal/ventral pattern formation Inferred from mutant phenotype Ref.2. Source: ZFIN inactivation of MAPK activity Inferred from mutant phenotype Ref.2. Source: ZFIN negative regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype Ref.2. Source: ZFIN
Cellular_component	integral to membrane Inferred from sequence or structural similarity Ref.2. Source: ZFIN
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

26

Potential

Chain

719

Interleukin-17 receptor D

PRO_0000041874

Regions

Topological domain

272

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

426

Cytoplasmic Potential

Domain

165

SEFIR

Compositional bias

9

Poly-Ser

Compositional bias

6

Poly-Ser

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

1

S → N in AAL76112. Ref.1

Sequence conflict

1

S → T in AAL76112. Ref.1

Sequence conflict

1

T → N in AAL78817. Ref.2

Sequence conflict

1

L → F in AAL78817. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q8QHJ9 [UniParc].

Last modified September 13, 2005. Version 2.
Checksum: 6F8998D63D9DA24F
Show »

745

83,391

        10         20         30         40         50         60 
MAGSRRLAHF FMASCLFLCY TASVNGGKRG NSDKCSYKQG TQTSSMDEGA RKLGVTFRYD 

        70         80         90        100        110        120 
NCSVNWSPLG KHAIHEVNNI SFSHLSCDSQ AAVVVHWMAS PLGIEHVKGF RVYLEDKNPE 

       130        140        150        160        170        180 
RKQCQHLILK DPRQLNFSYK TIRMSSQPFS SLAFETDYMV RIVPFPTFLN DSFFPPSFLR 

       190        200        210        220        230        240 
TNSCEVLLGP DNLVCKPFWK PKMLNVSQLG SNLHVVFDHA PSTFGFSIYY LYYKLRQEGP 

       250        260        270        280        290        300 
FRLKRCKPEQ NGPKTTCVLQ DVTPGTYAIE LRDDSNNTRR QTQYHVSQVH SPWAGPIRAM 

       310        320        330        340        350        360 
AITVPLVIMS AFATLFTVMC RKKQQENIYS HLDEESSESS SQTTALSADR PWPRPKIFIC 

       370        380        390        400        410        420 
YSSRDGAKHL AVIQSFAFFL QDFCGCEVSL DLWEHLEICK EGQMSWLSRR IDEAHFIITV 

       430        440        450        460        470        480 
CSKGLKHFVE KRHRKGKATS KEKNREPSAS DSSSSSRDLF IVASAIISEK LKEVHQKSSD 

       490        500        510        520        530        540 
LSRFMSVYFD YSHETDVPTS LSLAPKFKLM DQLPQLFARL HSRQLSLTDR EPQPPNVSKR 

       550        560        570        580        590        600 
NYFCSKSGRS LYVAIYNMHQ HVTQEPDWLE KELMPPPLPN KRTIPEKVDS GLVLNEVKLK 

       610        620        630        640        650        660 
HGSESECPPV RSNVLILPQT PQVGVSLSLS REDLGEGSSS QDAGSCRPVL HTDGSASPPE 

       670        680        690        700        710        720 
MPRDSGIYDS SVPSSELSIP LMDGLSPDHA DNSSLADSVS SSSGLGDEEP PAVSSLHCTA 

       730        740 
HTICKADLHH QHLHPSEGLI AAAST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of Sef, a novel modulator of FGF signalling." Tsang M., Friesel R., Kudoh T., Dawid I. Nat. Cell Biol. 4:165-169(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FGFR1 AND FGFR2.
[2]	"Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling." Fuerthauer M., Lin W., Ang S.-L., Thisse B., Thisse C. Nat. Cell Biol. 4:170-174(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441. Tissue: Larva.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF364103 mRNA. Translation: AAL76112.1. AF401232 mRNA. Translation: AAL78817.1. BC094998 mRNA. Translation: AAH94998.1. Sequence problems.
IPI	IPI00508449.
RefSeq	NP_705946.1. NM_153660.1.
UniGene	Dr.12379.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	171474.
KEGG	dre:171474.
Organism-specific databases
CTD	54756.
ZFIN	ZDB-GENE-020320-5. il17rd.
Phylogenomic databases
eggNOG	NOG45649.
HOGENOM	HOG000060160.
HOVERGEN	HBG081777.
InParanoid	Q8QHJ9.
KO	K05167.
OrthoDB	EOG451DQ6.
Family and domain databases
InterPro	IPR013568. SEFIR. [Graphical view]
Pfam	PF08357. SEFIR. 1 hit. [Graphical view]
PROSITE	PS51534. SEFIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20797123.

Entry information

Entry name

I17RD_DANRE

Accession

Primary (citable) accession number: Q8QHJ9
Secondary accession number(s): Q4VBV6, Q8QHJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	April 3, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents