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Q8QHJ9

- I17RD_DANRE

UniProt

Q8QHJ9 - I17RD_DANRE

Protein

Interleukin-17 receptor D

Gene

il17rd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation.2 Publications

    GO - Biological processi

    1. dorsal/ventral pattern formation Source: ZFIN
    2. inactivation of MAPK activity Source: ZFIN
    3. negative regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17 receptor D
    Short name:
    IL-17 receptor D
    Short name:
    IL-17RD
    Alternative name(s):
    Similar expression to FGF genes protein
    Short name:
    Sef
    Gene namesi
    Name:il17rd
    Synonyms:cb208, sef
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-020320-5. il17rd.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ZFIN

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 745719Interleukin-17 receptor DPRO_0000041874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with fgfr1 and fgfr2.1 Publication

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 298272ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini320 – 745426CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini354 – 518165SEFIRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi448 – 4569Poly-Ser
    Compositional biasi698 – 7036Poly-Ser

    Sequence similaritiesi

    Contains 1 SEFIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45649.
    HOGENOMiHOG000060160.
    HOVERGENiHBG081777.
    InParanoidiQ8QHJ9.
    KOiK05167.
    PhylomeDBiQ8QHJ9.

    Family and domain databases

    InterProiIPR013568. SEFIR.
    [Graphical view]
    PfamiPF08357. SEFIR. 1 hit.
    [Graphical view]
    PROSITEiPS51534. SEFIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8QHJ9-1 [UniParc]FASTAAdd to Basket

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    MAGSRRLAHF FMASCLFLCY TASVNGGKRG NSDKCSYKQG TQTSSMDEGA    50
    RKLGVTFRYD NCSVNWSPLG KHAIHEVNNI SFSHLSCDSQ AAVVVHWMAS 100
    PLGIEHVKGF RVYLEDKNPE RKQCQHLILK DPRQLNFSYK TIRMSSQPFS 150
    SLAFETDYMV RIVPFPTFLN DSFFPPSFLR TNSCEVLLGP DNLVCKPFWK 200
    PKMLNVSQLG SNLHVVFDHA PSTFGFSIYY LYYKLRQEGP FRLKRCKPEQ 250
    NGPKTTCVLQ DVTPGTYAIE LRDDSNNTRR QTQYHVSQVH SPWAGPIRAM 300
    AITVPLVIMS AFATLFTVMC RKKQQENIYS HLDEESSESS SQTTALSADR 350
    PWPRPKIFIC YSSRDGAKHL AVIQSFAFFL QDFCGCEVSL DLWEHLEICK 400
    EGQMSWLSRR IDEAHFIITV CSKGLKHFVE KRHRKGKATS KEKNREPSAS 450
    DSSSSSRDLF IVASAIISEK LKEVHQKSSD LSRFMSVYFD YSHETDVPTS 500
    LSLAPKFKLM DQLPQLFARL HSRQLSLTDR EPQPPNVSKR NYFCSKSGRS 550
    LYVAIYNMHQ HVTQEPDWLE KELMPPPLPN KRTIPEKVDS GLVLNEVKLK 600
    HGSESECPPV RSNVLILPQT PQVGVSLSLS REDLGEGSSS QDAGSCRPVL 650
    HTDGSASPPE MPRDSGIYDS SVPSSELSIP LMDGLSPDHA DNSSLADSVS 700
    SSSGLGDEEP PAVSSLHCTA HTICKADLHH QHLHPSEGLI AAAST 745
    Length:745
    Mass (Da):83,391
    Last modified:September 13, 2005 - v2
    Checksum:i6F8998D63D9DA24F
    GO

    Sequence cautioni

    The sequence AAH94998.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671S → N in AAL76112. (PubMed:11802164)Curated
    Sequence conflicti81 – 811S → T in AAL76112. (PubMed:11802164)Curated
    Sequence conflicti167 – 1671T → N in AAL78817. (PubMed:11802165)Curated
    Sequence conflicti739 – 7391L → F in AAL78817. (PubMed:11802165)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF364103 mRNA. Translation: AAL76112.1.
    AF401232 mRNA. Translation: AAL78817.1.
    BC094998 mRNA. Translation: AAH94998.1. Sequence problems.
    RefSeqiNP_705946.1. NM_153660.1.
    UniGeneiDr.12379.

    Genome annotation databases

    GeneIDi171474.
    KEGGidre:171474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF364103 mRNA. Translation: AAL76112.1 .
    AF401232 mRNA. Translation: AAL78817.1 .
    BC094998 mRNA. Translation: AAH94998.1 . Sequence problems.
    RefSeqi NP_705946.1. NM_153660.1.
    UniGenei Dr.12379.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 171474.
    KEGGi dre:171474.

    Organism-specific databases

    CTDi 54756.
    ZFINi ZDB-GENE-020320-5. il17rd.

    Phylogenomic databases

    eggNOGi NOG45649.
    HOGENOMi HOG000060160.
    HOVERGENi HBG081777.
    InParanoidi Q8QHJ9.
    KOi K05167.
    PhylomeDBi Q8QHJ9.

    Miscellaneous databases

    NextBioi 20797123.

    Family and domain databases

    InterProi IPR013568. SEFIR.
    [Graphical view ]
    Pfami PF08357. SEFIR. 1 hit.
    [Graphical view ]
    PROSITEi PS51534. SEFIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Sef, a novel modulator of FGF signalling."
      Tsang M., Friesel R., Kudoh T., Dawid I.
      Nat. Cell Biol. 4:165-169(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FGFR1 AND FGFR2.
    2. "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling."
      Fuerthauer M., Lin W., Ang S.-L., Thisse B., Thisse C.
      Nat. Cell Biol. 4:170-174(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441.
      Tissue: Larva.

    Entry informationi

    Entry nameiI17RD_DANRE
    AccessioniPrimary (citable) accession number: Q8QHJ9
    Secondary accession number(s): Q4VBV6, Q8QHJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3