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Q8QHJ9 (I17RD_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor D

Short name=IL-17 receptor D
Short name=IL-17RD
Alternative name(s):
Similar expression to FGF genes protein
Short name=Sef
Gene names
Name:il17rd
Synonyms:cb208, sef
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length745 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Ref.1 Ref.2

Subunit structure

Interacts with fgfr1 and fgfr2. Ref.1

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 SEFIR domain.

Sequence caution

The sequence AAH94998.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 745719Interleukin-17 receptor D
PRO_0000041874

Regions

Topological domain27 – 298272Extracellular Potential
Transmembrane299 – 31921Helical; Potential
Topological domain320 – 745426Cytoplasmic Potential
Domain354 – 518165SEFIR
Compositional bias448 – 4569Poly-Ser
Compositional bias698 – 7036Poly-Ser

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict671S → N in AAL76112. Ref.1
Sequence conflict811S → T in AAL76112. Ref.1
Sequence conflict1671T → N in AAL78817. Ref.2
Sequence conflict7391L → F in AAL78817. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8QHJ9 [UniParc].

Last modified September 13, 2005. Version 2.
Checksum: 6F8998D63D9DA24F

FASTA74583,391
        10         20         30         40         50         60 
MAGSRRLAHF FMASCLFLCY TASVNGGKRG NSDKCSYKQG TQTSSMDEGA RKLGVTFRYD 

        70         80         90        100        110        120 
NCSVNWSPLG KHAIHEVNNI SFSHLSCDSQ AAVVVHWMAS PLGIEHVKGF RVYLEDKNPE 

       130        140        150        160        170        180 
RKQCQHLILK DPRQLNFSYK TIRMSSQPFS SLAFETDYMV RIVPFPTFLN DSFFPPSFLR 

       190        200        210        220        230        240 
TNSCEVLLGP DNLVCKPFWK PKMLNVSQLG SNLHVVFDHA PSTFGFSIYY LYYKLRQEGP 

       250        260        270        280        290        300 
FRLKRCKPEQ NGPKTTCVLQ DVTPGTYAIE LRDDSNNTRR QTQYHVSQVH SPWAGPIRAM 

       310        320        330        340        350        360 
AITVPLVIMS AFATLFTVMC RKKQQENIYS HLDEESSESS SQTTALSADR PWPRPKIFIC 

       370        380        390        400        410        420 
YSSRDGAKHL AVIQSFAFFL QDFCGCEVSL DLWEHLEICK EGQMSWLSRR IDEAHFIITV 

       430        440        450        460        470        480 
CSKGLKHFVE KRHRKGKATS KEKNREPSAS DSSSSSRDLF IVASAIISEK LKEVHQKSSD 

       490        500        510        520        530        540 
LSRFMSVYFD YSHETDVPTS LSLAPKFKLM DQLPQLFARL HSRQLSLTDR EPQPPNVSKR 

       550        560        570        580        590        600 
NYFCSKSGRS LYVAIYNMHQ HVTQEPDWLE KELMPPPLPN KRTIPEKVDS GLVLNEVKLK 

       610        620        630        640        650        660 
HGSESECPPV RSNVLILPQT PQVGVSLSLS REDLGEGSSS QDAGSCRPVL HTDGSASPPE 

       670        680        690        700        710        720 
MPRDSGIYDS SVPSSELSIP LMDGLSPDHA DNSSLADSVS SSSGLGDEEP PAVSSLHCTA 

       730        740 
HTICKADLHH QHLHPSEGLI AAAST 

« Hide

References

« Hide 'large scale' references
[1]"Identification of Sef, a novel modulator of FGF signalling."
Tsang M., Friesel R., Kudoh T., Dawid I.
Nat. Cell Biol. 4:165-169(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FGFR1 AND FGFR2.
[2]"Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling."
Fuerthauer M., Lin W., Ang S.-L., Thisse B., Thisse C.
Nat. Cell Biol. 4:170-174(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441.
Tissue: Larva.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF364103 mRNA. Translation: AAL76112.1.
AF401232 mRNA. Translation: AAL78817.1.
BC094998 mRNA. Translation: AAH94998.1. Sequence problems.
RefSeqNP_705946.1. NM_153660.1.
UniGeneDr.12379.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171474.
KEGGdre:171474.

Organism-specific databases

CTD54756.
ZFINZDB-GENE-020320-5. il17rd.

Phylogenomic databases

eggNOGNOG45649.
HOGENOMHOG000060160.
HOVERGENHBG081777.
InParanoidQ8QHJ9.
KOK05167.
PhylomeDBQ8QHJ9.

Family and domain databases

InterProIPR013568. SEFIR.
[Graphical view]
PfamPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20797123.

Entry information

Entry nameI17RD_DANRE
AccessionPrimary (citable) accession number: Q8QHJ9
Secondary accession number(s): Q4VBV6, Q8QHJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families