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Q8QHJ9

- I17RD_DANRE

UniProt

Q8QHJ9 - I17RD_DANRE

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Protein

Interleukin-17 receptor D

Gene

il17rd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation.2 Publications

GO - Biological processi

  1. dorsal/ventral pattern formation Source: ZFIN
  2. inactivation of MAPK activity Source: ZFIN
  3. negative regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor D
Short name:
IL-17 receptor D
Short name:
IL-17RD
Alternative name(s):
Similar expression to FGF genes protein
Short name:
Sef
Gene namesi
Name:il17rd
Synonyms:cb208, sef
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020320-5. il17rd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 298272ExtracellularSequence AnalysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence AnalysisAdd
BLAST
Topological domaini320 – 745426CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 745719Interleukin-17 receptor DPRO_0000041874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with fgfr1 and fgfr2.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini354 – 518165SEFIRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi448 – 4569Poly-Ser
Compositional biasi698 – 7036Poly-Ser

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45649.
HOGENOMiHOG000060160.
HOVERGENiHBG081777.
InParanoidiQ8QHJ9.
KOiK05167.
PhylomeDBiQ8QHJ9.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QHJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSRRLAHF FMASCLFLCY TASVNGGKRG NSDKCSYKQG TQTSSMDEGA
60 70 80 90 100
RKLGVTFRYD NCSVNWSPLG KHAIHEVNNI SFSHLSCDSQ AAVVVHWMAS
110 120 130 140 150
PLGIEHVKGF RVYLEDKNPE RKQCQHLILK DPRQLNFSYK TIRMSSQPFS
160 170 180 190 200
SLAFETDYMV RIVPFPTFLN DSFFPPSFLR TNSCEVLLGP DNLVCKPFWK
210 220 230 240 250
PKMLNVSQLG SNLHVVFDHA PSTFGFSIYY LYYKLRQEGP FRLKRCKPEQ
260 270 280 290 300
NGPKTTCVLQ DVTPGTYAIE LRDDSNNTRR QTQYHVSQVH SPWAGPIRAM
310 320 330 340 350
AITVPLVIMS AFATLFTVMC RKKQQENIYS HLDEESSESS SQTTALSADR
360 370 380 390 400
PWPRPKIFIC YSSRDGAKHL AVIQSFAFFL QDFCGCEVSL DLWEHLEICK
410 420 430 440 450
EGQMSWLSRR IDEAHFIITV CSKGLKHFVE KRHRKGKATS KEKNREPSAS
460 470 480 490 500
DSSSSSRDLF IVASAIISEK LKEVHQKSSD LSRFMSVYFD YSHETDVPTS
510 520 530 540 550
LSLAPKFKLM DQLPQLFARL HSRQLSLTDR EPQPPNVSKR NYFCSKSGRS
560 570 580 590 600
LYVAIYNMHQ HVTQEPDWLE KELMPPPLPN KRTIPEKVDS GLVLNEVKLK
610 620 630 640 650
HGSESECPPV RSNVLILPQT PQVGVSLSLS REDLGEGSSS QDAGSCRPVL
660 670 680 690 700
HTDGSASPPE MPRDSGIYDS SVPSSELSIP LMDGLSPDHA DNSSLADSVS
710 720 730 740
SSSGLGDEEP PAVSSLHCTA HTICKADLHH QHLHPSEGLI AAAST
Length:745
Mass (Da):83,391
Last modified:September 13, 2005 - v2
Checksum:i6F8998D63D9DA24F
GO

Sequence cautioni

The sequence AAH94998.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → N in AAL76112. (PubMed:11802164)Curated
Sequence conflicti81 – 811S → T in AAL76112. (PubMed:11802164)Curated
Sequence conflicti167 – 1671T → N in AAL78817. (PubMed:11802165)Curated
Sequence conflicti739 – 7391L → F in AAL78817. (PubMed:11802165)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364103 mRNA. Translation: AAL76112.1.
AF401232 mRNA. Translation: AAL78817.1.
BC094998 mRNA. Translation: AAH94998.1. Sequence problems.
RefSeqiNP_705946.1. NM_153660.1.
UniGeneiDr.12379.

Genome annotation databases

GeneIDi171474.
KEGGidre:171474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364103 mRNA. Translation: AAL76112.1 .
AF401232 mRNA. Translation: AAL78817.1 .
BC094998 mRNA. Translation: AAH94998.1 . Sequence problems.
RefSeqi NP_705946.1. NM_153660.1.
UniGenei Dr.12379.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171474.
KEGGi dre:171474.

Organism-specific databases

CTDi 54756.
ZFINi ZDB-GENE-020320-5. il17rd.

Phylogenomic databases

eggNOGi NOG45649.
HOGENOMi HOG000060160.
HOVERGENi HBG081777.
InParanoidi Q8QHJ9.
KOi K05167.
PhylomeDBi Q8QHJ9.

Miscellaneous databases

NextBioi 20797123.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Sef, a novel modulator of FGF signalling."
    Tsang M., Friesel R., Kudoh T., Dawid I.
    Nat. Cell Biol. 4:165-169(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH FGFR1 AND FGFR2.
  2. "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling."
    Fuerthauer M., Lin W., Ang S.-L., Thisse B., Thisse C.
    Nat. Cell Biol. 4:170-174(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441.
    Tissue: Larva.

Entry informationi

Entry nameiI17RD_DANRE
AccessioniPrimary (citable) accession number: Q8QHJ9
Secondary accession number(s): Q4VBV6, Q8QHJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3