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Protein

DNA-dependent protein kinase catalytic subunit

Gene

PRKDC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-351433. ATM mediated phosphorylation of repair proteins.
R-GGA-353423. Non-homologous end joining (NHEJ).

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-dependent protein kinase catalytic subunit (EC:2.7.11.1)
Short name:
DNA-PK catalytic subunit
Short name:
DNA-PKcs
Gene namesi
Name:PRKDC
Synonyms:XRCC7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 41344134DNA-dependent protein kinase catalytic subunitPRO_0000225633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2055 – 20551Phosphoserine; by autocatalysisBy similarity
Modified residuei2609 – 26091Phosphothreonine; by autocatalysisBy similarity
Modified residuei2612 – 26121Phosphoserine; by autocatalysisBy similarity
Modified residuei2638 – 26381Phosphothreonine; by autocatalysisBy similarity
Modified residuei2647 – 26471Phosphothreonine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated on Ser-2055, Thr-2609, Thr-2638 and Thr-2647. Ser-2055 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C. Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8QGX4.
PRIDEiQ8QGX4.

Interactioni

Subunit structurei

DNA-PK is a heterotrimer of PRKDC and the Ku p70/YRCC6-p86/XRCC5 dimer. Formation of this complex may be promoted by interaction with ILF3. Associates with the DNA-bound Ku heterodimer, but it can also bind to and be activated by free DNA. The DNA-PK heterotrimer associates with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex. Additional components of the NHEJ complex include NHEJ1/XLF and PAXX.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024527.

Structurei

3D structure databases

ProteinModelPortaliQ8QGX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati900 – 93738HEAT 1Add
BLAST
Repeati1000 – 103637HEAT 2Add
BLAST
Repeati1050 – 108536HEAT 3Add
BLAST
Repeati1265 – 130541TPR 1Add
BLAST
Repeati1722 – 175534TPR 2Add
BLAST
Repeati2207 – 224034TPR 3Add
BLAST
Domaini2894 – 3545652FATPROSITE-ProRule annotationAdd
BLAST
Domaini3754 – 4021268PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini4102 – 413433FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 3 HEAT repeats.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000168371.
HOVERGENiHBG053681.
InParanoidiQ8QGX4.
KOiK06642.
PhylomeDBiQ8QGX4.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR012582. NUC194.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view]
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF08163. NUC194. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM01344. NUC194. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 9 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QGX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGVQECLQ ELHGCLQPGD AMRGYGLLRG LGEACLTCLA GGALALHVSL
60 70 80 90 100
VFAPERGLLA FVCRSLGVEE FRECREEALK FLCVFLERIG ERAHPYACSL
110 120 130 140 150
KQTCISVYTK ERAAKCKIPA LELLIKLLQS LRRSCLMEEM KVGEIFNKFY
160 170 180 190 200
GELAVRSKIS DTVLEKIYEL LGVLGEVHPA DMINNSEKLF RAYLGELKTQ
210 220 230 240 250
MTSATRVPKL PIVAGCLRGL TALMYNFTKS VDEDAQTSKE IFDFAVKAIR
260 270 280 290 300
PQVDQKRYAV HLAGLQLFSW HAAQFGTLLL DSYVMLFETM CRWCGHTNQE
310 320 330 340 350
LKKAGHNALD SFLKQMSLMV AKDAELHKSK LKFFMEQFYG IIRRMDSSNK
360 370 380 390 400
ELSIAIRGYG LFAAPCKAMH PADVDAMYIE LLQRCKQMYL TEAETIDDHL
410 420 430 440 450
YQLPSFLQSI ASVIFHLDTI PEVYTPVLEH LVVLQINSFP RYSEKMQLVC
460 470 480 490 500
CRSIIKVFLA LSIKGPVLWN FISTVVHQGL IRVFSKPMKF SKDVFGKETS
510 520 530 540 550
GSEEFPESGE VDTARWKVPT YKDYLYLFRS LLSCDTMKES IFEEENFLTG
560 570 580 590 600
NSPLQSLNRL LYDELIKSIL KIIEKLDLTV QKLNVHEQDE NETDSAFIGP
610 620 630 640 650
TSDPASNLQP KKPTDFIAFI NLVEFCRDIL PDKHVEYFQP WVYSFGYELI
660 670 680 690 700
IHSTRLPLIS GFYKLLSVTM KIAKKIKYFE GVGPKSLRKA TEDPEKSSCF
710 720 730 740 750
ALFAKFGKEV TAKMKQYKDE LLASCLNFLL SLPHDIVMLD IKAYIPALQN
760 770 780 790 800
AFKLGLSCTP MADLGLDALE DWSAHIPRHI MQPYYKDVLP LLDGYLKNSA
810 820 830 840 850
TTVEPQNNWE VRKLSRAAQK GFNKIVIQRL RKAKTSSLDD NPSLEAVRTR
860 870 880 890 900
VARLLGSLGG QINHNLITAT SAEEMMKKCV SWDTKNHLSF AVPFADMKPV
910 920 930 940 950
IYLDVFLPRV TDLALSASDR QTKIAACELL HSIVAYMLGK ASQMPERQQG
960 970 980 990 1000
PPPMHQLYKR IFPVLLRLAC DVDQVTRQLY EPLVMQLIHW FTNNKKFESQ
1010 1020 1030 1040 1050
DTVTFLEAIL SGIVDPVDST LRDFCGQCVR EFLKWSIKQT TPKQQEKSPA
1060 1070 1080 1090 1100
NTKSLFKRLY SLALHPSAFK RLGAALAFNS IYREFREENS LVEQFVFEAL
1110 1120 1130 1140 1150
VVFLESLALT HTDEKSLGTT QQCCDAINHL KRIIKHKAPA LNKEGKRRVP
1160 1170 1180 1190 1200
RGFPATKSVC LQDVVMWLLV QCGRPQTECR HKAMELFYEF VPLLPGNNSP
1210 1220 1230 1240 1250
SSWLADVLKK RDVSFLINKF EGGGSDAKSP SGILSQPTLR DMQEPFSLLT
1260 1270 1280 1290 1300
VMRWMDMFLA ALDCYNTFFE LRMIKPHEIL GVNERSSFLE AVDFFLETIA
1310 1320 1330 1340 1350
LHDIHAAEQC FDCRSRGNIF SPQEREVYNY SKCTIIVRIM EFVTMILEIC
1360 1370 1380 1390 1400
QQDFWKLLEK ELLNANFIEL LVMTVCDPSH IGFNTADVQV MKNLPDISVR
1410 1420 1430 1440 1450
LLKALMKSPY KEYLQLCLKK RITPQSFEDL CSVDLFNSDA RFDQVRFSAV
1460 1470 1480 1490 1500
LSACKQLQKS GLLHSVLHSQ DERPHPSIGS KLLSVVYKSI APGSERSSLP
1510 1520 1530 1540 1550
AVDISSKRLA DRLLQLAFAI DDQCEELVSL LLNTVVLSVP LSKASERNFV
1560 1570 1580 1590 1600
DFSHGQYFYS LFSDTINQQL LKNLDVIVIH LMESSVSNPQ MVGSILNGML
1610 1620 1630 1640 1650
DQSFRERTIR KQQGVKLVTA VLRNWKRLDS WWAKDSSPES KMAVLTLLAK
1660 1670 1680 1690 1700
VLQIDSSVSF NTSHEAFTAV FDTYTSLLTD QNLGLNLKGH AVIILPFFTN
1710 1720 1730 1740 1750
LSGEKLHDLK NALDQLVAFN FPMSSDEFPK GTLKHNNYVD CTKKFLDALE
1760 1770 1780 1790 1800
LSQSPMLLQL MTEVLCRDHR HSMEDLFQAS FKRISRRSST DKQVVLLDTV
1810 1820 1830 1840 1850
HKMFQNEDLL SNIVRQAFVD RSLLTLMSHC SLDALREFFC KIIVQAMDTL
1860 1870 1880 1890 1900
NSRFTKSNEC VFDTQITKKM GYYKMLEVMY IRLSKDDVHS KDSKINQAYR
1910 1920 1930 1940 1950
GSVSVEGNEL TKALIKLCYD AFTENMAGEN QLLEKRRQYH CAAYNCAIAV
1960 1970 1980 1990 2000
ISCVFTESKF YQGFLFTEKS EKNLLIFENL IDLKRQYVFP VEIEVPLERK
2010 2020 2030 2040 2050
KRYIAIRKEA REAWNDGQDE PKYLASASYM MDSSLSEEMS QFDFSTGVQG
2060 2070 2080 2090 2100
FSYSSQDVTA SSAHFRRKET SEYMVLNDEM ELEMDELNQH ECMAPLTTLI
2110 2120 2130 2140 2150
KHMQRNQITP KVEEGVIPVD LPLWMKFLHS KLGNPSVPLN IRLFIAKLIV
2160 2170 2180 2190 2200
NTEDVFRPYA KQWLGPMLQL VVSGDNGGEG IHYMVVEIAV TVLSWTSVTT
2210 2220 2230 2240 2250
PKGNIKDEIL ANRLLEFLMK NAFHQKRAVF RHNLEIIKTV IECWKNCLSI
2260 2270 2280 2290 2300
PYSLIFEKFS SGDPDTKDNS VGIQLLGIVL ANNLPPFDLK CEIDRVRYFQ
2310 2320 2330 2340 2350
ALVSNMGLLR YKEVYAAAAE VLGLALQYIA ERQNILEDPV YDCVIKQLKR
2360 2370 2380 2390 2400
HQNTQQDKFI ICLNKVVKNF PPLADRFMNA VFFLIPKLHG VMKNYCLEVI
2410 2420 2430 2440 2450
MCRAEEIPDL YLQLKSKDFI QIMKHRDDER QRVCLDIIYK MLSTLKPPEL
2460 2470 2480 2490 2500
KELLPGVTGF ISHPSVICRQ RMYDILMWIY DNYSDPESQA DGDSQEVLSL
2510 2520 2530 2540 2550
AKEILLQGLI DENAELQLIV RNFWSDETRL PANILDRMLM LLNSLYSAKI
2560 2570 2580 2590 2600
ETQYLSLITN FLLEMTSKSP DYSRKIFEHP LSECKFHDFV IDSSWRYRST
2610 2620 2630 2640 2650
MLTPMFVETQ ASQSTNRNSS QERSLSISGS VGGRVRATQR QYEFTPTQNV
2660 2670 2680 2690 2700
SGRSSFNWLT GNSIDTLAEY TVPSSSESLS SSMLLVNKRS EKFKQAAFKP
2710 2720 2730 2740 2750
VGPDFGKKRL SLPGDKVDSK TKGIDERAEI LRLRRRFLKD QEKVSLIYAR
2760 2770 2780 2790 2800
KGVAEQKREK EMKSELKMKF DGQVTLYRSY RVGDLPDIQI EHCSLIAPLQ
2810 2820 2830 2840 2850
GLAQKDPTFA KQLFSSLFGG IFCEVKKSKI PSEKKAIIQK LLKDFNHFLS
2860 2870 2880 2890 2900
TSVSYFPPFI ACIQEISYKH RELLELDSAN VSTSCLASLQ QPVGILLLEH
2910 2920 2930 2940 2950
ALMALSPAEE PPSKRMRGRT ELPPDVVKWL ELAKLYRSLG DYDVLRGIFS
2960 2970 2980 2990 3000
GKIGTKDITQ QALLAEARSD YAEAAKCYDE ALSKEDWEDG EPTEAEKDFW
3010 3020 3030 3040 3050
ELASLECYDH LTEWKSLEYC ATVNIDSGKP PDLNKTWSDP FYQETYLPYI
3060 3070 3080 3090 3100
IRSKLKLLLN GENDQTLLTF IDEAMKTEQK KALIEMHYSQ ELSLLYILQD
3110 3120 3130 3140 3150
DFDRAKYYIG NGIQIFMQSY SSIDTLLYQS RMSKLQSVQA LTEIQDFINF
3160 3170 3180 3190 3200
MTKTSNIASQ AKSLKRLLRT WTSRYPDAKM DPMNIWDDII TNRCFFLDKL
3210 3220 3230 3240 3250
QEKFLCDKAN DSMEVDEESS VGDQMEVDQQ DEDIHSMIRS CKFNMKLKMI
3260 3270 3280 3290 3300
ESARKQNSFS IAKKLLKGLR REAKTREDWL VRWNYAYCRF VHSCSQSQSC
3310 3320 3330 3340 3350
PERVLSVLKT ISLLEDTKSD YLNKNIMAFR NQNLLLGTTY HIMANALSQD
3360 3370 3380 3390 3400
PKCCEQIEEE KTGKILELSG ESSESPEKIL AGLNKRAFQC FSSAARKSEE
3410 3420 3430 3440 3450
EVQSLSMEHV DVKGVIDAYM TLVGFCDQHL RKEEEGSLEI NAADLQLFPA
3460 3470 3480 3490 3500
IVVEKMIKAL KLNSREARLR FPRLLQIIER YPAETLGLVT RELPSVPCWQ
3510 3520 3530 3540 3550
FIGWISQMMA LLDKDEAVAV QHTVEEIVDT YPQAIIYPFT ISSESYCFKD
3560 3570 3580 3590 3600
TAAGCRNKEF VASIKNKLDR GGVVQDFIHA LEQLSNPVML FKDWVADVRN
3610 3620 3630 3640 3650
ELVKTQRNKI ILKEMYEGMY KNLGDVKAPG LGWLRKRFVQ AFGKDFDSHF
3660 3670 3680 3690 3700
GKGGSKLLDM KISDFNEITT ALLTKMNKTH KEPGNLKECS PWMSEFRAEF
3710 3720 3730 3740 3750
LRNELEVPGQ YDGKGKPLPE YHVKISGFDE RIMVLESLRK PKRITIRGSD
3760 3770 3780 3790 3800
EQEHPFLVKG GEDLRQDQRI EQLFDVMNIV LSRDAACSQR NMQLKTYQVI
3810 3820 3830 3840 3850
PMTTRLGLIK WLENTCTLKE FLRNSMTEEE DANYNSLKGP RAAYSDWLSK
3860 3870 3880 3890 3900
MGGKAQGLSR YNAMYKNASR TETVIAFKSR ESSVPEDLLR RAFVKMSTSP
3910 3920 3930 3940 3950
EAFLALRSHF VSSHALMCVS HWILGIGDRH LSNFMINKET GGMVGIDFGH
3960 3970 3980 3990 4000
AFGSATQFLP VPELMPFRLT RQFVNLMMPV KEWGLIYSVM VHALRAYRAD
4010 4020 4030 4040 4050
PDLLISTMDV FVKEPSLDWK NFEQRQLKKG GTWIKEINTA EVNWYPLQKV
4060 4070 4080 4090 4100
SYVKRKLTGA NPARITCDEL RLGYEKLPFY NDFAAVARGS ADHNIRAKEP
4110 4120 4130
EDRLSEETQV RCLIDQATDP NLLGRVWEGW EPWM
Length:4,134
Mass (Da):472,657
Last modified:June 1, 2002 - v1
Checksum:i8907B1EA6E7E9AA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3796 – 38049TYQVIPMTT → VHISEYFCS in AAB41106 (Ref. 3) Curated
Sequence conflicti3965 – 39684MPFR → DALP in AAB41106 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016240 mRNA. Translation: BAA36956.1.
AB028136 Genomic DNA. Translation: BAB91148.1.
U83109 mRNA. Translation: AAB41106.1.
RefSeqiNP_989989.2. NM_204658.2.
UniGeneiGga.189.

Genome annotation databases

GeneIDi395376.
KEGGigga:395376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016240 mRNA. Translation: BAA36956.1.
AB028136 Genomic DNA. Translation: BAB91148.1.
U83109 mRNA. Translation: AAB41106.1.
RefSeqiNP_989989.2. NM_204658.2.
UniGeneiGga.189.

3D structure databases

ProteinModelPortaliQ8QGX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024527.

Proteomic databases

PaxDbiQ8QGX4.
PRIDEiQ8QGX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395376.
KEGGigga:395376.

Organism-specific databases

CTDi5591.

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000168371.
HOVERGENiHBG053681.
InParanoidiQ8QGX4.
KOiK06642.
PhylomeDBiQ8QGX4.

Enzyme and pathway databases

ReactomeiR-GGA-351433. ATM mediated phosphorylation of repair proteins.
R-GGA-353423. Non-homologous end joining (NHEJ).

Miscellaneous databases

PROiQ8QGX4.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR012582. NUC194.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
[Graphical view]
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF08163. NUC194. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM01344. NUC194. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 9 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphocyte.
  2. "Sequence analysis of 193.4 and 83.9 kbp of mouse and chicken genomic DNAs containing the entire Prkdc (DNA-PKcs) gene."
    Fujimori A., Hashimoto H., Araki R., Saito T., Sato S., Kasama Y., Tsutsumi Y., Mori M., Fukumura R., Ohhata T., Tatsumi K., Abe M.
    Radiat. Res. 157:298-305(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Nucleotide sequence of a putative member of the chicken phosphatidylinositol 3-kinase family."
    Wang H., Meury L., Morais R.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3796-3968.
    Strain: White leghorn.

Entry informationi

Entry nameiPRKDC_CHICK
AccessioniPrimary (citable) accession number: Q8QGX4
Secondary accession number(s): P79791, Q9DEI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.