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Q8QGQ8

- PER2_CHICK

UniProt

Q8QGQ8 - PER2_CHICK

Protein

Period circadian protein homolog 2

Gene

PER2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation By similarity.By similarity

    GO - Molecular functioni

    1. signal transducer activity Source: InterPro

    GO - Biological processi

    1. circadian rhythm Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Period circadian protein homolog 2
    Short name:
    cPER2
    Alternative name(s):
    Circadian clock protein PERIOD 2
    Gene namesi
    Name:PER2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13441344Period circadian protein homolog 2PRO_0000261154Add
    BLAST

    Proteomic databases

    PaxDbiQ8QGQ8.
    PRIDEiQ8QGQ8.

    Expressioni

    Inductioni

    Exhibits circadian rhythm expression. Peak levels in early morning and low levels at early night.1 Publication

    Interactioni

    Subunit structurei

    Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins. Interacts directly with PER3, and through a C-terminal domain, with CRY1 and CRY2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8QGQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini231 – 29868PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini371 – 43767PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 48844PACAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni530 – 5345Important for protein stabilityBy similarity
    Regioni610 – 832223CSNK1E binding domainBy similarityAdd
    BLAST
    Regioni1244 – 1344101CRY binding domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi161 – 17010Nuclear export signal 1By similarity
    Motifi358 – 3625LXXLL
    Motifi512 – 52110Nuclear export signal 3By similarity
    Motifi851 – 86515Nuclear localization signalBy similarityAdd
    BLAST
    Motifi1138 – 11425LXXLL

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi78 – 15275Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG253593.
    HOGENOMiHOG000231111.
    HOVERGENiHBG008167.
    InParanoidiQ8QGQ8.
    KOiK02633.
    PhylomeDBiQ8QGQ8.

    Family and domain databases

    InterProiIPR001610. PAC.
    IPR000014. PAS.
    IPR022728. Period_circadian-like_C.
    [Graphical view]
    PfamiPF12114. Period_C. 1 hit.
    [Graphical view]
    SMARTiSM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    PROSITEiPS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8QGQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDCIEVRGFY SSTEEQNPEQ QADISENISS LFSLKEQQKM SEYSGLASNH     50
    SQMIAEDSEI QPKPEHSPEV LQEDIEMSSG SSGNDFSGNE TNENYSSGHD 100
    SHGHESDENG KDSAMLMESS DCHKSSSSNA FSLMIANSEH NQSSSGCSSE 150
    QSTKAKTQKE LLKTLQELKA HLPAEKRIKG KSSVLTTLKY ALKSIKQVKA 200
    NEEYYQLLMI NESQPSGLNV SSYTVEEVET ITSEYIMKNA DMFAVAVSLI 250
    TGKIVYISDQ AAAILRCKRS YFKNAKFVEL LAPQDVSVFY TSTTPYRLPS 300
    WNICSRAESS TQDCMEEKSF FCRISAGKER ENEICYHPFR MTPYLIKVQD 350
    PEVAEDQLCC VLLAEKVHSG YEAPRIPPDK RIFTTTHTPT CLFQDVDERA 400
    VPLLGYLPQD LIGTPVLVHL HPNDRPLMLA IHKKILQYGG QPFDYSPIRF 450
    CTRNGDYITM DTSWSSFINP WSRKVSFIIG RHKVRTGPLN EDVFAAPNYT 500
    EDRILHPSVQ EITEQIYRLL LQPVHNSGSS GYGSLGSNGS HEHLMSVASS 550
    SDSTGNNNDD TQKDKTISQD ARKVKTKGQH IFTENKGKLE YKREPSAEKQ 600
    NGPGGQVKDV IGKDTTATAA PKNVATEELA WKEQPVYSYQ QISCLDSVIR 650
    YLESCNVPGT AKRKCEPSSS VNSSVHEQKA SVNAIQPLGD STVLKSSGKS 700
    SGPPVVGAHL TSLALPGKPE SVVSLTSQCS YSSTIVHVGD KKPQPELEMI 750
    EDGPSGAEVL DTQLPAPPPS STHVNQEKES FKKLGLTKEV LAVHTQKEEQ 800
    SFLNKFKEIK RFNIFQSHCN YYLQDKPKGR PGERGGRGQR NGTSGMDQPW 850
    KKSGKNRKSK RIKPQESSDS TTSGTKFPHR FPLQGLNTTA WSPSDTSQAS 900
    YSAMSFPTVM PAYPLPVFPA AAGTVPPAPE TSVSGFNQLP DSGNTCSMQP 950
    SQFSAPLMTP VVALVLPNYV YPEMNNSLPQ TLYHSQANFP THPAFSSQTV 1000
    FPAQPPFTTP SPFPQQAFFP MQPFHYNPPA EIEKVPVTET RNEPSRSCTP 1050
    QSVGPQDQAS PPLFQSRCSS PLNLLQLEEN TKTVESGAPA GLHGALNEEG 1100
    TIGKIMTTDA GSGKGSLPAE SPMDAQNSDA LSMSSVLLDI LLQEDACSGT 1150
    GSASSGSGVS AAAESLGSGS NGCDMSGSRT GSSETSHTSK YFGSIDSSEN 1200
    HHKTKMKAEI EESEHFIKYV LQDPIWLLMA NTDDTVMMTY QLPSRDLETV 1250
    LKEDKLKLKQ MQKLQPKFTE DQKRELIEVH PWIQQGGLPK TVANSECIFC 1300
    EDNIQSNFYT SYDEEIHEMD LNEMIEDSGE NNLVPLSQVN EEQT 1344
    Length:1,344
    Mass (Da):147,942
    Last modified:June 1, 2002 - v1
    Checksum:iA34EC8265066A2A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF246956 mRNA. Translation: AAL98705.1.
    RefSeqiNP_989593.1. NM_204262.1.
    UniGeneiGga.39390.

    Genome annotation databases

    GeneIDi374116.
    KEGGigga:374116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF246956 mRNA. Translation: AAL98705.1 .
    RefSeqi NP_989593.1. NM_204262.1.
    UniGenei Gga.39390.

    3D structure databases

    ProteinModelPortali Q8QGQ8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8QGQ8.
    PRIDEi Q8QGQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374116.
    KEGGi gga:374116.

    Organism-specific databases

    CTDi 8864.

    Phylogenomic databases

    eggNOGi NOG253593.
    HOGENOMi HOG000231111.
    HOVERGENi HBG008167.
    InParanoidi Q8QGQ8.
    KOi K02633.
    PhylomeDBi Q8QGQ8.

    Miscellaneous databases

    NextBioi 20813632.
    PROi Q8QGQ8.

    Family and domain databases

    InterProi IPR001610. PAC.
    IPR000014. PAS.
    IPR022728. Period_circadian-like_C.
    [Graphical view ]
    Pfami PF12114. Period_C. 1 hit.
    [Graphical view ]
    SMARTi SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    PROSITEi PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation."
      Okano T., Yamamoto K., Okano K., Hirota T., Kasahara T., Sasaki M., Takanaka Y., Fukada Y.
      Genes Cells 6:825-836(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
      Tissue: Pineal gland.

    Entry informationi

    Entry nameiPER2_CHICK
    AccessioniPrimary (citable) accession number: Q8QGQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3