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Q8QGQ8 (PER2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Period circadian protein homolog 2

Short name=cPER2
Alternative name(s):
Circadian clock protein PERIOD 2
Gene names
Name:PER2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation By similarity. Ref.1

Subunit structure

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins. Interacts directly with PER3, and through a C-terminal domain, with CRY1 and CRY2 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 By similarity.

Induction

Exhibits circadian rhythm expression. Peak levels in early morning and low levels at early night. Ref.1

Sequence similarities

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13441344Period circadian protein homolog 2
PRO_0000261154

Regions

Domain231 – 29868PAS 1
Domain371 – 43767PAS 2
Domain445 – 48844PAC
Region530 – 5345Important for protein stability By similarity
Region610 – 832223CSNK1E binding domain By similarity
Region1244 – 1344101CRY binding domain By similarity
Motif161 – 17010Nuclear export signal 1 By similarity
Motif358 – 3625LXXLL
Motif512 – 52110Nuclear export signal 3 By similarity
Motif851 – 86515Nuclear localization signal By similarity
Motif1138 – 11425LXXLL
Compositional bias78 – 15275Ser-rich

Sequences

Sequence LengthMass (Da)Tools
Q8QGQ8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: A34EC8265066A2A0

FASTA1,344147,942
        10         20         30         40         50         60 
MDCIEVRGFY SSTEEQNPEQ QADISENISS LFSLKEQQKM SEYSGLASNH SQMIAEDSEI 

        70         80         90        100        110        120 
QPKPEHSPEV LQEDIEMSSG SSGNDFSGNE TNENYSSGHD SHGHESDENG KDSAMLMESS 

       130        140        150        160        170        180 
DCHKSSSSNA FSLMIANSEH NQSSSGCSSE QSTKAKTQKE LLKTLQELKA HLPAEKRIKG 

       190        200        210        220        230        240 
KSSVLTTLKY ALKSIKQVKA NEEYYQLLMI NESQPSGLNV SSYTVEEVET ITSEYIMKNA 

       250        260        270        280        290        300 
DMFAVAVSLI TGKIVYISDQ AAAILRCKRS YFKNAKFVEL LAPQDVSVFY TSTTPYRLPS 

       310        320        330        340        350        360 
WNICSRAESS TQDCMEEKSF FCRISAGKER ENEICYHPFR MTPYLIKVQD PEVAEDQLCC 

       370        380        390        400        410        420 
VLLAEKVHSG YEAPRIPPDK RIFTTTHTPT CLFQDVDERA VPLLGYLPQD LIGTPVLVHL 

       430        440        450        460        470        480 
HPNDRPLMLA IHKKILQYGG QPFDYSPIRF CTRNGDYITM DTSWSSFINP WSRKVSFIIG 

       490        500        510        520        530        540 
RHKVRTGPLN EDVFAAPNYT EDRILHPSVQ EITEQIYRLL LQPVHNSGSS GYGSLGSNGS 

       550        560        570        580        590        600 
HEHLMSVASS SDSTGNNNDD TQKDKTISQD ARKVKTKGQH IFTENKGKLE YKREPSAEKQ 

       610        620        630        640        650        660 
NGPGGQVKDV IGKDTTATAA PKNVATEELA WKEQPVYSYQ QISCLDSVIR YLESCNVPGT 

       670        680        690        700        710        720 
AKRKCEPSSS VNSSVHEQKA SVNAIQPLGD STVLKSSGKS SGPPVVGAHL TSLALPGKPE 

       730        740        750        760        770        780 
SVVSLTSQCS YSSTIVHVGD KKPQPELEMI EDGPSGAEVL DTQLPAPPPS STHVNQEKES 

       790        800        810        820        830        840 
FKKLGLTKEV LAVHTQKEEQ SFLNKFKEIK RFNIFQSHCN YYLQDKPKGR PGERGGRGQR 

       850        860        870        880        890        900 
NGTSGMDQPW KKSGKNRKSK RIKPQESSDS TTSGTKFPHR FPLQGLNTTA WSPSDTSQAS 

       910        920        930        940        950        960 
YSAMSFPTVM PAYPLPVFPA AAGTVPPAPE TSVSGFNQLP DSGNTCSMQP SQFSAPLMTP 

       970        980        990       1000       1010       1020 
VVALVLPNYV YPEMNNSLPQ TLYHSQANFP THPAFSSQTV FPAQPPFTTP SPFPQQAFFP 

      1030       1040       1050       1060       1070       1080 
MQPFHYNPPA EIEKVPVTET RNEPSRSCTP QSVGPQDQAS PPLFQSRCSS PLNLLQLEEN 

      1090       1100       1110       1120       1130       1140 
TKTVESGAPA GLHGALNEEG TIGKIMTTDA GSGKGSLPAE SPMDAQNSDA LSMSSVLLDI 

      1150       1160       1170       1180       1190       1200 
LLQEDACSGT GSASSGSGVS AAAESLGSGS NGCDMSGSRT GSSETSHTSK YFGSIDSSEN 

      1210       1220       1230       1240       1250       1260 
HHKTKMKAEI EESEHFIKYV LQDPIWLLMA NTDDTVMMTY QLPSRDLETV LKEDKLKLKQ 

      1270       1280       1290       1300       1310       1320 
MQKLQPKFTE DQKRELIEVH PWIQQGGLPK TVANSECIFC EDNIQSNFYT SYDEEIHEMD 

      1330       1340 
LNEMIEDSGE NNLVPLSQVN EEQT 

« Hide

References

[1]"Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation."
Okano T., Yamamoto K., Okano K., Hirota T., Kasahara T., Sasaki M., Takanaka Y., Fukada Y.
Genes Cells 6:825-836(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
Tissue: Pineal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF246956 mRNA. Translation: AAL98705.1.
RefSeqNP_989593.1. NM_204262.1.
UniGeneGga.39390.

3D structure databases

ProteinModelPortalQ8QGQ8.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ8QGQ8.
PRIDEQ8QGQ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374116.
KEGGgga:374116.

Organism-specific databases

CTD8864.

Phylogenomic databases

eggNOGNOG253593.
HOGENOMHOG000231111.
HOVERGENHBG008167.
InParanoidQ8QGQ8.
KOK02633.
PhylomeDBQ8QGQ8.

Family and domain databases

InterProIPR001610. PAC.
IPR000014. PAS.
IPR022728. Period_circadian-like_C.
[Graphical view]
PfamPF12114. Period_C. 1 hit.
[Graphical view]
SMARTSM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF55785. SSF55785. 1 hit.
PROSITEPS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813632.
PROQ8QGQ8.

Entry information

Entry namePER2_CHICK
AccessionPrimary (citable) accession number: Q8QGQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families