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Q8QGQ8

- PER2_CHICK

UniProt

Q8QGQ8 - PER2_CHICK

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Protein
Period circadian protein homolog 2
Gene
PER2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation By similarity.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. circadian rhythm Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Period circadian protein homolog 2
Short name:
cPER2
Alternative name(s):
Circadian clock protein PERIOD 2
Gene namesi
Name:PER2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13441344Period circadian protein homolog 2
PRO_0000261154Add
BLAST

Proteomic databases

PaxDbiQ8QGQ8.
PRIDEiQ8QGQ8.

Expressioni

Inductioni

Exhibits circadian rhythm expression. Peak levels in early morning and low levels at early night.1 Publication

Interactioni

Subunit structurei

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins. Interacts directly with PER3, and through a C-terminal domain, with CRY1 and CRY2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8QGQ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini231 – 29868PAS 1
Add
BLAST
Domaini371 – 43767PAS 2
Add
BLAST
Domaini445 – 48844PAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni530 – 5345Important for protein stability By similarity
Regioni610 – 832223CSNK1E binding domain By similarity
Add
BLAST
Regioni1244 – 1344101CRY binding domain By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi161 – 17010Nuclear export signal 1 By similarity
Motifi358 – 3625LXXLL
Motifi512 – 52110Nuclear export signal 3 By similarity
Motifi851 – 86515Nuclear localization signal By similarity
Add
BLAST
Motifi1138 – 11425LXXLL

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 15275Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG253593.
HOGENOMiHOG000231111.
HOVERGENiHBG008167.
InParanoidiQ8QGQ8.
KOiK02633.
PhylomeDBiQ8QGQ8.

Family and domain databases

InterProiIPR001610. PAC.
IPR000014. PAS.
IPR022728. Period_circadian-like_C.
[Graphical view]
PfamiPF12114. Period_C. 1 hit.
[Graphical view]
SMARTiSM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8QGQ8-1 [UniParc]FASTAAdd to Basket

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MDCIEVRGFY SSTEEQNPEQ QADISENISS LFSLKEQQKM SEYSGLASNH     50
SQMIAEDSEI QPKPEHSPEV LQEDIEMSSG SSGNDFSGNE TNENYSSGHD 100
SHGHESDENG KDSAMLMESS DCHKSSSSNA FSLMIANSEH NQSSSGCSSE 150
QSTKAKTQKE LLKTLQELKA HLPAEKRIKG KSSVLTTLKY ALKSIKQVKA 200
NEEYYQLLMI NESQPSGLNV SSYTVEEVET ITSEYIMKNA DMFAVAVSLI 250
TGKIVYISDQ AAAILRCKRS YFKNAKFVEL LAPQDVSVFY TSTTPYRLPS 300
WNICSRAESS TQDCMEEKSF FCRISAGKER ENEICYHPFR MTPYLIKVQD 350
PEVAEDQLCC VLLAEKVHSG YEAPRIPPDK RIFTTTHTPT CLFQDVDERA 400
VPLLGYLPQD LIGTPVLVHL HPNDRPLMLA IHKKILQYGG QPFDYSPIRF 450
CTRNGDYITM DTSWSSFINP WSRKVSFIIG RHKVRTGPLN EDVFAAPNYT 500
EDRILHPSVQ EITEQIYRLL LQPVHNSGSS GYGSLGSNGS HEHLMSVASS 550
SDSTGNNNDD TQKDKTISQD ARKVKTKGQH IFTENKGKLE YKREPSAEKQ 600
NGPGGQVKDV IGKDTTATAA PKNVATEELA WKEQPVYSYQ QISCLDSVIR 650
YLESCNVPGT AKRKCEPSSS VNSSVHEQKA SVNAIQPLGD STVLKSSGKS 700
SGPPVVGAHL TSLALPGKPE SVVSLTSQCS YSSTIVHVGD KKPQPELEMI 750
EDGPSGAEVL DTQLPAPPPS STHVNQEKES FKKLGLTKEV LAVHTQKEEQ 800
SFLNKFKEIK RFNIFQSHCN YYLQDKPKGR PGERGGRGQR NGTSGMDQPW 850
KKSGKNRKSK RIKPQESSDS TTSGTKFPHR FPLQGLNTTA WSPSDTSQAS 900
YSAMSFPTVM PAYPLPVFPA AAGTVPPAPE TSVSGFNQLP DSGNTCSMQP 950
SQFSAPLMTP VVALVLPNYV YPEMNNSLPQ TLYHSQANFP THPAFSSQTV 1000
FPAQPPFTTP SPFPQQAFFP MQPFHYNPPA EIEKVPVTET RNEPSRSCTP 1050
QSVGPQDQAS PPLFQSRCSS PLNLLQLEEN TKTVESGAPA GLHGALNEEG 1100
TIGKIMTTDA GSGKGSLPAE SPMDAQNSDA LSMSSVLLDI LLQEDACSGT 1150
GSASSGSGVS AAAESLGSGS NGCDMSGSRT GSSETSHTSK YFGSIDSSEN 1200
HHKTKMKAEI EESEHFIKYV LQDPIWLLMA NTDDTVMMTY QLPSRDLETV 1250
LKEDKLKLKQ MQKLQPKFTE DQKRELIEVH PWIQQGGLPK TVANSECIFC 1300
EDNIQSNFYT SYDEEIHEMD LNEMIEDSGE NNLVPLSQVN EEQT 1344
Length:1,344
Mass (Da):147,942
Last modified:June 1, 2002 - v1
Checksum:iA34EC8265066A2A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF246956 mRNA. Translation: AAL98705.1.
RefSeqiNP_989593.1. NM_204262.1.
UniGeneiGga.39390.

Genome annotation databases

GeneIDi374116.
KEGGigga:374116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF246956 mRNA. Translation: AAL98705.1 .
RefSeqi NP_989593.1. NM_204262.1.
UniGenei Gga.39390.

3D structure databases

ProteinModelPortali Q8QGQ8.
ModBasei Search...

Proteomic databases

PaxDbi Q8QGQ8.
PRIDEi Q8QGQ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374116.
KEGGi gga:374116.

Organism-specific databases

CTDi 8864.

Phylogenomic databases

eggNOGi NOG253593.
HOGENOMi HOG000231111.
HOVERGENi HBG008167.
InParanoidi Q8QGQ8.
KOi K02633.
PhylomeDBi Q8QGQ8.

Miscellaneous databases

NextBioi 20813632.
PROi Q8QGQ8.

Family and domain databases

InterProi IPR001610. PAC.
IPR000014. PAS.
IPR022728. Period_circadian-like_C.
[Graphical view ]
Pfami PF12114. Period_C. 1 hit.
[Graphical view ]
SMARTi SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 1 hit.
PROSITEi PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation."
    Okano T., Yamamoto K., Okano K., Hirota T., Kasahara T., Sasaki M., Takanaka Y., Fukada Y.
    Genes Cells 6:825-836(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    Tissue: Pineal gland.

Entry informationi

Entry nameiPER2_CHICK
AccessioniPrimary (citable) accession number: Q8QGQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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