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Protein

Carboxypeptidase Z

Gene

CPZ

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves substrates with C-terminal arginine residues. Modulates the Wnt signaling pathway, probably by cleaving some undefined protein. Regulates the development of skeletal elements during development, probably by activating WNT4.1 Publication

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi245Zinc; catalyticBy similarity1
Metal bindingi248Zinc; catalyticBy similarity1
Metal bindingi377Zinc; catalyticBy similarity1
Active sitei469Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Developmental protein, Hydrolase, Metalloprotease, Protease
Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM14.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Z (EC:3.4.17.-)
Short name:
CPZ
Short name:
cCPZ
Gene namesi
Name:CPZ
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025245919 – 647Carboxypeptidase ZAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 106PROSITE-ProRule annotation
Disulfide bondi48 ↔ 99PROSITE-ProRule annotation
Disulfide bondi90 ↔ 126PROSITE-ProRule annotation
Disulfide bondi115 ↔ 154PROSITE-ProRule annotation
Disulfide bondi119 ↔ 143PROSITE-ProRule annotation
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8QGP3.

Expressioni

Tissue specificityi

In the early embryo it is initially expressed throughout the somites and subsequently becomes restricted to the sclerotome. Expressed in somites, paraxial head mesoderm and apical ectodermal ridge.1 Publication

Interactioni

Subunit structurei

Interacts with WNT4 vie its FZ domain.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025103.

Structurei

3D structure databases

ProteinModelPortaliQ8QGP3.
SMRiQ8QGP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 157FZPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649. Eukaryota.
ENOG410XX0H. LUCA.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ8QGP3.
PhylomeDBiQ8QGP3.

Family and domain databases

CDDicd03867. M14_CPZ. 1 hit.
InterProiView protein in InterPro
IPR008969. CarboxyPept-like_regulatory.
IPR020067. Frizzled_dom.
IPR034239. M14_CPZ_CPD.
IPR000834. Peptidase_M14.
PfamiView protein in Pfam
PF01392. Fz. 1 hit.
PF00246. Peptidase_M14. 1 hit.
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM00631. Zn_pept. 1 hit.
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS50038. FZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QGP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPSLLLLLT GLFRATEPAP RCETGQETLG QCQTAQKAKC VDISLSSCTD
60 70 80 90 100
VTYTQTMYPN FLDQKSREVI EYSSEYILIS VLHNLLQGEC NPDLRLLGCS
110 120 130 140 150
VLAPQCEKDK VIKPCRHVCE NLKKNCLSAF DAIDMAWPYF LDCDRFFAGE
160 170 180 190 200
EEGCFDPLAK LRGEVAVEED LPSDFPATFI QFKHHSYSQM VSTLKKTASR
210 220 230 240 250
CSHIATTYSI GRSFEGKDLF VIEFSTKPGH HELLKPEFKY IGNMHGNEVV
260 270 280 290 300
GKELLYTLRS ICVQKYLLGN PRIQTLINNT RIHLLPSLNP DGYERAAEEG
310 320 330 340 350
AGYNGWVIGR QTAQNLDLNR NFPDLTSEAY RRAGIRGARL DHIPIPQSYW
360 370 380 390 400
WGKVAPETKA VMKWMRSIPF VLSASLHGGE LVVTYPYDYS RHPMEEKEFS
410 420 430 440 450
PTPDEKMFKM LAKAYADAHP VISDRSEHRC GGNFVKRGGI INGAEWYSFT
460 470 480 490 500
GGMADFNYLH TNCFEVTVEV GCEKFPLEEE LFTIWHENRD ALLNYMEMVH
510 520 530 540 550
RGIKGIVSDK FGNPIKNARI SVRGIQHDIT TAADGDYWRL LPPGTYIVTA
560 570 580 590 600
QAMGYTKVMK RVTLPIKMKR AGRVDFVLRP IEIWPNKLLR RPMEDMYDQY
610 620 630 640
DPLELFDPHA QHAQARGGSQ QVREKPWWWS YFSSLDLHKP LWLLKQH
Length:647
Mass (Da):73,919
Last modified:June 1, 2002 - v1
Checksum:i8624E514B6E9F514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351205 mRNA. Translation: AAL84280.1.
UniGeneiGga.3745.

Similar proteinsi

Entry informationi

Entry nameiCBPZ_CHICK
AccessioniPrimary (citable) accession number: Q8QGP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families