Q8QGH2 (SUMO1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small ubiquitin-related modifier 1
Short name=SUMO-1

Gene names

Name:	SUMO1
ORF Names:	RCJMB04_2j18

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins By similarity.
Subunit structure	Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Covalently attached to a number of proteins By similarity.
Subcellular location	Nucleus. Cytoplasm By similarity.
Post-translational modification	Cleavage of precursor form by a sentrin-specific protease is necessary for function By similarity.
Sequence similarities	Belongs to the ubiquitin family. SUMO subfamily. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
PTM	Isopeptide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 97	97	Small ubiquitin-related modifier 1		PRO_0000267614
	Propeptide	98 – 101	4	By similarity		PRO_0000267615
Regions
	Domain	20 – 97	78	Ubiquitin-like
Amino acid modifications
	Cross-link	97		Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8QGH2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 9415E7C69554FB33	FASTA	101	11,557
	10 20 30 40 50 60 MSDQEAKPSA EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN 70 80 90 100 SLRFLFEGQR ITDNHTPKEL GMEEEDVIEV YQEQTGGHST V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein-protein interactions of Kvbeta." Venkataramu C.R., Sokolowski B.H.A. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Inner ear.
[2]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF461015 mRNA. Translation: AAL85281.1. AJ719470 mRNA. Translation: CAG31129.1.
IPI	IPI00592480.
RefSeq	NP_989466.1. NM_204135.2.
UniGene	Gga.8466.
3D structure databases
HSSP	HSSP built from PDB template 1Y8R based on UniProtKB P63165.
ProteinModelPortal	Q8QGH2.
SMR	Q8QGH2. Positions 1-101.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8QGH2.
Proteomic databases
PRIDE	Q8QGH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	373930.
KEGG	gga:373930.
Organism-specific databases
CTD	7341.
Phylogenomic databases
eggNOG	veNOG20926.
GeneTree	ENSGT00390000018808.
HOGENOM	HBG436396.
HOVERGEN	HBG053025.
InParanoid	Q8QGH2.
OrthoDB	EOG42JNSX.
PhylomeDB	Q8QGH2.
Family and domain databases
InterPro	IPR022617. SUMO. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
KO	K12160.
Pfam	PF11976. Rad60-SLD. 1 hit. [Graphical view]
SMART	SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUMO1_CHICK

Accession

Primary (citable) accession number: Q8QGH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 1, 2002
Last modified:	November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program