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Protein

Small ubiquitin-related modifier 1

Gene

SUMO1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-GGA-3065679. SUMO is proteolytically processed.
R-GGA-3108214. SUMOylation of DNA damage response and repair proteins.
R-GGA-3232118. SUMOylation of transcription factors.
R-GGA-4570464. SUMOylation of RNA binding proteins.
R-GGA-4615885. SUMOylation of DNA replication proteins.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5693571. Nonhomologous End-Joining (NHEJ).
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-69473. G2/M DNA damage checkpoint.
R-GGA-877312. Regulation of IFNG signaling.
R-GGA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 1
Short name:
SUMO-1
Gene namesi
Name:SUMO1
ORF Names:RCJMB04_2j18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity
  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676141 – 97Small ubiquitin-related modifier 1Add BLAST97
PropeptideiPRO_000026761598 – 101By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond

Proteomic databases

PaxDbiQ8QGH2.

Expressioni

Gene expression databases

BgeeiENSGALG00000008435.

Interactioni

Subunit structurei

Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Covalently attached to a number of proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013729.

Structurei

3D structure databases

ProteinModelPortaliQ8QGH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 97Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ8QGH2.
KOiK12160.
OMAiTDNHTPK.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ8QGH2.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiIPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QGH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQEAKPSA EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES
60 70 80 90 100
YCQRQGVPMN SLRFLFEGQR ITDNHTPKEL GMEEEDVIEV YQEQTGGHST

V
Length:101
Mass (Da):11,557
Last modified:June 1, 2002 - v1
Checksum:i9415E7C69554FB33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461015 mRNA. Translation: AAL85281.1.
AJ719470 mRNA. Translation: CAG31129.1.
RefSeqiNP_989466.1. NM_204135.2.
UniGeneiGga.8466.

Genome annotation databases

EnsembliENSGALT00000013744; ENSGALP00000013729; ENSGALG00000008435.
GeneIDi373930.
KEGGigga:373930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461015 mRNA. Translation: AAL85281.1.
AJ719470 mRNA. Translation: CAG31129.1.
RefSeqiNP_989466.1. NM_204135.2.
UniGeneiGga.8466.

3D structure databases

ProteinModelPortaliQ8QGH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013729.

Proteomic databases

PaxDbiQ8QGH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013744; ENSGALP00000013729; ENSGALG00000008435.
GeneIDi373930.
KEGGigga:373930.

Organism-specific databases

CTDi7341.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ8QGH2.
KOiK12160.
OMAiTDNHTPK.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ8QGH2.

Enzyme and pathway databases

ReactomeiR-GGA-3065679. SUMO is proteolytically processed.
R-GGA-3108214. SUMOylation of DNA damage response and repair proteins.
R-GGA-3232118. SUMOylation of transcription factors.
R-GGA-4570464. SUMOylation of RNA binding proteins.
R-GGA-4615885. SUMOylation of DNA replication proteins.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5693571. Nonhomologous End-Joining (NHEJ).
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-69473. G2/M DNA damage checkpoint.
R-GGA-877312. Regulation of IFNG signaling.
R-GGA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Miscellaneous databases

PROiQ8QGH2.

Gene expression databases

BgeeiENSGALG00000008435.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiIPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO1_CHICK
AccessioniPrimary (citable) accession number: Q8QGH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.