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Protein

Small ubiquitin-related modifier 1

Gene

SUMO1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-GGA-3065676. SUMO is conjugated to E1 (UBA2:SAE1).
R-GGA-3065678. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
R-GGA-3065679. SUMO is proteolytically processed.
R-GGA-3108214. SUMOylation of DNA damage response and repair proteins.
R-GGA-3232118. SUMOylation of transcription factors.
R-GGA-4570464. SUMOylation of RNA binding proteins.
R-GGA-4615885. SUMOylation of DNA replication proteins.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5693571. Nonhomologous End-Joining (NHEJ).
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-69473. G2/M DNA damage checkpoint.
R-GGA-877312. Regulation of IFNG signaling.
R-GGA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 1
Short name:
SUMO-1
Gene namesi
Name:SUMO1
ORF Names:RCJMB04_2j18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity
  • Cell membrane By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676141 – 97Small ubiquitin-related modifier 1Add BLAST97
PropeptideiPRO_000026761598 – 101By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond

Proteomic databases

PaxDbiQ8QGH2.

Expressioni

Gene expression databases

BgeeiENSGALG00000008435.

Interactioni

Subunit structurei

Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Covalently attached to a number of proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013729.

Structurei

3D structure databases

ProteinModelPortaliQ8QGH2.
SMRiQ8QGH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 97Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ8QGH2.
KOiK12160.
OMAiTDNHTPK.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ8QGH2.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiView protein in InterPro
IPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF11976. Rad60-SLD. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8QGH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQEAKPSA EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES
60 70 80 90 100
YCQRQGVPMN SLRFLFEGQR ITDNHTPKEL GMEEEDVIEV YQEQTGGHST

V
Length:101
Mass (Da):11,557
Last modified:June 1, 2002 - v1
Checksum:i9415E7C69554FB33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461015 mRNA. Translation: AAL85281.1.
AJ719470 mRNA. Translation: CAG31129.1.
RefSeqiNP_989466.1. NM_204135.2.
UniGeneiGga.8466.

Genome annotation databases

EnsembliENSGALT00000013744; ENSGALP00000013729; ENSGALG00000008435.
GeneIDi373930.
KEGGigga:373930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461015 mRNA. Translation: AAL85281.1.
AJ719470 mRNA. Translation: CAG31129.1.
RefSeqiNP_989466.1. NM_204135.2.
UniGeneiGga.8466.

3D structure databases

ProteinModelPortaliQ8QGH2.
SMRiQ8QGH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013729.

Proteomic databases

PaxDbiQ8QGH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013744; ENSGALP00000013729; ENSGALG00000008435.
GeneIDi373930.
KEGGigga:373930.

Organism-specific databases

CTDi7341.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ8QGH2.
KOiK12160.
OMAiTDNHTPK.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ8QGH2.

Enzyme and pathway databases

ReactomeiR-GGA-3065676. SUMO is conjugated to E1 (UBA2:SAE1).
R-GGA-3065678. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
R-GGA-3065679. SUMO is proteolytically processed.
R-GGA-3108214. SUMOylation of DNA damage response and repair proteins.
R-GGA-3232118. SUMOylation of transcription factors.
R-GGA-4570464. SUMOylation of RNA binding proteins.
R-GGA-4615885. SUMOylation of DNA replication proteins.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-5693571. Nonhomologous End-Joining (NHEJ).
R-GGA-5693607. Processing of DNA double-strand break ends.
R-GGA-5696395. Formation of Incision Complex in GG-NER.
R-GGA-69473. G2/M DNA damage checkpoint.
R-GGA-877312. Regulation of IFNG signaling.
R-GGA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Miscellaneous databases

PROiPR:Q8QGH2.

Gene expression databases

BgeeiENSGALG00000008435.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiView protein in InterPro
IPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF11976. Rad60-SLD. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO1_CHICK
AccessioniPrimary (citable) accession number: Q8QGH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: May 10, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.