Q8QG74 (BDNF_CYCMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-derived neurotrophic factor
Short name=BDNF

Gene names

Name:

BDNF

Organism

Cyclophiops major (Giant green snake)

Taxonomic identifier

192173 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Colubridae › Colubrinae › Cyclophiops

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 127	109	By similarity		PRO_0000346672
	Chain	128 – 246	119	Brain-derived neurotrophic factor		PRO_5000063074
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Disulfide bond	140 ↔ 207		By similarity
	Disulfide bond	185 ↔ 236		By similarity
	Disulfide bond	195 ↔ 238		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8QG74 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: BA01780349F37856	FASTA	246	27,773
	10 20 30 40 50 60 MTILFLTMVI SYLSCMKATP MKEVSIRGQG SLAYPGLRTQ GNLETLSGPN DATRGLTSLA 70 80 90 100 110 120 DTFEHVIEEL LDERQVIQPS KENKDADLYS SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN 130 140 150 160 170 180 MSMRVRRHSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF 190 200 210 220 230 240 YETKCSTKGY AKEGCRGIDK RYWNSQCRTT QSYVRALTTD NKKRVGWRFI RIDTSCVCTL TIKRGR

References

[1]	"Molecular cloning of brain derived neurotrophic factor gene from amphibians and reptiles and its application in the research of phylogeny and taxonomy." Cao M., Yang Y.H., Zhang Y.Z. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF497715 Genomic DNA. Translation: AAM18716.1.
3D structure databases
HSSP	HSSP built from PDB template 1B8M based on UniProtKB P23560.
ProteinModelPortal	Q8QG74.
SMR	Q8QG74. Positions 135-243.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006494.
Family and domain databases
InterPro	IPR020430. Brain-der_neurotrophic_factor. IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. [Graphical view]
PANTHER	PTHR11589. PTHR11589. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01912. BDNFACTOR. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BDNF_CYCMA

Accession

Primary (citable) accession number: Q8QG74

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	June 1, 2002
Last modified:	October 3, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program